EGb761 suppressed vascular dementia via modulating Wnt/β-catenin signaling pathway-induced apoptosis and autophagy in hippocampal neuronal cells by Nan Yin, Zhipeng Tang, Yanyan Yang, Xiuqin Li, Ruisheng Duan, Guodong Xu, Peiyuan Lv

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Mitigation of sepsis-induced liver injury by Clemastine via modulating GSDMD/NLRP-3/Caspase-1/NF-κB signalling pathways by Mahmoud Abdelnaser, Mina Ezzat Attya, Mahmoud A. El-Rehany, Moustafa Fathy

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A novel transcriptional regulator, CdeR, modulates the type III secretion system via c-di-GMP signaling in Dickeya dadantii by Alaleh Ghasemi, Xiaochen Yuan, Ching-Hong Yang

“…Additionally, we found that removing helical regions within the Helix-Turn-Helix DNA-binding domain of CdeR completely disrupted its regulation of the T3SS, underscoring the essential role of this domain in CdeR’s functional activity. This study is the first to identify CdeR as a potential transcriptional regulator involved in T3SS regulation. …”
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Discovery of 1,3-disubstituted prop-2-en-1-one derivatives as inhibitors of neutrophilic inflammation via modulation of MAPK and Akt pathways by Mohammad Abdel-Halim, Dalia S. El-Gamil, Mennatallah A. Hammam, Mohamed El-Shazly, Yi-Hsuan Wang, Po-Hsiung Kung, Yu-Cheng Chen, Michal Korinek, Ashraf H. Abadi, Matthias Engel, Tsong-Long Hwang

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<i>Hylocereus polyrhizus</i> Pulp Residues Polysaccharide Alleviates High-Fat Diet-Induced Obesity by Modulating Intestinal Mucus Secretion and Glycosylation by Guanghui Li, Kit-Leong Cheong, Yunhua He, Ahluk Liew, Jiaxuan Huang, Chen Huang, Saiyi Zhong, Malairaj Sathuvan

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Targeting LIF With Cyclovirobuxine D to Suppress Tumor Progression via LIF/p38MAPK/p62‐Modulated Mitophagy in Hepatocellular Carcinoma by Yingying Shao, Di Lu, Wenke Jin, Sibao Chen, Lifeng Han, Tao Wang, Leilei Fu, Haiyang Yu

“…ABSTRACT Leukemia inhibitory factor (LIF) exerts an oncogenic function in several types of cancer, including hepatocellular carcinoma (HCC). …”
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<i>Lactobacillus johnsonii</i> modulation of bone marrow-derived dendritic cells generated from mice with null mutation of the Muc2 gene by E. A. Blinova, E. P. Goncharova, G. V. Kalmykova, N. I. Akulova, E. A. Litvinova

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Application of root exudates derived from peanut/maize intercropping system promotes peanut growth and yield via modulating nitrogen turnover processes by Tong Si, Lijian Yang, Jinhao Lu, Yimin Lin, Xiaona Yu, Xiaojun Zhang, Xiaoxia Zou

“…Abstract Background Legume-based intercropping systems function in boosting crop productivity. However, the precise physiological mechanisms by which root exudates derived from these systems on crop growth have not been characterized. …”
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Exploring the interactome of the Staphylococcus aureus sRNA Srn_9342 identified a complex formation with RNAIII leading to the modulation of δ-hemolysin expression by Julie Bronsard, Chloé Silard, Julie Legros, Noëlla Germain-Amiot, Marc Hallier, Yoann Augagneur

“…Results We showed that Srn_9342 is expressed under two isoforms of different lengths (Srn_9342S and Srn_9342L) whose transcript levels are divergent as a function of growth phase with Srn_9342S being expressed at low cell-density, then being substituted by Srn_9342L at high cell-density. …”
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Induced neural stem cells ameliorate blood-brain barrier injury by modulating the calcium signaling pathway of astrocyte in cerebral ischemia-reperfusion rats by Xueyun Liang, Chuanshang Cao, Ningmei Liu, Dongmei Chen, Ting Liu, Haibin Ma, Jiaxin Liu, Taojuan Wu, Jianguo Niu

“…Additionally, iNSCs downregulated the expression level of pCaMK-II, increased the expression level of superoxide dismutase, and inhibited the expression of caspase 9 in both brain of MCAO/R rats and OGD-damaged astrocytes.ConclusioniNSCs transplantation improved BBB function by modulating calcium signaling pathway of astrocyte in MCAO/R rats, which proved iNSCs may be a new promising neural stem cells origin for the treatment of cerebral ischemia-reperfusion injury.…”
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Active dry yeast enhances immunity through modulation of gut microbiota and serum metabolic processes in captive forest musk deer (Moschus berezovskii) by Zaixiang Ying, Qinlin Yang, Shan Xie, Mingcheng Cai, Wenqiao Fan, Hanyu Gao, Xiaolan Feng, Yongjiang Wu

