Preclinical pharmacology of alogabat: a novel GABAA-α5 positive allosteric modulator targeting neurodevelopmental disorders with impaired GABAA signaling by Giuseppe Cecere, Theresa M. Ballard, Frederic Knoflach, Michael Honer, Joerg F. Hipp, Pilar Garces, Thomas Mueggler, Basil Künnecke, Andreas Bruns, Eric P. Prinssen, Philipp Schoenenberger, Philipp Janz, Roger Redondo, Barbara Biemans, Henner Knust, Andrés Olivares-Morales, Alessandro Brigo, Jan Michael Schulz, Daniel Bertrand, Michael Saxe, Eoin C. O’Connor, Maria-Clemencia Hernandez

“…BackgroundAlterations in the GABAergic system contribute to the pathophysiology of neurodevelopmental disorders, including autism spectrum disorder (ASD) and Angelman syndrome (AS), particularly in cases involving large deletions in the 15q11–13 region. Positive modulation of GABAA-α5 receptors may provide a novel therapeutic approach without the typical side effects associated with non-selective GABAA positive allosteric modulators such as diazepam.MethodsAlogabat was assessed for binding and functional activity at GABAA-α5β3γ2 receptors in vitro and in electrophysiological studies using hippocampal slices. …”
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Surface Defect Detection of Frozen Dumplings Based on Improved RetinaNet Model by Zhigen FEI, Xing GUO, Xiaoxiao SONG, Hao LU, Xinchang ZHAO

“…The addition of the convolutional block attention module (CBAM) and the use of the Swish activation function could effectively suppress the influence of background noise. …”
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The Growth, Pathogenesis, and Secondary Metabolism of <i>Fusarium verticillioides</i> Are Epigenetically Modulated by Putative Heterochromatin Protein 1 (FvHP1) by Andrés G. Jacquat, Natalia S. Podio, María Carmen Cañizares, Pilar A. Velez, Martín G. Theumer, Vanessa A. Areco, María Dolores Garcia-Pedrajas, José S. Dambolena

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Chi-circ_0009659 modulates goat intramuscular adipocyte differentiation through miR-3431-5p/STEAP4 axis by Xin Li, Hao Zhang, Yong Wang, Yanyan Li, Youli Wang, Yan Xiong, Wei Liu, Yaqiu Lin

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Thymol, Alpha‐Tocopherol and Ascorbyl Palmitate as a Natural Feed Supplements to Modulate Immune Variables and Heterophil to Lymphocyte Ratio in Broiler Chickens by Emiliano Ariel Videla, Jorge Martin Caliva, Romina Paula Andrea Picco, Raúl Héctor Marín, Agustin Luna, Franco Nicolas Nazar

“…Global policies are banning antimicrobial growth promoters mainly due to antimicrobial resistance. Antioxidants modulate immunity by reducing oxidative stress, which impairs immune function. …”
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Ramulus Mori (Sangzhi) alkaloids ameliorate high-fat diet induced obesity in rats by modulating gut microbiota and bile acid metabolism by Xin Shang, Xin Shang, Yu Fu, Ying Wang, Shuxun Yan

“…This activation helps to alleviate HFD-fed intestinal inflammation and restore intestinal barrier damage by modulating inflammatory cytokines and bolstering the intestinal barrier’s capabilities.ConclusionsOur findings indicate that SZ-A effectively modulates BW, serum lipid profiles, and liver function in HFD-fed rats. …”
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MODELING OPTICAL INTENSITY MODULATORS BASED ON MACH-ZEHNDER INTERFEROMETER BY SOFTWARE TOOL OF MICROWAVE CIRCUITS CALCULATION NI AWR DESIGN ENVIRONMENT by М. Е. Belkin, V. V. Golovin, Yu. N. Tyschuk, S. A. Kudzh, A. S. Sigov

“…One of the most suitable solution of this complex problem is in using working on symbolic level CAD tool NI AWR Design Environment (AWRDE) from National Instruments, which has extensive built-in library of multi-parametric models for electronic and topological components, functional modules, or system units. Following it, in the paper we offer an upgraded nonlinear physical equivalent-circuit model of the double-sideband optical modulator, fully implemented based on AWRDE Schematic library elements. …”
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Glutathione precursor N-acetyl-cysteine modulates EEG synchronization in schizophrenia patients: a double-blind, randomized, placebo-controlled trial. by Cristian Carmeli, Maria G Knyazeva, Michel Cuénod, Kim Q Do

“…<h4>Unlabelled</h4>Glutathione (GSH) dysregulation at the gene, protein, and functional levels has been observed in schizophrenia patients. …”
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The rice OsCBL3-OsCIPK31 module regulates root development via abscisic acid and auxin signaling pathways by Shicong Yu, Shuqin Zheng, Jing Ning, Yuanzhu Shi, Daiming Guo, Ruxian Luo, Guizong Xiao, Saira Saleem, Asif Ali, Hao Zhou, Xianjun Wu

