Efficacy and brain modulation mechanisms of acupuncture for chronic prostatitis/chronic pelvic pain syndrome revealed by structural MRI changes by Zhen Wang, Jinmei Wu, Cong Deng, Yongbo Hu, Songshan Shi, Shaowei Liu, Xinfei Huang, Jianhuai Chen

“…IntroductionChronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) has been considered to be associated with abnormal brain function and structure. Acupuncture is a promising therapy for CP/CPPS, however, the underlying brain modulation mechanisms of acupuncture for CP/CPPS are still unclear.MethodsA total of 25 CP/CPPS patients and 25 matched-healthy controls (HCs) were enrolled. …”
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CircRFWD3 promotes HNSCC metastasis by modulating miR-27a/b/PPARγ signaling by Zihao Wei, Ying Wang, Jiakuan Peng, Honglin Li, Junjie Gu, Ning Ji, Taiwei Li, Xikun Zhou, Xin Zeng, Jing Li, Qianming Chen

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Histone lysine crotonylation accelerates ACSL4-mediated ferroptosis of keratinocytes via modulating autophagy in diabetic wound healing by Fengjuan Li, Haowen Ye, Lanlan Li, Qingling Chen, Xianwu Lan, Liangxiu Wu, Bin Li, Lishan Li, Chuxian Guo, Milad Ashrafizadeh, Gautam Sethi, Jun Guo, Liangyan Wu

“…The ACSL4 knockdown was achieved using adenovirus in wounds to examine the impact of ferroptosis modulation on healing diabetic wounds. MB-3 was utilized to block the H3K27 crotonylation (H3K27cr) in order to clarify the regulatory function of crotonylation in both autophagy and ferroptosis. …”
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Modulation of miR-145 in a mouse model of multiple sclerosis: A promising approach to attenuate inflammation and degeneration by Monique Marylin Alves de Almeida, Samantha F. Kornfeld, Yves De Repentigny, Majd Al-Aarg, Ibrahim Ghani, Sarah E. Cummings, Emma R. Sutton, Rebecca Yaworski, Kelsea S. McKay, Sabrina Gagnon, Ariane Beauvais, Rashmi Kothary

“…Multiple sclerosis (MS) is a progressive inflammatory disease of the central nervous system (CNS) marked by myelin loss, which impairs nerve function. Current therapies fail to halt disease progression or prevent myelin and axonal degeneration. …”
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PGF2α facilitates pathological retinal angiogenesis by modulating endothelial FOS‐driven ELR+ CXC chemokine expression by Yan Zhao, Yi Lei, Huying Ning, Yaqiang Zhang, Guilin Chen, Chenchen Wang, Qiangyou Wan, Shumin Guo, Qian Liu, Ruotian Xie, Yujuan Zhuo, Shuai Yan, Jing Zhao, Fengjiang Wei, Lu Wang, Xiaohong Wang, Weidong Li, Hua Yan, Ying Yu

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m6A-methylase METTL3 promotes retinal angiogenesis through modulation of metabolic reprogramming in RPE cells by Qian Zhou, Xianyang Liu, Huiping Lu, Na Li, Jiayu Meng, Jiaxing Huang, Zhi Zhang, Jiangyi Liu, Wei Fan, Wanqian Li, Xingran Li, Xiaoyan Liu, Hangjia Zuo, Peizeng Yang, Shengping Hou

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Jab1 regulates HRR mRNA stability to modulate PARP inhibitor sensitivity in triple-negative breast cancer by Xin Peng, Yingying Wang, Zixiang Yu, Shengfan Huang, Shaolu Zhang, Zhenxing Zhong, Yongzhe Wang, Shanshan Liu, Kailin Wang, Christophe Nicot, Francois X. Claret, Dexin Kong

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20(S)-Ginsenoside Rh2 overcomes gemcitabine resistance in pancreatic cancer by inhibiting LAMC2-Modulated ABC transporters by Yulin Wu, Juan Zhang, Yuanyang Tian, William Chi Shing Cho, Hong-Xi Xu, Zhi-Xiu Lin, Yan-Fang Xian

“…However, the biological function of LAMC2 in GEM resistance and its molecular mechanisms are still unclear. 20(S)-Ginsenoside Rh2 (Rh2), one of the principal active components isolated from Ginseng Radix et Rhizoma, possesses strong anti-tumor effects. …”
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hUC-MSCs and derived exosomes attenuate DEX-induced muscle atrophy through modulation of estrogen signaling pathway by Na Li, Xiaoqin Liu, Qiong Wang, Yushu Chen, Chao Han, Chao Qu, Xin Guan, Wei Zou, Xiaomin Wang, Ang Li, Yin Zhang, Liping Zhu, Ruoyutong Du, Jing Liu, Yanfu Wang

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Dual-Wavelength Polarization Multifunction Metalens Based on Spatial Multiplexing by Xiangshuo Shang, Haiyang Huang, Yi Zhou, Jiaheng Gong, Yang Liu, Wei Li

