Ginsenoside Rh4 inhibits colorectal cancer via the modulation of gut microbiota-mediated bile acid metabolism by Xue Bai, Zhiguang Duan, Jianjun Deng, Zhuo Zhang, Rongzhan Fu, Chenhui Zhu, Daidi Fan

“…Finally, we elucidated the pivotal role of key functional bacteria and metabolites regulated by Rh4 in CRC. …”
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Oxidative, Inflammatory, and Constipation Stress Modulation by a Heteropolysaccharide from <i>Lacticaseibacillus rhamnosus</i> CRL75 by René Emanuel Lobo, Ana Magdalena Ávila, Jonathan Laiño, Verónica Molina, Diego Navarro, María Inés Gómez, María Inés Torino, María Pía Taranto

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Regulatory T cells suppress GM-CSF-producing T helper cells via IL-2 modulation to restrain immunopathology by Sara Costa-Pereira, Margit Lanzinger, Nicolás Núñez, Juan Villar-Vesga, Myrto Andreadou, Francesco Prisco, Philipp Häne, Elsa Roussel, Sinduya Krishnarajah, Rachel Chanel Lindemann, Laura Oberbichler, Frederike Westermann, André Fonseca Da Silva, Virginia Cecconi, Mirjam Pinzger, Sonia Tugues, Sarah Mundt, Melanie Greter, Donatella De Feo, Burkhard Becher

“…Here, we combine in vivo gene targeting and fate-mapping with high-dimensional cytometry to identify Treg cells’ steady-state function and suppressive mechanisms that prevent autoimmune inflammation and dissect the T helper (TH) cell-derived cytokines and responding cells executing tissue damage upon global loss of peripheral tolerance. …”
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Parkin inhibits iron overload-induced cardiomyocyte ferroptosis by ubiquitinating ACSL4 and modulating PUFA-phospholipids metabolism by Dandan Xiao, Wenguang Chang, Xiang Ao, Lin Ye, Weiwei Wu, Lin Song, Xiaosu Yuan, Luxin Feng, Peiyan Wang, Yu Wang, Yi Jia, Xiaopeng Tang, Jianxun Wang

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Rosemary Extract Reduces Odor in Cats Through Nitrogen and Sulfur Metabolism by Gut Microbiota–Host Co-Modulation by Ziming Huang, Miao Li, Zhiqin He, Xiliang Yan, Yinbao Wu, Peiqiang Mu, Jun Jiang, Xu Wang, Yan Wang

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Improvement of the inflammation-damaged intestinal barrier and modulation of the gut microbiota in ulcerative colitis after FMT in the SHIME® model by Anna Kamlárová, Monika Kvaková, Ľuboš Ambro, René Link, Izabela Bertková, Zdenka Hertelyová, Martin Janíčko, Emília Hijová, Jana Štofilová

“…Metabolites present after FMT may improve the function and integrity of the intestinal barrier, reduce inflammation, and thus induce remission in an UC patient. …”
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Elocalcitol mitigates high-fat diet-induced microglial senescence via miR-146a modulation by Keerthana Chithanathan, Monika Jürgenson, Katrina Ducena, Anu Remm, Kalev Kask, Ana Rebane, Li Tian, Alexander Zharkovsky

“…Among them, miR-146a has emerged as a key modulator of inflammation, but its role in obesity-induced senescence remains unexplored. …”
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APOE modulates ferroptosis to drive macrophage polarization toward the M2 type and enhance PTC migration and invasion by Ziwen Li, Min Li, Sinuo Sun, Yu Bin, Suwei Zuo, Ronghua Huo, Jiayin Song, Gang Xue, Xu Lin, Jingfang Wu

“…Results: In PTC tissues, Fe2+ accumulation was lower than in adjacent normal tissues, while the expression of APOE, xCT, GPX4, and FTH1 was significantly higher compared to adjacent normal tissues. Functional assays demonstrated that APOE inhibited ferroptosis in PTC cells, potentially by regulating ferroptosis through the PI3K/AKT1 pathway and modulating Fe2+ accumulation. …”
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Plant-based milk alleviates antibiotics-induced intestinal barrier damage associated with modulation of gut microbiome and metabolome by Xiaoyan Ma, Yashu Chen, Zhenxia Xu, Chao Wang, Xu Wang, Zhitao Chen, Shufang Xu, Chen Yang, Qianchun Deng

“…In conclusion, plant-based milk could alleviate antibiotic-related imbalance of barrier function damage, gut microbiota disorders and the reduction of metabolic disorders, which lays a foundation for exploring anti-inflammatory and intestinal micro-ecological approach to plant-based milk.…”
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The novel organoselenium compound 4aa ameliorates osteoporosis by modulating gut microbiota composition and fecal metabolite profiles by Chaoming Hu, Yichi Zhang, Yao Wu, Junhao Tu, Mengjia Yi, Yixin Mao, Yixin Mao, Yang Chen, Yang Chen, Xiaoyu Sun, Xiaoyu Sun, Zengqiang Song, Shengbin Huang, Shengbin Huang, Shufan Zhao, Shufan Zhao, Bin Li

“…Moreover, 4aa elevated butyric acid levels and reduced the accumulation of α-ketoisovaleric acid (α-KIV), contributing to the inhibition of osteoclast differentiation.Conclusion4aa prevents estrogen deficiency-induced bone loss by modulating gut microbial composition and function. These findings support the therapeutic of 4aa as a microbiota-targeted therapeutic strategy for osteoporosis management.…”
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Enhancement of oxaliplatin efficacy and amelioration of intestinal epithelial damage by Lactobacillus rhamnosus GG through modulation of gut microbiota by Zijie Zhang, Zijie Zhang, Rui Li, Yilin Ren, Yilin Ren, Yalan Ni, Yalan Ni, Xiaoyu Shen, Xiaoyu Shen, Deli Yi, Deli Yi, Zheng-hong Xu, Yan Geng, Yan Geng, Qingjun You, Qingjun You

