HSF1 in macrophages suppressed the progression of asthma via modulating SIRPα/SHP2—Dectin-1/ SYK mediated ROS and inflammatory responses by Xiaojuan Liu, Yingqian Zhang, Huifang Wu, Jingli Zhang, Yingxue Wang, Huifeng Zhang

“…In in vivo experiments, OVA-induced asthmatic mice exhibited severe airway resistance, collagen deposition, and elevated ROS and pro-inflammatory cytokines.HSF1A treatment improved lung function, reduced fibrosis, and restored redox balance. …”
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Genome-Wide Characterization and Haplotype Module Stacking Analysis of the <i>KTI</i> Gene Family in Soybean (<i>Glycine max</i> L. Merr.) by Huilin Tian, Zhanguo Zhang, Shaowei Feng, Jia Song, Xue Han, Xin Chen, Candong Li, Enliang Liu, Linli Xu, Mingliang Yang, Qingshan Chen, Xiaoxia Wu, Zhaoming Qi

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Resveratrol attenuates hepatic oxidative stress and preserves gut mucosal integrity in high-fat diet-fed rats by modulating antioxidant and anti-inflammatory pathways by Tahmina Yasmin, Sreelakshmi N. Menon, Ajay Pandey, Shahnaz Siddiqua, Syed Abdul Kuddus, Md. Mizanur Rahman, Ferdous Khan, Nazia Hoque, Md. Sohel Rana, Nusrat Subhan, Emran Habibi, Fatemeh Ramezani, Satyajit D. Sarker, Lutfun Nahar, Md. Ashraful Alam, Raquibul Hasan

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17β Estradiol Modulates Perfusion Pressure and Expression of 5-LOX and CYP450 4A in the Isolated Kidney of Metabolic Syndrome Female Rats by A. M. Zúñiga-Muñoz, V. Guarner Lans, E. Soria-Castro, E. Diaz-Diaz, R. Torrico-Lavayen, E. Tena-Betancourt, I. Pérez-Torres

“…In conclusion, the loss of estradiol increases renal damage while the treatment with estradiol benefits renal function by modulating arachidonic acid metabolism through the 5-lipoxygenase and cytochrome p450 4A pathways.…”
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Novel NUDCD1 gene variant predisposes to severe COVID-19 disease in Asians through modulation of antiviral DHX15- and MAVS-mediated signalling by Aseervatham Anusha Amali, Douglas Jie Wen Tay, Douglas Jie Wen Tay, Yiqi Seow, Marie Loh, Marie Loh, Marie Loh, Sharada Ravikumar, Jocelyn Jin Yu, Shaun Seh Ern Loong, Siew Wai Fong, Chang Jie Mick Lee, Jonathan Jordon Cailu Lim, Louis Hanqiang Gan, Winston Lian Chye Koh, Ying Ding, Qi Hui Sam, Zhaohong Tan, Rachel Ying Min Tan, Chong Boon Lua, Justin Jang Hann Chu, Justin Jang Hann Chu, Justin Jang Hann Chu, Amit Singhal, Shyam Prabhakar, Wee Joo Chng, Wee Joo Chng, Laurent Renia, Laurent Renia, David Chien Boon Lye, David Chien Boon Lye, Lisa F. P. Ng, Lisa F. P. Ng, Kai Sen Tan, Kai Sen Tan, Roger Foo, Roger Foo, Chang Chuan Melvin Lee, Chang Chuan Melvin Lee, Barnaby Young, Barnaby Young, Louis Yi Ann Chai, Louis Yi Ann Chai

“…BackgroundGenome-wide associative studies can potentially uncover novel pathways which modulate anti-viral immune responses against SARS-CoV-2 or identify drivers of severe disease. …”
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Modulating D-Band Center of SrTiO₃ by Co Doping for Boosted Peroxymonosulfate (PMS) Activation Under Visible Light by Kaining Sun, Xinyi Yang, Fei Qi, Yingjie Liu, Lijing Wang, Bo Feng, Jiankang Yu, Guangbo Che

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LL-37 and citrullinated-LL-37 modulate IL-17A/F-mediated responses and selectively suppress Lipocalin-2 in bronchial epithelial cells by Anthony Altieri, Dylan Lloyd, Padmanie Ramotar, Anne M van der Does, Mahadevappa Hemshekhar, Neeloffer Mookherjee

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Modulation of NETosis in Swine Neutrophil–Spermatozoa Co-Cultures In Vitro: Effects of Butylated Hydroxytoluene, Albumin, Prostaglandin E₂, and Seminal Plasma by Fabiola Zambrano, Felipe Pezo, André Furugen Cesar de Andrade, Rodrigo Rivera-Concha, Pamela Uribe, Mabel Schulz, Henricco Zapparoli, Luan Mendes de Oliveira Bezerra, Carlos Hermosilla, Anja Taubert, Raúl Sánchez

“…In swine reproduction, immune-mediated mechanisms such as neutrophil extracellular trap (NET) formation can affect sperm function and reduce fertility outcomes. This study evaluated the capacity of antioxidant and reproductive compounds—butylated hydroxytoluene (BHT), prostaglandin E₂ (PGE₂), bovine serum albumin (BSA), and seminal plasma (SP)—to modulate NETosis in co-cultures of swine neutrophils and cryopreserved spermatozoa. …”
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Annonacin induces apoptosis and modulates programmed death-ligand 1 and interferon-gamma expression in triple-negative breast cancer: Integrated in silico and in vitro analysis by Retina Yunani, Sri Agus Sudjarwo, Mustofa Helmi Effendi, Rochmah Kurnijasanti, Nurul Hidayah

