SHP099-containing multi-targeting hydrogel promotes rapid skin reconstruction through modulating a variety of cells by Zhixiao Liu, Lei Chen, Bingbing Hao, Yijin Hou, Chuan Lv, Yuanjie Zhu, Chaofeng Han, Chaofeng Han

“…IntroductionAdult wound scarring result in functional skin deficits. However, the development of effective measures to modulate the entire wound healing to encourage the skin function reconstruction is still a clinical challenge, as multiple cells are involved in wound healing hierarchically. …”
Get full text

Revealing the Role of Hydrogen in Highly Efficient Ag-Substituted CZTSSe Photovoltaic Devices: Photoelectric Properties Modulation and Defect Passivation by Xiaoyue Zhao, Jingru Li, Chenyang Hu, Yafang Qi, Zhengji Zhou, Dongxing Kou, Wenhui Zhou, Shengjie Yuan, Sixin Wu

Get full text

Therapeutic restoration of miR-96 prevents hearing loss in mice through modulation of noise-induced and genetic pathways by Ruilong Xia, Chenxi Jin, Siying Fei, Tingting Dong, Ting Wen, Fengting Zhu, Yunxin Shi, Qian Zhou, Yong Tao, Changgeng Peng

Get full text

Melatonin attenuates Helicobacter pylori-mediated cholangiocarcinoma-associated fibroblast activation via modulating integrin/FAK signaling pathway by Sirinapha Klungsaeng, Nuttanan Hongsrichan, Apisit Chaidee, Kitti Intuyod, Porntip Pinlaor, Sittiruk Roytrakul, Kulthida Vaeteewoottacharn, Sawanya Charoenlappanit, Rungtiwa Dangtakot, Narumon Mahaamnad, Somchai Pinlaor

“…We aimed to demonstrate the effect and mechanism of H. pylori on function of CAFs in vitro as well as the role of melatonin as an anti-fibrotic agent capable of modulating CAFs. …”
Get full text

Preserving Early Neurovascular Responses: The Effect of tACS on the Hemodynamics in Stressed Individuals by M. N. Afzal Khan, Usman Tariq, Yara Badr, Sandra Mary Prasad, Hasan Al-Nashash

“…This study examines the impact of transcranial alternating current stimulation (tACS) on the initial dip; an initial decrease in oxygenated hemoglobin (HbO) that arises during early neural activation, in individuals experiencing mental stress. Using functional near-infrared spectroscopy (fNIRS), we examined the effects of tACS on the initial dip and prefrontal activation in 40 participants subjected to mental stress induced by the Stroop Color-Word Task. …”
Get full text

Vericiguat Modulates Osteoclast Differentiation and Bone Resorption via a Balance between VASP and NF-κB Pathways by Kaiqiang Sun, Fanqi Kong, Feng Lin, Fudong Li, Jingchuan Sun, Changzhen Ren, Bing Zheng, Jiangang Shi

“…Taken together, our present study demonstrated the dual effects of Vericiguat on the formation of functional OCs. The regulatory effects of Vericiguat on OCs were achieved by the bidirectional modulation of the IκB-α/NF-κB signaling pathway, and a potential balance between the IκB-α/NF-κB signaling pathway and sGC/cGMP/VASP may exist.…”
Get full text

Enhanced thyroid nodule detection and diagnosis: a mobile-optimized DeepLabV3+ approach for clinical deployments by Changan Yang, Muhammad Awais Ashraf, Mudassar Riaz, Pascal Umwanzavugaye, Kavimbi Chipusu, Hongyuan Huang, Yueqin Xu

“…To improve segmentation performance, we integrated MobileNetV2 and Depthwise Separable Dilated Convolution into the Atrous Spatial Pyramid Pooling (ASPP) module, incorporating the Pyramid Pooling Module (PPM) and attention mechanisms. …”
Get full text

CircRNAs in colorectal cancer: potential roles, clinical applications, and natural product-based regulation by Jingjing Yang, Jingjing Yang, Qiqi Fan, Yiyun Wang, Yuanyue Liu, Xiaoning Xu, Yeqi Liang, Jiakang Xie, Jiajie Li, Fengting Ai, Yong Cao, Shangzhen Yu, Jinman Liu

“…In recent years, circular RNAs (circRNAs), a novel class of non-coding RNA molecules, have emerged as a research focus due to their unique stability and functional roles. CircRNAs regulate tumor-related signaling pathways through interactions with microRNAs (miRNAs) and proteins, playing key roles in tumorigenesis, progression, invasion, metastasis, and chemoresistance. …”
Get full text

