Preclinical assessment of the selective androgen receptor modulator RAD140 to increase muscle mass and bone mineral density by Jake Puskas, Teja Guda, Sarah Niccoli, Christopher R. Rathbone, Benjamin Tan‐Johnson, David Puskas, Ryan Middleton, Jeffrey S. Otis, Simon J. Lees

“…This study aimed to determine if the SARM RAD140 had additive effects on muscle hypertrophy when combined with the functional overloading (FO) of the plantaris muscle. …”
Get full text

Exploring the outcomes of non-surgical periodontal therapy in modulating periodontal parameters, renal function, and inflammatory biomarkers in chronic kidney disease patients with periodontitis by Harishini Rajaratinam, Nurul Aliya Abdul Rahman, Muhammad Hafiz Hanafi, Siti Lailatul Akmar Zainuddin, Hanim Afzan Ibrahim, Muhammad Imran Kamarudin, Wan Mohd Saifuhisam Wan Zain, Sirajudeen Kuttulebbai Nainamohamed Salam, Salbiah Isa, Nur Karyatee Kassim

“…Six weeks following treatment, periodontal parameters, renal function tests and inflammatory markers were re-evaluated to determine any modulation in these outcomes. …”
Get full text

Congee Containing Carotenoids-Enriched Functional Ingredient from Tomato Improves Cognition, Serum α-Synuclein, Monoaminergic Function, and Gut-Brain Axis Functions in the Elderly... by Jintanaporn Wattanathorn, Supaporn Muchimapura, Wipawee Thukham-mee, Terdthai Tong-un

“…Taking all data together, the carotenoid-enriched congee enhances cognitive function and working memory. The mechanisms may partly involve the increase in monoaminergic function, while the modulation of the gut–brain axis may require further confirmation.…”
Get full text

QUALITY ASSESSMENT OF MULTIFOCAL DIFFRACTIVE LENS IMAGES by V. G. Kolobrodov, G. S. Timchik, Ie. A. Siryi

Subjects: Get full text

Modulation of pAKT and NF-κB pathways by Moringa oleifera silver nanoparticles: inducing apoptosis in cervical cancer cells by Naura Luviezka Choirunnisa, Debora Chris Kezia, Aiko Zavira Permana, Nik Ahmad Nizam Nik Malek, Fahrul Nurkolis, Happy Kurnia Permatasari

Get full text

Advanced Circuit Design and Implementation of a Highly Digitalized Third-Order VCO-Based Sigma-Delta Modulator With Enhanced Noise Transfer Function by Shuenn-Yuh Lee, Yi-Ting Hsieh, Ju-Yi Chen

Subjects: Get full text

Gut microbial metabolite TMAO impairs cognitive function and induces hippocampal synaptic plasticity decline through modulation of GSK-3β activity by Yachen Shi, Pan Wang, Jingyu Deng, Yunuo Chen, Feng Wang, Yan Han, Hui Wang, Yang Li, Xiangming Fang, Jiaojie Hui, Guangjun Xi

Get full text

Adult Patients Affected by Cystic Fibrosis in Therapy with Cystic Fibrosis Transmembrane Regulator Modulators and Lung Transplant: Renal Function, Metabolic and Nutritional Status by Silvia Lai, Sandro Mazzaferro, Anna Paola Mitterhofer, Francesca Tinti, Enea Bonci, Antonello Giovannetti, Claudio Casella, Adolfo Marco Perrotta, Domenico Bagordo, Manuel Murciano, Alessandro Galani, Camilla Celani, Patrizia Troiani, Giuseppe Cimino, Paolo Palange

“…Moreover, we showed a lower inflammatory status in patients on CFTR modulators therapy. Therefore, we suggest early and careful monitoring of renal function, metabolic, and nutritional parameters in CF patients, whether they are on conservative therapy, CFTR modulators therapy, and LRs patients.…”
Get full text

Coptisine ameliorates colitis in mice by modulating cPLA2/TRPM8/CGRP-1 signaling pathways and strengthening intestinal barrier function by Wenbin Wu, Changcheng Shu, Lisheng Chen, Shizhang Wei, Manyi Jing, Hui Li, Haotian Li, Yanling Zhao

“…Our study revealed that COP enhanced intestinal barrier function by modulating the cPLA2/TRPM8/CGRP-1 signaling pathway, thus shedding light on the mechanism by which COP mitigates inflammation in the intestinal mucosa. …”
Get full text

Role of <i>opuB</i> in Modulating Membrane Vesicle Composition and Function in <i>Streptococcus mutans</i> Under Neutral and Acidic Conditions by Wenyu Wang, Yiyi Huang, Huancai Lin, Yina Cao

