Molecular mechanisms of signaling transduction pathways of drug target molecules with recent advancements and future perspectives for successful therapy: a comprehensive and explor... by Sujana Kamepalli, Sambamoorthy Unnam, Satyabrata Bhanja, Krishna Reddy Yeduru, Pratap Kumar Patra, Nasreen Sulthana, Roja Pathakota, Renukadevi Thota, Arun Kumar Sanapala

“…The notion of cellular signaling and the range of signaling pathways that control important cellular functions are first explained in this chapter. It highlights the intricate interactions between the essential elements of signaling pathways, such as effectors, ligands, receptors, and intercellular messengers. …”
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Exploring the perspectives of phytobiotics and their role in aquaculture: Present status and future trends by Bala Akhila Pudota, Neeraja Tambireddy, Rajanidhi Chennu, Lavanya Chethurajupalli, Haseena Shaik, Ranjit Kumar Nadella, Niladri Sekhar Chatterjee, Anand Prasad Paturi

“…The purpose of this review is to synthesize recent advances on the use of phytobiotics in aquaculture, focusing on their biological functions, mechanisms of action, and practical applications. …”
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YTHDF2-mediated m6A modification regulates mRNA stability of Immediate early response gene 3 to modulate cell death in Staphylococcus aureus-induced bovine mastitis by Yue Xing, Siyuan Mi, Siqian Chen, Xinyue Tao, Zihan Zhang, Yuanjun Shi, Xingping Wang, Ying Yu

“…Overexpression of YTHDF2 restored mRNA stability, reduced apoptosis, and preserved mitochondrial function.ConclusionYTHDF2 regulates m6A-modified mRNA stability to modulate apoptosis and inflammation during S. aureus infection. …”
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Possibilities of Evaluating the Dynamics of Left Ventricular Perfusion and Contractility in Patients with Chronic Heart Failure after Implantation of a Heart Contractility Modulato... by V. A. Amanatova, A. A. Safiullina, T. M. Uskach, A. A. Ansheles, V. B. Sergienko, S. N. Tereshchenko

“…These methods of nuclear cardiology can be performed in patients with reduced renal function, as well as the presence of implanted devices such as implantable cardioverters-defibrillators, resynchronizing devices and cardiac modulating therapy, which is their undeniable advantage. …”
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Thymoquinone mitigates diclofenac-induced hepatorenal toxicity in male Wistar rats by balancing the redox state and modulating Bax/Bcl-2/caspase-3 apoptotic pathways and NF-κB sign... by Amir Safi, Shakila Mohammadi, Mina Emami, Alireza Radaei, Ali Kalantari-Hesari, Ali Nouri, Mohammad Rahimi-Madiseh, Reza Ahmadi

“…TQ improved liver and kidney function, reduced oxidative stress markers, suppressed inflammation, modulated apoptosis-related gene expression, and ameliorated histopathological damage. …”
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M <inline-formula> <tex-math notation="LaTeX">$\times$</tex-math></inline-formula> N Wavelength Selective Switches Using Beam Splitting By Space Light Modulators by K. Yamaguchi, Y. Ikuma, M. Nakajima, K. Suzuki, M. Itoh, T. Hashimoto

“…The increase in the insertion loss caused by the MPMT switching function is 3 dB due to beam splitting and 3&#x2013;4.1 dB due to imperfections in the holographic phase modulations. …”
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Modulating Effects of L-Arginine and <i>Tribulus terrestris</i> Extract on Fipronil-Induced Interference in the Male Reproductive System of Rats: Antioxidant Potential, Androgen Re... by Doaa H. Elsayed, Ahmed A. Bakhashwain, Eman A. Ahmed, Hatim A. Al-Abbadi, Heba M. A. Abdelrazek, Menna Allah I. El-Menyawy, Wafaa K. Teleb, Noran M. Tawfik, Ibrahim E. Helal, Heba N. Gad EL-Hak

