Tacrolimus (FK506) promotes placentation and maternal-fetal tolerance through modulating FASN-CEACAM1 pathway by Xinhang Meng, Minfeng Shi, Jinfeng Qian, Yujie Luo, Liyuan Cui, Dajin Li, Songcun Wang

“…To further characterize its function in early pregnancy, we explored the effect of FK506 on the human-derived first trimester extravillous trophoblast cells (HTR8/SVneo cells) and found that FK506 promoted invasion, tube formation and proliferation, but inhibited apoptosis of HTR8/SVneo cells. …”
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Differential Effects of Alcoholic and Non-Alcoholic Beer Intake on Renin–Angiotensin System Modulation in Spontaneous Hypertensive Rats by María Dolores Mayas, Cristina Cueto-Ureña, María Jesús Ramírez-Expósito, José Manuel Martínez-Martos

“…Systolic blood pressure (SBP), body weight, and biochemical parameters (electrolytes, glucose, renal and liver function, lipid profile) were monitored, and the RAS enzyme activity in serum and various tissues was analyzed. …”
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Novel Spectrum Inversion-Based Double-Sideband Modulation with Low Complexity for a Self-Coherent Detection System by Peng Qin, Jiahao Huo, Haolin Bai, Xiaoying Zhang, Jianlong Tao, Keping Long

“…However, DSB-SCD is fundamentally constrained by the non-ideal receiver transfer function, necessitating a guard band between the carrier and signal. …”
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Water-soluble garlic polysaccharide (WSGP) improves ulcerative colitis by modulating the intestinal barrier and intestinal flora metabolites by Xin Shao, JiaLong Li, Qi Shao, Rong Qu, Xin Ouyang, Yong Wang, ChunBo Chen

“…This study demonstrates that WSGP supplementation attenuates UC mice by suppressing the NF-κB/STAT3 signaling pathway, enhancing mucosal barrier function, reducing pro-inflammatory cytokines, and modulating gut microbial metabolites.…”
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HJURP modulates cell proliferation and chemoresistance via the MYC/TOP2A transcriptional axis in gastric cancer by Xu Li, Xu Li, Xiwen Li, Yanlin Ren, Ling Wang, Zehao Mao, Shikun Gao, Shikun Gao, Peng Ma, Junjie Chen, Junjie Chen

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Neuroregulation of the Hypothalamus-Pituitary-Adrenal (HPA) Axis in Humans: Effects of GABA-, Mineralocorticoid-, and GH-Secretagogue-Receptor Modulation by Roberta Giordano, Micaela Pellegrino, Andreea Picu, Lorenza Bonelli, Marcella Balbo, Rita Berardelli, Fabio Lanfranco, Ezio Ghigo

“…In agreement with animal studies, MRs seem to play a crucial role in the maintenance of the circadian ACTH and cortisol rhythm, through the modulation of CRH and AVP release. GABA agonists (mainly ALP), ghrelin, as well as MR agonists/antagonists, may represent good tools to explore the activity of the HPA axis in both physiological conditions and pathological states characterized by an impaired control of the corticotroph function.…”
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Time-restricted feeding attenuated hypertension-induced cardiac remodeling by modulating autophagy levels in spontaneously hypertensive rats by Xin Yi, Razif Abas, Raja Abdul Wafy Raja Muhammad Rooshdi, Jie Yan, Canzhang Liu, Jiaxu An, Ummi Nadira Daut

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Epigenetic Therapy as a Putative Molecular Target to Modulate B Cell Biology and Behavior in the Context of Immunological Disorders by Thayse Pinheiro da Costa, Marcia Cury El-Cheikh, Katia Carneiro

“…Besides these promising already approved iHDACs, we highlight a range of studies focusing on the HDAC-dependent epigenetic control of B cell development, behavior, and/or function. Here, we highlight 21 iHDACs which have been studied in the literature in the context of B cell development and/or dysfunction mostly focused on B cell lymphomagenesis. …”
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Developing The E-Module of The Cidayu (Chinese, Dayak, and Malay) Community’s Local Wisdom Using Fliphtml5 Software by Dina Anika Marhayani, Dodik Kariadi, Rini Setyowati, Mertika Mertika, Evinna Cinda H, Wasis Suprapto, Fajar Wulandari

“…Therefore, it can be concluded that this electronic module can function as an independent learning resource that can be accessed for individual learning, so that it can improve students' learning achievements in terms of learning outcomes.…”
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Identification of Lutzomyia longipalpis Odorant Binding Protein Modulators by Comparative Modeling, Hierarchical Virtual Screening, and Molecular Dynamics by Isis Bugia Santana, Franco Henrique Andrade Leite, Manoelito Coelho Santos Junior

