Mannan-oligosaccharide modulates gut microbiota and enhances immune-metabolic functions in Chinese mitten crab (Eriocheir sinensis): Insights from an in vitro fermentation model by Wei Li, Shubin Liu, Kaiqi Huang, Xiaoling Zhang, Xiaodan Wang, Jian G. Qin, Liqiao Chen, Erchao Li

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WDJ-S4, a standardized herbal formula, promotes gastrointestinal motility via modulation of the acetylcholine pathway in a loperamide-induced functional dyspepsia mice by Seung-Ju Hwang, Chang-Seob Seo, Dong-Cheol Baek, Tae-Wook Woo, Jing-Hua Wang, Jin-Seok Lee, Yu-Jin Choi, Ji-Yeon Gu, Dong-Seon Kim, Chang-Gue Son

“…Context WDJ-S4, a standardized herbal formula, has been prescribed for refractory functional dyspepsia (FD) in Korea, but the detailed mechanisms are lacking.Objective The present study investigates the acceleration of gastrointestinal (GI) motility by WDJ-S4 and its potential mechanisms.Materials and methods For five days, WDJ-S4 (50, 100 and 200 mg/kg) or mosapride (3 mg/kg) was orally given to BALB/c mice. …”
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Oxygen Concentration Plays a Critical Role in Fibrinogen-Mediated Platelet Activation via Inactivation of α_IIbβ₃ and Modulation of Fibrinogen by Sophie V. L. Leonard, Zoe Booth, Leigh Naylor-Adamson, Lewis Bibby, Katie S. Wraith, Giordano Pula, Monica Arman, Simon D. J. Calaminus

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Isoniazid preventive therapy modulates Mycobacterium tuberculosis-specific T-cell responses in individuals with latent tuberculosis and type 2 diabetes by Phillip Ssekamatte, Diana Sitenda, Rose Nabatanzi, Marjorie Nakibuule, Davis Kibirige, Andrew Peter Kyazze, David Patrick Kateete, Bernard Ssentalo Bagaya, Obondo James Sande, Reinout van Crevel, Stephen Cose, Irene Andia Biraro

“…These findings suggest that IPT modulates and normalises specific T-cell memory phenotypes and functional responses in LTBI-DM participants, potentially contributing to improved long-term immunity and protection against TB. …”
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Rangeland management practices modulated trait-based plant community assembly through environmental filtering in Hulun Buir Steppe by Danyu Wang, Le Wang, Xiaohui Yang, Yuanjun Zhu, SeMyung Kwon, Zhongjie Shi, Jiankang Liu, Tuvshintogtokh Indree

“…Further analysis indicated that community structure under grazing-only management responded more stably to environmental changes, potentially due to the modulating influence of plant productivity and photosynthetic functional traits, such as Leaf Dry Matter Content (LDMC) and Leaf Area Index (LAI). …”
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Soymilk yogurt prepared using Pediococcus pentosaceus TOKAI 759m ameliorates cognitive function through gut microbiota modulation in high-fat diet mice by Yuki Nakashima, Tomoyuki Hibi, Masafumi Urakami, Maki Hoshino, Taiki Morii, Hikari Sugawa, Nana Katsuta, Yuki Tominaga, Himeno Takahashi, Asako Otomo, Shinji Hadano, Shin Yasuda, Ayaka Hokamura, Saki Imai, Hideki Kinoshita

“…In conclusion, soymilk yogurt prepared using P. pentosaceus TOKAI 759m may modulate gut microbiota and prevent neuroinflammation, thereby leading to a possible improvement in cognitive function.…”
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Promucetin, a new C-type lectin-like protein modulates coagulation by activating platelets via GPIb by Xiao-Qin Yu, Qi-Yun Zhang, Shu-Ting Zhou, Qing-Yu Lu, Qian-Yun Sun

“…Conclusion: Promucetin exhibits significant ability to modulate coagulation function and effectively inhibit thrombosis by activating platelet via GPIb and reducing platelet count, which helps us understand its biological function in snake bites, it exhibits the potential to be a candidate for anticoagulant therapy.…”
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Sulfated fucan polysaccharide from Holothuria scabra attenuates LPS-induced inflammation in RAW264.7 macrophages via modulation of NF-κB and MAPK signalling pathways by Kidprasert Arunrat, Sutee Wangtueai, Subramanian Palanisamy, SangGuan You, Weerawan Rod-in, Utoomporn Surayot

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Cardiac Autonomic Modulation and Cognitive Performance in Community-Dwelling Older Adults: A Preliminary Study by Paula Andreatta Maduro, Luiz Alcides Ramires Maduro, Polyana Evangelista Lima, Ana Clara Castro Silva, Rita de Cássia Montenegro da Silva, Alaine Souza Lima Rocha, Maria Jacqueline Silva Ribeiro, Juliana Magalhães Duarte Matoso, Bruno Bavaresco Gambassi, Paulo Adriano Schwingel

