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Modulation of Network Oscillatory Activity and GABAergic Synaptic Transmission by CB1 Cannabinoid Receptors in the Rat Medial Entorhinal Cortex
Published 2008-01-01“…These data indicate that cannabinoid-mediated effects on inhibitory synaptic activity may be constitutively active in vitro, and that modulation of CB1R activation using inverse agonists unmasks complex effects of CBR function on network activity.…”
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Mechanosensitive ion channel Piezo1 modulates the response of rat hippocampus neural stem cells to rapid stretch injury.
Published 2025-01-01“…In this study, we aimed to determine the impact of rapid stretch on the viability, proliferation, and differentiation of NSC isolated from rat hippocampus (Hipp-NSC) and to determine the role of the stretch-activated ion channel Piezo-1 in modulating their response to mechanical stress. We found that while rapid stretch (30 and 50 PSI) reduced Hipp-NSC viability (measured as a function of LDH release), it did not change their proliferation and differentiation potentials. …”
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Acoustic and linguistic influences on rise-time modulations in natural English speech: evidence from a sensorimotor synchronization paradigm
Published 2025-07-01“…Modulations of amplitude rise-time are considered fundamental to speech rhythm. …”
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Attention-Module-Guided Time-Lapse Leakage Plume Imaging Driven by LeakInv-CUNet GPR Inversion Framework
Published 2025-01-01“…Specifically, the training process utilizes the inversion result of GPR datasets corresponding to different leakage permittivity distributions, with feedbacks provided through functional mapping based on the Topp equation for water content distribution imaging. …”
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Model-Based Dose Selection of a Sphingosine-1-Phosphate Modulator, Etrasimod, in Patients with Various Degrees of Hepatic Impairment
Published 2024-12-01“…Background/Objectives: Etrasimod is a newly FDA-approved Sphingosine-1-Phosphate modulator indicated for moderate and severe ulcerative colitis. …”
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Aged garlic attenuates neuroinflammation via modulating the NF-κB pathway: Insights from multi-omics analyses
Published 2025-07-01“…Aged garlic extract (AGE) is a functional food with well-documented antioxidant and anti-inflammatory properties, but its role in mitigating neuroinflammation remains unclear. …”
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Bisphenol A interferes with TTF-1 and PAX8 modulation of dual oxidase 2 human thyroid promoter activity
Published 2025-05-01“…An in silico study proposed the molecular interaction of BPA with PAX8 and TTF-1, suggesting that BPA could interfere in the signaling of both transcription factors (TFs) in the thyroid. Moreover, functional studies showing the effect of BPA on the modulation of thyroid Duox 2 expression controlled by PAX8 and TTF-1 are missing. …”
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Hypoxic preconditioning modulates BDNF signaling to alleviate depression-like behaviors in mice and its whole transcriptome sequencing analysis
Published 2025-05-01“…Functional enrichment analysis revealed that these genes are related to synapses, neurogenesis and neurotrophin signaling. …”
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