Temporal dynamics of neutrophil functions in multiple sclerosis by Shishi Shen, Shilin Wu, Yuge Wang, Li Xiao, Xiaobo Sun, Wenxuan Sun, Yipeng Zhao, Rui Li, Jiaqi Zhang, Zhanhang Wang, Shaoli Zhou, Shixiong Huang, Yanyu Chang, Yaqing Shu, Chen Chen, Zhengqi Lu, Wei Cai, Wei Qiu

“…Neutrophils are forerunners to neural lesions in MS, yet the temporal alterations of their functions in MS remains unclear. This study demonstrated a positive correlation between circulatory neutrophil counts and disease activity and severity in treatment-naïve MS patients. …”
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Distinctive function of Tetraspanins: Implication in viral infections by Yuzhi Zhang, Chengwei Pan, Sijie Wang, Yidan Zhou, Jiawei Chen, Xiaoyu Yu, Ruining Peng, Nu Zhang, Hui Yang

“…Harboring four transmembrane domains in their structural hallmark, Tetraspanins (Tspans) are a family of glycoproteins with pivotal functions in a variety of biological and cellular processes. …”
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Functional architecture of intracellular oscillations in hippocampal dendrites by Zhenrui Liao, Kevin C. Gonzalez, Deborah M. Li, Catalina M. Yang, Donald Holder, Natalie E. McClain, Guofeng Zhang, Stephen W. Evans, Mariya Chavarha, Jane Simko, Christopher D. Makinson, Michael Z. Lin, Attila Losonczy, Adrian Negrean

“…Our data reveal how the organization of electrical signaling in dendrites maps onto the anatomy of the dendritic tree across behavior, oscillatory network, and functional cell states.…”
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A multimodal model for protein function prediction by Yu Mao, WenHui Xu, Yue Shun, LongXin Chai, Lei Xue, Yong Yang, Mei Li

“…Abstract Protein function, which is determined by sequence, structure, and other characteristics, plays a crucial role in an organism’s performance. …”
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Small Nucleolar RNAs: Biological Functions and Diseases by Yi Wang, Min Fu, Zaiyong Zheng, Jianguo Feng, Chunxiang Zhang

“…Here, we provide a comprehensive overview of snoRNAs, encompassing their classification, biogenesis, and both canonical and noncanonical functions. Canonical roles include guiding RNA modifications such as 2′‐O‐methylation, pseudouridylation, and N4‐acetylcytidine modification in targeted RNA molecules, as well as facilitating ribosome biogenesis. …”
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Functional constraints of wtf killer meiotic drivers. by Ananya Nidamangala Srinivasa, Samuel Campbell, Shriram Venkatesan, Nicole L Nuckolls, Jeffrey J Lange, Randal Halfmann, Sarah E Zanders

“…These drivers often employ toxic proteins that target essential cellular functions to cause the destruction of driver- gametes. …”
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Expanded genetic and functional diversity of oceanic fungi by Xuefeng Peng, David L. Valentine

“…Although a few studies utilizing cultivation-based methods and metabarcoding have been conducted, the diversity, ecological roles, and functional activities of fungi in the open ocean remain vastly underexplored. …”
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<i>Gastrodia elata</i>, <i>Polygonatum sibiricum</i>, and <i>Poria cocos</i> as a Functional Food Formula: Cognitive Enhancement via Modulation of Hippocampal Neuroinflammation and Neuroprotection in Sleep-Restricted Mice by Yiwen Zhang, Fang Chen, Xueyan Li, Yanfei Xu, Xinmin Liu, Muhammad Qasim Barkat, Muhammad Iqbal Choudhary, Qi Chang, Ning Jiang

“…These herbs are combined in the Compound Gastrodia elata Formula (CGEF), a functional food formulation. Amidst growing interest in functional foods, this study explores the cognitive-enhancing effects of CGEF, focusing on cognitive function improvement. …”
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Deciphering the Structural and Functional Effects of the R1150W Non-Synonymous Variant in SCN9A Linked to Altered Pain Perception by Faisal A. Al-Allaf, Zainularifeen Abduljaleel, Mohammad Athar