“…These results highlight its potential as a dual-function anticancer agent, warranting further preclinical evaluation for use as a monotherapy or in combination with immunotherapies.…”
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PF4 inhibits ferroptosis-mediated intracerebral hemorrhage through modulating the CXCR3/AKT1/SLC7A11 signaling pathway by Na Hu, Guohong Zhang, Liping An, Wei Wang, Ran An, Yunfeng Li

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Effect of 1-DNJ on Oxidative Stress-Induced Apoptosis in Porcine Ovarian GCs Through Modulation of the PERK-ATF4/MFN2 Signaling Pathway by Wenwen Xing, Mengxuan Li, Binbin Wang, Lele Huo, Wanru Tian, Fangcai Ge, Manman Shen, Liumei Sun, Jiying Liu, Shali Yu

“…This study aimed to investigate the mechanisms by which 1-DNJ affects oxidative damage and apoptosis induced by OS in porcine follicular GCs by regulating mitochondrial function, MAMs, and ER interactions. Here, we found that GCs suffered from OS, accompanied by the up-regulation of ROS and MDA, alongside reduced activity of antioxidant enzymes (CAT and T-SOD). …”
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PINK1 modulates Prdx2 to reduce lipotoxicity‐induced apoptosis and attenuate cardiac dysfunction in heart failure mice with a preserved ejection fraction by Hao Zhang, Tianyu Xu, Xiyuan Mei, Qiming Zhao, Qiling Yang, Xianghui Zeng, Zhuang Ma, Haobin Zhou, Qingchun Zeng, Dingli Xu, Hao Ren

“…Notably, PINK1, in addition to its role in mitochondrial autophagy, can increase Prdx2 expression, effectively remove ROS and attenuate cardiomyocyte apoptosis by modulating the JNK and p38 pathways, thereby alleviating myocardial lipotoxicity and improving HFpEF cardiac function. …”
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The KNAT3a1-WND2A/3A module positively regulates fiber secondary cell wall biosynthesis in Populus tomentosa by Kuan Sun, Di Fan, Yingying Peng, Chang Liu, Lingfei Kong, Ting Lan, Xianqiang Wang, Dan Li, Chaofeng Li, Keming Luo

“…Meanwhile, the studies also demonstrate that the KNAT3 has functional differentiation in xylem development. Taken together, these data suggest that the KNAT3a1-WND2A/3A module positively regulates fiber development of the secondary xylem in poplar via the WND2A/3A-mediated hierarchical regulatory network, and supplies useful information for fiber SCW formation. …”
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Polylactic acid electrospun membranes coated with chiral hierarchical-structured hydroxyapatite nanoplates promote tendon healing based on a macrophage-homeostatic modulation strat... by Gang Luo, Juehong Li, Shuai Chen, Zhengqiang Yuan, Ziyang Sun, Tengfei Lou, Zhenyu Chen, Hang Liu, Chao Zhou, Cunyi Fan, Hongjiang Ruan

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Sea Cucumber Hydrolysates Alleviate Cognitive Deficits in D-Galactose-Induced C57BL/6J Aging Mice Associated with Modulation of Gut Microbiota by Han Gong, Hang Zhao, Xueying Mao

“…Functional prediction revealed that alterations in gut microbiota were related to signal transduction. …”
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METTL3 Intensifies the Progress of Oral Squamous Cell Carcinoma via Modulating the m6A Amount of PRMT5 and PD-L1 by Yilong Ai, Shiwei Liu, Hailing Luo, Siyuan Wu, Haigang Wei, Zhe Tang, Xia Li, Xiaozhi Lv, Chen Zou

“…As a known component in the m6A methyltransferase complex, METTL3 (methyltransferase-like 3) plays an essential role in m6A methylation. Till now, the functions of METTL3 in oral squamous cell carcinoma (OSCC) and its relative mechanism remain to be explored. …”
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Hydrogen-Releasing Micromaterial Dressings: Promoting Wound Healing by Modulating Extracellular Matrix Accumulation Through Wnt/β-Catenin and TGF-β/Smad Pathways by Pengxiang Zhao, Yufei Li, Boyuan Guo, Ziyi Liu, Xujuan Zhang, Mengyu Liu, Xuemei Ma

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Iron oxide nanoparticles enhance alkaline stress resilience in bell pepper by modulating photosynthetic capacity, membrane integrity, carbohydrate metabolism, and cellular antioxid... by Raheel Shahzad, Sri Koerniati, Putri Widyanti Harlina, Bernadetta Rina Hastilestari, Ivica Djalovic, P. V. Vara Prasad

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FGA modulates immune infiltration and tumor progression via SLC7A11/xCT-mediated disulfidptosis in the tumor microenvironment of lung adenocarcinoma by Gen Li, Qiuping Li, Qiuping Li, Sheng Yang, Dongmei Guo, Yanling Tao, Yan Jia

“…This study reveals that FGA functions as a tumor suppressor that can impede the tumorigenesis of LUAD by modulating xCT expression, suggesting a novel therapeutic strategy enabling modulation of disulfidptosis for LUAD management.…”
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A UFD1 variant encoding a microprotein modulates UFD1f and IPMK ubiquitination to play pivotal roles in anti-stress responses by Xiuzhi Li, Xiaolin Wang, Xu Liu, Ge Shan, Liang Chen

“…Here, we identified a mammalian conserved SR-mRNAiso, UFD1s, which encodes a microprotein with anti-stress functions. UFD1s decreased the K63-linked ubiquitination levels of UFD1 full-length protein (UFD1f) via competitive binding to the E3 ubiquitin ligase MARCH7, and therefore regulated the dynamics of protein ubiquitination. …”
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