African swine fever virus modulates the endoplasmic reticulum stress-ATF6-calcium axis to facilitate viral replication by Yanjin Wang, Jiaqi Li, Hongwei Cao, Lian-Feng Li, Jingwen Dai, Mengxiang Cao, Hao Deng, Dailang Zhong, Yuzi Luo, Yongfeng Li, Meilin Li, Dingkun Peng, Zitao Sun, Xiaowei Gao, Assad Moon, Lijie Tang, Yuan Sun, Su Li, Hua-Ji Qiu

“…As intracellular parasitic organisms, viruses have evolved several strategies to modulate ER functions to favor their life cycles. We have previously demonstrated that the differentially expressed genes associated with unfolded protein response (UPR), which represents a response to ER stress, are significantly enriched upon ASFV infection. …”
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TOP2A modulates signaling via the AKT/mTOR pathway to promote ovarian cancer cell proliferation by Kaiwen Zhang, Xingyu Zheng, Yiqing Sun, Xinyu Feng, Xirong Wu, Wenlu Liu, Chao Gao, Ye Yan, Wenyan Tian, Yingmei Wang

“…Topoisomerase II α (TOP2A) is commonly regarded as an oncogene that is associated with malignant disease progression in a variety of cancers, its mechanistic functions in OC have yet to be firmly established. …”
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Therapeutic Implications of Traditional Chinese Medicine in Clinically Relevant Diseases: Perspectives From microRNA-Modulated Apoptotic Signaling by Xu Q, Wu D, Tan J, Khan FA, Pandupuspitasari NS, Huang C

“…In this study, we aim to provide a concise overview delineating the contemporary understanding of the functions of TCMs in miRNA-mediated apoptosis across malignant and non-malignant pathologies, including cancer, neurological disorders, and cardiovascular diseases. …”
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Efflux pump modulation by Montelukast and its roles in restoring antibiotic susceptibility in multidrug-resistant Staphylococcus aureusResearch in context by Suvendu Ojha, Simran Sinsinwar, Puja Chatterjee, Sarmistha Biswal, Pinkilata Pradhan, Tushar Kant Beuria

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Computational Design and Synthesis of Phthalimide Derivatives as TGF-β Pathway Inhibitors for Cancer Therapeutics by Héctor M. Heras-Martínez, Blanca Sánchez-Ramírez, Linda-Lucila Landeros-Martínez, Víctor H. Ramos-Sánchez, Alejandro A. Camacho-Dávila, Kostiantyn O. Marichev, Alejandro Bugarin, David Chávez-Flores

“…Using the M06 meta-GGA hybrid functional with a polarized 6-311G(d,p) basis set, computational evaluations assessed their impact on apoptosis modulation in colon cancer cells. …”
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Dynamic overmodulation strategy based on torque and flux optimal tracking for DTC‐SVM of surface‐mounted PMSM drives by Peihe Li, Anwen Shen, Qipeng Tang, Xin Luo, Jinbang Xu

“…Then, by using an equivalent geometric path to intuitively express the weightless cost function, the minimum cost function can be easily solved and the optimal output voltage vector can be determined correspondingly, to achieve the fast‐tracking of both the torque and stator flux linkage. …”
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My Back Exercise app: an automated exercise intervention supported by educational notifications, a sleep programme and diet advice to improve function in people with chronic non-sp... by Manuela L Ferreira, Kim L Bennell, Christopher J Gordon, Josielli Comachio, Paulo Ferreira, Rachel K Nelligan, Serigne N Lo, Paula Beckenkamp, Anelise Moreti Cabral Silveira, Carlos Mesa-Castrillon, Katharine Roberts, Emma K Ho, Rowena J Field

“…The primary outcome will be self-reported physical function measured by the Patient-Specific Functional Scale at 6 weeks post-randomisation. …”
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The real polysemous meaning of real: a study in lexical pragmatics by Olivier Simonin, Sarah Bourse

“…Its meaning is scalar when it causes a potentially gradable head noun (Filippi-Deswelle [2014], Moreau [2022]) to be semantically adjusted by indicating that a high (or high enough) degree is reached for a property or set or properties associated with that noun while, syntactically, it shows a very strong bias towards the attributive function – which we measure within ICE-GB and then explain.…”
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COP Enhancement of Peltier-Based Dehumidifiers by Srithar Karuppiah, Venkatesan Raman, Rajkumar Natarajan, Saravanan Rajagopal

