Hsa_circ_0006988 Promotes Sorafenib Resistance of Hepatocellular Carcinoma by Modulating IGF1 Using miR-15a-5p by Rui Qiu, Zhifeng Zeng

“…Herein, a new circRNA, hsa_circ_0006988, was identified, and its levels were markedly enhanced in SOR-resistant (SOR-R) HCC tissues. Functionally, hsa_circ_0006988 strongly suppressed SOR toxicity in vitro. …”
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Applying the blended KTA-Sprint framework to a usability assessment of a digital health module for informal caregivers co-managing heart failure by Ting Xiong, Camila Benmessaoud, Kaylen J. Pfisterer, Noor El-Dassouki, Raima Lohani, Karen Young, Quynh Pham

“…Aims: The main purpose of this study was to design and evaluate core features of a patient-informal caregiver shared digital health module, Caretown, to support chronic disease management. …”
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Millimeter-Wave Imaging with Range-Resolved 3D Depth Extraction Using Glow Discharge Detection and Frequency-Modulated Continuous Wave Radar by Arun Ramachandra Kurup, Daniel Rozban, Amir Abramovich, Yitzhak Yitzhaky, Natan Kopeika

“…Reflected signals are processed by the GDD, which functions as a heterodyne receiver, and Fast Fourier Transform (FFT) is used to extract range data. …”
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First principles investigation of bandgap modulation and light matter interaction in cubic X₂ScInI₆ halide double perovskites for emerging energy applications by Muhammad Yar Khan, Muhammad Awais Jehangir, It Ee Lee, Qamar Wali, Tariq Usman, Li Xiaojie, Abdullah Al Souwaileh

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ELK3-CYFIP2 axis-mediated actin remodeling modulates metastasis and natural killer cell responses in triple-negative breast cancer by Seung Hee Choi, Hye Jung Jang, Joo Dong Park, Ki Seo Ryu, Eunchong Maeng, Seohyun Cho, Hail Park, Hae-Yun Jung, Kyung-Soon Park

“…E26 transformation-specific transcription factor (ELK3) is highly expressed in TNBCs, and functions as a regulator of epithelial-mesenchymal transition and immune responses. …”
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Harnessing mushrooms for poultry nutrition: Boosting health, immunity, and productivity by Md Salahuddin, Venkatesh Balan, Kayla G. Stamps, Ahmed A.A. Abdel-Wareth, Maedeh Mohammadi, Woo Kyun Kim, Weihang Zhu, Jayant Lohakare

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Improve The Capacity Of Data Transmission In Orbital Angular Momentum Multiplexing By Adjusting Link Structure by Lin Zhao, Ting Jiang, Min Mao, Yangjie Zhang, Hongzhan Liu, Zhongchao Wei, Dongmei Deng, Aiping Luo

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Micro nutrients as immunomodulators in the ageing population: a focus on inflammation and autoimmunity by Bhavani Sowndharya Balamurugan, Mathan Muthu Chinnakannu Marimuthu, Vickram Agaram Sundaram, Bharath Saravanan, Prasanth Chandrababu, Hitesh Chopra, Tabarak Malik

“…This review will cover these hologenomic interactions, including how micro nutrients can modulate immune cell function and/or cytokine production to benefit their hosts with healthy mucous-associated immunity along with a sustainable immunologic homeostasis. …”
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Mechanical structures with enhanced layout characteristics by A. A. Ефименко, А. П. Карлангач

“…The authors propose solutions for constructing mechanical structures for electronic equipment in terms of plug-in units and subracks, allowing to increase the layout characteristics of electronic modules, sections and desktop devices and increase their functional capacity without changing the architecture of standard mechanical structures. …”
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Clinical Efficacy and Safety of Ivacaftor/Lumacaftor Combination in Patients with Cystic Fibrosis: International Studies Review by Nataliya Yu. Kashirskaya, Nika V. Petrova, Rena A. Zinchenko

“…It was shown that Iva/Lum increases lung function, reduce the number of acute conditions of bronchopulmonary process (including those that require antibiotics and hospitalization), partially restores pancreas exocrine function, increases body weight and mass growth index, and improves quality of life. …”
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Clinical Application of Transcranial Magnetic Stimulation for Stroke Rehabilitation by Yi WU

“…TMS has shown its potential to modulate brain plasticity in humans, and has become a research focus of precision rehabilitation after stroke.In this paper, we would summarize the research status of TMS applications in rehabilitation after stroke, mainly elaborate the principles and methods of single pulse and paired pulse TMS, repetitive transcranial magnetic stimulation(rTMS), and theta burst stimulation(TBS), as well as their applications in motor dysfunction, aphasia, cognitive dysfunction and swallowing dysfunction after stroke.However, the mechanisms and optimal stimulation parameters of TMS are still unclear.Developing individualized TMS intervention scheme with the combination of assessments and biomarkers, and combining TMS intervention with other functional training will be the research direction of precise neural modulation in the future.…”
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Generalizations of prime submodules over non-commutative rings by Emel Aslankarayigit Ugurlu

