Absolute Quantitative Metagenomic Analysis Provides More Accurate Insights for the Anti-Colitis Effect of Berberine via Modulation of Gut Microbiota by Jiaguo Zhan, Jiale Cheng, Wenhui Chang, Yuying Su, Xixin Yue, Chongming Wu

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Cognitive impairment following maternal separation in rats mediated by the NAD+/SIRT3 axis via modulation of hippocampal synaptic plasticity by Keke Hao, Fashuai Chen, Shilin Xu, Ying Xiong, Rui Xu, Huan Huang, Chang Shu, Yisheng Lv, Gaohua Wang, Huiling Wang

“…However, there is limited understanding of the molecular mechanisms regulating mitochondria in neural circuits that govern cognitive impairment relevant to schizophrenia, and their impact on neuronal structure and function. A 24-h MS rat model was utilized to simulate features associated with schizophrenia. …”
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CircPWWP2A promotes renal interstitial fibrosis through modulating miR-182/ROCK1 axis by Qian Huang, Kaiyi Zhong, Jiali Wei

“…Renal fibrosis is a long-term and progressively worsening condition that impacts kidney function during aging and in the context of chronic kidney disease (CKD). …”
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Phillyrin ameliorates DSS-induced colitis in mice via modulating the gut microbiota and inhibiting the NF-κB/MLCK pathway by Tong Li, Guiqiu Hu, Shoupeng Fu, Di Qin, Zheyu Song

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Sinomenine restrains breast cancer cells proliferation, migration and invasion via modulation of miR-29/PDCD-4 axis by Guanglei Gao, Xiaolin Liang, Wenyan Ma

“…The research attempted to probe the anti-tumor function of Sino in breast cancer cells and divulge the feasible molecular mechanism. …”
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Tannic acid-iron stabilized probiotic silver nano hybrids: Multi-target gut microbiota modulation and intestinal barrier restoration by Saisai Gong, Zhibo Zeng, Mingjue Liu, Xianfu Wang, Chuxian Quan, Muhammed Farhan Rahim, Yaping Wang, Aoyun Li, Md. F. Kulyar, Zhexue Lu, Jiakui Li

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CCT8 drives colorectal cancer progression via the RPL4-MDM2-p53 axis and immune modulation by Yangyang Teng, Hao Lin, Zijian Lin, Xichen Li, Yejiao Ruan, Binhui Pan, Jinlin Ge, Yuesheng Zhu, Daopo Lin, Qingji Ying, Zhenzhai Cai, Xuanping Xia

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Leucine-rich repeat-containing 56 promotes breast cancer progression via modulation of the RhoA/ROCKs signaling axis by Xiqian Zhou, Jiaxin Wang, Meiling Lu, Lin Fang, Junyong Zhao, Dengfeng Li

“…However, the role for LRRC56 in breast cancer progression and regulation of IFT88 and associated pathways in metastatic progression of breast cancer has not been defined. Via in vitro functional assessments, we found that LRRC56 pivotally influences the proliferative, migratory and invasive capabilities of cancer cells. …”
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Pharmacological inhibition of Septins with Forchlorfenuron attenuates thrombus formation in experimental thrombotic mice models with modulating multiple signaling pathways in plate... by Zhen Hao, Minghui Yan, Reyisha Tuerhong, Luying Zhang, Zhen Zhang, Habib Alam, Jun Wu, Yuanhua Qin, Feng Zhao, Lei Shi

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Targeting CD74 in microglia to modulate experimental cerebral ischemia and reperfusion injury: insights from Single-Cell and bulk transcriptomics by Chang Cao, Ting Liu, Lu Peng, Lianxin Li, Zhongmou Xu, Xiang Li, Gang Chen, Haiying Li, Lei Bai

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High Rosmarinic Acid Content <i>Melissa officinalis</i> L. Phytocomplex Modulates Microglia Neuroinflammation Induced by High Glucose by Giacomina Videtta, Chiara Sasia, Nicoletta Galeotti

