Cardiovascular and Metabolic Effects of Modulating Circulating Ketone Bodies With 1,3‐Butanediol in Patients With Heart Failure With Reduced Ejection Fraction by Halvor Guldbrandsen, Nigopan Gopalasingam, Kristian Hylleberg Christensen, Oskar Kjærgaard Hørsdal, Roni Nielsen, Henrik Wiggers, Kristoffer Berg‐Hansen

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Fucoidan Alleviates Porcine Epidemic Diarrhea Virus-Induced Intestinal Damage in Piglets by Enhancing Antioxidant Capacity and Modulating Arginine Metabolism by Qian Zhang, Maojing Wang, Zhonghua Li, Di Zhao, Yongqing Hou, Tao Wu

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Celastrol suppresses neovascularization in rat aortic vascular endothelial cells stimulated by inflammatory tenocytes via modulating the NLRP3 pathway by Yang Yong, Wang Huajun, Hou Huige, Chen Jiwen, Chen Xiaolei, Zheng Hongjian, Zheng Kai, Ye Baofei, Wu Chunhui, Zheng Xiaofei, Yuan Shiguo, Zheng Boyuan

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Response Analysis on Electrical Pulses under Severe Nuclear Accident Temperature Conditions Using an Abnormal Signal Simulation Analysis Module by Kil-Mo Koo, Jin-Ho Song, Sang-Baik Kim, Kwang-Il Ahn, Won-Pil Baek, Kil-Nam Oh, Gyu-Tae Kim

“…The program links signal analysis tool code to abnormal signal simulation engine code not only as a one body order system, but also as a part of functions of a PC-based ASSA (abnormal signal simulation analysis) module developed to obtain a varying range of the R-C circuit elements in high temperature conditions. …”
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Synergistic therapy of Chinese herbal medicine and gut microbiota modulation for post-stroke cognitive recovery: focus on microbial metabolite and immunoinflammation by Shihui Ge, Shihui Ge, Shuangli Zhang, Shuangli Zhang, Linjing She, Tianning Gu, Tianning Gu, Shicong Wang, Shicong Wang, Xin Huang, Xin Huang, Lanlan Wang, Lanlan Wang, Mingsan Miao, Mingsan Miao, Mingsan Miao

“…Recent studies have highlighted the role of gut microbiota and their metabolites in modulating immunoinflammation and cognitive function via the gut-brain axis. …”
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Immune Checkpoint PD‐L1 Modulates Retinal Microglial Activation to Alleviate Vascular Leakage in Choroidal Neovascularization via ERK by Yue Zou, Junliang Jiang, Yunqin Li, Xinyi Ding, Qiuping Tong, Ying Shi, Lei Xiao, Ling Chen

“…This study explores the role of Programmed cell death ligand 1 (PD‐L1), an immune checkpoint (ICP) in microglia, known for limiting neuroinflammation in neurodegenerative diseases, and its potential function in NVAMD. This work finds increased PD‐L1 expression in retinal microglia following laser injury. …”
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Xuesaitong Protects Podocytes from Apoptosis in Diabetic Rats through Modulating PTEN-PDK1-Akt-mTOR Pathway by Rui Xue, Ruonan Zhai, Ling Xie, Zening Zheng, Guihua Jian, Teng Chen, Jun Su, Chongting Gao, Niansong Wang, Xifei Yang, Youhua Xu, Dingkun Gui

“…XST (5 mg/kg·d) or Losartan (10 mg/kg·d) was given to diabetic rats for 12 weeks. Albuminuria, renal function markers, and renal histopathology morphological changes were examined. …”
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RBM10 deficiency promotes brain metastasis by modulating sphingolipid metabolism in a BBB model of EGFR mutant lung adenocarcinoma by Gang Xu, Bo An, Ruqiong Wang, Bo Pan, Huiting Hao, Xingmei Ren, Zihan Jing, Weitong Gao, Yajie Li, Yan Jin, Enguang Lin, Lihua Shang, Dexin Jia, Yan Yu

“…Results This study demonstrates that RBM10 plays a vital role in inhibiting brain metastasis from EGFR-mutated LUAD by modulating sphingolipid metabolism. When RBM10 expression is low, GALC enters the nucleus to function. …”
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Modulating the CXCR2 Signaling Axis Using Engineered Chemokine Fusion Proteins to Disrupt Myeloid Cell Infiltration in Pancreatic Cancer by Benjamin N. Christopher, Lena Golick, Ashton Basar, Leticia Reyes, Reeder M. Robinson, Aaron O. Angerstein, Carsten Krieg, G. Aaron Hobbs, Denis C. Guttridge, John P. O’Bryan, Nathan G. Dolloff

“…MDSCs suppress effector cell function, making them attractive targets for restoring anti-tumor immunity. …”
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Modulation of RuO2 Nanocrystals with Facile Annealing Method for Enhancing the Electrocatalytic Activity on Overall Water Splitting in Acid Solution by Kangjin Song, Feng Bao, Zheling Wang, Shengding Chang, Na Yao, Haiqing Ma, Yadong Li, Caizhen Zhu, Hong Xia, Fushen Lu, Yibing Song, Jin Wang, Muwei Ji

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Thyroid Dysfunction After Intensity-Modulated Radiotherapy and PD⁃1 Inhibitor Treatment for Locally Advanced Nasopharyngeal Carcinoma by Shang K, He Q, Xu X, Luo X, Zhao C, Liu L, Li Z, Li Y, Jin F

