In vitro digestion and fecal fermentation behaviors of exopolysaccharide from Morchella esculenta and its impacts on hypoglycemic activity via PI3K/Akt signaling and gut microbiota... by Weihong Guo, Xuerui Wang, Biao Wang, Yajie Zhang, Fengyun Zhao, Yuling Qu, Liang Yao, Jianmin Yun

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Complex probiotics can reduce diarrhea by boosting immunity and balancing gut microbiota in weaned piglets by Mingyu Wang, Xian Zhou, Lea Hübertz Birch Hansen, Yongshuai Sheng, Bing Yu, Jun He, Jie Yu, Ping Zheng

“…Growth performance, fecal microorganisms, serum immunity, and intestinal barrier function were assessed. Experimental data were analyzed using SPSS 27.0 for one-way ANOVA, and multiple comparisons were made using the DUNCAN method.ResultsCompared with the control, SLV 200 and SLV 400 significantly reduced diarrhea rate (P < 0.05). …”
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Neuroprotective effects of ethanol extraction from Rubia yunnanensis Diels on chronic cerebral hypoperfusion: modulation of the System Xc-/GSH/GPX4 axis to alleviate oxidative stre... by Jianghao Cheng, Xiaoxia Ma, Jie Tao, Xiaoli Jiang, Pu Chen, Xiaohua Duan

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lncRNA DARS-AS1 Modulates TSPAN1-Mediated ITGA2 Hypomethylation by Interaction with miR-194-5p Thus Promoting Ovarian Cancer Progression by Jun Li, Haoyu Gao, Beibei Chen, Li Li, Qianqing Wang, Zhihui Gao

“…The OC cell model exhibited overexpressed lncRNA DARS-AS1 compared to normal cells. lncRNA DARS-AS1 knockdown led to reduced OC cell growth and metastasis while inducing the apoptosis in the OC cell model. lncRNA DARS-AS1 positively regulated TSPAN1 expression by binding with miR-194-5p and TSPAN1-mediated ITGA2 hypomethylation in OC cells. Further rescue function studies demonstrated that lncRNA DARS-AS1 affected OC cell viability, migration, invasion, and apoptosis ability by modulating miR-194-5p and TSPAN1 expressions. …”
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Identification of Cancer Stem Cell (CSC)-Associated Genes, Prognostic Value, and Candidate Drugs as Modulators of CSC-Associated Signaling in Carcinomas Through a Multiomics Data A... by Pallabi Mondal, Poulami Singh, Krishna Mahanti, Sankar Bhattacharyya

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The GhCEWT1-GhCEWT2-GhCes4D/GhCOBL4D module orchestrates plant cell elongation and cell wall thickness by Liping Zhu, Jiaojie Zhu, Xin Zhou, Yarou Lin, Liyong Hou, Hongbin Li, Guanghui Xiao

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Investigating Glial Fibrillary Acidic Protein Expression and Cell Morphology in a Rat Brain Following Exposure to a Weak Electromagnetic Field and Nitric Oxide Modulation During De... by Stephanie M. Sissons, Nirosha J. Murugan, Blake T. Dotta

“…Background/Objectives: Nitric oxide (NO) and electromagnetic fields (EMFs) have been reported to influence central nervous system (CNS) function and organization. This study explores the effects of NO modulation and EMF exposure on neurodevelopment and glial fibrillary acidic protein (GFAP) expression and cell morphology, extending the prior work on perinatal EMF exposure in Wistar rats. …”
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Augmented epigenetic repression of hepatitis B virus covalently closed circular DNA by interferon-α and small-interfering RNA synergy by Kongying Hu, Wenjing Zai, Mingzhu Xu, Haiyu Wang, Xinluo Song, Chao Huang, Jiangxia Liu, Juan Chen, Qiang Deng, Zhenghong Yuan, Jieliang Chen

“…These findings deepen the understanding of cccDNA modulation and strengthen the scientific basis for the potential of combination therapy.IMPORTANCESince there are currently no approved drugs targeting and silencing covalently closed circular DNA (cccDNA), achieving a “functional cure” remains difficult. …”
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Protective role of RGS2 in PM2.5-induced ovarian injury in rats: Modulation of Gq/11 signaling to maintain granulosa cell [Ca2 + ]i stability by Zhenhua Ma, Xiaohui Du, Cuizhu Zhao, Yize Sun, Yunna Jia, Xiaojun Liang, Xiuzhen Yu, Yunhang Gao

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Activated NK cells reprogram MDSCs via NKG2D-NKG2DL and IFN-γ to modulate antitumor T-cell response after cryo-thermal therapy by Peng Peng, Lisa X Xu, Yue Lou, Shicheng Wang, Junjun Wang, Zelu Zhang, Peishan Du, Jiamin Zheng

“…Targeting MDSCs to alleviate their protumor functions and immunosuppressive activities is intimately associated with cancer immunotherapy. …”
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Long non-coding RNA Malat1 modulates CXCR4 expression to regulate the interaction between induced neural stem cells and microglia following closed head injury by Qin Dong, Pengyu Chen, Wenqiao Qiu, Zhijun Yang, Yanteng Li, Yuhui Zhou, Lili Guo, Dan Zou, Ruxiang Xu, Mou Gao

