Pericytes Modulate Third‐Generation Tyrosine Kinase Inhibitor Sensitivity in EGFR‐Mutated Lung Cancer Cells Through IL32‐β5‐Integrin Paracrine Signaling by Cheng Huang, Xi Huang, Xiaoyi Qiu, Xiangzhan Kong, Chunmiao Wu, Xue Jiang, Mingkang Yao, Minghui Wang, Liangping Su, Cui Lv, Ping‐Pui Wong

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Development and usability of a traditional game simulation module with augmented reality technology (AR-SiGaSTEM) in online learning to strengthen STEM skills among students by Mazlini Adnan, Laili Farhana Md Ibharim, Yoke Seng Wong, I-van Yee, Sukirman

“…The objectives were i) to identify teachers' perspectives on accepting AR-integrated teaching modules for online learning; ii) to develop an AR-SiGaSTEM module and game with content, functions and features suitable for online STEM learning; and iii) to evaluate the module's usability in teaching to enhance STEM skills across the curriculum. …”
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HDAC6 inhibition by ITF3756 modulates PD-L1 expression and monocyte phenotype: insights for a promising immune checkpoint blockade co-treatment therapy by Valeria Spadotto, Chiara Ripamonti, Andrea Ghiroldi, Elisabetta Galbiati, Pietro Pozzi, Roberta Noberini, Tiziana Bonaldi, Tiziana Bonaldi, Christian Steinkühler, Gianluca Fossati

“…In vivo, ITF3756 treatment led to reduced tumor growth in a colon cancer model.DiscussionThese findings demonstrate that selective HDAC6 inhibition by ITF3756 modulates myeloid cell functionality by diminishing inhibitory signals and promoting T cell activation. …”
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TGFβ-specific T cells induced by a TGFβ-derived immune modulatory vaccine both directly and indirectly modulate the phenotype of tumor-associated macrophages and fibroblasts by Mads Hald Andersen, Inés Lecoq, Evelina Martinenaite, Maria Perez-Penco, Lucia Lara de la Torre

“…TAMs tend to have tumor-promoting functions, harbor an immunosuppressive phenotype and are linked to decreased overall survival in pancreatic cancer when they harbor an M2-like phenotype. …”
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Surface charge modulation in metal-crosslinked sodium alginate-chitosan composite adsorbent: Optimized anionic-to-cationic polysaccharide component ratio for Cd and Cr removal from... by Aminat Mohammed Ahmed, Mhamed Berrada, Menbere Leul Mekonnen, Ayalew H. Assen, Ephriem Tadesse Mengesha, Redouane Beniazza, Kebede Nigussie Mekonnen, Youssef Belmabkhout

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Telomere length sensitive regulation of interleukin receptor 1 type 1 (IL1R1) by the shelterin protein TRF2 modulates immune signalling in the tumour microenvironment by Ananda Kishore Mukherjee, Subhajit Dutta, Ankita Singh, Shalu Sharma, Shuvra Shekhar Roy, Antara Sengupta, Megha Chatterjee, Soujanya Vinayagamurthy, Sulochana Bagri, Divya Khanna, Meenakshi Verma, Dristhi Soni, Anshul Budharaja, Sagar Kailasrao Bhisade, Vivek Anand, Ahmad Perwez, Nija George, Mohammed Faruq, Ishaan Gupta, Radhakrishnan Sabarinathan, Shantanu Chowdhury

“…In summary, using TNBC cancer tissue (>90 patients), tumour-derived organoids, cancer cells, and xenograft tumours with either long or short telomeres, we uncovered a heretofore undeciphered function of telomeres in modulating IL1 signalling and tumour immunity.…”
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Autoinducer-2 enhances the defense of Vibrio furnissii against oxidative stress and DNA damage by modulation of c-di-GMP signaling via a two-component system by Heng Zhang, Wenjin Zhao, Wenguang Yang, Huimin Zhang, Xinyu Qian, Kai Sun, Qiao Yang, Xihui Shen, Lei Zhang

“…However, unknown AI-2 receptors in bacteria may be more than what has been discovered so far, and there are still many unknown functions for this signal waiting to be explored. Here, we have identified a membrane-bound histidine kinase of the pathogenic bacterium Vibrio furnissii, AsrK, as a receptor that specifically detects AI-2 under low boron conditions. …”
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Dragon Fruit Peel (<i>Hylocereus undatus</i>) Modulates Hepatic Lipid Metabolism and Inflammation in a Rat Model of High-Fat, High-Fructose-Induced Metabolic Dysfunction by Siriwan Chumroenvidhayakul, Thavaree Thilavech, Mahinda Yapa Abeywardena, Michael Conlon, Julie Dallimore, Michael Adams, Beverly Muhlhausler, Sirichai Adisakwattana

“…Dragon fruit (<i>Hylocereus undatus</i>) peel waste, rich in bioactive compounds such as dietary fibers, phenolics, and betacyanins, represents a promising functional ingredient for managing these disorders. …”
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N-Lactoyl-Phenylalanine modulates lipid metabolism in microglia/macrophage via the AMPK-PGC1α-PPARγ pathway to promote recovery in mice with spinal cord injury by Weiyang Ying, Weidong Weng, Peifang Wang, Chi Pan, Jiani Qiu, Qianqian Huang, Gonghao Zhan, Xiaoli Chen