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An Azomethine Derivative, BCS3, Targets XIAP and cIAP1/2 to Arrest Breast Cancer Progression Through MDM2-p53 and Bcl-2-Caspase Signaling Modulation by Reetuparna Acharya, Pran Kishore Deb, Katharigatta N. Venugopala, Shakti Prasad Pattanayak

“…One such class of apoptotic regulators is inhibitors of apoptosis proteins (IAP) which are a class of E3 ubiquitin ligases that actively function to support cancer growth and survival. <b>Methods</b>: The current study reports design, synthesis, docking analysis (based on binding to IAP-BIR3 domains), anti-proliferative and anti-tumor potential of the azomethine derivative, 1-(4-chlorophenyl)-N-(4-ethoxyphenyl)methanimine (<b>BCS3</b>) on breast cancer (in vitro and in vivo) and its possible mechanisms of action. …”
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Melatonin promoted the therapeutic potential of cisplatin in a rat model of hepatocellular carcinoma: COX-2 and MDM2/p53/miR-155 modulation associated with cytoprotection and tumou... by Asmaa Mohammed ShamsEldeen, Laila Rashed, Abbas Mohamed, Ebtehal Gamal Abdelhady, Sara Adel Hosny, Hala Hassan Mohamed, Yara Sayed Eldosouky, Mohamed Hassan Gad, Hind Awad Zafrah, Hayam Ateyya, Hend Ashour

“…In conclusion, melatonin and cisplatin co-administration may be a viable strategy to preserve liver function by shielding healthy hepatocytes from the cytotoxic effects of cisplatin.…”
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Antidiabetic Effects of Quercetin and Silk Sericin in Attenuating Dysregulation of Hepatic Gluconeogenesis in Diabetic Rats Through Potential Modulation of PI3K/Akt/FOXO1 Signaling... by Heba M. Abdou, Ghada M. Abd Elmageed, Hussein K. Hussein, Imane Yamari, Samir Chtita, Lamia M. El-Samad, Mohamed A. Hassan

“…Administration of QCT and SS to diabetic male albino rats markedly restored the levels of glucose, insulin, advanced glycation end-products (AGEs), liver function enzymes, alpha-fetoprotein (AFP), globulin, and glycogen, in addition to hepatic carbohydrate metabolizing enzymes and gluconeogenesis in comparison with diabetic rats. …”
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Irradiation-responsive PRDM10-DT modulates the angiogenic response in human NSCLC cells in an SP1-dependent manner via the miR-663a/TGF-β1 axis by Hao Huang, Ying Xu, Zi Guo, Miaomiao Zhang, Wanshi Li, Yidan Song, Jing Nie, Wentao Hu, Tom K. Hei, Guangming Zhou

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Muscarinic receptor agonists and positive allosteric modulators in animal models of psychosis: protocol for a systematic review and meta-analysis [version 2; peer review: 1 approve... by Spyridon Siafis, Johannes Schneider-Thoma, Alexandra Bannach-Brown, Oliver D. Howes, Virginia Chiocchia, Ulf Tölch, Natascha I. Drude, Sabine M. Hölter, Andrea de Bartolomeis, Anthony C. Vernon, Georgia Salanti, Sridhar Natesan, Stefan Leucht, Irene Bighelli, Sameer Jauhar, Ioannis Mantas, Josef Priller, Francesca Tinsdeall, Wulf-Peter Hansen, Fiona J. Ramage, Nobuyuki Nomura, Malcolm R. Macleod

“…Background Muscarinic receptor agonism and positive allosteric modulation is a promising mechanism of action for treating psychosis, not present in most D2R-blocking antipsychotics. …”
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SARS-CoV-2 proteases PLpro and 3CLpro cleave IRF3 and critical modulators of inflammatory pathways (NLRP12 and TAB1): implications for disease presentation across species by Mehdi Moustaqil, Emma Ollivier, Hsin-Ping Chiu, Sarah Van Tol, Paulina Rudolffi-Soto, Christian Stevens, Akshay Bhumkar, Dominic J. B. Hunter, Alexander N. Freiberg, David Jacques, Benhur Lee, Emma Sierecki, Yann Gambin