Wood Panel Defect Detection Based on Improved YOLOv8n by Rui Li, Shilu Zhong, Xuemei Yang

“…A hybrid encoder was added to improve localization accuracy. The loss function was optimized to improve detection accuracy and convergence speed. …”
Get full text

Hyaluronan-Binding Protein Promotes Fibroblast Transformation and Heart Failure by Modulating the STAT5A–MMP13 Pathway by Hui Yan, Bing Huang, Bofang Zhang, Yunyao Li, Qiping Zhou, Ayipali Abudoureyimu, Guiqiu Cao, Hong Jiang

“…This study investigated the role of HYBID as a key profibrotic factor in the progression of adverse cardiac remodeling with a focus on its functional impact on cardiac fibroblasts and underlying molecular mechanisms. …”
Get full text

Novel insights into ORFV B2L DNA vaccine-mediated gut microbiota modulation and immune augmentation in rats by Umar Farooq, Umar Farooq, Guiqiong Liu, Guiqiong Liu, Sohail Ahmed, Sohail Ahmed, Huiguo Yang, Mehboob Ahmed, Xunping Jiang, Xunping Jiang

“…To this end, composition and function of gut microbiota were thoroughly examined through the implementation of 16S rRNA gene sequencing and PICRUSt-2 functional prediction. …”
Get full text

SK4 potentially modulates the alternative splicing profile associated with papillary thyroid cancer development in BHT101 cells by Alimujiang Wupuer, Xuekelaiti Kuerban, Gong Ye

Get full text

Protective Effect of Rosmarinic Acid on Endotoxin-Induced Neuronal Damage Through Modulating GRP78/PERK/MANF Pathway by Li Q, Zheng JW, Wang ZY, Liao SP, Zhu L, Wang X, Wan LH

Get full text

FLT3LG modulates the infiltration of immune cells and enhances the efficacy of anti-PD-1 therapy in lung adenocarcinoma by Fengyu Zhao, Han Bai, Yiwei Liu, Shuoze Gao, Chengcheng Yang, Jie Wu, Hao Cheng, Jiao Ma, Yuanyuan Li, Hong Ren, Junke Fu, Shanzhi Gu, Xinhan Zhao, Sida Qin

Get full text

The Sarcoplasmic/Endoplasmic reticulum Ca2+-ATPase (SERCA) is present in pig sperm and modulates their physiology over liquid preservation by Ferran Garriga, Jesús Martínez-Hernández, Ainhoa Parra-Balaguer, Marc Llavanera, Marc Yeste

Get full text

Scutellaria baicalensis extracts alleviate zymosan-induced irritable bowel syndrome symptoms by modulating inflammation and ion channel activity by Na Ri Choi, Woo-Gyun Choi, Joon Park, Yun Tai Kim, Joo Hyun Nam, Byung Joo Kim

Get full text

Gut microbiota‐derived butyric acid regulates calcific aortic valve disease pathogenesis by modulating GAPDH lactylation and butyrylation by Chunli Wang, Zongtao Liu, Tingwen Zhou, Jiaqin Wu, Fan Feng, Shunshun Wang, Qingjia Chi, Yongqiang Sha, Shuai Zha, Songren Shu, Linghang Qu, Qianqian Du, Huiming Yu, Li Yang, Anna Malashicheva, Nianguo Dong, Fei Xie, Guixue Wang, Kang Xu

Get full text

Long-Term Aerobic Exercise Enhances Hepatoprotection in MAFLD by Modulating Exosomal miR-324 via ROCK1 by Yang Zhang, Qiangman Wei, Xue Geng, Guoliang Fang

“…Post-exercise, precursor and mature miR-324 increased in adipose tissue and decreased in muscle, suggesting its adipose origin and inverse regulation. Functional assays demonstrated that miR-324 modulates insulin resistance by targeting ROCK1. …”
Get full text

Modulating Cognition-Linked Histone Acetyltransferases (HATs) as a Therapeutic Strategy for Neurodegenerative Diseases: Recent Advances and Future Trends by Huong Anh Mai, Christina M. Thomas, Gu Gu Nge, Felice Elefant

Get full text

All-Fiber and Calibration-Free Intrinsically Stable Polarization-Modulated Units for Measurement-Device-Independent Quantum Key Distribution by Yongjie Chen, Naida Mo, Jindong Wang, Jianling Yin, Tianming Zhao, Zhengjun Wei, Yafei Yu, Zhiming Zhang

Get full text