“…The compounds were scored by Grid Score function and top five ranked poses had their intermolecular complex interactions analyzed in PLIP server. …”
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TET1 mitigates prenatal fluoride-induced cognition impairment by modulating Bcl2 DNA hydroxymethylation level by Yongle Cai, Xingdong Zeng, Mengyan Wu, Haonan Chen, Miao Sun, Hao Yang

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MOTIVATIONAL COMPONENT AS A SUCCESS TO ORGANIZE AN INDEPENDENT WORK OF STUDENTS AT THE DEPATMENT OF THERAPEUTIC DENTISTRY by Yu. V. Sidash

“…The above-mentioned conditions for the development of independence in the conditions of a credit-module system together with pedagogical means, forms and methods of teaching provide a developing personality function during educational activities. …”
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Nanoengineered-based delivery systems to modulate CD4+ T cell responses in cancer: emerging paradigms in cancer immunotherapy by Nekhat Shahreen, Anukrati Agnihotri, Asfi Rizwan, Faizul Hasan, Mohd Danish Ansari, Zarif Mohamed Sofian, Nur Akmarina B. M. Said, Kenneth K. W. To, Syed Mahmood, Syed Mahmood, Syed Mahmood, Syed Mahmood

“…Targeting CD4+ T-cells with novel drug delivery systems, particularly nanoparticle-based formulations, offers a promising approach to enhancing antitumor immune responses while minimizing systemic toxicity.ObjectiveThis review aims to explore the immunological significance of CD4+ T-cells in cancer and their modulation using novel drug delivery systems. The focus is on understanding CD4+ T-cell subtypes, their functional roles in tumor progression and suppression, and the application of novel drug delivery systems to selectively regulate these cells.MethodsA comprehensive analysis of CD4+ T-cell subsets, including Th1, Th2, Th17, Tregs, and Tfh, was conducted, along with their immunological roles in cancer. …”
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The TaCLE24b peptide signaling cascade modulates lateral root development and drought tolerance in wheat by Wen Yang, Man Feng, Kuohai Yu, Jie Cao, Guangxian Cui, Yumei Zhang, Huiru Peng, Yingyin Yao, Zhaorong Hu, Zhongfu Ni, Feng Qin, Fuminori Takahashi, Qixin Sun, Mingming Xin

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Modulation of Physical Activity to Optimize Pain Sensation following an Intra-Articular Corticosteroid Injection in Patients with Knee Osteoarthritis by Yoann Dessery, Étienne L. Belzile, Sylvie Turmel, Jean Doré, Binta Diallo, Philippe Corbeil

“…This study aims to assess the impact after an intra-articular corticosteroid injection treatment on objective and subjective measurement of physical function in knee osteoarthritis patients. Methods. …”
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Specific modulation of CRISPR transcriptional activators through RNA-sensing guide RNAs in mammalian cells and zebrafish embryos by Oana Pelea, Sarah Mayes, Quentin RV Ferry, Tudor A Fulga, Tatjana Sauka-Spengler

“…Engineered sgRNAs become activated upon recognising complementary RNAs, thus enabling Cas9 to perform its function. Our approach enables CRISPR activation in response to RNA detection in both HEK293T cells and zebrafish embryos. …”
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The plant growth-promoting Burkholderia vietnamiensis produces acyl-homoserine lactones and modulates the quorum-sensing signaling in the rhizosphere by Selvaraj Poonguzhali, Selvaraj Poonguzhali, Kiyoon Kim, Munusamy Madhaiyan, Munusamy Madhaiyan, Munusamy Madhaiyan, Tongmin Sa, Tongmin Sa

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The superoxide dismutase mimetic TEMPOL modulates nicotine-induced hyperlocomotor activity and nicotine-taking behavior in male rats by Kyung Oh Jeon, Jordan T. Yorgason, Lauren Ford, Joel T. Woolley, Seong-Hoon Park, Byoung-Seok Lee, Eun Kyeong Lee, Jaerang Rho, Eun Young Jang

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MicroRNA-155 modulates methotrexate-induced spatial memory impairment by disruption of the blood-brain barrier integrity by Yu-Chieh Chen, Li-Tung Huang, Hong-Ren Yu, Jiunn-Ming Sheen

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Asxl1 regulates optic cup development through interaction with Lhx2 and epigenetic modulation of Wnt signaling by Seungtae Moon, Nackhyuong Kim, A-Reum Kim, Kyeong Hwan Moon, Jin Woo Kim, Soo-Jong Um

“…Following ChIP analysis showed that the gain of function of Asxl1 increased repressive histone marks (H3K27me3, H3K9me3) and reduced active marks (H3K4me3) at Lhx2-binding motifs within the cis-regulatory regions of canonical Wnt ligand genes. …”
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