Alternative splicing of ZmHsf23 modulates maize heat tolerance by regulating sHSPs and TIL1 expression by Jing Wang, Nannan Song, Qianqian Qin, Anqi Su, Weina Si, Beijiu Cheng, Leiming Wu, Xiaojian Peng, Haiyang Jiang

“…In this study, we demonstrate that the alternative splicing of ZmHsf23 modulates heat stress tolerance in maize. Hsf23 produced two functional transcripts, Hsf23L and Hsf23S, which differ by the presence of a cryptic mini-exon in Hsf23L that is spliced out in Hsf23S. …”
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Zuojinwan ameliorates depressive-like behavior and gastrointestinal dysfunction in mice by modulating the FXR-bile acid-gut microbiota pathway by Dan Qiao, Dan Qiao, Bo Chen, Yuzhen Huang, Yuzhen Huang, Kunhan Su, Kunhan Su, Hao Wu, Hao Wu, Weiwei Tao, Weiwei Tao, Wanli Liu, Wanli Liu

“…Antidepressant efficacy was evaluated using a battery of behavioral assessments, while gastrointestinal function was assessed by measuring total gastrointestinal transit time, colonic motility, gastric residual volume, and small intestine propulsion rate. …”
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Rotenone inhibited osteosarcoma metastasis by modulating ZO-2 expression and location via the ROS/Ca2+/AMPK pathway by Xiang Ma, Zhen Li, Hengwei Ma, Kun Jiang, Bao Chen, Weiquan Wang, Ziqiang Zhu, Jianqiang Wang, Zuozhang Yang, Wang Yunqing, Suwei Dong

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Effect of CFTR modulators on glucose homeostasis in children and young adults with cystic fibrosis-related diabetes: a systematic review by Paola Giordano, Giuseppina Leonetti, Vanja Granberg, Rosa Maria Pia Casolino, Giuseppe Lassandro, Maurizio Delvecchio, Giovanna Linguiti

“…The advent of CFTR modulators, including ivacaftor, lumacaftor/ivacaftor, and elexacaftor/tezacaftor/ivacaftor (ETI), has revolutionized CF management by improving pulmonary function, nutritional status, and overall survival. …”
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TRIM56 Modulates YBX1 Degradation to Ameliorate ZBP1‐Mediated Neuronal PANoptosis in Spinal Cord Injury by Junsheng Lou, Yiting Mao, Wu Jiang, Honghao Shen, Yunpeng Fan, Qing Yu, Conghui Zhou, Ziyao Wei, Kailiang Zhou, Mengran Jin, Junsong Wu

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Modulation of the thiol redox proteome by sugarcane ash-derived silica nanoparticles: insights into chronic kidney disease of unknown etiology by Arthur D. Stem, Cole R. Michel, Peter S. Harris, Keegan L. Rogers, Matthew Gibb, Carlos A. Roncal-Jimenez, Richard Reisdorph, Richard J. Johnson, James R. Roede, Kristofer S. Fritz, Jared M. Brown

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Efficacy of Zingiber officinale for the Modulation of Growth, Feed Utilisation and Health Status of Magur (Clarias batrachus) in Cage Culture System by Nasib Uddin, Fardin Shahriar, A. H. E. Azaz Ibnasina, Md. Tawheed Hasan, Md. Abu Kawsar, Fatema Jannat Munny

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Engineered nerve guide conduit enhances peripheral nerve regeneration by modulating the microenvironment through macrophage-triggered cascade reactions by Xindi Yang, Xiao Liang, Binyi Wang, Xing Gao, Wenqiang Yang, Jiajun Li, Huaan Cai, Zan Tong, Yun Chen

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Research on frequency modulation of thermal power units combined with compressed air energy storage based on model predictive control by You Lv, Hao Sun, Bin Wu, Yijun Shi, Fang Fang

“…Firstly, by considering the dynamic characteristics and operational mechanism, fundamental transfer function models for TPU and the CAES system are established; based these models, the frequency modulation model of a two-area power grid incorporating TPU and CAES is presented. …”
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Tirzepatide mitigates Stroke-Induced Blood-Brain barrier disruption by modulating Claudin-1 and C/EBP-α pathways by Duozi Wang, Jianhong Wang, Binghu Li, Shu Yang, Fuqiang Guo, Bo Zheng, Jian Wang

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Modulating IL-21-driven B cell responses in idiopathic inflammatory myopathies via inhibition of the JAK/STAT pathway by Ana Merino-Vico, Merve Kocyigit, Giulia Frazzei, Lisa Landman, Louis Boon, Ester M. van Leeuwen, Ingrid E. Lundberg, Anneke J. van der Kooi, Joost Raaphorst, Jan Piet van Hamburg, Sander W. Tas

