BAM8-22 targets spinal MrgC receptors to modulate UPRmt activity in the mechanism of bone cancer pain by Mingming Xie, Dan Li, Haohao Zeng, Yulin Huang, Rui Xu, Zhen Wang, Jiacheng Yu, Yu’e Sun, Yu’e Sun

“…Notably, G protein-coupled receptors (GPCRs), a major class of membrane receptors, modulate mitochondrial function through diverse molecular mechanisms. …”
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Modulation of Second Messenger Signaling in the Brain Through PDE4 and PDE5 Inhibition: Therapeutic Implications for Neurological Disorders by Min Kyu Park, Hyun Wook Yang, Seo Young Woo, Dong Yeon Kim, Dae-Soon Son, Bo Young Choi, Sang Won Suh

“…PDE4 and PDE5 are promising therapeutic targets for neurological disorders. Pharmacological modulation of these enzymes offers potential to enhance cognitive function and mitigate pathological mechanisms underlying brain injuries, neurodegenerative diseases, and psychiatric disorders. …”
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KAT6A chimeras form a self-reinforcing epigenetic module with NURF and MLL/COMPASS to sustain AML by Junhui Lv, Zhinang Yin, Conghui Li, Honglin Wen, Jian Ni, Peiyuan Yang, Zemin Song, Ying Xiang, Honghong Wang, Rui Lu, Li Huang, Ying Zhou, Hai-Bing Zhou, Ruijing Xiao, Pingping Fang, Kaiwei Liang

“…Disrupting NURF-chromatin interactions via depletion or small-molecule inhibition of its subunit, Bromodomain PHD Finger Transcription Factor (BPTF), impairs K/C recruitment and disrupts MLL/COMPASS-mediated H3K4me2 deposition, defining a functional epigenetic module involving KAT6A chimeras, NURF, and MLL/COMPASS. …”
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Evaluation of the Effectiveness of Using the CFTR Modulator Ivacaftor/Lumacaftor in Children with Cystic Fibrosis in the Sverdlovsk Region (Prospective Cohort Study) by Yuliya O. Vasenyova, Irina V. Vakhlova, Oleg Yu. Averyanov

“…Drugs whose action is aimed at restoring the function of the CFTR protein are called CFTR modulators. …”
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Astragaloside IV alleviated bone loss in mice with ovariectomy-induced osteoporosis via modulating gut microbiota and fecal metabolism by Huichao Wang, Huichao Wang, Zhongyue Huang, Guangnan Chen, Yang Li, Yang Li, Youwen Liu, Huijie Gu, Yujing Cao, Yujing Cao

“…Correlation analysis was performed to explore relationships between differential bacteria, key metabolites, and bone loss.ResultsAS-IV improved the femur microarchitecture and modulated bone turnover in OVX mice. AS-IV treatment strengthened the intestinal barrier function and decreased gut permeability. …”
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Protective effects of sumatriptan against optic nerve injury in rats via modulation of kynurenine pathway, oxidative stress and apoptosis by Moein Ala, Razieh Mohammad Jafari, Leila Aghajanpour, Mehdi Sanatkar, Masoud Aghsaei Fard, Sepideh Goudarzi, Amir Shadboorestan, Ahmad Reza Dehpour

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GPATCH3, a splicing regulator that facilitates tumor immune evasion via the modulation of ATPase activity of DHX15 by Tingrong Ren, Gaigai Wei, Gaigai Wei, Jingjing Yi, Jingjing Yi, Yuqi Zhang, Haiping Zhao, Nana Wu, Huiling Zhang, Zhihan Guo, Yihan Wang, Jiating Kuang, Zhaoying Sheng, Duanwu Zhang

“…Here, we identify GPATCH3, a previously uncharacterized G-patch domain–containing protein, as a critical modulator of alternative splicing and immune regulation in cancer.MethodsWe employed biochemical studies, splicing reporter assays, and transcriptomic analyses to elucidate the function of GPATCH3. …”
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Tomato Powder Modulates NF-κB, mTOR, and Nrf2 Pathways during Aging in Healthy Rats by Kazim Sahin, Cemal Orhan, Mehmet Tuzcu, Hakki Tastan, Birdal Bilir, Nurhan Sahin, Deniz Aslar Oner, Omer Kucuk

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Self‐Powered UV Photodetectors With Ultrahigh Performance Enabled by Graphene Oxide‐Modulated CuI Hole Transport Layer by Baofen Cen, Yabing Wang, Hongrong Zhang, Mingfen Mao, Tengfei Wang, Kaixiang Liu, Qinghong Li, Jing Zhang, Shengyun Luo, Guangcan Luo