“…Thus we define the concept as following: Assume that S(M) is the set of all submodules of M and Ø : S(M) ! S(M) [ f;g is a function. For every Y 2 S(M) and ideal I of R; a proper submodule X of M is called Ø-prime, if YI ⊆ X and YI ⊄ Ø(X); then Y ⊆ X or I ⊆ (X :R M): Then we examine the properties of Ø-prime submodules and characterize it when M is a multiplication module.…”
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Rab7a is an enhancer of TPC2 activity regulating melanoma progression through modulation of the GSK3β/β-Catenin/MITF-axis by Carla Abrahamian, Rachel Tang, Rebecca Deutsch, Lina Ouologuem, Eva-Maria Weiden, Veronika Kudrina, Julia Blenninger, Julia Rilling, Colin Feldmann, Solveig Kuss, Youli Stepanov, Anna Scotto Rosato, Guadalupe T. Calvo, Maria S. Soengas, Doris Mayr, Thomas Fröhlich, Thomas Gudermann, Martin Biel, Christian Wahl-Schott, Cheng-Chang Chen, Karin Bartel, Christian Grimm

“…Humans carrying gain-of-function polymorphisms in the melanosomal/endolysosomal two-pore cation channel TPC2 present with hypopigmentation, blond hair, and albinism. …”
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A homeostatic model of IκB metabolism to control constitutive NF‐κB activity by Ellen L O'Dea, Derren Barken, Raechel Q Peralta, Kim T Tran, Shannon L Werner, Jeffrey D Kearns, Andre Levchenko, Alexander Hoffmann

“…Simulations reveal a homeostatic NF‐κB signaling module in which differential degradation rates of free and bound pools of IκB represent a novel cross‐regulation mechanism that imparts functional robustness to the signaling module.…”
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APPLICATION OF MODELS OF INFORMATION AND ANALYTICAL SUPPORT SYSTEMS FIRE FIGHTING RESCUE UNITS by O. I. Stepanov, S. A. Khudyakova

“…Objectives It was proposed to review the structure of the fire and rescue divisions management system, based on the decomposition of the forces and means of the subdivisions into fire extinguishing positions and ensuring fire extinguishing actions.Method The structural and functional model of the development of the fire and rescue divisions management system has been clarified, which allows to present the stages of the development of the system as components of a single fire extinguishing process. …”
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Dietary L-proline supplementation ameliorates autism-like behaviors and modulates gut microbiota in the valproic acid-induced mouse model of autism spectrum disorder by Jingjing Fang, Ruixuan Geng, Seong-Gook Kang, Kunlun Huang, Tao Tong

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Efficacy and safety of remote electrical neuromodulation in migraine: a comprehensive systematic review and meta-analysis by Asmaa Zakria Alnajjar, Mohamed M. M. Mustafa, Omar Khaled Abdelsalam, Israa Sharabati, Amr K. Hassan, Meran Allam, Moaz Elsayed Abouelmagd

“…Additionally, 59% (95% CI: 0.548 to 0.637), and 54% (95% CI: 0.471 to 0.609) of patients reported sustained pain relief and sustained pain-free status at 24 h, respectively. Marked functional improvement was achieved in 59% (95% CI: 0.577–0.607) of patients within 2 h post-treatment with REN, and 54.6% (95% CI: [0.519 to 0.574]) reported the disappearance of their most bothersome symptom (MBS). …”
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Screening of Human Milk Oligosaccharide Combinations for Immunomodulatory Activity and Immunomodulatory Effects of Milk Formula Containing Them on Mice by MENG Liping, YANG Chang, XU Xiaomin, WANG Meihua, SHI Hanxu, YE Wanyun, LIU Siyuan, QIAN Wentao, LI Hongliang, XU Yajun

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Cryptochrome-mediated blue light regulates cell lignification via PbbHLH195 activation of the PbNSC in pear fruits by Qi Wang, Xinyi Wu, Mei Ren, Fanghang Zhang, Yang Zhang, Yueyang Wang, Wen Li, Zhihua Xie, Kaijie Qi, Shaoling Zhang, Katsuhiro Shiratake, Yingying Niu, Shutian Tao

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D-cycloserine effects on COPD and depression in a murine experimental model by Uriel Heresco-Levy, Uriel Heresco-Levy, Jacob Haviv, Yehezkel G. Caine, Jimmy Bao, Jimmy Bao, Tai-Yu Huang, Chien-Chang Shen, Naama R. Bogot

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