Carvacrol acetate activated Nrf2 modulates mitophagy for the treatment of neurocyte oxidative stress induced by chlorpyrifos by Hong-Ling Zhou, Bei-Bei Wang, Xu-Li Fan, Xiao-Min Zhang, Ying Song

“…These findings suggest that CAA modulates mitochondrial function and autophagy by regulating the Nrf2 signalling pathway to mitigate the toxic damage. …”
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Aurones as new modulators of hypoxia inducible factor-1 (HIF-1) to prevent cardiac cell death by Léa Di Maria, Brayan Roulier, Morane Beaumet, Romain Haudecoeur, Ahcène Boumendjel, Elise Belaïdi, Basile Pérès

“…The extent of infarct size, determined by the degree of cardiomyocyte death, is a major factor in post-MI functional recovery. Therefore, cardioprotective strategies focus on limiting infarct size. …”
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Elevation of ISG15 promotes diabetic kidney disease by modulating renal tubular epithelial cell pyroptosis by Lingzhi Huang, Xinyi Chen, Yawen Shao, Shujun Deng, Chen Wang, Jianqiao Chen, Yongsheng Xie, Siming Yuan, Liqin Tang

“…The deletion of ISG15 alleviated renal functional damage, fibrosis and inflammation, which correlated with reduced ISGylation levels. …”
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Different factors modulate visceral and subcutaneous fat accumulation in adults: a single-center study in Brazil by Camila Lima Chagas, Nadja Fernandes da Silva, Isa Galvão Rodrigues, Isa Galvão Rodrigues, Gabriela Maria Pereira Floro Arcoverde, Gabriela Maria Pereira Floro Arcoverde, Victoria Domingues Ferraz, Dário Celestino Sobral Filho, Dário Celestino Sobral Filho, Alcides da Silva Diniz, Cláudia Porto Sabino Pinho, Cláudia Porto Sabino Pinho, Poliana Coelho Cabral, Ilma Kruze Grande de Arruda

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The Renin–Angiotensin System Modulates SARS-CoV-2 Entry via ACE2 Receptor by Sophia Gagliardi, Tristan Hotchkin, Hasset Tibebe, Grace Hillmer, Dacia Marquez, Coco Izumi, Jason Chang, Alexander Diggs, Jiro Ezaki, Yuichiro J. Suzuki, Taisuke Izumi

“…The renin–angiotensin system (RAS) plays a central role in cardiovascular regulation and has gained prominence in the pathogenesis of Coronavirus Disease 2019 (COVID-19) due to the critical function of angiotensin-converting enzyme 2 (ACE2) as the entry receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). …”
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Cisd2 delays atrial aging via a modulation of calcium homeostasis that mitigates atrial myopathy by Chi-Hsiao Yeh, Zhao-Qing Shen, Li-Hsien Chen, Carol Seah, Tsai-Yu Tzeng, Chien-Yi Tung, Wen-Tai Chiu, Cheng-Heng Kao, Ting-Fen Tsai

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Dietary areca nut extract supplementation modulates the growth performance and immunity of Jiaji ducks (Cairina moschata) by Xiaohui Zhang, Lehuan Wu, Lihong Gu, Qicheng Jiang, Zhongchun He, Yanxia Qi, Xinli Zheng, Tieshan Xu

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Lonicerae flos and turmeric extracts alleviate necrotic enteritis in broilers by modulating gut-liver health and microbiota by Xingbo Liu, Yunru Ji, Huiyuan Lv, Zhong Wang, Zengpeng Lv, Yuming Guo, Wei Nie

“…Furthermore, LTE alleviated oxidative stress in ileal cells and protected mitochondrial structure and function in NE broilers. NE infection induced intestinal permeability in broilers, leading to increased serum pro-inflammatory cytokines and intestinal-derived endotoxin levels, which caused liver damage. …”
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Histidine metabolism drives liver cancer progression via immune microenvironment modulation through metabolic reprogramming by Pengcheng Liu, Fuxin Huang, Peixu Lin, Jiayao Liu, Pincheng Zhou, Jie Wang, Huanhuan Sun, Fan Xing, Haiqing Ma

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Aloin ameliorates cecal ligation and puncture-induced sepsis in mice by attenuating inflammation and modulating gut microbiota by Jingqian Su, Jianbin Xiao, Siyuan Chen, Heng Zhao, Xiaoni Zhang, Zhihua Feng, Kunsen Chen, Biyun Guan, Wenzhi Chen, Youqiang Chen, Duo Chen, Chen Qi

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Itaconate: A Nexus Metabolite Fueling <i>Leishmania</i> Survival Through Lipid Metabolism Modulation by Ayyoub Kihel, Hajar El Filaly, Dounia Darif, Aicha Assouab, Myriam Riyad, Imane Nait Irahal, Khadija Akarid