Get full text

Biochanin a modulates steroidogenesis and cellular metabolism in human granulosa cells through TAS2Rs activation: a spotlight on ovarian function by Francesca Paola Luongo, Sofia Passaponti, Alesandro Haxhiu, Irene Ortega Baño, Rosetta Ponchia, Giuseppe Morgante, Paola Piomboni, Alice Luddi

Get full text

β3-Adrenergic receptor antagonism improves cardiac and vascular functions but did not modulate survival in a murine resuscitated septic shock model by Eugénie Hagimont, Marc-Damien Lourenco-Rodrigues, Benjamin-Glenn Chousterman, Frances Yen-Potin, Manon Durand, Antoine Kimmoun

“…Abstract Background Recent findings suggest that β3-adrenergic receptors (β3-AR) could play a role in the hemodynamic regulation, but their function in septic shock remains unclear. This study investigates the modulation of β3-AR in an experimental murine model of resuscitated septic shock on in vivo hemodynamic, ex vivo vasoreactivity, inflammation and survival. …”
Get full text

Dual-site beta transcranial alternating current stimulation during a bimanual coordination task modulates functional connectivity between motor areas by Mareike A. Gann, Ilenia Paparella, Catharina Zich, Ioana-Florentina Grigoras, Silvana Huertas-Penen, Sebastian W. Rieger, Axel Thielscher, Andrew Sharott, Charlotte J. Stagg, Bettina C. Schwab

“…Background: Communication within brain networks depends on functional connectivity. One promising approach to modulate such connectivity between cortical areas is dual-site transcranial alternating current stimulation (tACS), which non-invasively applies weak alternating currents to two brain areas. …”
Get full text

Partial replacement of corn silage with sorghum-sudangrass silage improves growth performance and rumen function in Hu sheep via microbial and metabolic modulation by Chuang Li, Zhiqiang Cheng, Xuezhao Sun, Jingquan Yang, Ning Chen, Kailun Yang, Mengzhi Wang

Get full text

The Gut Microbiome Modulates the Association Between Healthful Plant-Based Diet and Age-Related Cognitive Function Among Community-Dwelling Older Adults by Jie Shen, Zhonghan Sun, Huiling Song, Yuhui Huang, Liyan Huang, Xiaofeng Wang, Changzheng Yuan, Yan Zheng

Get full text

Prolonged Proofing Modulates the Acrylamide Content, Nutritional and Functional Characteristics of Pumpkin (<i>Cucurbita maxima</i> Plomo) and Soft Wheat Composite Bread by Durim Alija, Remigiusz Olędzki, Daniela Nikolovska Nedelkoska, Agata Wojciechowicz-Budzisz, Ewa Pejcz, Vezirka Jankuloska, Gafur Xhabiri, Joanna Harasym

Get full text

Restoration of autonomic balance and cortical and cerebral structures functions harmonization indicators by means of gamma-aminobutyric acid system modulation in patients with primary hypertension by V. V. Batushkin, I. О. Lavrinchuk

Get full text

Comprehensive identification of cotton EPF/EPFL receptors and functional characterization of the GhEPFL1-1-GhER1 module in drought tolerance by Shichang He, Huijian Sun, Qing Chen, Yanlong Yang, Zixin Zhou, Saiwen Chang, Shuaiqi Lu, Zhencai Liang, Julan Yang, Xiao fei

Get full text

NLRP3 inflammasome-modulated angiogenic function of EPC via PI3K/ Akt/mTOR pathway in diabetic myocardial infarction by Jia-Peng Li, Shu Qiu, Guang-Jie Tai, Yi-Ming Liu, Wei Wei, Meng-Meng Fu, Pan-Qi Fang, Joseph Nicolao Otieno, Tungalag Battulga, Xiao-Xue Li, Ming Xu

“…Meanwhile, we found that USP14 selectively suppressed NLRP3 protein degradation through the USP motif on the NACHT domain in mediating inflammasome activation. Cardiac functional outcomes in recipient mice after intramyocardial injection of shNlrp3 EPC overexpressing CEBPB or USP14 validated the modulation of EPC function by regulating Nlrp3 transcription or post-translational modification. …”
Get full text

P79 | AN INNOVATIVE FUNCTIONAL COOKIE MODULATES THE MUCOSA AND MYENTERIC PLEXUS IN THE GUT OF 3xTg-AD MOUSE MODEL OF ALZHEIMER’S DISEASE

“…Moreover, in the ENS, gliosis was decreased in functional cookies supplemented mice without a clear modulation of enteric cholinergic and nitrergic neurons. …”
Get full text