Interactive Effect of Residue Quality and Agroecologies Modulate Soil C- and N-Cycling Enzyme Activities, Microbial Gene Abundance, and Metabolic Quotient by Birhanu Agumas, Getachew Agegnehu, Tesfaye Feyisa

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Activating transcription factor 3 is an antitumor gene synergizing with growth differentiation factor 15 to modulate cell growth in human bladder cancer by Syue-Ting Chen, Kang-Shuo Chang, Wei-Yin Lin, Shu-Yuan Hsu, Hsin-Ching Sung, Yu-Hsiang Lin, Tsui-Hsia Feng, Chen-Pang Hou, Horng-Heng Juang

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A Protein Kinase Cε/Protein Kinase D3 Signalling Axis Modulates RhoA Activity During Cytokinesis by Ursula Braun, Michael Leitges

“…However, defined statements regarding PKD isoform specificity and in vivo functions are rare. Methods: Here, we use PKD3-depleted mouse embryonic fibroblast cells and employ various cell culture-based assays and fluorescence microscopy. …”
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The Aβ42:Aβ40 ratio modulates aggregation in beta-amyloid oligomers and drives metabolic changes and cellular dysfunction by Annika Haessler, Stefanie Gier, Nathalie Jung, Maike Windbergs

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TRIM21 modulates stability of pro-survival non-coding RNA vtRNA1-1 in human hepatocellular carcinoma cells. by EunBin Kong, Norbert Polacek

“…Recent studies expanded our knowledge of diverse pro-survival functions of short non-coding vault RNAs. One of the human vault RNA paralogs, vtRNA1-1, modulates several intracellular processes, including proliferation, apoptosis, autophagy, and drug resistance in various types of human cancer cells. …”
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Boosting LiMn2O4 Diffusion Coefficients and Stability via Fe/Mg Doping and MWCNT Synergistically Modulating Microstructure by Natasha Ross, Shane Willenberg, Thando Juqu, Emanuela Carleschi, Bryan P. Doyle

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Bifidobacterium animalis suppresses non-small cell lung cancer progression and modulates tumor immunity through indole-3-acetic acid by Qian Song, Xinpei Li, Qing Li, Shijie Shang, Shuling Ma, Zijun Zhai, Fengxin Sun, You Mo, Ling Wei, Meng Wu, Yuequn Ma, Jinming Yu, Dawei Chen

“…Moreover, B. animalis and IAA diminish polarization of M2 macrophage and enhance CD8+ T cell functions by suppressing interleukin-6 (IL-6). B. animalis and its derived IAA protect against NSCLC by modulating AHR/METTL3/STAT3 and bolstering antitumor immunity through gut-lung axis. …”
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HMGB1 Modulates High Glucose-Induced Erroneous Differentiation of Tendon Stem/Progenitor Cells through RAGE/β-Catenin Pathway by Panpan Lu, Guangchun Dai, Liu Shi, Yingjuan Li, Ming Zhang, Hao Wang, Yunfeng Rui

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A mucosal vaccine prevents eosinophilic allergic airway inflammation by modulating immune responses to allergens in a murine model of airway disease by Carmen Sevilla-Ortega, Alba Angelina, Leticia Martín-Cruz, Mario Pérez-Diego, Angel Maldonado, Begoña Lavín, Beatriz Marcos-Ramiro, Luis Pérez de Llano, Auba Gayá, Francisco X. Real, Laura Conejero, José Luis Subiza, Oscar Palomares

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Design and synthesis of 8-nitroquinoline azine D-π-A module chemosensors: Fluorogenic onsite detection of sarin gas mimic- DCP by Sentamil Selvi Ramasamy, Kaviyarasu Adhigaman, Vandana Nandakumar, Akilesh Muralidharan, Shankar Ramasamy, Suresh Thangaraj

“…The consequent mechanistic pathway proposed for the sensing systems are PET combined with ICT for NQH, while the NQH-1 system functions through ESIPT coupled with ICT processes. …”
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Chronic hepatitis B virus infection imbalances short-chain fatty acids and amino acids in the liver and gut via microbiota modulation by Wendi Zhang, Yuwei Wu, Min Cheng, Haiming Wei, Rui Sun, Hui Peng, Zhigang Tian, Yongyan Chen