“…Abstract The hole transport layer (HTL) with a function of charge extraction and transport plays a pivotal role in enhancing the performance of ultraviolet photodetectors (UV PDs). …”
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TIFAB modulates metabolic pathways in KMT2A::MLLT3−induced AML through HNF4A by Yang Wang, Yan Xiu, Qianze Dong, Jinming Zhao, Kelao Neumbo, Masaru Miyagi, Nicholas Borcherding, Lin Fu, Havana De Celis, Nicolas Pintozzi, Daniel T. Starczynowski, Chen Zhao

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Semaglutide and High-Intensity Interval Exercise Attenuate Cognitive Impairment in Type 2 Diabetic Mice via BDNF Modulation by Sijie Lai, Zhenghong Kang, Jianting Sun, Ziyu Wang, Yanzi Xu, Sisi Xing, Mengying Feng, Yiyi Wang, Hua Liu

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Ethylene signals through an ethylene receptor to modulate biofilm formation and root colonization in a beneficial plant-associated bacterium. by T Scott Carlew, Eric Brenya, Mahbuba Ferdous, Ishita Banerjee, Lauren Donnelly, Eric Heinze, Josie King, Briana Sexton, Randy F Lacey, Arkadipta Bakshi, Gladys Alexandre, Brad M Binder

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Gut microbiota modulates depressive-like behaviors induced by chronic ethanol exposure through short-chain fatty acids by Hui Shen, Chaoxu Zhang, Qian Zhang, Qing Lv, Hao Liu, Huiya Yuan, Changliang Wang, Fanyue Meng, Yufu Guo, Jiaxin Pei, Chenyang Yu, Jinming Tie, Xiaohuan Chen, Hao Yu, Guohua Zhang, Xiaolong Wang

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Genome‐Wide Silencer Screening Reveals Key Silencer Modulating Reprogramming Efficiency in Mouse Induced Pluripotent Stem Cells by Xiusheng Zhu, Lei Huang, Guoli Li, Biao Deng, Xiaoxiao Wang, Hu Yang, Yuanyuan Zhang, Qiuhan Wen, Chao Wang, Jingshu Zhang, Yunxiang Zhao, Kui Li, Yuwen Liu

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How do agricultural polders modulate nutrient dynamics under extreme flooding: Insights for water management in lowland areas by Hui Xie, Yunliang Li, Meiqi Shang, Jianwei Dong, Xiaoxian Tang, Nengsheng Wan, Yang Wang, Xijun Lai

“…When facing extreme floods, they are also used to store floodwater temporarily. This function shift significantly affects nutrient dynamics and transport process, which, however, remains poorly understood. …”
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Biochemical and biophysical cues of the extracellular matrix modulates stem cell fate: Progress and prospect in extracellular matrix mimicking biomaterials by Anuska Mishra, Unnati Modi, Rahul Sharma, Dhiraj Bhatia, Raghu Solanki

“…These biomaterials provide essential biophysical and biochemical cues necessary for mechanotransduction, thereby enhancing the efficacy and safety of stem cell therapies by precisely modulating stem cell fate. In this review, we discuss the critical role of the stem cell niche and its interplay with ECM, detailing its structural composition and functional significance. …”
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Identification of cyst nematode B-type CLE peptides and modulation of the vascular stem cell pathway for feeding cell formation. by Xiaoli Guo, Jianying Wang, Michael Gardner, Hiroo Fukuda, Yuki Kondo, J Peter Etchells, Xiaohong Wang, Melissa Goellner Mitchum

“…Here we report the identification of a new class of CLE peptides from cyst nematodes with functional similarity to the B-type CLE peptide TDIF (tracheary element differentiation inhibitory factor) encoded by the CLE41 and CLE44 genes in Arabidopsis. …”
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NaHS modulates astrocytic EAAT2 expression to impact SNI-induced neuropathic pain and depressive-like behaviors by Man-Man Qi, Heng-Yue Peng, Tian-Ge Zhang, Yan Li, Meng-Ya Gao, Wen-Bo Sun, Xu-Peng Wang

“…The study further demonstrates NaHS’s potential in reducing glutamate levels in the spinal cord and the discharge frequency of neurons in the primary somatosensory cortex hindlimb region (S1HL) brain area, suggesting a novel therapeutic approach for neuropathic pain through the modulation of astrocyte function and EAAT2 expression.…”
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DFT-based insights into novel Ga6N6 nanoring for pollutant gas adsorption: energetics and electronic modulations by Rajib K. Sutradhar, Vidit B. Zala, Rishit S. Shukla, Sanjeev K. Gupta, P. N. Gajjar

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Delta opioid receptors engage multiple signaling cascades to differentially modulate prefrontal GABA release with input and target specificity by Ryan P.D. Alexander, Kevin J. Bender

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