Modulation of cerebral cortex activity by acupuncture combined with continuous theta-burst stimulation in post-stroke upper limb spasticity: an fNIRS study by Junfeng Zhang, Junfeng Zhang, Junfeng Zhang, Meng Wang, Hao Chen, Shiyu Fan, Shiyu Fan, Shiyu Fan, Rongshan Sun, Rongshan Sun, Rongshan Sun, Lin Wang, Shan Cong, Shan Cong, Shan Cong, Tao Yu, Tao Yu, Yulin Qian

“…The F wave amplitude was significantly lower than before intervention, and the difference was significant (p < 0.05).ConclusionAcupuncture combined with cTBS can relieve upper limb spasticity, enhance motor function, improve daily living ability, and reduce excessive spinal cord excitability. …”
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GNB2L1 and its O-GlcNAcylation regulates metastasis via modulating epithelial-mesenchymal transition in the chemoresistance of gastric cancer. by Shimeng Cheng, Qiqi Mao, Yabing Dong, Jie Ren, Lina Su, Jianlan Liu, Qingmei Liu, Jing Zhou, Xiaolu Ye, Shudan Zheng, Ningwen Zhu

“…Next, we investigate the function of GNB2L1 and its O-GlcNAcylation on gastric cancer metastasis during chemoresistance, and confirmed Ser124 as the major O-GlcNAcylation site on GNB2L1 that regulated its function on metastasis. …”
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Author Correction: Palbociclib and dsRNA sensor co-operate to enhance anti-cancer effects through ER stress and modulation of immune evasion by Victoria Roulstone, Joan Kyula-Currie, James Wright, Emmanuel C. Patin, Isaac Dean, Lu Yu, Aida Barreiro-Alonso, Miriam Melake, Jyoti Choudhary, Richard Elliott, Christopher J. Lord, David Mansfield, Nik Matthews, Ritika Chauhan, Victoria Jennings, Charleen Chan Wah Hak, Holly Baldock, Francesca Butera, Elizabeth Appleton, Pablo Nenclares, Malin Pedersen, Shane Foo, Amarin Wongariyapak, Antonio Rullan, Tencho Tenev, Pascal Meier, Richard Vile, Hardev Pandha, Alan Melcher, Martin McLaughlin, Kevin J. Harrington

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ChCpc1, a bZIP transcription factor, coordinates amino acid synthesis and autophagy and modulates conidiation and virulence in Cochliobolus heterostrophus by Huilin Yu, Jiyue Zhang, Longhao Su, Mengjiao Jia, Yuanyuan Tian, Hongyu Pan, Xianghui Zhang

“…However, although conserved in fungal plant pathogens, Cpc1 function and regulatory mechanisms are still largely unknown. …”
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Non-canonical CRL4A/4B(CDT2) interacts with RAD18 to modulate post replication repair and cell survival. by Sarah Sertic, Claudio Evolvi, Emanuela Tumini, Paolo Plevani, Marco Muzi-Falconi, Giuseppe Rotondo

“…This function prevents replication stress, ATR hyper-signaling and, ultimately, apoptosis. …”
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The truncated isoform of the receptor for hyaluronan-mediated motility (RHAMMΔ163) modulates shelterin and telomerase reverse transcriptase transcription affecting telomerase activ... by Kaustuv Basu

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The Role of Umbilical Cord Mesenchymal Stem Cell-Derived Extracellular Vesicles in Modulating Dermal Fibroblast Activity: A Pathway to Enhanced Tissue Regeneration by Muttiah Barathan, Kow Jack Ham, Hui Yin Wong, Jia Xian Law

“…This study investigates the effects of UC-MSC-derived EVs on dermal fibroblast function, and their potential in wound healing applications. …”
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Modulation of NMDA receptor signaling and zinc chelation prevent seizure-like events in a zebrafish model of SLC13A5 epilepsy. by Deepika Dogra, Van Anh Phan, Sinan Zhang, Cezar Gavrilovici, Nadia DiMarzo, Ankita Narang, Kingsley Ibhazehiebo, Deborah M Kurrasch

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STAT1β modulates the tumor immune microenvironment to improve prognosis in ovarian cancer: a comprehensive study of transcriptional and protein expression differences by Ning Lan, Xintong Li, Yifan Qiao, Siyi Zhang, Min Chen, Xiaofeng Yang, Yuliang Zou, Juan Ren, Meili Pei

“…Abstract Objectives As a central regulator of the JAK/STAT signaling pathway, STAT1 generates functionally distinct α and β protein isoforms through alternative splicing. …”
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Melatonin Modulates Endoplasmic Reticulum Stress and Akt/GSK3-Beta Signaling Pathway in a Rat Model of Renal Warm Ischemia Reperfusion by Kaouther Hadj Ayed Tka, Asma Mahfoudh Boussaid, Mohamed Amine Zaouali, Rym Kammoun, Mohamed Bejaoui, Sonia Ghoul Mazgar, Joan Rosello Catafau, Hassen Ben Abdennebi

