BLISTER-regulated vegetative growth is dependent on the protein kinase domain of ER stress modulator IRE1A in Arabidopsis thaliana. by Zheng-Hui Hong, Tao Qing, Daniel Schubert, Julia Anna Kleinmanns, Jian-Xiang Liu

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Unlocking vinpocetine's oncostatic potential in early-stage hepatocellular carcinoma: A new approach to oncogenic modulation by a nootropic drug. by Osama A Mohammed, Mahmoud E Youssef, Rabab S Hamad, Mustafa Ahmed Abdel-Reheim, Lobna A Saleh, Mohannad Mohammad S Alamri, Muffarah Hamid Alharthi, Jaber Alfaifi, Masoud I E Adam, Ali M S Eleragi, Ahmed Senbel, Alshaimaa A Farrag, Assad Ali Rezigalla, Hend S El-Wakeel, Mohammed A Attia, Hussein M El-Husseiny, Tohada M Al-Noshokaty, Ahmed S Doghish, Ahmed Gaafar Ahmed Gaafar, Sameh Saber

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Amonabactin Synthetase G Regulates <i>Aeromonas hydrophila</i> Pathogenicity Through Modulation of Host Wnt/β-catenin Signaling by Yiyang Tang, Xiaofeng Liu, Chuyi Zeng, Yujun Liu, Ye Yang, Jiayi Hu, Pingyuan Li, Zejun Zhou

“…Conclusions: AmoG plays a crucial role in <i>A. hydrophila</i> pathogenicity by modulating host Wnt/β-catenin signaling and gut mucosal barrier function. …”
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Implementation of digital sigma-delta modulators for high-resolution audio digital-to-analog converters based on field programmable gate array by Zbigniew KULKA, Piotr WOSZCZEK

“…The field programmable gate array (FPGA)-based hardware is particularly suitable for the implementation of basic functional blocks of audio sigma-delta DACs. This paper presents the design, simulation, and the FPGA implementation of the lowpass digital sigma-delta modulators (SDMs) in various configurations. …”
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Uric Acid Causes Pancreatic β Cell Death and Dysfunction via Modulating CHOP-Mediated Endoplasmic Reticulum Stress Pathways by Xueyan Li, Yunan Chen, Lei Su, Jialin He

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Oleuropein Regulates Bile Acid Metabolism via Modulating the Gut Microbiota, Thereby Alleviating DSS-Induced Ulcerative Colitis in Mice by Rongxin Zang, Rui Zhou, Yaodong Li, Zhouliang Liu, Huihao Wu, Liping Lu, Hongwei Xu

“…Therefore, this study was conducted to explore the mechanisms for OLE to alleviate UC induced by dextran sulfate sodium (DSS), with the focus placed on its regulatory function in the gut microbiota. The results indicated that OLE mitigated DSS-induced UC by enhancing the intestinal barrier function, reshaping the gut microbiota, and modulating bile acid metabolism. …”
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The role of dietary sodium intake on the modulation of T helper 17 cells and regulatory T cells in patients with rheumatoid arthritis and systemic lupus erythematosus. by Rossana Scrivo, Laura Massaro, Cristiana Barbati, Marta Vomero, Fulvia Ceccarelli, Francesca Romana Spinelli, Valeria Riccieri, Alessandra Spagnoli, Cristiano Alessandri, Giovambattista Desideri, Fabrizio Conti, Guido Valesini

“…We aimed at investigating whether the frequency and function of T helper 17 (Th17) and regulatory T cells (Treg) are affected by a restriction of dietary sodium intake in patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). …”
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Gut-derived Faecalibaculum rodentium exerts anti-cancer effects on colorectal cancer by modulating PDPN-CLEC-2 signaling pathway by Xiaojuan Yang, Miao Liu, Ting Wang, Xinjuan Ma, Zhirong Guan, Bin Ma, Xiangguo Duan, Chunxia Su

“…Changes in anti-tumor immune responses were evaluated by flow cytometry. The functional metabolites produced by F. rodentium were identified by gas chromatography‒mass spectrometry (GC‒MS). …”
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Date pomace polysaccharides-capped selenium nanoparticles: Biosynthesis, optimization, physicochemical characterization, biological activities, stability and gut microbiota modulat... by Gafar Babatunde Bamigbade, Athira Subhash, Mohammed Abdin, Hebah Jarusheh, Basim Abu-Jdayil, Shao-Quan Liu, Giovanni Palmisano, Abdelmoneim Ali, Afaf Kamal Eldin, Mutamed Ayyash

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Modulating food craving-related neural oscillations using tACS: study protocol for a randomized sham-controlled trial by Milos Ljubisavljevic, Milos Ljubisavljevic, Fransina C. King, Fransina C. King, Fatima Yousif Ismail, Yauhen Statsenko, Yauhen Statsenko, Shahid Bashir, Osama Abdullah, Osama Abdullah, Bas Rokers, Bas Rokers

“…Electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) will be conducted pre- and post-intervention. …”
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Dimethyl fumarate modulates M1/M2 macrophage polarization to ameliorate periodontal destruction by increasing TUFM-mediated mitophagy by Liang Chen, Pengxiao Hu, Xinhua Hong, Bin Li, Yifan Ping, ShuoMin Chen, Tianle Jiang, Haofu Jiang, Yixin Mao, Yang Chen, Zhongchen Song, Zhou Ye, Xiaoyu Sun, Shufan Zhao, Shengbin Huang