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A chemosensory-like histidine kinase is dispensable for chemotaxis in vitro but regulates the virulence of Borrelia burgdorferi through modulating the stability of RpoS. by Ching Wooen Sze, Kai Zhang, Michael J Lynch, Radha Iyer, Brian R Crane, Ira Schwartz, Chunhao Li

“…First, microscopic analyses using green-fluorescence-protein (GFP) tags reveal that CheA1 has a unique and dynamic cellular localization. Second, loss-of-function studies indicate that CheA1 is not required for chemotaxis in vitro despite sharing a high sequence and structural similarity to its counterparts from other bacteria. …”
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Wuling powder ameliorates diarrhea-predominant irritable bowel syndrome in mice by modulating gut mucosal microbiota and alleviating intestinal inflammation by Qianghong Tian, Donglin Yu, Junxi Shen, Leyao Fang, Ying Cai

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Targeted metabolomics reveals the role of ginsenoside Rb1 in modulating inflammation and cellular senescence in sepsis-induced acute lung injury by Fushuang Zheng, Wei Wang, Linlin Gao, Zhiling Fu

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miR-107 modulates EMT progression of OSCC by targeting SNCG and inhibiting the ERK/NF-κB signaling pathways by Han Liu, Jun Zheng, Zuodong Ren, Kangyuan Shen, Yan Zeng

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Modulation of Sel1L can alleviate altered ER homeostasis towards white matter damage in CKD-stroke complex by Aishika Datta, Priti Patale, Debarati Ghosh, Priya Jagtap, Jinagna Shah, Mounika Katamneni, Anita Kumari, Nikita Malik, Gautam Karmarkar, Anirban Barik, Bijoyani Ghosh, Pooja Dhakne, Vinod Pathulothu, Deepaneeta Sarmah, Harpreet Kaur, Nikita Rana, Rajeshwari Rathod, Anupom Borah, Pinaki Sengupta, Pallab Bhattacharya

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Strong Amplitude Modulation of Hard-band X-Ray Quasiperiodic Oscillation with Soft-band Flux in RE J1034+396 by Ruisong Xia, Hao Liu, Yongquan Xue

“…They are highly correlated, with an average cross-correlation function (CCF) peak coefficient of 0.61 and a lag of approximately 3 ks. …”
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Aerobic exercise ameliorates atherosclerosis-induced cognitive impairment via hippocampal IL-33/NF-κB signaling modulation by Jianwei Peng, Zaoshang Chang, Jinyun Wang, Zijie Liao, Yunjie Yang, Lianwei Mu, Shen Wang, Junhao Huang, Jingbo Xia, Min Hu

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SIRPα modulates microglial efferocytosis and neuroinflammation following experimental subarachnoid hemorrhage via the SHP1/STAT6 axis by Bingtao Zhang, Yan Zou, Qikai Tang, Zixuan Yuan, Kun Jiang, Zhaoxiang Zhang, Shujuan Chen, Qi Wu, Xiaoming Zhou, Xin Zhang

“…Signal regulatory protein alpha (SIRPα) plays a crucial role in efferocytosis by acting as a “don’t eat-me” signal, modulating inflammation and tissue homeostasis. However, the precise function and regulatory mechanisms of SIRPα in efferocytosis remain unclear. …”
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Gut commensal bacteria-derived methionine is required for host reproduction by modulating RNA m6A methylation of the insulin receptor by Qiuyuan Zhang, ZhuRong Deng, Xiaoxue Li, Jiao Qiao, Ziniu Li, Peipei Liu, Alfred M. Handler, Bruno Lemaitre, Weiwei Zheng, Hongyu Zhang

“…Summary: Gut commensal bacteria promote host reproduction by modulating metabolism and nutrition, but the molecular mechanisms by which microbes regulate reproduction remain unclear. …”
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