Early postnatal exposure to bicuculline modulates E/I balance and induces ASD-like behavioral phenotypes in mice by Dongpil Shin, Eunbi Cho, Kwanghoon Park, ChiHye Chung, Dong Hyun Kim, Se Jin Jeon, Chan Young Shin

“…This study investigated early-life modulation of the GABAergic system’s impact on E/I balance and ASD-like behaviors in mice. …”
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The role of physical activity in modulating immune biomarkers and oxidative stress among cancer patients: a systematic review by La Saudi, Fiona Paramitha, Aby Nugrah Septanto, Novianti Lailiah, Nurullia Hanum Hilfida, Anja Hesnia Kholis, Wendi Muhammad Fadhli, Safaruddin Safaruddin, Yeni Septia Ningsi

“…It aids in boosting the function of immune cells, including CD8⁺ T lymphocytes and NK cells, and promotes the activation of antioxidant enzymes such as SOD, CAT, and GPX. …”
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Identification of novel antisense long non-coding RNA APMAP-AS that modulates porcine adipogenic differentiation and inflammatory responses by Lin-zhen ZHANG, Li HE, Ning WANG, Jia-hua AN, Gen ZHANG, Jin CHAI, Yu-jie WU, Chang-jiu DAI, Xiao-han LI, Ting LIAN, Ming-zhou LI, Long JIN

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Macrophage immune modulation: TGF-β1's influence on IL-1β dynamics in dengue virus infection by Javier Serrato Salas, Brenda Ramírez Agüero, José Luis Montiel Hernández, Judith González Christen

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Ulinastatin modulates TRPM4 expression and apoptosis to mitigate cognitive dysfunction in aged perioperative neurocognitive disorder rats by Xiaohui Xia, Jiayi Li, Mengmeng Zhang, Chunyan Zhang, Keliang Lu, Huirong han

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Adipose-Derived Mesenchymal Stem Cells Modulate Fibrosis and Inflammation in the Peritoneal Fibrosis Model Developed in Uremic Rats by Elerson C. Costalonga, Camilla Fanelli, Margoth R. Garnica, Irene L. Noronha

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Revealing age-related changes in the intraocular microenvironment and senescence modulators using aqueous humor proteomics and machine learning by Xiaosheng Huang, Tiansheng Chou, Tiansheng Chou, Xinhua Liu, Kun Zeng, Liangnan Sun, Zonghui Yan, Shaoyi Mei, Wenqun Xi, Zongyi Zhan, Yi Liu, Songguo Dong, Siqi Liu, Jun Zhao

“…Aging proteins (APs) and their functional enrichment were evaluated using various statistical and bioinformatics methods, while aging modulators were predicted using multiple machine-learning models.ResultsAH proteomic expression patterns exhibited various types of linear and nonlinear changes across the age groups. …”
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Assessing clenbuterol’s modulation of metabolic and inflammatory pathways in Nile tilapia (Oreochromas niloticous) fed high fat diet by Aya G. Rashwan, Doaa H. Assar, Abdallah S. Salah, Muyassar H. Abualreesh, Shimaa M. R. Salem, Norah Althobaiti, Zizy I. Elbialy

“…Clenbuterol inclusion significantly improves growth performance and antioxidant defenses by modulating nrf2 signaling and reducing inflammatory response, reduces fatty acid synthesis, and enhances mitochondrial β-oxidation not only functioning as a lipid regulator and effectively alleviating fat accumulation in the liver but playing an essential role in the control of glucose metabolism by reducing hepatic glucose production in high-fat diet-fed Nile tilapias well.…”
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A molecular framework for the GS2-SUG1 module-mediated control of grain size and weight in rice by Yingjie Li, Ke Huang, Limin Zhang, Baolan Zhang, Penggen Duan, Guozheng Zhang, Xiahe Huang, Chen Zhou, Nannan Han, Leiying Zheng, Yingchun Wang, Yunhai Li

“…Here we report a suppressor of the gain-of-function allele G S2 AA (SUG1) that encodes a plant-specific protein DEP2/SRS1/EP2/OsRELA and acts as a transcriptional regulator. …”
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Unlocking Modulation Rule of Heterointerface Engineering Induced D‐Band Center on Polysulfides Conversion in Lithium–Sulfur Batteries by Wenbin Li, Ni Wang, Jingjie Pei, Dongyan Li, Guiqiang Cao, Ruixian Duan, Jingjing Wang, Xifei Li

“…Precisely pinpointing the active center in the heterostructure and unlocking the modulation rule of heterostructure on polysulfides (LiPSs) conversion are particularly important. …”
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Lentiviral CRISPRa/i in the adult prairie vole brain: modulating neuronal gene expression without DNA cleavage by Meredith K. Loth, Kendall T. Mesch, Celine Herrera-Garcia, Liza E. Brusman, Zoe R. Donaldson, Zoe R. Donaldson