“…Patients with thyroid dysfunction had longer overall survival, progression-free survival, and distant metastasis-free survival at both one and two years compared to patients with normal thyroid function, but the difference was not statistically significant (p > 0.05). …”
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Intra-BLA alteration of interneurons’ modulation of activity in rats, reveals a dissociation between effects on anxiety symptoms and extinction learning by Rinki Saha, Lisa-Sophie Wüstner, Darpan Chakraborty, Rachel Anunu, Silvia Mandel, Joyeeta Dutta Hazra, Martin Kriebel, Hansjuergen Volkmer, Hanoch Kaphzan, Gal Richter-Levin

“…Activity within the BLA is tightly modulated by GABAergic interneurons, and thus inducing lasting alteration of GABAergic modulation of principal neurons may have an impactful metaplastic effect on BLA functioning. …”
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A molecular dynamics study of membrane positioning for 7-transmembrane RGS proteins to modulate G-protein-mediated signaling in plants by Celio Cabral Oliveira, Eduardo Bassi Simoni, Mariana Abrahão Bueno Morais, Elizabeth Pacheco Batista Fontes, Pedro A. Braga dos Reis, Daisuke Urano, Alan M. Jones

“…This study presents the novel function of a highly conserved, known phosphorylation site, Ser278, within this linker region utilizing molecular dynamics (MD) simulations with in vivo experimental validation. …”
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Targeting casein kinase 2 and ubiquitin-specific protease 7 to modulate RUNX2-mediated osteogenesis in chronic kidney disease by Haifeng Lan, Xiao-Jun Yu, Guangsheng Ling, Yuwei Zeng, Yixi Yang, Meiyang He, Yixiao Yu, Ming Shao

“…In vivo and in vitro experiments were conducted to assess the effects of CK2-mediated phosphorylation and USP7-induced deubiquitination on RUNX2 stability and function. Histomorphometry, Enzyme-Linked Immunosorbent Assay (ELISA), and micro-CT analyses were performed to evaluate bone density, strength, and metabolic markers. …”
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Association of nociceptive, neurocognitive, psychological and genetic profile on conditioned pain modulation in women with migraine: protocol for a case–control study by Lars Arendt-Nielsen, Margarita Cigarán-Méndez, César Fernández De las Peñas, Silvia Ambite-Quesada, Ana I de-la-Llave-Rincón, Gustavo Plaza-Manzano, Cristina Gómez-Calero, Francisco G Fernández-Palacios, Juan C Pacho-Hernández, Angela Tejera-Alonso, Juan A Valera-Calero, Beatriz Alvarez-Mariño, Carlos Ordás-Bandera

“…Introduction Migraine is a primary headache showing a multifactorial component that includes altered pain processing, psychological/emotional problems, neurocognitive and executive function deficits, all with a possible genetic association. …”
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Human placental mesenchymal stem cells ameliorates premature ovarian insufficiency via modulating gut microbiota and suppressing the inflammation in rats. by Shudan Liu, Ting Wang, Yuanyuan Liu, Yiwei Li, Junbai Ma, Qikuan Hu, Hao Wang, Xiaoxia Zhang

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Melatonin-induced Bacillus tequilensis enhanced the disease resistance of Camellia oleifera against anthracnose by modulating cell wall and phenylpropanoid metabolism by Aiting Zhou, Aiting Zhou, Huiqin Zhou, Huiqin Zhou, Ruiqi Peng, Ruiqi Peng, Di Liu, Di Liu, Jianrong Wu, Jianrong Wu, Jia Deng, Jia Deng, Fang Wang, Fang Wang

“…In addition, MT-DZY 6715 promoted the expression of secondary metabolism-related genes, such as PAL, CAL, Laccase, HCT, and CHI, and inhibited the activity of enzymes related to cell wall degradation (pectinase and cellulase), thereby coordinating and enhancing the accumulation of secondary metabolites and strengthening the mechanical properties of the cell wall.DiscussionThe results of this study demonstrate that MT-DZY 6715 enhances the resistance of C. oleifera to anthracnose by modulating leaf morphology, regulating stomatal function, and promoting the accumulation of secondary metabolites. …”
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Zinc methionine mitigates intestinal mucosal injury of broilers challenged with Salmonella by modulating mucus secretion, tight junction and microbial composition by Yuxin Shao, Yanrui Suo, Zheng Wang, Huiling Sun, Yifang Cui, Fangfang Guo, Dongmei Lin, Tenghe Ma, Fuzhou Xu

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Multi-omics profiling reveals Poria cocos polysaccharides mitigate PEDV-induced intestinal injury by modulating lipid metabolism in piglets by Qian Zhang, Shuaijie Wang, Mengjun Wu, Zihan Tan, Tao Wu, Dan Yi, Lei Wang, Di Zhao, Yongqing Hou

“…Improved intestinal function was further evidenced by elevated plasma D-xylose levels and decreased diamine oxidase activity (P < 0.05). …”
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N-glycosylation of PD-L1 modulates the efficacy of immune checkpoint blockades targeting PD-L1 and PD-1 by Bar Kaufman, Muhammad Abu-Ahmad, Olga Radinsky, Eman Gharra, Tal Manko, Baisali Bhattacharya, Daniela Gologan, Nofar Erlichman, Tsipi Meshel, Yoav Nuta, Tomer Cooks, Moshe Elkabets, Adit Ben-Baruch, Angel Porgador

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