“…The combined treatment modulated genes linked to intestinal barrier function and inflammation, upregulated Occludin and Mucin2, and downregulating Tnf-α and Il-1β in colon tissues. …”
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Probiotics mitigate stress and inflammation in malnourished adults via gut microbiota modulation: a randomized controlled trial by Maryam Ahmadi-Khorram, Maryam Ahmadi-Khorram, Alireza Hatami, Alireza Hatami, Parastoo Asghari, Parastoo Asghari, Ali Jafarzadeh Esfehani, Asma Afshari, Fateme Javdan, Fateme Javdan, Mohsen Nematy, Mohsen Nematy

“…ObjectiveMalnutrition negatively affects mental health by altering neurotransmitter function and increasing stress responses. The gut-brain axis is pivotal in this process, and probiotics may mitigate stress. …”
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Nettle supplementation improves antioxidant status and modulates inflammatory response by altering lysophosphatidylcholines and enterolactone metabolism in dairy cows by Qian Zhang, Na Ta, Jize Zhang, Xiaozhen Liu, He Ding, Xiaoqing Zhang

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Aurantio-obtusin modulates Wilms Tumour 1 within the breast tumour microenvironment reducing immunosuppression and tumour growth by Rui Li, Dómhnall J O’Connor, Barry Digby, Pilib Ó. Broin, Xiao Hu, Ning Ge, Paul G. Loftus, Vatsal Kumar, Eoin McEvoy, Stephen J. Elliman, Michael J. Kerin, Laura R. Barkley

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Plastocyanin affects photosynthesis and high light acclimation by modulating redox states of electron transport chain in Chlamydomonas reinhardtii by Guangxi Wu, Song Bin, Jun Chen, Jiayi Li, Heng Yi, Chuyi Wei, Huiqi Zheng, Chen Chen, Byeong-ha Lee, Xiaoxiong Wang, Wenqiang Yang, Zhangli Hu, Xiaozheng Li

“…These findings highlight the critical function of PC as a redox capacitor in affecting PET, CO2 fixation, and high light acclimation by modulating the redox states of the electron transport chain (ETC) and its potential for optimizing photosynthetic processes.…”
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Dynamic Brain Lipid Profiles Modulate Microglial Lipid Droplet Accumulation and Inflammation Under Ischemic Conditions in Mice by Wei Wei, Seyed Siyawasch Justus Lattau, Wenqiang Xin, Yongli Pan, Lars Tatenhorst, Lin Zhang, Irina Graf, Yaoyun Kuang, Xuan Zheng, Zhongnan Hao, Aurel Popa‐Wagner, Stefan T. Gerner, Sabine Huber, Manuel Nietert, Christian Klose, Ertugrul Kilic, Dirk M. Hermann, Mathias Bähr, Hagen B. Huttner, Hua Liu, Dirk Fitzner, Thorsten R. Doeppner

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A Combined Water Extract of Frankincense and Myrrh Alleviates Neuropathic Pain in Mice via Modulation of TRPV1 by Danyou Hu, Changming Wang, Fengxian Li, Shulan Su, Niuniu Yang, Yan Yang, Chan Zhu, Hao Shi, Lei Yu, Xiao Geng, Leying Gu, Xiaolin Yuan, Zhongli Wang, Guang Yu, Zongxiang Tang

“…We hypothesized that the water extraction of frankincense and myrrh (WFM) exerted its analgesia effect by modulating the neuronal function of TRPV1. In our study, WFM was verified by UHPLC-TQ/MS assay. …”
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The Fiber Cell-Specific Overexpression of <i>COMT2</i> Modulates Secondary Cell Wall Biosynthesis in Poplar by Hanyu Chen, Hong Wang, Zhengjie Zhao, Jiarui Pan, Yao Yao, Yihan Wang, Keming Luo, Qin Song

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Metabolic reprogramming by Acly inhibition using SB-204990 alters glucoregulation and modulates molecular mechanisms associated with aging by Alejandro Sola-García, María Ángeles Cáliz-Molina, Isabel Espadas, Michael Petr, Concepción Panadero-Morón, Daniel González-Morán, María Eugenia Martín-Vázquez, Álvaro Jesús Narbona-Pérez, Livia López-Noriega, Guillermo Martínez-Corrales, Raúl López-Fernández-Sobrino, Alejandro Castillo-Peña, Lina M. Carmona-Marin, Enrique Martínez-Force, Oscar Yanes, Maria Vinaixa, Daniel López-López, José Carlos Reyes, Joaquín Dopazo, Franz Martín, Benoit R. Gauthier, Morten Scheibye-Knudsen, Vivian Capilla-González, Alejandro Martín-Montalvo

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14-3-3ζ allows for adipogenesis by modulating chromatin accessibility during the early stages of adipocyte differentiation by Sabri A. Rial, Zhipeng You, Alexis Vivoli, Fédéric Paré, Daphné Sean, Amal AlKhoury, Geneviève Lavoie, Mete Civelek, Aida Martinez-Sanchez, Philippe P. Roux, Thomas M. Durcan, Gareth E. Lim

“…Objective: We previously established the scaffold protein 14-3-3ζ as a critical regulator of adipogenesis and adiposity, but whether 14-3-3ζ exerted its regulatory functions in mature adipocytes or in adipose progenitor cells (APCs) remained unclear. …”
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