Advances in the study of artemisinin and its derivatives for the treatment of rheumatic skeletal disorders, autoimmune inflammatory diseases, and autoimmune disorders: a comprehens... by Zhiyong Long, Wang Xiang, Wei Xiao, Yu Min, Fei Qu, Bolin Zhang, Liuting Zeng

“…These downstream targets regulate various immune cell functions, apoptosis, proliferation, signal transduction, and antioxidant responses, ultimately intervening in systemic autoimmune diseases and autoimmune responses in organs such as the kidneys, nervous system, skin, liver, and biliary system by modulating immune dysregulation and inflammatory responses. …”
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Development and Validation of a New LC-MS/MS Method for Simultaneous Quantification of Ivacaftor, Tezacaftor and Elexacaftor Plasma Levels in Pediatric Cystic Fibrosis Patients by Alessandro Mancini, Raffaele Simeoli, Luca Cristiani, Sara Cairoli, Fabiana Ciciriello, Alessandra Boni, Federico Alghisi, Chiara Rossi, Giacomo Antonetti, Carlo Dionisi Vici, Alessandro Giovanni Fiocchi, Renato Cutrera, Bianca Maria Goffredo

“…<b>Background</b>: “CFTR modulators” (also named “caftor”) have been developed and introduced into clinical practice to improve the functionality of defective CFTR protein. …”
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Passive physical barrier modulates UVB-induced METosis-related MPO expression and activity, 25-hydroxyvitamin D3-1alpha-hydroxylase, and the shift of tissue-resident macrophages to... by Farah Sara Meterfi, Souad Zoudji, Nour Elhouda Bendjeffel, Rabia Messali, Fadila Boudjelal, Chahrazed El Mezouar, Chahrazed El Mezouar, Nawal Brikci Nigassa, Nawal Brikci Nigassa, Zineb Mekkaoui, Slimane Brikhou, Franck JD Mennechet, Chafia Touil-Boukoffa, Chafia Touil-Boukoffa, Xin Li, Xin Li, Abdelouahab Bellou, Abdelouahab Bellou, Abdelouahab Bellou, Abdelouahab Bellou, Abdelouahab Bellou, Abdelouahab Bellou, Mourad Aribi, Mourad Aribi, Mourad Aribi

“…Finally, intracellular free calcium ion (ifCa2+) levels remained unaffected by UVB but showed a slight increase with the barrier.ConclusionsUVB exposure enhances tissue-resident macrophage function in a preclinical rat model, increasing respiratory burst, phagocytosis, and M1-like polarization. …”
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Antiaging Effect of 2-<i>O</i>-β-D-Glucopyranosyl Ascorbic Acid Derived from <i>Lycium barbarum</i> L. Through Modulating the IIS Pathway and Gut Microbiota in <i>Caenorhabditis el... by Jiayue Fang, Wei Dong, Jingqian Zheng, Boxuan Han, Yuying Zhang, Jianing Wang, Xiaoxiong Zeng

“…Transcriptomic analysis identified the insulin/insulin-like growth factor (IGF)-1 signaling pathway as a key regulator, with quantitative real-time polymerase chain reaction confirming the upregulation of longevity-associated genes. Functional studies showed that the transcription factors DAF-16, HSF-1, and SIR-2.1 were essential for the lifespan-extending effects of AA-2βG, as mutations in these genes abolished lifespan extension. …”
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Wharton’s jelly mesenchymal stromal cells derived from preterm umbilical cord reveal a hepatogenic potential by F. Timoneri, M. Lo Iacono, S. Corrao, G. Alberti, G. Amico, T. Corsello, P. G. Conaldi, Eleonora Russo, Eleonora Russo, G. La Rocca

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Phospholipid-Rich DC-Vesicles with Preserved Immune Fingerprints: A Stable and Scalable Platform for Precision Immunotherapy by Ramon Gutierrez-Sandoval, Francisco Gutierrez-Castro, Natalia Muñoz-Godoy, Ider Rivadeneira, Adolay Sobarzo, Luis Alarcón, Wilson Dorado, Andy Lagos, Diego Montenegro, Ignacio Muñoz, Rodrigo Aguilera, Jordan Iturra, Francisco Krakowiak, Cristián Peña-Vargas, Andres Toledo

“…<b>Objective</b>: This study evaluates dendritic cell-derived vesicles (DC-Vesicles), embedded in a phospholipid-rich structural scaffold, as a multi-functional and scalable platform for immune modulation and therapeutic delivery. …”
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Receiving of direct-sequence spread spectrum signal with quadrature phase-shift keying in case of multiple access interference and internal Gaussian noise by G. S. Nakhmanson, S. V. Kozlov

“…Broadband phase modulated signal bit error rate as a function of signal-to-noise ratio, signal-to-interference ratio, number of interferences and false positive probability has been analyzed.…”
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Breaking the Efficiency–Quality Tradeoff via Temperature–Velocity Co-Optimization: Multiscale Calculations and Experimental Study of Epitaxial Growth of Iridium on MgO(100) by Yang Wang, Junhao Chen, Shilin Yang, Jiaqi Zhu

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MODERN OPPORTUNITIES IN UVEITIS TREATMENT by D. A. Krakhmaleva, E. A. Pivin, S. V. Trufanov, S. A. Malozhen

