Gene2role: a role-based gene embedding method for comparative analysis of signed gene regulatory networks by Xin Zeng, Shu Liu, Bowen Liu, Weihang Zhang, Wanzhe Xu, Fujio Toriumi, Kenta Nakai

“…Additionally, we quantified the stability of gene modules between two cellular states by measuring the changes in the gene embeddings within these modules. …”
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Lactylation-mediated miRNA regulation in cancer therapy resistance by Yiyi Shou, Ruiqi Liu, Hao Xiong, Xiaoyan Chen, Luanluan Huang, Ran Huang, Hailong Sheng, Haibo Zhang, Yanwei Lu, Haiwei Guo

“…We begin with a focused overview of tumour metabolic reprogramming and the enzymology of lactylation, establishing the biochemical context for its regulatory functions. We then examine how miRNAs interpret and reinforce metabolic cues, particularly through three interrelated regulatory frameworks. …”
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RPL35A Downregulation Suppresses Hepatocellular Carcinoma Cell Proliferation via NCAPG2 Inactivation by Liang Chen, Yujie Lin, Yu Lai, Yanshan Li, Tao Chen, Xingxi Luo, Yibiao Ye

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RNA-sequencing studies suggest that microRNAs and alternative splicing of pre-mRNAs modulate immune and inflammatory responses in Holstein cattle infected with Mycobacterium avium... by Gerard Badia-Bringué, Marta Alonso-Hearn

“…Nevertheless, interest in AS is growing, driven by its recognized role in tissue-specific functions and disease mechanisms. Recent findings have revealed distinct miRNAs and AS profiles in MAP-infected cattle compared to uninfected cows, indicating that post-transcriptional regulatory mechanisms are altered during MAP infection. …”
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AS03-adjuvanted H5N1 vaccine enhances immune response by modulating NR4A1, SDC1, ID3 genes, and reducing cortisol by Lairun Jin, Jingxin Li, Fengcai Zhu

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Small Extracellular Vesicle (sEV) Uptake from Lung Adenocarcinoma and Squamous Cell Carcinoma Alters T-Cell Cytokine Expression and Modulates Protein Profiles in sEV Biogenesis by Hafiza Padinharayil, Jinsu Varghese, Pulikkottil Raphael Varghese, Cornelia M. Wilson, Alex George

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Toxicity mechanism analysis of cGAS-STING-TBK1 signaling pathway small molecule modulator based on network toxicology and molecular docking strategy: quinacrine acetate as an examp... by Jinchao Zhu, Qingyuan Lin, Honglin Zhu, Siqi Xie, Shengdong Nie

“…GO and KEGG analyses were employed to elucidate related functions and molecular mechanisms. STRING and Cytoscape software were utilized to identify key hub genes, while molecular docking validation was performed using the CB-Dock2 database. …”
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Safety, tolerability, pharmacokinetic and pharmacodynamic effects of the muscarinic M1 positive allosteric modulator VU0467319 for Alzheimer’s disease: a single ascending-dose stud... by Alexander C. Conley, Alexandra P. Key, Jennifer U. Blackford, Jason K. Russell, Kimberly M. Albert, Xuewen Gong, Michael Bubser, Jerri M. Rook, P. Jeffrey Conn, Craig W. Lindsley, Carrie K. Jones, Paul A. Newhouse

“…Target engagement results suggest stimulation of the cholinergic system functioning in healthy adults following a single dose of VU319. …”
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RhIL-11 reverses liver damage in septic mice by STAT3-mediated M-MDSCs induction modulated by a parallel mTORC1 signaling branch by Yuefang Liu, Shujun Gao, Zhanghui Li, Lei Yin, Shiyao Ge, Yangjing Zhao, Hui Wang, Bing Wan, Qixiang Shao

“…The results of in vitro studies declared that rhIL-11 promoted differentiation of BM cells into M-MDSCs phenotypically and functionally via activating STAT3 signaling, which was cross-regulated by the mTORC1. …”
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Passively Mode-Locked Tm:YAP Laser Utilizing a Mo₂TiAlC₂ MAX Phase Saturable Absorber for Modulation by Chen Wang, Tianjie Chen, Zhe Meng, Sujian Niu, Zhaoxue Li, Xining Yang

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Calcium bridges built by mitochondria-associated endoplasmic reticulum membranes: potential targets for neural repair in neurological diseases by Yichen Peng, Li Zhou, Yaju Jin, Danli Wu, Na Chen, Chengcai Zhang, Hongpeng Liu, Chunlan Li, Rong Ning, Xichen Yang, Qiuyue Mao, Jiaxin Liu, Pengyue Zhang