“…By refining SCN9A’s molecular blueprint and highlighting its therapeutic potential as a target for precision analgesics, this work provides a roadmap for mitigating pain-related disorders through channel-specific modulation. Integrating structural bioinformatics with functional genomics, this study deciphers SCN9A’s role in pain biology, laying the groundwork for novel strategies to manage pathological pain.…”
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Interleukin-4 prevents increased endothelial permeability by inducing pericyte survival and modulating microglial responses in diabetic retinopathy by Jang-Hyuk Yun

“…IL-4 promoted pericyte survival via PI3K/AKT activation and modulated microglial functional profiles through STAT6 signaling, favoring an anti-inflammatory phenotype. …”
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Tryptophan metabolic reprogramming modulates cytokine networks in nucleos(t)ide analogue-treated chronic hepatitis B patients by Xuedan Gao, Xuedan Gao, Xuedan Gao, Xiaojuan Wu, Xiaojuan Wu, Xiaojuan Wu, Yi Li, Yi Li, Yi Li, Xinhua Dai, Xinhua Dai, Xinhua Dai, Bei Cai, Bei Cai, Bei Cai

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HPK1 kinase inhibitor: a sufficient approach to target HPK1 to modulate T cell activation in cancer immunotherapy compared with degraders by Qin Wang, Xinyi Zhu, Jing Li, Sanjia Xu, Ali Wang, Xinwen Zhang, Xingxing Wang, Xiaopeng Cai, Haimei Xing, Ye Liu, Xuesong Liu, Zhiwei Wang, Lai Wang, Lai Wang, Xi Yuan

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Efficient Small Object Detection You Only Look Once: A Small Object Detection Algorithm for Aerial Images by Jie Luo, Zhicheng Liu, Yibo Wang, Ao Tang, Huahong Zuo, Ping Han

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Micronized purified flavonoid fraction (daflon) improves sexual function by modulating NF-kB /NO/cGMP and steroidogenic signaling in cisplatin-treated male Wistar rats by Akhigbe RE, Akhigbe TM, Adegbola CA

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Lactate modulates the function of myeloid-derived suppressor cells via Ten-Eleven-Translocation-2-mediated demethylation of glucocorticoid-inducible kinase 1 in lung cancer model by Ying Chu, Ying Chu, Ying Chu, Hua Shen, Hua Shen, Hua Shen, Qiu Li, Qiu Li, Bo Shen, Yan Zhang, Deqiang Wang, Wei Zhu, Wei Zhu, Shengjun Wang, Jie Ma, Jie Ma

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Nano-Biomimetic Fibronectin/Lysostaphin-Co-Loaded Silk Fibroin Dressing Accelerates Full-Thickness Wound Healing via ECM-Mimicking Microarchitecture and Dual-Function Modulation by Liu CT, Huang LD, Liu K, Pang KF, Tang H, Li T, Huang YP, Zhang WQ, Wang JJ, Yin GL, Hua KZ

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The potential role of 1,25(OH)2D3 (Active vitamin D3) in modulating macrophage function; implications for chronic obstructive pulmonary disease (COPD) by Hy Thai, Rei Hassanen, Trevor Whittall, Paul Kirkham

“…Conversely, restoring vitamin D3 levels reduces oxidative damage, suppresses pro-inflammatory gene expression, and improves alveolar macrophage function highlighting its therapeutic potential in modulating inflammation.…”
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Activation of the Innate Immune Checkpoint CLEC5A on Myeloid Cells in the Absence of Danger Signals Modulates Macrophages’ Function but Does Not Trigger the Adaptive T Cell Immune Response by Milena J. Tosiek, Kerstin Groesser, Anton Pekcec, Monika Zwirek, Gavuthami Murugesan, Eric Borges

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Improved MTF Measurement of Medical Flat-Panel Detectors Based on a Slit Model by Haiyang Zhang, Zhiyong Ji

Subjects: “…modulation transfer function (MTF)…”
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Analgesic activity of a new cannabinoid CB₁ receptor modulator by N. V. Gurkin, V. V. Bykov, A. V. Bykova, V. S. Motov, V. V. Larchenko, I. V. Il’ina, V. A. Khazanov, K. P. Volcho, N. F. Salakhutdinov, A. I. Vengerovskii

“…To study the analgesic activity, the effect on motor functions, and the potential ulcerogenic effect of a new 2H-chromene derivative, a cannabinoid CB1 receptor modulator (code name – CHR).Materials and methods. …”
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