“…Moreover, the polarization of microglia/macrophage shifts toward the anti-inflammatory M2 phenotype, providing substantial support for the regenerative process of the injured spinal cord. Functional analysis revealed that mice treated with L-P exhibited significantly improved motor function compared to the control group. …”
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Autophagy as a potential therapeutic target in regulating improper cellular proliferation by Prashant Kumar, Akash Choudhary, Sumit Kinger, Yuvraj Anandrao Jagtap, Vijay Kumar Prajapati, Deepak Chitkara, Subashchandrabose Chinnathambi, Rahul Kumar Verma, Amit Mishra

“…Autophagy performs a crucial function in keeping cell genomic integrity stable. …”
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Anomaly-Guided Double Autoencoders for Hyperspectral Unmixing by Hongyi Liu, Chenyang Zhang, Jianing Huang, Zhihui Wei

“…In the endmember network, to improve the spectral discrimination, a logarithm spectral angle distance (SAD), integrated with anomaly-guided weight, is developed as the loss function. Specifically, the logarithm function is used to boost the reliability of a pixel based on its high SAD similarity to other pixels. …”
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Harnessing cytokinins with chemistry: new frontiers and challenges for precision plant growth control by Liang Cheng, Liang Cheng

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A review on advancement of materials for terahertz applications by Neeta Amitkumar Ukirade

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Stateful Full Adder Using Silicon Diodes by Jaemin Son, Juhee Jeon, Kyoungah Cho, Sangsig Kim

“…Herein, stateful full adders consisting of silicon p+–n–p–n+ diodes that exhibit switching and memory functions through band modulation are demonstrated. …”
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Protective effects of Bifidobacterium longum subsp. longum BL21 against cyclophosphamide-induced reproductive dysfunction in zebrafish by Yao Dong, Jiazhi Zhou, Hairui Tian, Zhonghui Gai, Kang Zou, Quanwei Wei, Mei Han

“…Abstract This study aimed to investigate the effects of probiotic Bifidobacterium longum subsp. longum BL21 on reproductive health in zebrafish (Danio rerio), focusing on hormonal modulation, sperm vitality, and overall reproductive function improvement. …”
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Joint estimation of interference frequency offset and time delay in PCMA system by Xue-juan WEI, Yong YANG, Yi-ming GUO, Dong-ling ZHANG

“…For cooperative received high-order modulation PCMA (paired carrier multiple access) signals,joint estima-tion of frequency offset and time delay was proposed.The sequence samples stored locally were used as auxiliary data.Estimation of frequency offset and time delay was calculated by optimizing the objective function,which was obtained from the cross-correlation computation of the auxiliary data and mixed signal,and the optimized process was accom-plished by utilizing two-dimensional search.By setting the threshold of joint estimation,the calculated amount was greatly reduced.Modified Cramer-Rao bound (MCRB) of interference frequency offset and time delay was derived,which provided theoretical basis for performance of the proposed algorithm.Simulation results show that the algorithm has similar performance with existing algorithms,but its complexity is reduced by two-thirds.…”
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Joint estimation of interference frequency offset and time delay in PCMA system by Xue-juan WEI, Yong YANG, Yi-ming GUO, Dong-ling ZHANG

“…For cooperative received high-order modulation PCMA (paired carrier multiple access) signals,joint estima-tion of frequency offset and time delay was proposed.The sequence samples stored locally were used as auxiliary data.Estimation of frequency offset and time delay was calculated by optimizing the objective function,which was obtained from the cross-correlation computation of the auxiliary data and mixed signal,and the optimized process was accom-plished by utilizing two-dimensional search.By setting the threshold of joint estimation,the calculated amount was greatly reduced.Modified Cramer-Rao bound (MCRB) of interference frequency offset and time delay was derived,which provided theoretical basis for performance of the proposed algorithm.Simulation results show that the algorithm has similar performance with existing algorithms,but its complexity is reduced by two-thirds.…”
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A Control Strategy of IGBT Junction Temperature for Electric Vehicle during Start-up Process by LIU Peng, CHEN Zhichu, TANG Xionghui, ZHANG Siyu, ZHANG Shibing, GU Qiang

“…By analyzing the mathematical relationship among speed, current and switching frequency during the starting process, a torque release function is constructed according to the speed feedback, and the upper limit of torque is constantly released to control the junction temperature on the basis of improving the dynamic performance of the vehicle as much as possible. …”
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The Experience of Synchronization of Professional Standards and Educational Bachelor Degree Programs in Economics, Specialization “Accounting, Analysis and Auditing” by Natalia D. Brovkina

“…The article focuses on the main questions of formation of educational programs and training modules to meet the requirements of the newly established or still under development professional standards. …”
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Harnessing Brain Plasticity: The Therapeutic Power of Repetitive Transcranial Magnetic Stimulation (rTMS) and Theta Burst Stimulation (TBS) in Neurotransmitter Modulation, Receptor... by Minoo Sharbafshaaer, Giovanni Cirillo, Fabrizio Esposito, Gioacchino Tedeschi, Francesca Trojsi

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