“…Dimethyl fumarate (DMF) has been used in the treatment of various immune-inflammatory diseases due to its excellent anti-inflammatory and antioxidant functions. Here, we investigated for the first time the therapeutic effect of DMF on periodontitis. …”
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Interferon Regulatory Factor 4 dose-dependently controls peripheral Treg cell differentiation and homeostasis by modulating chromatin accessibility in mice by Leonie Caroline Voß, Constantin Schmidt, Constantin Schmidt, Aenne Harberts, Aenne Harberts, Aenne Harberts, Michael Spohn, Michael Spohn, Michael Spohn, Peter Bradtke, Alina Borchers, Alina Borchers, Alina Borchers, Stefanie Fertig, Joanna Schmid, Friedrich Koch-Nolte, Christian F. Krebs, Christian F. Krebs, Christian F. Krebs, Friederike Raczkowski, Hans-Willi Mittrücker, Hans-Willi Mittrücker

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Palbociclib and dsRNA sensor co-operate to enhance anti-cancer effects through ER stress and modulation of immune evasion by Victoria Roulstone, Joan Kyula-Currie, James Wright, Emmanuel C. Patin, Isaac Dean, Lu Yu, Aida Barreiro-Alonso, Miriam Melake, Jyoti Choudhary, Richard Elliott, Christopher J. Lord, David Mansfield, Nik Matthews, Ritika Chauhan, Victoria Jennings, Charleen Chan Wah Hak, Holly Baldock, Francesca Butera, Elizabeth Appleton, Pablo Nenclares, Malin Pedersen, Shane Foo, Amarin Wongariyapak, Antonio Rullan, Tencho Tenev, Pascal Meier, Richard Vile, Hardev Pandha, Alan Melcher, Martin McLaughlin, Kevin J. Harrington

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Cancer cell-intrinsic resistance to BiTE therapy is mediated by loss of CD58 costimulation and modulation of the extrinsic apoptotic pathway by Cong Li, Ye Shen, Patrick Collins, Lingming Liang, Olivier Nolan-Stevaux, Jason S Eng, Flordeliza Fajardo, Donato Tedesco

“…While signs of clinical activity have been demonstrated, efficacy of T-cell engagers (TCEs) in solid tumors settings, molecular determinants of response, and underlying mechanisms of resistance to BiTE therapy require more investigation.Methods To uncover cancer cell-intrinsic genetic modifiers of TCE-mediated cytotoxicity, we performed genome-wide CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) loss-of-function and CRISPRa (CRISPR activation) gain-of-function screens using TCEs against two distinct tumor-associated antigens (TAAs). …”
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Wnt signalling facilitates neuronal differentiation of cochlear Frizzled10-positive cells in mouse cochlea via glypican 6 modulation by Man Wang, Yuechen Han, Weibin An, Xue Wang, Fang Chen, Junze Lu, Yu Meng, Yan Li, Yanqing Wang, Jingxin Li, Chunjie Zhao, Renjie Chai, Haibo Wang, Wenwen Liu, Lei Xu

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Characterization of Toll-Like Receptor-4 (TLR-4) in the Spleen and Thymus of Swiss Albino Mice and Its Modulation in Experimental Endotoxemia by Chandrayee Ghosh, Biswadev Bishayi

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EP300 Modulates MCM8 Transcription and Augments the Malignant Phenotype of Hepatitis B Virus–Positive Hepatocellular Carcinoma Cells by Fang Xue, Tian‐Feng Sun

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T2 cytokine-driven alarmin and antiviral responses in asthma: insights into immune modulation and the role of IL-4Rα targeting by Jelena Pesic, Juan José Nieto-Fontarigo, Juan José Nieto-Fontarigo, Katerina Pardali, Stephen Delaney, Henric Olsson, Lena Uller

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Beneficial modulation of the gut microbiome by leachates of Penicillium purpurogenum in the presence of clays: A model for the preparation and efficacy of historical Lemnian Earth. by Simon Milling, Umer Zeeshan Ijaz, Danae Venieri, George E Christidis, Nicholas J W Rattray, Iosifina Gounaki, Anna Andrusaite, Aravind Hareendran, Charles W Knapp, Alexander X Jones, Effie Photos-Jones

“…Our results show: (a) the leachate of the Pp+smectite co-culture is antibacterial in vitro, inhibiting the growth of both Gram-positive and Gram-negative bacteria; (b) in vivo, supplementation of regular mouse diet with leachates of Pp+smectite increases intestinal microbial diversity; (c) Pp+kaolin does not produce similar results; (d) untargeted metabolomics and analysis of bacterial functional pathways indicates that the Pp+smectite-induced microbiome amplifies production of short-chain fatty acids (SCFAs) and amino acid biosynthesis, known to modulate intestinal and systemic inflammation. …”
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Peripheral blood cells enriched by adhesion to CYR61 are heterogenous myeloid modulators of tissue regeneration with early endothelial progenitor characteristics by M Herrmann, J Schneidereit, S Wiesner, M Kuric, M Rudert, M Lüdemann, M Srivastava, N Schütze, R Ebert, D Docheva, F Jakob

“…Introduction: Circulating precursor cell populations of various lineages have been identified with putative functions in tissue regeneration, which may have potential for cell based individual regenerative strategies. …”
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