“…Therefore, the OsCBL3–OsCIPK31 module functioned in ABA and auxin signal transduction, ensuring proper root growth. …”
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CRABP2 promotes myoblast differentiation and is modulated by the transcription factors MyoD and Sp1 in C2C12 cells. by Jing Yuan, Zhonglin Tang, Shulin Yang, Kui Li

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THE FIRST STEP IN VALIDATING THE PedsQL™ – FAMILY IMPACT MODULE QUESTIONNAIRE IN ROMANIA. THE QUALITY OF LIFE OF PARENTS WITH CHILDREN WITH AUTISTIC SPECTRUM DISORDER by Camelia POPA, Ana DRAGU, Elisabeta NIȚĂ, Cornelia RADA

“…Its use highlighted significant deteriorations in total quality of life scores and scores for emotional, social, cognitive functioning, communication, worry, daily activities, and family relationships scales. …”
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In vivo tracking of grape marc biomarkers, bioconversion, metabolic tracers, and microbiota modulation in swine fed a polyphenol-rich extract diet. by Aly Castillo, Maria Celeiro, Beatriz Martínez-Vallespín, Laura Rubio, Diego Gonzalez-Iglesias, Rocío Facorro, Carmen Garcia-Jares, Jürgen Zentek, Marta Lores

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The RhoGDIβ-Rac1-CARD9 Signaling Module Mediates Islet β-Cell Dysfunction Under Chronic Hyperglycemia by Anjaneyulu Kowluru, Jie-Mei Wang

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Dendrobium officinale polysaccharide attenuates type 2 diabetes in mice model by modulating gut microbiota and alleviating intestinal mucosal barrier damage by Xiaoxia Chen, Chun Chen, Changyang Ma, Wenyi Kang, Junlin Wu, Xiong Fu

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A novel cyclic peptide (Naturido) modulates glia-neuron interactions in vitro and reverses ageing-related deficits in senescence-accelerated mice. by Shinichi Ishiguro, Tetsuro Shinada, Zhou Wu, Mayumi Karimazawa, Michimasa Uchidate, Eiji Nishimura, Yoko Yasuno, Makiko Ebata, Piyamas Sillapakong, Hiromi Ishiguro, Nobuyoshi Ebata, Junjun Ni, Muzhou Jiang, Masanobu Goryo, Keishi Otsu, Hidemitsu Harada, Koichi Suzuki

“…These findings of in vitro glia-neuron interactions led us to evaluate the effects of oral administration of the peptide on brain function and hair ageing in senescence-accelerated mice (SAMP8). …”
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Daily intake of a dairy-based nutritional supplement improved self-reported gastrointestinal symptoms and modulated microbiota in adult Chinese volunteers by Klaudyna Borewicz, Yifan Zhao, Yaqiong Zhu

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A peptidic unconjugated GRP78/BiP ligand modulates the unfolded protein response and induces prostate cancer cell death. by Danilo Maddalo, Antje Neeb, Katja Jehle, Katja Schmitz, Claudia Muhle-Goll, Liubov Shatkina, Tamara Vanessa Walther, Anja Bruchmann, Srinivasa M Gopal, Wolfgang Wenzel, Anne S Ulrich, Andrew C B Cato

“…The molecular chaperone GRP78/BiP is a key regulator of protein folding in the endoplasmic reticulum, and it plays a pivotal role in cancer cell survival and chemoresistance. Inhibition of its function has therefore been an important strategy for inhibiting tumor cell growth in cancer therapy. …”
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Nanoparticle-mediated delivery of herbal-derived natural products to modulate immunosenescence-induced drug resistance in cancer therapy: a comprehensive review by Lichang Yang, Wei Wu, Jing Yang, Manman Xu

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Astaxanthin-rich Nannochloropsis oculata mitigates high-fat diet-induced liver dysfunction in zebrafish by modulating lipid metabolism and oxidative stress by Shima Jafari, Mohammad Akhavan-Bahabadi, Seyed Pezhman Hosseini Shekarabi, Mehdi Shamsaie Mehrgan, Elly Lowen, Kasra Lotfi, Azin Azari

“…These protective effects are attributed to astaxanthin’s role in boosting mitochondrial β-oxidation, suppressing lipogenesis, and modulating inflammatory pathways. These findings suggest that N. oculata is a promising functional feed additive for mitigating diet-induced liver dysfunctions in aquaculture. …”
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Estradiol Reverses Ovariectomy-Induced Disruption of Hypothalamic Gene Expression and Behavior via Modulation of Gonadotropin Releasing Hormone and Calcium Signaling Pathways by Asim Muhammad, Mubashir Muhammad, Xiaohuan Chao, Chunlei Zhang, Jiahao Chen, Huan Yang, Shuhan Liu, Yuan Ding, Ziming Wang, Hongwei Bi, Wen Guo, Junhong Fan, Bo Zhou

“…Estrogen plays a crucial role in regulating reproductive and neuroendocrine functions, yet the molecular mechanisms underlying its effects on the hypothalamus remain incompletely understood. …”
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