Plant growth-promoting endophytic consortium improved artemisinin biosynthesis via modulating antioxidants, gene expression, and transcriptional profile in Artemisia annua (L.) und... by Arpita Tripathi, Praveen Pandey, Shakti Nath Tripathi, Alok Kalra

“…In summary, our study reflects the potential of the endophytic consortium for strengthening one endophyte's functional vulnerability with another to gain maximum artemisinin yield and plant tolerance against various stresses via regulating essential metabolic pathway genes.…”
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LncRNA HCG18 regulates the progression of spinal tuberculosis by modulating the hsa-miR-146a-5p/TGF-β1/SMADs pathway by Feng Li, Hongdong Tan, Xiao Zhang, Xiaodong Zhao, Xiaopeng Li, Gaoyang Chen

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Stomatobaculum longum-Derived Extracellular Vesicles Enhance Oral Squamous Cell Carcinoma Malignancy Through BRCA1/EXO1/TP53BP1 Modulation by Yan L, Wu F, Jiao J, Maimaiti A, Li Y, Shao L, Liang Q, Xiong X, Qin Z

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CCR2 recruits monocytes to the lung, while CX3CR1 modulates positioning of CD11cpos cells in the lymph node during pulmonary tuberculosis by Alexander Mohapatra, Brian A. Norris, Zachary Howard, Joel D. Ernst

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The Activation of the NF-κB Pathway in Human Adipose-Derived Stem Cells Alters the Deposition of Epigenetic Marks on H3K27 and Is Modulated by Fish Oil by Jussara de Jesus Simao, Andressa França de Sousa Bispo, Victor Tadeu Gonçalves Plata, Ana Beatriz Marques Abel, Raphael Justa Saran, Júlia Fernandes Barcella, João Carlos Cardoso Alonso, André Valente Santana, Lucia Maria Armelin-Correa, Maria Isabel Cardoso Alonso-Vale

“…Conclusions: FO demonstrates potential in modulating inflammation-induced epigenetic changes and preserving adipocyte function.…”
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Ginsenoside Rg1 alleviates ochratoxin A-induced liver inflammation in ducklings: Involvement of intestinal microbiota modulation and the TLR4/NF-κB pathway inhibition by Shuangshuang Zhai, Xin Peng, Cheng Liu, Ran Zhang, Chunlong Jin, Xiayu Jiang, Peishi Feng, Yuting Liang, Xi Yuan, Jinqiu Zhang, Ye Yang

“…The results revealed that Rg1 reduced OTA residues in the cecum and enhanced intestinal barrier function. Moreover, Rg1 ameliorated the intestinal microbiota composition in OTA-treated ducklings by decreasing the relative abundance of lipopolysaccharide (LPS)-related bacteria. …”
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Lycopene alleviates 5-fluorouracil-induced nephrotoxicity by modulating PPAR-γ, Nrf2/HO-1, and NF-κB/TNF-α/IL-6 signals by Ghadeer M. Albadrani, Ahmed E. Altyar, Osama A. Kensara, Mohie A.M Haridy, Amany A. Sayed, Zuhair M. Mohammedsaleh, Muath Q. Al-Ghadi, Rasha Mohammed Saleem, Mohamed M. Abdel-Daim

“…LYC attenuated the loss of renal function induced by 5-FU in a dose-dependent manner. …”
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Cooling redistributed endotoxin across different biofluids via modulating the ruminal microbiota and metabolome without altering quorum sensing signal levels in heat-stressed beef... by Zuo Wang, Qingyang Wu, Weijun Shen, Fachun Wan, Jianhua He, Lei Liu, Shaoxun Tang, Zhiliang Tan

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TsR-0072 inhibits colorectal cancer progression through modulating lipid and vitamin D3 metabolic reprogramming and inactivating the Wnt/β-catenin signalling pathway by Qianyi Qi, Bairong Chen, Jinran Wu, Jing Xu, Hongyi Bao, Kangfeng Jin, Lin Chen, Guang Zhu, Feng Wang

“…The target genes of tsR-0072 were verified using a dual luciferase reporter assay, and enzyme-linked immunosorbent assay (ELISA), Western blotting, and qRT-PCR were employed to analyse the potential mechanisms of CRC.Results TsR-0072 was downregulated in CRC and was found to be associated with TNM stage, T stage, lymph node metastasis and the prognosis of CRC patients. Functional experiments revealed that tsR-0072 inhibited CRC growth and metastasis both in vivo and in vitro. …”
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ASIC1a Promotes nucleus pulposus derived stem cells apoptosis through modulation of SIRT3-dependent mitochondrial redox homeostasis in intervertebral disc degeneration by Zhi-Gang Zhang, Liang Kang, Lu-Ping Zhou, Yan-Xin Wang, Chong-Yu Jia, Chen-Hao Zhao, Bo Zhang, Jia-Qi Wang, Hua-Qing Zhang, Ren-Jie Zhang, Cai-Liang Shen

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Coordinated improvement of maize grain yield and protein quality by the ZmMADS8-ZmMADS47-O2 module and a G protein gamma subunit by Yunfu Li, Qiang Ning, Ran Zhao, Dan Liu, Nan Li, Qing Xiong, Qin Sun, Yanfang Du, Ruijie Mao, Jimin Zhan, Zuxin Zhang, Lei Liu