“…Furthermore, changes in microbial functions were revealed. There were no significant differences in the levels of SCFAs in fecal and serum; however, decreased propionic acid and acetic acid were detected in the livers of HBs-HepR mice, which was negatively related to the abundance of Geobacillus in the liver. …”
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Puerarin pretreatment provides protection against myocardial ischemia/reperfusion injury via inhibiting excessive autophagy and apoptosis by modulation of HES1 by Yong Yuan, Songqing Lai, Tie Hu, Fajia Hu, Chenchao Zou, Xiuqi Wang, Ming Fang, Jichun Liu, Huang Huang

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The modulating effect of coat color mutations on the generation and neutralization of reactive oxygen species in the Аmerican mink (Neovison vison) as a model by S. N. Sergina, V. A. Ilyukha, I. V. Baishnikova, T. N. Ilyina

“…It was found that the functioning of both RO S generation and neutralization systems was genotypespecific. …”
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Deubiquitylase USP52 Promotes Bladder Cancer Progression by Modulating Ferroptosis through Stabilizing SLC7A11/xCT by Jianmin Liu, Yongwen Luo, Siming Chen, Gang Wang, Wan Jin, Wenyu Jiang, Mingxing Li, Yejinpeng Wang, Jingtian Yu, Houyi Wei, Renjie Zhang, Fenfang Zhou, Lingao Ju, Yi Zhang, Yu Xiao, Kaiyu Qian, Xinghuan Wang

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Osteomodulin modulates the inflammatory responses via the interleukin-1 receptor 1/nuclear factor-κB signaling pathway in dental pulpitis by Yueyi Yang, Xuchen Hu, Meiling Jing, Xiaohan Zhu, Xiaoyu Liu, Wenduo Tan, Zhanyi Chen, Chenguang Niu, Zhengwei Huang

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Targeted Delivery of Bortezomib Using Retinoid-Based Nanoparticle: Modulating Liver Fibrosis through the TGF-β1/Smad3 Pathway by Samaneh Siapoush, Mohammad Rahmati, Morteza Milani, Behzad Hatami, Nosratollah Zarghami, Abbas Ebrahimi-Kalan, Mohammad Reza Zali, Kaveh Baghaei

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Sodium butyrate alleviates DSS-induced inflammatory bowel disease by inhibiting ferroptosis and modulating ERK/STAT3 signaling and intestinal flora by Yingyin Liu, Nachuan Chen, Huaxing He, Lulin Liu, Suxia Sun

“…In addition, NaB regulates the composition and functions of flora related to IBD.Conclusion NaB alleviates IBD by inhibiting ferroptosis and modulating ERK/STAT3 signaling and the intestinal flora.KEYWORDS Sodium butyrate; IBD; ferroptosis; STAT3; ERK; gut microbiota…”
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Vitamin D and omega-3 fatty acids attenuate MSG-induced neurodegeneration by modulating tau pathology, neuroinflammation, and VDR expression in rats by Rasha Z. Alshahawy, Sally M. Safwat, Sanad S. El-Kholy, Soheir F. El-basiony, Sara El-Desouky, Soheir M. Helmi

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NAD+ metabolism enzyme NNMT in cancer-associated fibroblasts drives tumor progression and resistance to immunotherapy by modulating macrophages in urothelial bladder cancer by Jian Huang, Bo Wang, Dong Yan, Tianxin Lin, Lu Pei, Hao Yu, Wang He, Kaiwen Li, Meihua Yang, Weibin Hou, Honghui Zeng, Xin-Ke Zhang, Long Huang, Haide Qin

“…A series of experiments, including chromatin immunoprecipitation assay, liquid chromatography tandem mass spectrometry assay, and CRISPR‒Cas9 (Clustered Regularly Interspaced Short Palindromic Repeats and CRISPR-associated protein 9) knockout, together with in vivo models, have been established to determine the molecular functions of NNMT in CAFs in UBC.Results We demonstrated that elevated expression of the nicotinamide adenine dinucleotide (NAD+) metabolism enzyme NNMT in CAFs (NNMT+ CAFs) was significantly associated with non-response to programmed death-ligand 1 (PD-L1) blockade immunotherapy in patients with UBC and predicted the unfavorable prognosis of UBC in two independent large cohorts. …”
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Adaptive Thermogenesis and Lipid Metabolism Modulation in Inguinal and Perirenal Adipose Tissues of <i>Hezuo Pigs</i> in Response to Low-Temperature Exposure by Yao Li, Hai-Xia Shi, Jie Li, Hong Du, Rui Jia, Yu-Hao Liang, Xiao-Yu Huang, Xiao-Li Gao, Shuang-Bao Gun, Qiao-Li Yang

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