Health status and risk profiles for brain aging of rural‐dwelling older adults: Data from the interdisciplinary baseline assessments in MIND‐China by Yongxiang Wang, Xiaolei Han, Xianda Zhang, Zhonglin Zhang, Lin Cong, Shi Tang, Tingting Hou, Cuicui Liu, Xiaojuan Han, Qinghua Zhang, Jianli Feng, Ling Yin, Lin Song, Yi Dong, Rui Liu, Yuanjing Li, Tiia Ngandu, Miia Kivipelto, Heather Snyder, Maria Carrillo, Jonas Persson, Laura Fratiglioni, Lenore J Launer, Jianping Jia, Yifeng Du, Chengxuan Qiu

“…The baseline assessments consisted of core module and specific modules. Specific modules included brain magnetic resonance imaging (MRI), blood biomarkers, ActiGraph, cardiopulmonary coupling (CPC), pure‐tone audiometry (PTA), and optical coherence tomography (OCT).…”
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Identification of the Kelch family protein Nd1-L as a novel molecular interactor of KRIT1. by Paolo Guazzi, Luca Goitre, Elisa Ferro, Valentina Cutano, Chiara Martino, Lorenza Trabalzini, Saverio Francesco Retta

“…Furthermore, using distinct KRIT1 isoforms and mutants, we defined the role of KRIT1 domains in the Nd1-L/KRIT1 interaction. Finally, functional assays showed that Nd1-L may contribute to the regulation of KRIT1 nucleocytoplasmic shuttling and cooperate with KRIT1 in modulating the expression levels of the antioxidant protein SOD2, opening a novel avenue for future mechanistic studies. …”
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Causal relationships between immune cell subtypes and risk of Pneumocystis pneumonia and lung cancer: a Mendelian randomization study by Zhongqiu Tian, Wenfang Tang, Long Wen, Zhixiong He, Yanyan Fang, Yubin Fan, Yan Peng, Linyan Xu, Bin Li, Xuelian Chen

“…We characterized gene functions using GO analysis, evaluated immune cell infiltration with CIBERSORT/ESTIMATE, and performed weighted gene co-expression network analysis to identify functional gene modules associated with phenotypic traits. …”
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Phenobot: An Autodigital Modeling System for in situ Phenotyping in Horticulture by Kewei Hu, Yaoqiang Pan, Tianhao Liu, Hugh Zhou, Chao Chen, Hanwen Kang

“…This study explores the deployment of emerging robotics and digital technology in plant phenotyping to improve performance and efficiency. Three critical functional modules, environmental understanding, robotic motion planning, and in situ phenotyping, are introduced to automate the entire process. …”
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The A-C linker controls centriole structural integrity and duplication by Lorène Bournonville, Marine. H. Laporte, Susanne Borgers, Paul Guichard, Virginie Hamel

“…Moreover, we uncover an unexpected function of the A-C linker in centriole duplication through torus regulation, underscoring the interplay between these protein modules.…”
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Research and application of key technologies for data delivery in railway engineering design based on metadata by Xiangru Lyu, Xunxiao Yin, Kun Wang, Yongwen Wei

“…The railway engineering collaborative design platform mainly includes functional modules such as metadata management, design collaboration, design delivery management, model component library, model rendering services, and Building Information Modeling (BIM) application services. …”
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Integrated transcriptomics of multiple sclerosis peripheral blood mononuclear cells explored potential biomarkers for the disease by Arman Mokaram Doust Delkhah

“…Methods: After identification of differentially expressed genes (DEGs), functional enrichment analyses were performed, and PPI and miRNA-mRNA regulatory networks were constructed. …”
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SnRK2s: Kinases or Substrates? by Yunmin Wei, Linzhu Peng, Xiangui Zhou

“…While SnRK2 substrates have been extensively identified, the existing literature lacks a systematic classification of these components and their functional implications. This review synthesizes recent advances in characterizing SnRK2-phosphorylated substrates in <i>Arabidopsis thaliana</i>, providing a mechanistic framework for their roles in stress signaling and developmental regulation. …”
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Network heterogeneous information integrated management system based on improved RNN multi-source fusion algorithm by LI Lin, WANG Wei

“…By synchronously integrating and processing the data output from the multi-source fusion model, all data was transmitted to the system database for storage, and the integrated management of multi-source heterogeneous data was completed through the designed functional modules. The experimental results show that the data fusion integrity of the network heterogeneous information integration management system with WHO-RNN multi-source fusion algorithm as the core is maintained at a high level of 0.700~0.800, and as the data volume increases, the ultimate update level (UUL) index gradually approaches 80%. …”
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Demystifying User Needs in Wardrobe Furniture Design: A Network Analysis via Text Mining and DEMATEL-ANP Integration by Xinlian Li, Peijun Jia, Jinyang Xu

“…DEMATEL was employed to quantify the causal intensity and centrality of the identified factors; ANP was subsequently utilized to construct a network hierarchy, revealing the feedback mechanisms between functional modules and user experience. Finally, TOPSIS was applied to rank three design proposals, among which Option 3—featuring flexible space partitioning, auto-sensing lighting, and anti-tip design—was selected as the optimal solution. …”
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A virtual-component-embedded equivalent circuit model for lithium-ion battery state estimation by Zelin Guo, Yiyan Li, Zhenghao Zhou, Chen Zhang, Zheng Yan, Mo-Yuen Chow