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A triterpene-enriched natural extract from Eucalyptus tereticornis modulates the expression of genes involved in adipogenesis, lipolysis, and extracellular matrix remodeling in a p... by Sergio Acin, Alejandro Mejia-Garcia, Geysson Javier Fernandez, Norman Balcazar

“…The natural extract modulates PPAR, Wnt, and Extracellular Matrix organization pathways significantly in both cellular models. …”
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Endocannabinoid system modulation for visceral abdominal pain in inflammatory bowel disease and irritable bowel syndrome: A protocol for systematic review and meta-analysis [versio... by Rebecca M. Lane, Declan P. McKernan, Siobhain M. O'Mahony, Laurence J. Egan, David P. Finn, Brian E. McGuire

“…Secondary outcomes will include any change in pain intensity, physical and emotional functioning, fatigue and sleep measures, quality of life, gastrointestinal disease or symptom severity, and adverse effects. …”
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Calcium Release-Activated Calcium Modulator ORAI1-Sensitive Serine Dehydratase Regulates Fatty Acid-Induced CD4⁺ Th17/Treg Imbalance in Dairy Cows by Bingbing Zhang, Jingjing Wang, Ming Li, Jianan Wen, Juan J. Loor, Shuang Wang, Ziwei Ji, Xinquan Lv, Guihua Wang, Cheng Xia, Wei Yang, Chuang Xu

“…High concentrations of free fatty acids (FFAs) caused by negative energy balance render the cow more prone to inflammatory diseases in part due to an imbalance in the types of immune cells and their specific functions. We previously demonstrated that ORAI calcium release-activated calcium modulator 1 (ORAI1) was associated with increased CD4⁺ Th17 content, but the precise mechanisms remain unclear. …”
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Diabetes is causally associated with increased breast cancer mortality by inducing FIBCD1 to activate MCM5-mediated cell cycle arrest via modulating H3K27ac by Binbin Tan, Yang Liu, Qianqian Chen, Weijie Yang, Wenhan Yang, Kaiping Gao, Li Fu, Tiantian Zhang, Penglong Chen, Yongyi Huang, Yuting Wang, Guoqiang Zhang, Juan Xiong, Rihong Zhai

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IGF2BP3 Modulates mRNA Splicing and Stability to Promote Trophoblast Progression via Interaction with PDE3A and Suppression by miR-196a-5p in Preeclampsia by Chunyan Li, Pingpo Ming, Cuifang Fan, Jiao Chen, Jing Yang

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Pancreatic, nutritional and clinical outcomes in children 0–5 years with cystic fibrosis during the first 2 years of CFTR modulator therapy (PaNC): a multicentre prospective observ... by Tamarah Katz, Sophie King, Gillian M Nixon, Caitlin Miles, Jodi Grunert, Kristyn Ford, Carla Hall, Charlotte Hawthorn, Denise Wong See, Mylie McMahon, Hannah Vass, Sarah Watkins, Gemma Zanardo, Isabella Brookes, Siobhan Handley, Talia Woodward, Jasmin Wademan, Bella Cameron, Zoe Davidson

“…There is a lack of robust, real-world longitudinal data on CFTR modulator therapy in infants and young children where extrapulmonary outcomes such as growth, micronutrient status and pancreatic function are the key focus.Methods and analysis Pancreatic, nutritional and clinical outcomes in children 0–5 years with CF during the first 2 years of CFTR modulator therapy (PaNC) is a prospective cohort study involving all eight tertiary paediatric CF centres in Australia. …”
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<i>MdGRF22</i>, a 14-3-3 Family Gene in Apple, Negatively Regulates Drought Tolerance via Modulation of Antioxidant Activity and Interaction with <i>MdSK</i> by Jiaxuan Ren, Hong Wang, Mingxin Zhao, Guoping Liang, Shixiong Lu, Juan Mao

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