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Inhibition of histone deacetylase 6 activity mitigates neurological impairment and post-hemorrhagic hydrocephalus after intraventricular hemorrhage by modulating pyroptosis and aut... by Hao-Xiang Wang, Zi-Ang Deng, Yuan-You Li, Jun Li, Ya-Xing Chen, Yan-Jie Zhao, Ke-Ru Huang, Wei-Ning Tian, Ai-Ping Tong, Liang-Xue Zhou

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Brain tumor detection across diverse MR images: An automated triple-module approach integrating reduced fused deep features and machine learning by Yugal Pande, Jyotismita Chaki

“…Brain tumors pose a significant threat to human health due to their potential to disrupt normal brain function. Early and accurate detection is crucial for effective treatment. …”
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Corneal sensory nerve loss induced by repeated subconjunctival and topical bupivacaine disrupts tear secretion and enhances bacterial adhesion via neuropeptide modulation. by Ananya Datta, Grace Kelly Orallo, Nahomy Nelson

“…This approach ensured precise modulation of corneal sensory function. Using this model, we investigated how sensory denervation influences microbial adhesion dynamics for Pseudomonas aeruginosa, Staphylococcus aureus, and Staphylococcus epidermidis, three clinically relevant pathogens with distinct adhesion mechanisms. …”
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CPAP modulation of sleep microstructure (N2-SSD and REM-AHI) as predictors of neurological recovery in ischemic stroke patients with moderate-to-severe OSA by Tianyu Jing, Tianyu Jing, Tianyu Jing, Liwen Xu, Liwen Xu, Shutong Sun, Wenyi Yu, Wenyi Yu, Yixi Zheng, Yixi Zheng, Gang Xu, Xinhao Shen, Tieyu Tang, Cheng Chu, Cheng Chu

“…N2-SSD, REM-AHI, and Mean SpO2 are mechanistically linked to functional prognosis and CPAP exerts therapeutic effects through the modulation of these biomarkers. …”
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Computational simulation of short-range order structures in high-entropy alloys: a review on formation patterns, multiscale characterization, and performance modulation mechanisms by Hongyang Liu, Bo Chen, Rong Chen, Jingzhi He, Dongdong Kang, Jiayu Dai

“…This review systematically summarizes recent advances in understanding SRO structures in HEAs, with a focus on computational simulation methods, including density functional theory (DFT), molecular dynamics (MD), Monte Carlo (MC), and emerging machine learning interatomic potentials(MLPs). …”
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BHLHE41 Overexpression Alleviates the Malignant Behavior of Colon Cancer Cells Induced by Hypoxia via Modulating HIF-1α/EMT Pathway by Sheng Chen, Quan-Jin Dong, Zi-Ang Wan, Shan Gao, Shi-Liang Tu, Rui Chai

“…After, CC cells were subjected to hypoxia treatment and BHLHE41 overexpression transfection, and the BHLHE41 expression, the effect of BHLHE41 on CC cell viability, apoptosis, migration, and invasion and cell cycle were tested by qRT-PCR and relevant cell functional experiments. HIF-1α and epithelial-mesenchymal transition- (EMT-) related proteins were tested by Western blot. …”
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Flavonoids-rich extract of Aframomum melegueta (black pepper) improves antioxidant status and modulates aging process in lead-induced neurotoxic Drosophila melanogaster by Mohammed Sani Jaafaru

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Sulfur-containing amino acids enhanced antioxidant of yellow mealworm proteins: GPx4 activation through structural modulation evidenced by spectroscopy method by Xin Cui, Yunfei Xie, Meng-Lei Xu, Yu Gao

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S-9-PAHSA ameliorates cognitive decline in a type 2 diabetes mouse model by inhibiting oxidative stress and apoptosis via CAIII modulation by Xin-Ru Wang, Xin-Ru Wang, Xin-Ru Wang, Shan-Shan Huang, Meng Wang, Jin-Hong Lin, Jian-Tao Wang, Jiao-Qi Ren, Cheng-Feng He, Wen-Jiao Xue, Yin Wang, Xue-Chun Wang, Yan-Li Zhang, Ji-Chang Xiao, Jing-Chun Guo, Hou-Guang Zhou

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Immune cell infiltration and modulation of the blood-brain barrier in a guinea pig model of tuberculosis: Observations without evidence of bacterial dissemination to the brain. by Amanda S Latham, Charlize E Geer, David F Ackart, Kristin N Weninger, Chase C Gross, Brendan K Podell, Randall J Basaraba, Julie A Moreno

“…Following Mtb infection, proteins critical to BBB function, including claudin V and collagen IV, are modulated without evidence of bacterial dissemination to the brain. …”
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