“…According to the results, thermoelectric dehumidification systems can function much better overall if heat transmission on the Peltier module’s hot side is optimized.…”
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Irrotational Nanobricks Based High-Efficiency Polarization-Independence Metasurfaces by Wei Wang, Zehan Zhao, Chong Guo, Fei Shen, Jinghua Sun, Zhongyi Guo

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Design of a Thermoelectric Cool Box with Electronic Mobile-Based Temperature Control and Monitoring System by Moh. Abdul Gofur, Rahajeng Kurnianingtyas, Fauzan Amri, Rofan Aziz

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Optical Sinc-Shaped Nyquist Pulses Generation From Frequency-Quadrupled Rectangular Frequency Comb by Hongyao Chen, Tigang Ning, Jing Li, Li Pei, Jingjing Zheng, Ling Liu, Jin Yuan

“…The remodulation structure is formed by a coupler, a photodiode, and an intensity modulator. Its function is similar to optical carrier suppression (OCS) modulation index amplifier, which can achieve the modulation index improve of approximately 77.9% in the OCS modulation. …”
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Regulation of aging-related chronic diseases by dietary polyphenols: An updated overview by Jingying Liu, Kexin Dong, Qiuyu Deng, Zhichao Zou, Siqi Chen, Nianjie Feng, Jingyi Wang, Huang Huang, Qian Wu

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GSNOR plays roles in growth, pathogenicity, and stress resistance by modulating mitochondrial protein COX6B S-nitrosylation in Colletotrichum gloeosporioides by Xing Yang, Yongbao Yang, Aoxue Wang, Zhihao Zhao, Hongli Luo, Bang An, Qiannan Wang

“…However, the functional significance of GSNOR in fungal pathogenicity remains insufficiently characterized. …”
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Virtual Validation and Uncertainty Quantification of an Adaptive Model Predictive Controller-Based Motion Planner for Autonomous Driving Systems by Mohammed Irshadh Ismaaeel Sathyamangalam Imran, Satyesh Shanker Awasthi, Michael Khayyat, Stefano Arrigoni, Francesco Braghin

“…The methodology is applied to a rule-defined Model Predictive Controller (MPC)-based motion planner, where uncertainty quantification (UQ) is performed across various scenarios, based on the intended functionality within the algorithm’s operational design domain (ODD). …”
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Modulation of Tumor Cell Survival, Proliferation, and Differentiation by the Peptide Derived from Tenascin-C: Implication of β1-Integrin Activation by Takuya Iyoda, Fumio Fukai

“…In this review, we show the function of the peptide TNIIIA2 in cell survival, proliferation, and differentiation and refer to the possibility of new strategy for tumor suppression by regulating cell adhesion status using the ECM-derived functional peptides.…”
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Nonsuicidal self-injury prediction with pain-processing neural circuits using interpretable graph neural network by Sichu Wu, Yuan Xue, Yaming Hang, Ya Xie, Pei Zhang, Minlu Liang, Yuan Zhong, Chun Wang

“…This study leverages graph neural networks to predict NSSI risk and examine the learned connectivity of neural underpinnings using multimodal data.Methods Resting-state functional MRI and diffusion tensor imaging were collected from 50 patients with NSSI, 79 healthy controls (HC), and 44 patients with mental disorder who did not engage in NSSI as disease controls (DC). …”
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Theta-frequency subthalamic stimulation enhances conflict resolution in Parkinson’s disease patients with freezing of gait through frontal cortex modulation by Hutao Xie, Yutong Bai, Yutong Zhuang, Jiansong Huang, Delong Wu, Xin Zhang, Lin Shi, Hua Zhang, Jian Li, Jing Fu, Anchao Yang, Fangang Meng, Quan Zhang, Yin Jiang, Jianguo Zhang

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Cardiac contractility modulation to enhance optimized medical therapy and improve cardiac remodeling in advanced heart failure: a case report by Lina Feng, Lina Feng, Lina Su, Jingyi Ren, Jingyi Ren

“…Cardiac contractility modulation (CCM) is a novel therapeutic approach that enhances myocardial contractility and reverses cardiac remodeling, thereby improving cardiac function and quality of life in patients with HFrEF. …”
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Lactobacillus Supplementation Modulates Rumen Microbiota and Metabolism in Yaks Under Fattening Feeding Conditions: A Comprehensive Multi-Omics Analysis by Jianlei Jia, Pengjia Bao, Ning Li, Siyuan Kong, Min Chu, Qian Chen, Ping Yan

“…However, the biological mechanisms by which rumen microbiota and its metabolites enable Lactobacillus to modulate rumen structure and maintain functional homeostasis under fattening feeding conditions remain poorly understood. …”
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