“…Metalenses, known for their precision in wavefront shaping and functional versatility, represent a breakthrough in optical modulation. …”
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Enhanced fire hazard detection in solar power plants: an integrated UAV, AI, and SCADA-based approach by Andrii Lysyi, Anatoliy Sachenko, Pavlo Radiuk, Mykola Lysyi, Oleksandr Melnychenko, Oleksii Ishchuk, Oleg Savenko

“…This formal logic model intelligently fuses four key binary features, namely, primary defect cause (damage vs. soiling), visual evidence, thermal anomaly severity, and bypass diode functional status, to produce a definitive and context-aware fire risk assessment. …”
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INFORMATION TECHNOLOGY FOR AUTOMATED ANALYSIS OF DEGRADATION AND RESTORATION PROCESSES OF COMPLEX ORGANIZATIONAL AND TECHNICAL SYSTEMS by Andrey V. Tristan, Sergey V. Osiyevskiy, Valery G. Patalaha

“…Modern information technologies wear away spatial borders between the objects of cooperation, from one side simplifying of communication processes, and from other - complicating their organizational and functional structure. Employment of the decision support systems (DSS) both in composition perspective control and combat systems and as separate programmatic modules is the long-range scientific research of contemporaneity, related to creation of intellectual information technologies. …”
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Preventive role of Pastinaca sativa in mitigating metabolic dysfunction-associated steatotic liver disease via modulation of metabolic endotoxemia by Ji-Eun Park, Hye-Bin Lee, Yu Ra Lee, Guijae Yoo, Hee-Kyoung Son, Sang Yoon Choi, Miri Park, Ho-Young Park

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Gender-modulated influence of BDNF concentration and Val66Met polymorphism on cognitive outcomes in chronic limb ischemia patients by Aleksandra Chyrek-Tomaszewska, Alicja Popiołek, Agnieszka Stachowicz-Karpińska, Jacek Budzyński, Katarzyna Linkowska, Mariusz Kozakiewicz, Adam Szelągowski, Alina Borkowska, Maciej Bieliński

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Expiratory Musculature Targeted Resistance Training Modulates Neural Connections During Swallowing Tasks: Preliminary fMRI Evidence by Rahul Krishnamurthy, Douglas H. Schultz, Yingying Wang, Steven M. Barlow, Angela M. Dietsch

“…Furthermore, our findings suggest that EMST may offer potential cognitive and neuroprotective benefits beyond improving upper aerodigestive functions.…”
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Intrinsic immunosuppressive features of monocytes suppress CAR-T19 through IL-1 pathway modulation in mantle cell lymphoma by Kun Yun, R. Leo Sakemura, Ismail Can, Omar Gutierrez Ruiz, Ekene J. Ogbodo, Shuwen Zhang, Ateka Saleh, Truc N. Huynh, Claudia Manriquez Roman, Olivia L. Sirpilla, Carli M. Stewart, James H. Girsch, Jennifer M. Feigin, Long Mai, Hong Xia, Brooke Kimball, Lionel A. Kankeu Fonkoua, Mehrdad Hefazi, Michael W. Ruff, Fariborz Rakhshan Rohakhtar, Vernadette Simon, Elizabeth L. Siegler, Mike Mattie, Sao-Mai Nguyen-Mau, Simone Filosto, Saad S. Kenderian

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Evolutionary Pro‐To‐Thr Mutation in the Intrinsically Disordered Domain of ANP32 Family Members Modulates Their Target Binding Modes by Blanca Baños‐Jaime, Ana B. Uceda‐Mayo, Francisco Rivero‐Rodríguez, Miguel Á. Casado‐Combreras, Alejandro Velázquez‐Cruz, Adrián Velázquez‐Campoy, Laura Corrales‐Guerrero, Miguel A. De la Rosa, Irene Díaz‐Moreno

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TRPM8 overexpression suppresses hepatocellular carcinoma progression and improves survival by modulating the RTP3/STAT3 pathway by Lichan Chen, Nansong Xu, DongMei Gou, Jianning Song, Mingqin Zhou, Yajun Zhang, Haohua Zhang, Liwen Zhu, Weihong Huang, Yue Zhu, Cheng Gao, Dayong Gu, Yong Xu, Hongzhong Zhou

“…Results TRPM8 expression was decreased in HCC tissues and was correlated with histological grade and poor patient prognosis. Functionally, TRPM8 repressed the proliferation and metastasis of HCC cells both in vitro and in vivo by modulating the RTP3/STAT3 signalling pathway. …”
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Responses to membrane potential-modulating ionic solutions measured by magnetic resonance imaging of cultured cells and in vivo rat cortex by Kyeongseon Min, Sungkwon Chung, Seung-Kyun Lee, Jongho Lee, Phan Tan Toi, Daehong Kim, Jung Seung Lee, Jang-Yeon Park

“…Membrane potential plays a crucial role in various cellular functions. However, existing techniques for measuring membrane potential are often invasive or have limited recording depth. …”
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Undaria pinnatifida extract attenuates combined allergic rhinitis and asthma syndrome by the modulation of epithelial cell dysfunction and oxidative stress by Yu Zhen Nan, Fan Yan Jing, Nguyen Thi Van, Piao Chun Hua, Lee Byung-Hoo, Lee So-Young, Shin Hee Soon, Kim Tae-Geum, Song Chang Ho, Chai Ok Hee

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