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Remote ischemia precondition protects against renal IRI through apoptosis associated vesicles carrying MIF protein via modulating DUSP6/JNK signaling axis by Nieke Zhang, Zhicong Huang, Yi Xia, Shuchun Tao, Tiange Wu, Si Sun, Yongkun Zhu, Guiya Jiang, Xun Lu, Yue Gao, Fangfang Guo, Rui Cao, Shuqiu Chen, Lei Zhang, Xiangyu Zou, Ming Chen, Guangyuan Zhang

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The ZmPIF4.1-ZmPTI1c-ZmMYB31 module regulates maize immunity to Gibberella stalk rot caused by Fusarium graminearum by Fugui Xie, Liang Ma, Huilan Zhang, Onyino Johnmark Okello, Junjie Cui, Qing Wang, Xiquan Gao

“…We found in this study that GSR resistance is regulated by the ZmPIF4.1 (Phytochrome-Interacting Factor 4)-ZmPTI1c (Pto-Interacting 1)-ZmMYB31 module coupled with photoperiod. The functional analysis of zmpti1c mutant indicated that ZmPTI1c negatively regulates maize GSR resistance. …”
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Regulatory role of lnc-MAP3K13-3:1 on miR-6894-3p and SHROOM2 in modulating cellular dynamics in hepatocellular carcinoma by Kuai Chen, Manqin Zhu, Qinghua Hu, Hui Huang, Ka Chen, Xia Shuai, Jinshi Huang, Qiang Tao, Zhibin Guo

“…The miR-6894-3p mimic regulated the activity of lnc-MAP3K13-3:1. Functional assays showed that lnc-MAP3K13-3:1 overexpression inhibited proliferation in HuH-7 and Li-7 cells, promoted apoptosis, reduced migration in Li-7 cells, but enhanced migration in HuH-7 cells. …”
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Dendritic cells pulsed with multifunctional Wilms’ tumor 1 (WT1) peptides combined with multiagent chemotherapy modulate the tumor microenvironment and enable conversion surgery in... by Machi Suka, Hiroyuki Yanagisawa, Nobuhiro Sato, Shigetaka Shimodaira, Masayuki Saruta, Shigeo Koido, Junichi Taguchi, Masamori Shimabuku, Shin Kan, Tuuse Bito, Takeyuki Misawa, Zensho Ito, Kan Uchiyama, Shintaro Tsukinaga, Toshifumi Ohkusa, Haruo Sugiyama

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IL-27 Modulates Mesenchymal Stem Cell Immunoplasticity for Enhanced Lupus Nephritis Therapy via the JAK1–STAT1–IDO Axis and Tryptophan Metabolic Orchestration by Cheng Zhou, Shunlai Shang, Jing Zhao, Yunzhao Yang, Meihan Shi, Ping Li, Qinggang Li, Jian Zhang, Wenge Li, Chuyue Zhang, Xue-Yuan Bai

“…While mesenchymal stem cells (MSCs) hold therapeutic promise, their efficacy varies substantially, likely due to their plasticity and capacity to adopt pro-inflammatory (MSC1) or anti-inflammatory (MSC2) functional states in response to different microenvironments. …”
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A novel mechanism of FTO modulating the progression of endometriosis through mediating the m6A methylation of GEF-H1 in a YTHDF1-dependent manner by Xin-Yu Ding, Hua-Ying Zhang, Jia-Hao Chen, Meng-Jie Yang, Zhi-Xiong Huang, Yi-Hong Lei, Qin-Kun Sun, Jian-Bin Bai, Dian-Chao Lin, Jian-Fa Lan, Lu-Lu Ren, Zheng-Yi Chen, Wei-Dong Zhou, Qiong-Hua Chen

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Serine Hydroxymethyltransferase Modulates Midgut Physiology in <i>Aedes aegypti</i> Through miRNA Regulation: Insights from Small RNA Sequencing and Gene Expression Analysis by Qian Pu, Yujiao Han, Zhuanzhuan Su, Houming Ren, Qingshan Ou, Symphony Kashyap, Shiping Liu

“…This study provides new insights into the molecular mechanisms through which <i>SHMT</i> influences the biological functions and nutritional metabolism of the mosquito midgut. …”
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A novel genome‐wide in vivo screen for metastatic suppressors in human colon cancer identifies the positive WNT‐TCF pathway modulators TMED3 and SOX12 by Arnaud Duquet, Alice Melotti, Sonakshi Mishra, Monica Malerba, Chandan Seth, Arwen Conod, Ariel Ruiz i Altaba

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Immunosuppression of Tumor-Derived Factors Modulated Neutrophils in Upper Tract Urothelial Carcinoma Through Upregulation of Arginase-1 via ApoA1-STAT3 Axis by Chih-Chia Chang, Chia-Bin Chang, Cheng-Huang Shen, Ming-Yang Lee, Yeong-Chin Jou, Chun-Liang Tung, Wei-Hong Lai, Chi-Feng Hung, Meilin Wang, Ya-Yan Lai, Pi-Che Chen, Shu-Fen Wu

“…This study aimed to investigate how UTUC tumor-derived factors modulate neutrophils and their impact on T cell immune responses. …”
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