Citral protects against metabolic endotoxemia, and systemic disorders caused by high-fat diet-induced obesity via intestinal modulation by Maycon Tavares Emílio-Silva, Vinicius Peixoto Rodrigues, Mariana Moraes Fioravanti, Antonio Jesús Ruiz-Malagon, Matheus Naia Fioretto, Priscila Romano Raimundo, Rie Ohara, Renata Assunção, Gabriela Bueno, Felipe Lima Dario, Luis Antonio Justulin, Alba Rodríguez-Nogales, Lucia Regina Machado da Rocha, Júlio Gálvez, Júlio Gálvez, Clélia Akiko Hiruma-Lima

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Bovine and goat milk fat globule membrane supplementation alleviates autism-like behavior by modulating lipid metabolism and gut microbiota by Rui Guo, Xiao Xiao, Chuanchuan Wang, Tian Yuan, Qianhui Zou, Tian Zhang, Jiarui Liang, Ying He, Zhuo Liu, Xuebo Liu, Shan Wu, Zhigang Liu

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The biodegradable polymer poly(butylene succinate-co-adipate) modulates the community structures of actively growing bacteria in rotifer culture water by Akito Taniguchi, Shuji Shirakashi, Tomoki Kawagishi, Ayumi Tanaka, Mitsuru Eguchi

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Small object detection in complex open-pit mine backgrounds based on improved YOLOv11 by ZHU Yongjun, CAI Guangqi, HAN Jin, MIAO Yanzi, MA Xiaoping, JIAO Wenhua

“…The original CIoU loss function was replaced with the Powerful-IoU (PIoU) loss function to solve the anchor box expansion issue during training, enabling the model to rapidly and accurately focus on small targets. …”
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Phytotherapeutic potential of herbal extracts on male reproductive organs in rat models by A.A. Ammari, A.R. Alhimaidi, R.A. Amran, A. Rady, H. aljawdah

“…Herbal extracts, recognized for their bioactive properties such as antioxidation and hormone modulation, were evaluated for their effects on testicular function, spermatogenesis, and reproductive hormone levels. …”
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Impact of elexacaftor/tezacaftor/ivacaftor on the small airways in cystic fibrosis by Sofia Campos Silva, Andreia Barroso, Maria Cunha, Elsa Fragoso, Pilar Azevedo

“…Among the patients within the cohort, the same parameters were evaluated separately in those who had advanced lung disease and in those who had previously undergone CFTR modulator therapy. Results: There was a significant post-treatment improvement in lung function, with a median increase of 0.42 L/s in the FEF25-75% (p < 0.001) and a 5% reduction in the mean RV/TLC ratio (p < 0.001). …”
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Design, Synthesis, and Biological Assessment of Novel Vanillin-Isoxazole Derivatives as Positive Allosteric Modulators of α7 Nicotinic Acetylcholine Receptor by Santiago Stabile, Juan Facundo Chrestia, Gabriel Radivoy, Cecilia Bouzat

“…Therefore, enhancing its function with positive allosteric modulators (PAMs) is a promising therapeutic approach for treating cognitive deficits and neurodegenerative disorders. …”
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BCG Vaccination Potentially Modulates the Transcriptome of Infant CD4 T Cells in Addition to Age-Dependent Immune Ontogeny-Associated Changes by Vidya Vijayan Karuvan Kandiyil, Eunchong Kang, Emily Coates, Portia Kamthunzi, Gerald Tegha, Mina Hosseinipour, Di Wu, Fei Zou, Kristina De Paris

“…Vaccination with BCG resulted in additional modulation of the CD4 T cell transcriptome and differentially expressed genes could be linked to metabolomic function. …”
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Electret‐Inspired Charge‐Injected Hydrogel for Scar‐Free Healing of Bacterially Infected Burns Through Bioelectrical Stimulation and Immune Modulation by Mujie Liu, Yuheng Wang, Haodong Wang, Lihong Qi, Yuxuan Shang, Jiajie Song, Xiulong Feng, Yiwei Chen, Waqar Ali Memon, Yuping Shen, Xiaodong Wu, Jiangbei Cao, Yifan Zhao, Zhuangde Jiang, Dingxin Liu, Shareen Shafique, Shengtao Li, Guanghao Lu, Zhixiang Wei, Zhijie Liu, Kun Zhou, Yuping Quan, Xiaoyu Zhang, Xin Zou, Xuefeng Wang, Na Liu, Yaqing Zhang, Yiwei Hu, Chao Han, Wen Wang