“…The development of this infection is influenced by immune responses, with an excessive anti-inflammatory reaction linked to negative outcomes through the modulation of various mediators. Itaconate, produced by the <i>Acod1</i> gene, is recognized for its anti-inflammatory effects, but its function in leishmaniasis is not well understood. …”
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PPM1J regulates meat quality feature and glycerophospholipids composition in broiler by modulating protein dephosphorylation by Manting Ma, Xin Yang, Yanan Zhang, Shuang Wang, Chenglong Jin, Weiguang Xia, Wei Chen, Bolin Cai, Chuntian Zheng

“…Gain- and loss-of-function analysis revealed that PPM1J induced muscular atrophy, improved meat quality and regulated the composition of glycerophospholipids. …”
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Spi1 aggravates neuropathic pain by modulating Clec7a-mediated neuroinflammation and microglial phagocytosis by Yin Xu, Xinli Liu, Hui Chen, Yun Zhao, Yubai Zhao, Yu Xie, Jiahui Pang, Hui Zeng, Yanyan Zeng, Weiwei Peng, Manxu Zheng, Wen Wu

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Modulation of rat aortic contractions by ultradisperse TiO2 nanoparticles of crystalline forms of anatase and rutile by Platon Zub, Olga Tsymbalyuk, Oleksandr Chunikhin, Tamara Davydovska, Stanislav Myakushko, Khrystyna Sholota, Ivan Voiteshenko, Oleksandr Tsuvariev, Sergiy Sukhopara, Valerii Skryshevskyi

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A Series of Novel Alleles of <i>Ehd2</i> Modulating Heading and Salt Tolerance in Rice by Peng Xu, Shulei Hao, Xiaoxia Wen, Guifang Ma, Qinqin Yang, Ling Liu, Galal Bakr Anis, Yingxin Zhang, Lianping Sun, Xihong Shen, Qunen Liu, Daibo Chen, Yongbo Hong, Yuyu Chen, Xiaodeng Zhan, Shihua Cheng, Liyong Cao, Weixun Wu

“…Using MutMap and map-based cloning, the causative gene was identified as a novel allele of <i>Ehd2</i>/<i>OsID1</i>/<i>RID1</i>/<i>Ghd10</i>. Functional validation through CRISPR/Cas9 knockout and complementation assays confirmed its role in regulating heading. …”
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Dysregulated balance of D- and L-amino acids modulating glutamatergic neurotransmission in severe spinal muscular atrophy by Amber Hassan, Raffaella di Vito, Tommaso Nuzzo, Matteo Vidali, Maria Jose Carlini, Shubhi Yadav, Hua Yang, Adele D'Amico, Xhesika Kolici, Valeria Valsecchi, Chiara Panicucci, Giuseppe Pignataro, Claudio Bruno, Enrico Bertini, Francesco Errico, Livio Pellizzoni, Alessandro Usiello

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FTTH and Two-Band RoF Transport Systems Based on an Optical Carrier and Colorless Wavelength Separators by C. H. Chang, P. C. Peng, Q. Huang, W. Y. Yang, H. L. Hu, W. C. Wu, J. H. Huang, C. Y. Li, H. H. Lu, H. H. Yee

“…In this case, the wavelength of the optical carrier can be flexibly assigned, and the frequency of the transmitted wireless signals can be easily adjusted without affecting the functionality of the developed optical fiber transport system. …”
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Analysis and Suppression of Harmonic Deteriorations Related to a Few-Submodule and Low-Switching-Frequency MMC-Based UPFC by Zhijun Chen, Jun Wang, Ke Zhang, Chao Yu, Yuting Zou, Yunlong Zhao, Mengjie Zhang, Chuyang Wang

“…An improved genetic algorithm is used to establish an objective function related to switching frequency harmonics and total inductance value, which can suppress a large number of high-order harmonics remaining from the CPS-PWM scheme, reduce the total inductance value, and compare this method with the single L filtering scheme widely used in UPFC engineering planning. …”
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Development of Thermosensitive Hydrogels with Tailor-Made Geometries to Modulate Cell Harvesting of Non-Flat Cell Cultures by Rubén García-Sobrino, Enrique Martínez-Campos, Daniel Marcos-Ríos, Zenen Zepeda-Rodríguez, Juan L. Valentín, Raúl Sanz-Horta, Marina León-Calero, Helmut Reinecke, Carlos Elvira, Alberto Gallardo, Juan Rodríguez-Hernández

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Simultaneous analysis of molecular positions and coordination bond formations by frequency modulation atomic force microscopy in liquid by Ryosuke Izumi, Masayuki Morimoto, SK Asif Ikbal, Shigehisa Akine, Akio Ohta, Hitoshi Asakawa

“…By employing frequency modulation atomic force microscopy with an amino-terminated tip, we examined the positions and their recognition functions at the single-molecular level. …”
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