“…Active dry yeast (ADY), as a commonly used feed additive, has been widely applied in domestic livestock to improve gut microbiota and enhance immune function. Whether dietary supplementation with ADY in captive FMD contributes to gut microbial homeostasis and physical health is still unclear. …”
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Assimilating multi-site eddy-covariance data to calibrate the wetland CH₄ emission module in a terrestrial ecosystem model by J. T. Kallingal, M. Scholze, P. A. Miller, J. Lindström, J. Rinne, M. Aurela, P. Vestin, P. Weslien

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Citrullination of NF‐κB p65 by PAD2 as a Novel Therapeutic Target for Modulating Macrophage Polarization in Acute Lung Injury by Xin Yu, Yujing Song, Tao Dong, Wenlu Ouyang, Chao Quan, Liujiazi Shao, Leonard Barasa, Paul R. Thompson, Mao Zhang, Jianjie Ma, Katsuo Kurabayashi, Yongqing Li

“…However, the mechanisms of PAD2 on macrophage function in Pseudomonas aeruginosa (PA)‐induced acute lung injury syndrome (ALI) remains unclear. …”
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Whole blood transcriptome profiles of trypanotolerant and trypanosusceptible cattle highlight a differential modulation of metabolism and immune response during infection by Trypan... by Peylhard, Moana, Berthier, David, Dayo, Guiguigbaza-Kossigan, Chantal, Isabelle, Sylla, Souleymane, Nidelet, Sabine, Dubois, Emeric, Martin, Guillaume, Sempéré, Guilhem, Flori, Laurence, Thévenon, Sophie

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Exogenous TSG-6 treatment alleviates DSS-induced colitis in mice by modulating Pou2f3 and promoting tuft cells differentiation by Shaopeng Yang, Yuqi Li, Rongwei Ruan, Jiangping Yu, Bo Zhu, Haibin Lou, Xiaolan Zhang, Shi Wang

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Ultrasound Stimulation Modulates Microglia M1/M2 Polarization and Affects Hippocampal Proteomic Changes in a Mouse Model of Alzheimer's Disease by Xinliang Lu, Wenxian Sun, Li Leng, Yuting Yang, Shuting Gong, Qi Zou, Haijun Niu, Cuibai Wei

“…This study investigated the effects of ultrasound stimulation on the proportion and function of microglia of different phenotypes, as well as on the levels of inflammatory factors. …”
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Chronic inflammation in post-acute sequelae of COVID-19 modulates gut microbiome: a review of literature on COVID-19 sequelae and gut dysbiosis by Najeeha Talat Iqbal, Hana Khan, Aqsa Khalid, Syed Faisal Mahmood, Nosheen Nasir, Iffat Khanum, Isadora de Siqueira, Wes Van Voorhis

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Short-Term Effects of Visceral Manual Therapy on Autonomic Nervous System Modulation in Individuals with Clinically Based Bruxism: A Randomized Controlled Trial by Cayetano Navarro-Rico, Hermann Fricke-Comellas, Alberto M. Heredia-Rizo, Juan Antonio Díaz-Mancha, Adolfo Rosado-Portillo, Lourdes M. Fernández-Seguín

“…<b>Conclusions</b>: The findings suggest that two sessions of VMT may lead to significant improvements in HRV-SDNN compared to the placebo, suggesting a modulatory effect on autonomic function. No consistent changes were observed for the viscoelastic properties of the masticatory muscles. …”
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Linoleic acid metabolite 13-Hydroxyoctadecadienoic acid as a biphasic ferroptosis modulator in granulosa cells: multi-omics analysis of ovine atretic follicles by Yukun Song, Erhan Hai, Lixia He, Ning Zhang, Nan Zhang, Junlan Wang, Yupeng Sun, Dengke Zeng, Jiaxin Zhang, Jiaxin Zhang

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Electroacupuncture enhances mesenchymal stem cell therapy via improved perfusion and inflammation modulation in peripheral nerve injury: an IVIM-MRI study in rats by Junfeng Li, Qiuyi Chen, Jintong Pan, Jintong Pan, Fanqi Meng, Wensheng Huang, Yingying Liang, Xuewen Yu, Ruirui Qi, Peiyin Luo, Haodong Qin, Yueyao Chen, Xiaofeng Lin

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