“…Subsequently, we predicted the target genes and performed gain- and loss-of-functional studies, dualluciferase reporter, RNA immunoprecipitation, biotin-coupled miRNA pulldown, fluorescence in situ hybridization and cell transplantation assays to further elucidate the mechanism underlying the immunoregulatory effects of iNSCs. …”
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Magnesium ions attenuate tendon graft fibrosis during its ligamentization after ACL reconstruction through modulation of fibroblast to myofibroblast trans-differentiation by promot... by Changhao Xu, Ying Luo, Zhining Cai, Jiali Ji, Zhiyu Guo, Zhaoji Cai, Chao You, Yibiao Zhou, Zhuoxuan Chen, Weijia Zhang, Ningji Gong, Jiali Wang

“…The ligamentization process of the tendon graft in anterior cruciate ligament (ACL) reconstruction is crucial for graft healing quality, thereby affecting knee joint function. Excessive scar tissue, caused by activation of trans-differentiation of fibroblasts to myofibroblasts, rather than orientated collagen fibers with normal composition and structure in the graft mid-substance seriously impacts ligamentization. …”
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RETRACTED: The long noncoding RNA AK002107 negatively modulates miR‐140‐5p and targets TGFBR1 to induce epithelial–mesenchymal transition in hepatocellular carcinoma by Yun‐Hua Tang, Guo‐Lin He, Shan‐Zhou Huang, Ke‐Bo Zhong, Hui Liao, Lei Cai, Yi Gao, Zhen‐Wei Peng, Shun‐Jun Fu

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Lactiplantibacillus plantarum 299v supplementation modulates β-cell ER stress and antioxidative defense pathways and prevents type 1 diabetes in gluten-free BioBreeding rats by Pinar Sargin, Mark F. Roethle, Shuang Jia, Tarun Pant, Ashley E. Ciecko, Samantha N. Atkinson, Nita H. Salzman, Ru-Jeng Teng, Yi-Guang Chen, Susanne M. Cabrera, Martin J. Hessner

“…Since Lactiplantibacillus plantarum 299 v (Lp299v) supplementation improves gut barrier function and reduces systemic inflammation, we studied its effects in spontaneously diabetic DRlyp/lyp rats provided a normal cereal diet (ND) or a gluten-free hydrolyzed casein diet (HCD). …”
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Indole-3-Acetic Acid: Promising Protective Agent Against Methotrexate-Induced Liver Injury via Modulation of TLR4/NF-κB/Caspase-3 Pathway by Sumayya A. Alturaif, Ahlam Alhusaini, Wedad Sarawi, Iman Hasan, Juman Alsaab, Rehab Ali, Raeesa Mohammed, Sahar S. Alotaibi, Faris Almutairi, Shaikha Alsaif, Ebtesam Alsultan, Ebtesam Aljasas, Sary Alsanea

“…<b>Methods:</b> Rats were allocated into five groups: control (group 1), IAA-treated (group 2), MTX-treated (group 3), quercetin (QUR) + MTX (group 4), and IAA + MTX (group 5). Hepatic function was assessed through the evaluation of serum liver enzymes, oxidative stress, and inflammatory and apoptotic markers using biochemical, molecular, histopathological, and immunohistochemical analyses. …”
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XYLEM NAC DOMAIN 1 (EjXND1) relieves cold-induced lignification by negatively regulating the EjHB1-EjPRX12 module in loquat fruit by Zihao Liang, Yanna Shi, Yiqing Huang, Jiao Lu, Mengxue Zhang, Xizhi Cao, Ruoqian Hu, Dongdong Li, Wenbo Chen, Changqing Zhu, Di Wu, Kunsong Chen

“…Methods: The target genes were isolated through the analysis of transcriptome. The gene function was analyzed by transient transgenic method in tobacco leaves and loquat fruit, respectively, as well as stable overexpression in liverwort. …”
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Peripheral blood immune cells from individuals with Parkinson's disease or inflammatory bowel disease share deficits in iron storage and transport that are modulated by non-steroid... by MacKenzie L. Bolen, Beatriz Nuñes Gomes, Blake Gill, Kelly B. Menees, Hannah Staley, Janna Jernigan, Nikolaus R. McFarland, Ellen M. Zimmermann, Christopher E. Forsmark, Malú Gámez Tansey

“…A mechanism linking chronic gut inflammation to iron dysregulation and mitochondrial function within peripheral immune cells has yet to be identified in conferring risk for PD. …”
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The spice clove effectively ameliorated hyperuricemia and hyperuricemia-induced kidney injury in mice by Fang Wang, Lin Fang, Jin-Juan Zhang, Qian Wang, Ya Wang, Qiong Fu, Yan Hong, Yan-Yan Gao, Xiao-Li Guo, Jing Li, Xue-Long Yan, Guo-Bo Xu, Xing-Jiang Liao, Xiang Fang, Shang-Gao Liao

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Applications and impacts of nanotechnology in poultry nutrition by Babak Hosseintabar-Ghasemabad, Silvia Ondrašovičová, Olga Vilorievna Kvan, Elena Vladimirovna Sheida, Artem Vladimirovich Bykov, Alireza Seidavi, Desiderio Rodriguez Velazquez, Mona M. M. Y. Elghnadour, Deli Nazmín Tirado-González, Susanne Kreuzer-Redmer, Abdelfattah Z. M. Salem

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Beyond awareness: the binding of reflexive mechanisms with the conscious mind: a perspective from default space theory by Ravinder Jerath, Connor Beveridge

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