“…So the  search continues to develop new therapies for use  in uveitis that  aim  to  suppress inflammatory  activit y,  prevent  accumulation of damage, and  preserve  visual function  for  patients with the minimum possible  side effects.…”
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Analysis of spectra of multi-frequency phase-manipulated signals by V.M. Kotenko, V.I. Korinenko, Yu.O. Kudriashov

“…It was established that the amplitude of the components of the spectrum and their number in the spectrum are determined by the parameters of the Bessel function of the first kind of the real argument – the phase modulation index. …”
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Fault Detection Technique for Active Phased Array Antenna Using Current Sensing by Hongwoo Park, Shin Young Cho, Won Jin Lee, Seunghee Seo, Hongjoon Kim

“…To facilitate channel control and status reporting of individual TRMs, a built-in test function was implemented in the field-programmable gate array within both the antenna controller and the TRU control board. …”
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Damage Detection Method for High-Strength Aramid Conveyor Belts by Ling Yang, Yimin Wang, Di Miao, Xiaoxian Duan

“…Meanwhile, the Adaptive Threshold Focal Loss Function (ATFL) is applied to address the imbalance between the background and the target in images of the aramid conveyor belt. …”
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CV-YOLOv10-AR-M: Foreign Object Detection in Pu-Erh Tea Based on Five-Fold Cross-Validation by Wenxia Yuan, Chunhua Yang, Xinghua Wang, Qiaomei Wang, Lijiao Chen, Man Zou, Zongpei Fan, Miao Zhou, Baijuan Wang

“…By introducing the MPDIoU loss function, the YOLOv10 network is optimized to effectively enhance the positioning accuracy of the model in complex background and improve detection of small target foreign objects. …”
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A Spatial Sigma-Delta Approach to Mitigation of Power Amplifier Distortions in Massive MIMO Downlink by Yatao Liu, Mingjie Shao, Wing-Kin Ma

“…Existing approaches to handle the nonlinear distortions, such as digital predistortion (DPD), typically require accurate knowledge, or acquisition, of the PA transfer function. In this paper, we present a new concept for mitigation of the PA distortions. …”
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Lung Segmentation with Lightweight Convolutional Attention Residual U-Net by Meftahul Jannat, Shaikh Afnan Birahim, Mohammad Asif Hasan, Tonmoy Roy, Lubna Sultana, Hasan Sarker, Samia Fairuz, Hanaa A. Abdallah

“…The study indicates that the Dice loss function is more effective in achieving better results. …”
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P4CN-YOLOv5s: a passion fruit pests detection method based on lightweight-improved YOLOv5s by Zhiping Tan, Zhiping Tan, Dapeng Ye, Jiancong Wang, Wenxiang Wang

“…Secondly, after analyzing the image set characteristics to be detected in this research, the point-line distance bounding box loss function is utilized to calculate the coordinate distance of the prediction box and target box, and aimed at improving detection speed. …”
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Biparatopic binding of ISB 1442 to CD38 in trans enables increased cell antibody density and increased avidity by Jeremy Loyau, Thierry Monney, Marco Montefiori, Fedir Bokhovchuk, Jeremy Streuli, Matthew Blackburn, Arnaud Goepfert, Lydia N. Caro, Samitabh Chakraborti, Stefania De Angelis, Camille Grandclément, Stanislas Blein, M. Lamine Mbow, Ankita Srivastava, Mario Perro, Stefano Sammicheli, Eugene A. Zhukovsky, Michael R. Dyson, Cyrille Dreyfus

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A Comprehensive Deep Learning System With MGRF Modeling for Predicting Breast Cancer Response to Neoadjuvant Chemotherapy by Ahmed Sharafeldeen, Fatma Taher, Norah Saleh Alghamdi, Eman Alnaghy, Reham Alghandour, Khadiga M. Ali, Sameh Shamaa, Abdelrahman Gamal, Mohammed Ghazal, Sohail Contractor, Ayman El-Baz

“…These results underscore the value of integrating the appearance model, functional (i.e., ADC) model, adaptive rescaling module, SE blocks, and clinical and molecular subtype markers for the precise prediction of NAC outcomes.…”
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A consortium of seven commensal bacteria promotes gut microbiota recovery and strengthens ecological barrier against vancomycin-resistant enterococci by Alan Jan, Perrine Bayle, Nacer Mohellibi, Clara Lemoine, Frédéric Pepke, Fabienne Béguet-Crespel, Isabelle Jouanin, Marie Tremblay-Franco, Béatrice Laroche, Pascale Serror, Lionel Rigottier-Gois

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S1PR4-dependent effects of Etrasimod on primary human myeloid immune cell activation by Fiona K. Sailer, Megan A. Palmer, Blerina Aliraj, Jan Heering, Jan Heering, Andreas Brockmann, Mohammed A. F. Elewa, Mohammed A. F. Elewa, Aissa Röhrig, Aissa Röhrig, Ewgenij Proschak, Ewgenij Proschak, Ewgenij Proschak, Dariusz T. Stepniak, Simeon Ramsey, Bernhard Brüne, Bernhard Brüne, Andreas Weigert

“…Among those are Ozanimod, an S1PR1/5 modulator approved for the treatment of ulcerative colitis and multiple sclerosis, and Etrasimod, an S1PR1/4/5 modulator approved for the treatment of ulcerative colitis. …”
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