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Lactic acid bacteria derived extracellular vesicles: emerging bioactive nanoparticles in modulating host health by Mohan Li, Bingyong Mao, Xin Tang, Qiuxiang Zhang, Jianxin Zhao, Wei Chen, Shumao Cui

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Neospora caninum infection specifically suppresses the expression of a host lncRNA XR_001919077.1 to facilitate parasite propagation by modulating host cell mitochondrial function and autophagy by Shan-Shan Zhao, De-Liang Tao, Jin-Ming Chen, Ming-Yi Zhang, Xin Yang, Jun-Ke Song, Qun Liu, Guang-Hui Zhao

“…In the present study, N. caninum, but not Toxoplasma gondii, which has similar morphological and biological features to N. caninum, specifically suppresses the expression of a host lncRNA, XR_ 001919077.1, to impair host’s defense through the competitive endogenous RNA mechanism to modulate the host cell mitochondrial function and autophagy to facilitate parasite propagation. …”
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Carotenoid and peptide supplementation from Caulerpa sp. (sea grapes) extract mitigate metabolic syndrome in cholesterol-enriched diet rats via modulation of gut microbiota by Rudy Kurniawan, Fahrul Nurkolis, Agussalim Bukhari, Andi Yasmin Syauki, Burhanudin Bahar, Andi Makbul Aman, Nurpudji Astuti Taslim

“…Recent evidence suggests that gut microbiome dysbiosis plays a significant role in MetS pathogenesis. Functional foods enriched with bioactive compounds, particularly those derived from marine sources, have emerged as promising interventions. …”
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Differential modulation of the cortical alpha rhythm and activation of distinct neural networks during tactile perception training by learners and non-learners by Kei Saito, Kei Saito, Naofumi Otsuru, Naofumi Otsuru, Kaito Tateishi, Ryuji Kurebayashi, Hideaki Onishi, Hideaki Onishi

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Parameter Estimation of Polynomial-Phase Signals by A. A. Monakov

Subjects: “…high-order ambiguity function…”
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Cyclopiazonic acid suppresses the function of Leydig cells in prepubertal male rats by disrupting mitofusin 1-mediated mitochondrial function by Hang Lin, Ming Su, He Zhu, Yang Yu, Jianmin Sang, Yiyan Wang, Qiqi Zhu, Yang Zhu, Xiaoheng Li, Xingwang Li, Ren-Shan Ge, Huitao Li

“…This research investigated the impact of cyclopiazonic acid (CPA), a mycotoxin, on the function of progenitor Leydig cells (PLCs) in prepubertal male rats, focusing on its potential disruption of mitochondrial integrity through mitofusin 1 (MFN1) modulation. …”
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Seagrass Enhalus acoroides extract mitigates obesity and diabetes via GLP-1, PPARγ, SREBP-1c modulation and gut microbiome restoration in diabetic zebrafish by Marcello Mikhael Kadharusman, Rony Abdi Syahputra, Rudy Kurniawan, Edwin Hadinata, Raymond Rubianto Tjandrawinata, Nurpudji Astuti Taslim, Raffaele Romano, Antonello Santini, Fahrul Nurkolis

“…These findings highlight SEAE as a promising marine-derived therapeutic candidate for metabolic syndrome and warrant further investigation as a functional food or nutraceutical. Clinical trial Not applicable.…”
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The WAC-downWAC domain in the yeast ISW2 nucleosome remodeling complex forms a structural module essential for ISW2 function but not cell viability by Ashish Kumar Singh, Sabine Ines Grünert, Lena Pfaller, Felix Mueller-Planitz

“…Results Here we show that the deletion encompasses a novel motif termed downWAC that forms a conserved structural module with the N-terminal WAC domain. The module is predicted to interact with DNA. …”
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<i>Lactiplantibacillus plantarum</i> 1008 Enhances Testicular Function and Spermatogenesis via the Modulation of Gut Microbiota in Male Mice with High-Fat-Diet-Induced Obesity by Chin-Yu Liu, Yi-Wen Chen, Tsung-Yu Tsai, Te-Hua Liu, Ting-Chia Chang, Chih-Wei Tsao

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Pirfenidone regulates seizures through the HMGB1/TLR4 axis to improve cognitive functions and modulate oxidative stress and neurotransmitters in PTZ-induced kindling in mice by Mansi Dahalia, Sparsh Gupta, Haya Majid, Divya Vohora, Nidhi

“…Pirfenidone also demonstrated significant improvements in cognitive function, as evidenced by enhanced performance in passive avoidance and elevated plus maze tests. …”
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Dietary Fish Meal Level and a Package of Choline, β-Glucan, and Nucleotides Modulate Gut Function, Microbiota, and Health in Atlantic Salmon (Salmo salar, L.) by Åshild Krogdahl, Elvis M. Chikwati, Aleksei Krasnov, Anusha Dhanasiri, Gerd M. Berge, Violetta Aru, Bekzod Khakimov, Søren Balling Engelsen, Hilde Vinje, Trond M. Kortner

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