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Modulation of erectile dysfunction-associated enzymes and oxidative stress markers by Albizia zygia and Pentaclethra macrophylla leaf extracts: an In vitro evaluation by Onyinyechi R. Nwagwe, Stephen A. Adefegha, Ganiyu Oboh, Ayomide Victor Atoki, Iyiola O. Owolabi

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Modulation of cardiac fatty acid or glucose oxidation to treat heart failure in preclinical models: a systematic review and meta-analysis by Tom Fischer, Christina Schenkl, Estelle Heyne, Peter Schlattmann, Torsten Doenst, P. Christian Schulze, T. Dung Nguyen

“…Therefore, we conducted a comprehensive meta-analysis to assess the effects of modulating myocardial GO or FAO on heart function. Methods We screened MEDLINE via Ovid, Scopus, and Web of Science until March 02, 2024 for interventional studies reporting significant changes in cardiac GO or FAO in established animal models of HF, such as ischemia-reperfusion, pressure overload, rapid pacing, and diabetic cardiomyopathy. …”
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Research on Diameter Protocol Monitoring Scheme of S6a Interface in LTE Network Tester by Chaoyang Wang, Longhan Cao, Zhizhong Zhang

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Model of the Elastic Plate Stiffened with the Regular System of Nanorods by L.A. Fil’shtinskii, Yu.V. Shramko, G.F. Burnatnaya

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TRIM29 upregulation contributes to chemoresistance in triple negative breast cancer via modulating S100P-β-catenin axis by Qitong Wu, Sumit Siddharth, Deepak Verma, Sheetal Parida, Dipali Sharma

“…Furthermore, an enrichment of β-catenin pathway in chemoresistant TNBC cells is observed. We uncovered a functional network where S100P, a metastasis inducing secretory factor, bidirectionally interacts with TRIM29, and modulates the expression of SERPINB3, SERPINB4, CEACAM5, CEACAM6 as well as β-catenin pathway genes. …”
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Effect of Cananga odorata modulates cholinergic, purinergic enzymes, and elevates antioxidant markers in diabetes-induced cognitive disorder rat brain by Jamiyu A. Saliu, Olajide R. Ojo, Idowu S. Oyeleye, Ganiyu Oboh

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Effect of <i>Brassica rapa</i> L. Polysaccharide on Lewis Lung Cancer Mice by Inflammatory Regulation and Gut Microbiota Modulation by Changhui Du, Yong Zhao, Fanglin Shen, He Qian

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CX3CR1 upregulation modulates microglial activation and preserves synapses in the hippocampus and frontal cortex of middle-aged mice by Jinfeng Liu, Zhongqing Sun, Xin Liu, Kin Chiu, Kin Chiu, Lan Ma, Lan Ma, Lan Ma, Jiantao Wang

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The role of SPI1/VSIG4/THBS1 on glioblastoma progression through modulation of the PI3K/AKT pathway by Jie Shen, Lihui Zhou, Ke Ye, Jiangbiao Gong, Fan Wu, Kangnan Mo, Yu Zhu, Chao Chen, Renya Zhan

“…Objectives: This research aims to explore the function and molecular mechanism involving VSIG4 in the malignant progression of glioma. …”
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Upregulation of ALOX12−12-HETE pathway impairs AMPK-dependent modulation of vascular metabolism in ApoE/LDLR−/− mice by Mariola Olkowicz, Agnieszka Karas, Piotr Berkowicz, Patrycja Kaczara, Agnieszka Jasztal, Zuzanna Kurylowicz, Filip Fedak, Hernando Rosales-Solano, Kanchan Sinha Roy, Agnieszka Kij, Elzbieta Buczek, Janusz Pawliszyn, Stefan Chlopicki

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Modulation of Long Non-coding RNA FAS-AS1/FAS/Caspase3 Axis in Endometriosis: A Cross-sectional Study by Amir Hossein Shayanfard, Zivar Salehi, Farhad Mashayekhi, Ziba Zahiri

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