“…Targeted modulation of these disease-related pathways and functional proteins can enhance neurological function and promote the regeneration and repair of damaged neurons. …”
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A curative effect evaluation of intensity-modulated radiation therapy combined with periorbital triamcinolone acetonide injection in treating thyroid eye disease patients with acti... by Hao Zhang, Weimin He

“…Patients with hyperthyroidism had worse effect than those with normal thyroid function. The higher the CAS, the better the effect.…”
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Inhibition of microRNA-21 via locked nucleic acid-anti-miR suppressed metastatic features of colorectal cancer cells through modulation of programmed cell death 4 by Reza Nedaeinia, Mohammadreza Sharifi, Amir Avan, Mohammad Kazemi, Abdolreza Nabinejad, Gordon A Ferns, Majid Ghayour-Mobarhan, Rasoul Salehi

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Environmental enrichment in combination with Bifidobacterium breve HNXY26M4 intervention amplifies neuroprotective benefits in a mouse model of Alzheimer's disease by modulating gl... by Guangsu Zhu, Min Guo, Jianxin Zhao, Hao Zhang, Gang Wang, Wei Chen

“…Collectively, combined B. breve intervention with EE treatment can alleviate AD-related cognitive impairment and improve brain function by regulating glutamine metabolism of the gut microbiome. …”
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Subchronic Chlorpyrifos Exposure Induces Thyroid Follicular Cell Pyroptosis to Exacerbate Thyroid Toxicity by Modulating Nrf2/Keap1/NF-κB Pathway in Male Mice by Gu B, Chen Y, Xu H, Zhan K, Zhu K, Luo H, Huang Y, Zeng H, Zheng W, Tian K, Ruan H

“…The findings demonstrate that CPF exposure compromises thyroid homeostasis through the induction of follicular cell pyroptosis and modulation of the Nrf2/Keap1/NF-κB signaling axis, highlighting the potential health risks associated with CPF exposure and its impact on thyroid function. …”
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Simvastatin Combined with Resistance Training Improves Outcomes in Patients with Chronic Heart Failure by Modulating Mitochondrial Membrane Potential and the Janus Kinase/Signal Tr... by Xiaowen Wang, Kaiyun Yan, Cuifeng Wen, Jiaqi Wang

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Paridis Rhizoma Saponins ameliorate CCl4-induced liver fibrosis via modulation of the Nrf2-HO-1/NQO-1 and TGF-β1/Smads signaling pathways by Yan Hong, Shuang Geng, Huihao Ao, Mengya Fu, Xiaojun Yang, Gang Cao, Yanquan Han

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Constitutive activity of the inhibitory G protein pathway mediated by non-visual opsin Opn7b reduces cFos activity in stress and fear circuits and modulates avoidance behavior by Hanna Böke, Hannah Schulte, Maria Worm, Julia Bihorac, Brix Mücher, Martin Hadamitzky, Ida Siveke, Ida Siveke, Stefan Herlitze, Katharina Spoida

“…Constitutive activity of G protein-coupled receptors (GPCRs) plays an important role in brain function and disease including neurodegenerative and psychiatric disorders. …”
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Long non-coding RNA MIR4435-2HG modulates pancreatic cancer stem cells and chemosensitivity to gemcitabine by targeting the miR-1252-5p/STAT1 by Baocheng Xie, Peishan Wu, Hongyu Liu, XiangDi Yang, Linxuan Huang

“…The aim of this study was to investigate the role of MIR4435-2HG in regulating CSC characteristics, tumorigenesis, and chemoresistance in pancreatic cancer. Functional assays were conducted to evaluate CSC self-renewal, tumorigenic potential, and chemoresistance in pancreatic cancer cells with altered expression of MIR4435-2HG. …”
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KAT8 catalyzes the acetylation of SEPP1 at lysine 247/249 and modulates the activity of CD8+ T cells via LRP8 to promote anti-tumor immunity in pancreatic cancer by Zhongfei Zhu, Gang Nie, Xiaobo Peng, Xianbao Zhan, Dan Ding

“…Bioinformatics analysis predicted that SEPP1 was low expressed in PC and related to tumor immune microenvironment, but its biological function was still unclear. Methods PC xenograft and liver metastasis mouse models, as well as PC cell-MDSCs co-culture system, were established for in vivo and in vitro studies, respectively. …”
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