“…First, the proposed hybrid modeling strategy is introduced, where a novel Frequency-Domain Multi-Layer Perceptron for Time Series (FreTS) is introduced as the neural network module to be embedded. Second, an iterative offline training strategy is designed to train the hybrid model by merging the battery state space equation into the FreTS modules’ loss function. …”
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Research and analysis of traction converter for EMU based on MBSE by WANG Baomin, YANG Jiuhe, ZHOU Jinxiang, WANG Haifang, CHE Jun

“…The requirements of traction converters were categorized into non-functional requirements and functional ones during the modeling process. …”
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Multi-omics analysis identified macrophages as key contributors to sex-related differences in ulcerative colitis by Xiaojie Fang, Jiahao Yang, Liu Yang, Yiyou Lin, Yanyan Li, Xin Yin, Xiaobing Dou, Chenyun Miao

“…RPS4Y1 expression was positively correlated with resting memory CD4+ T cells and eosinophils and negatively with M0 macrophages and resting mast cells. Macrophage function exhibited sex-based disparities. Increased immune cell infiltration was observed in female colon tissues compared with that in male colon tissues. …”
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Electrical modelling of a grid-connected battery energy storage system via EMS and BMS data by Mirko Ledro, Jan Martin Zepter, Morten Paludan, Mattia Marinelli

“…Finally, the energy capacity and PCS efficiency are reported as a function of the power of the PCS. The usable energy capacity per rack is approx. 59.7kWh, which is 91.5% of the rated DC energy capacity, and it is independent of the power at which the BESS is discharged. …”
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SIGLEC1 has the potential to be an immune-related prognostic indicator in colon adenocarcinoma: a study based on transcriptomic data and Mendelian randomization analysis by Jue Gu, Yaxuan Wang, Hui Zhang, Haijuan Gu, Haixia Zhu

“…Weighted gene coexpression network analysis (WGCNA) was performed to find modules of differentially expressed genes (DEGs) with high correlations followed by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses to determine the function of distant metastasis (M)-stage-related modules. …”
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Unveiling the molecular blueprint of SKP-SCs-mediated tissue engineering-enhanced neuroregeneration by Hui Zhu, Ying Wang, Siyuan Xu, Yunjian Song, Yifan Li, Yiting Wang, Qiuwen Sun, Muyuan Tong, Tianyi Huang, Yulin Pan, Hongkui Wang, Xi Xu, Chengbin Xue

“…This graft has been shown to promote sciatic nerve regeneration and functional restoration to a level comparable to that achieved by autologous nerve grafts, as evidenced by behavioral, histological, and electrophysiological assessments. …”
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Shared transcriptional regulators and network rewiring identify therapeutic targets linking type 2 diabetes mellitus and hypertension by Claudia Desireé Norzagaray-Valenzuela, Claudia Desireé Norzagaray-Valenzuela, Marco Antonio Valdez-Flores, Josue Camberos-Barraza, Josue Camberos-Barraza, Alberto Kousuke De la Herrán-Arita, Juan Fidel Osuna-Ramos, Javier Magaña-Gómez, Carla Angulo-Rojo, Alma Marlene Guadrón-Llanos, Katia Aviña-Padilla, Loranda Calderón-Zamora

“…This study aimed to uncover shared transcriptional programs and disease-specific regulatory networks contributing to cardiometabolic dysfunction.MethodsWe systematically selected transcriptomic datasets and employed an integrative systems biology approach that combined differential gene expression analysis, co-expression network construction, protein-protein interaction mapping, transcription factor activity inference, and network rewiring analysis. Functional enrichment analyses were conducted to elucidate biological processes associated with disease-specific modules.ResultsWe identified distinct regulatory modules: ME3 in T2DM, enriched in metabolic stress response, intracellular trafficking, and inflammation, and ME7 in HTN, enriched in immune response and vascular remodeling. …”
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A New Composite Integrative and Conjugative Element Mediates Multiple Drug Resistance from Streptococcus anginosus to Streptococcus agalactiae by Wang Y, Liu T, Yi S, Zhu Y

“…The conjugation transfer experiment and sequencing results confirmed the cross-species transfer of ICESan 26_rplL to S. agalactiae recipients at a relatively low frequency (2.13 × 10− 8). Moreover, core functional modules were retrieved from GenBank to search for any ICEs related to ICESan 26_rplL. …”
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El Diseño Modular en el contexto del desarrollo de Máquinas Herramienta Reconfigurables. // Modular Design in the development of reconfigurable Machine Tools´ context. by R. Pérez Rodríguez, H. Ahuett Garza, A. Molina Gutiérrez, C. Rodríguez González

“…The methodology takes as input a set of functional requirements and produces a description of the<br />modules that can be used to produce customized Machine Tools.…”
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Digital Fire and Salvage Unit: A New Level of Training for Emercom Cadets by Igor A. Malyj, Vladislav V. Bulgakov, Irina Yu. Sharabanova

“…In addition, the program provides a functional module “Forum” and “Personal messages”, designed for discussion between users of topical issues of training and professional activity.Conclusion. …”
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