“…The dual-vector design is readily adaptable to other gene targets, cell types, and brain regions, and can be multiplexed to provide a flexible and scalable framework for investigating gene function in behaviorally relevant circuits. These advances represent the first successful implementation of somatic CRISPRa/i in prairie voles and expand the genetic toolkit available for this species.…”
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Mediator MED23 controls oligodendrogenesis and myelination by modulating Sp1/P300-directed gene programs by Shuai Zhang, Xue Feng, Chong-Hui Li, Yuan-Ming Zheng, Meng-Ya Wang, Jun-Jie Li, Yun-Peng Dai, Naihe Jing, Jia-Wei Zhou, Gang Wang

“…Mutations in the transcription cofactor Mediator Med23 subunit are often associated with intellectual disability and white matter defects, although the precise functions and mechanisms of Mediator in myelination remain unclear. …”
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Thermomorphic pneumatic metamaterials: numerous and robust shape-locking under temperature modulation through 4D printing by Yafei Wang, Wei Cai, Jingyi Zhang, Weijia Guo, Biyun Qi, Yuheng Liu, Weimin Huang, Haibao Lu, Xueyong Wei, Richard Fu, Zhen Ding

“…This advance in 4D printing has the potential to significantly enhance its functional capabilities, performance, and applicability, opening up new horizons in additive manufacturing and design.…”
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GPR15LG binds CXCR4 and synergistically modulates CXCL12-induced cell signaling and migration by Dan Pascal Jean Albers, Sofya Novikova, Julio Vieyto-Nuñez, Yasser Almeida-Hernández, Chiara Pastorio, Florian Klassen, Dana Weiss, Pascal von Maltitz, Janeni Jaikishan, Moumita Datta, Hassan Jumaa, Billy Michael Chelliah Jebaraj, Stephan Stilgenbauer, Manish Kumar, Palash Chandra Maity, Christian Buske, Ulrich Stifel, Julia Zinngrebe, Pamela Fischer-Posovszky, Andy Chevigné, Frank Kirchhoff, Elsa Sanchez-Garcia, Jan Münch, Mirja Harms

“…Methods We investigated the effects of GPR15LG on CXCR4 signaling and downstream functions. Binding assays and computational modeling were performed to assess the interaction between GPR15LG and CXCR4. …”
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Opa-interacting protein 5 modulates docetaxel-induced cell death via regulation of mitophagy in gastric cancer by Tae Woo Kim, Seon-Jin Lee, Young-Jun Park, Sang Yoon Park, Byung Moo Oh, Yun Sun Park, Bo-Yeon Kim, Young-Ha Lee, Hee Jun Cho, Suk Ran Yoon, Yong-Kyung Choe, Hee Gu Lee

“…In this study, we show that Neisseria gonorrhoeae opacity-associated-interacting protein 5 loss and gain of function modulates mitophagy induced by treatment with docetaxel, a chemotherapy drug for gastric cancer. …”
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Solar Modulation of Galactic Cosmic Rays from Hydrogen to Nickel Based on a Modified Force-field Approach by Zhenning Shen, Caixia Li, Pingbing Zuo, Gang Qin, Xiaojun Xu

“…The local interstellar spectra (LIS) for elements from hydrogen to nickel are derived by fitting observations from Voyager, Payload for Antimatter Matter Exploration and Light-nuclei Astrophysics, Alpha Magnetic Spectrometer-02, Advanced Composition Explorer Cosmic Ray Isotope Spectrometer, HEAO3-C2, and others. The solar modulation potential ϕ ( E ) is described by a double power-law function with an exponential tail. …”
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Comparative efficacy of preventive vs. therapeutic resveratrol in modulating gut microbiota and alleviating inflammation in DSS-induced colitis by Senmei Qin, Zongjing Yang, Jinqing Lei, Qingli Xie, Linsui Jiang, Yuanyuan Fan, Yonggu Luo, Kecong Wei, Wei Luo, Bing Yu

“…Mechanistically, PRE normalized barrier function via transcriptional (ZO-1: 56.7% of CON; Occludin: 14-fold induction vs. …”
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Mosla Chinensis Extract Enhances Growth Performance, Antioxidant Capacity, and Intestinal Health in Broilers by Modulating Gut Microbiota by Wei Wang, Yuyu Wang, Peng Huang, Junjuan Zhou, Guifeng Tan, Jianguo Zeng, Wei Liu

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Modulation of atherogenesis biomarkers by PCSK9 inhibitors in Lp(a)-stimulated human coronary artery endothelial cells by Rahayu Zulkapli, Suhaila Abd Muid, Seok Mui Wang, Mohd Yusmiaidil Putera Mohd Yusof, Hapizah Nawawi

“…The expression of PCSK9, inflammatory (IL-6, NF-κB p65), endothelial activation (E-selectin, ICAM-1), and endothelial function (eNOS) biomarkers were quantified using ELISA and QuantiGene plex assays. …”
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In Vitro Modulation of Macrophage Inflammatory and Pro-Repair Properties Essential for Wound Healing by Calcium and Calcium-Alginate Dressings by Yara Adib, Kevin Serror, Jose Amaya Pinzon, Laura Duciel, Marine Delagrange, Bertrand Ducos, David Boccara, Maurice Mimoun, Marc Chaouat, Armand Bensussan, Marina Samardzic, Martine Bagot, Céline Des Courtils, Laurence Michel

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