“…The Janus kinase (JAK)-signal transducer and activator of transcription (STAT) signaling pathway is essential for B cell functions, making it a promising therapeutic target. …”
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C-Phycocyanin Extract Modulates Thermogenic and Inflammatory Markers in Brown Adipose Tissue of High-Fat Diet-Fed Animals by Artur Francisco Silva-Neto, Julia Ferreira Rocha, Gustavo Oliveira Lima, Juliana Miki Oguma, Vivien Cayres Giarola Suannes Pucci, Yasmin Alaby Martins Ferreira, Maria Isabel Alonso-Vale, Claudia Maria Oller do Nascimento, Mônica Marques Telles, Anna Rafaela Cavalcante Braga, Luciana Chagas Caperuto, Lila Missae Oyama

“…Therefore, this study demonstrated that supplementation with CPC reduces inflammatory cytokines associated with detrimental effects in the BAT, emerging as a tool in combating obesity and improving BAT function.…”
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Bioinformatics insights into the role of GFPT1 in breast invasive carcinoma: implications for tumor prognosis, immune modulation, and therapeutic applications by Jianghui Liang, Jianghui Liang, Xiaolian Deng, Xiaolian Deng, Yingyi Zhang, Yingyi Zhang, Tianchi Fei, Tianchi Fei, Muzi Ouyang, Muzi Ouyang, Chengjie Yu, Chengjie Yu, Yang Xiang, Yang Xiang, Dongwei Jia, Fangfang Duan, Fangfang Duan

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Zhishi Xiebai Guizhi Decoction modulates hypoxia and lipid toxicity to alleviate pulmonary vascular remodeling of pulmonary hypertension in rats by Min Fu, Yuan Li, Jingjing Liu, Junjie Liu, Jiaoxia Wei, Yuxin Qiao, Hanxin Zhong, Dongyang Han, Haitao Lu, Li Yao

“…ZXGD was also observed to modulate expressions of HIF-1α, ROS, and Nrf2 to alleviate hypoxia and oxidative stress. …”
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miR-34a-5p modulation of polycystic ovary syndrome via targeting the NOTCH signaling pathway by Kexin Zhang, Xiaomeng Wang, Fang Liu, Hong Lin, Yan Wang, Min Zhao, Xiaofei Wang, Yijing Chu, Lin Xu

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Gut microbiota modulation by Traditional Chinese Medicine: a translational strategy for metabolic dysfunction-associated steatotic liver disease by Ting Zhou, Ting Zhou, Ziwen Jin, Ziwen Jin, Rilei Jiang, Weiwei Li

“…Growing evidence highlights gut microbiota dysbiosis as a pivotal contributor to MASLD pathogenesis, characterized by disrupted intestinal barrier function, endotoxin translocation, and dysregulated bile acid (BA) and short-chain fatty acid (SCFA) metabolism. …”
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A Novel LSTM Architecture for Automatic Modulation Recognition: Comparative Analysis With Conventional Machine Learning and RNN-Based Approaches by Sam Ansari, Soliman Mahmoud, Sohaib Majzoub, Eqab Almajali, Anwar Jarndal, Talal Bonny

“…The recognition of modulation types in received signals is essential for signal detection and demodulation, with broad applications in telecommunications, defense, and wireless communications. …”
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The pasteurized Weissella cibaria alleviates sepsis-induced acute lung injury by modulation of intestinal mucus barrier and gut microbiota by Yuanzhe Li, Debin Yang, Huan Zhao, Liping Dou, Qian Chen, Yibing Cheng, Bo Hu, Yu Tang, Yongtao Duan, Caili Guo, Abbas Sakandar, Dong Li

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Yogurt in Combination with Inactivated <i>Pediococcus lactis</i> Modulated Feline Lipid Metabolism, Anti-Inflammation and Fecal Microbiota by Jintao Sun, Xinshu Gu, Jiaxue Wang, Xiumin Wang, Zhenlong Wang, Hui Tao, Jinquan Wang, Bing Han

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Lateral Spacing of TiO₂ Nanotube Coatings Modulates In Vivo Early New Bone Formation by Andreea Mariana Negrescu, Iuliana Ionascu, Madalina Georgiana Necula, Niculae Tudor, Maksim Kamaleev, Otilia Zarnescu, Anca Mazare, Patrik Schmuki, Anisoara Cimpean

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