Natriuretic peptides modulate monocyte-derived Langerhans cell differentiation and promote a migratory phenotype by Dorottya Horváth, Dorottya Horváth, Zsófia Pénzes, Zsófia Pénzes, Petra Molnár, Petra Molnár, István Rebenku, György Vereb, György Vereb, György Vereb, Magdolna Szántó, Szabolcs Muzsai, Szabolcs Muzsai, Andrea Szegedi, Andrea Szegedi, Zsolt Dajnoki, Zsolt Dajnoki, Kitti Pázmándi, Tünde Fekete, Attila Bácsi, Attila Bácsi, Attila Gábor Szöllősi, Attila Gábor Szöllősi

“…Cell surface markers of moLCs were assessed using flow cytometry, and NPR1 functionality was confirmed through intracellular cGMP assays. …”
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Fatty acids produced by the gut microbiota dampen host inflammatory responses by modulating intestinal SUMOylation by Chaima Ezzine, Léa Loison, Nadine Montbrion, Christine Bôle-Feysot, Pierre Déchelotte, Moïse Coëffier, David Ribet

“…The effect of gut commensal bacteria on host protein SUMOylation, an essential ubiquitin-like modification involved in various intestinal functions, remains, however, unknown. Here, we show that short chain fatty acids (SCFAs) and branched chain fatty acids (BCFAs) produced by the gut microbiota increase protein SUMOylation in intestinal cells in a pH-dependent manner. …”
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Oncogenic lncRNA transgene transcription modulates epigenetic memory at a naïve chromosomal locus by Sweta Sikder, Songjoon Baek, Yamini Dalal, Ganesan Arunkumar

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Advances in the study of Ophiopogon japonicus polysaccharides: structural characterization, bioactivity and gut microbiota modulation regulation by Jiani Li, Jiani Li, Jiani Li, LiQuan Zhou, LiQuan Zhou, LiQuan Zhou, ZuoWei Xiao, ZuoWei Xiao, ZuoWei Xiao

“…Despite these findings, comprehensive analyses of OJPS extraction and purification methodologies, structural elucidation, biological functionalities, and mechanistic insights into its crosstalk with the gut microbiota remain scarce. …”
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miRNAs Involvement in Modulating Signalling Pathways Involved in Ros-Mediated Oxidative Stress in Melanoma by José Daniel Escobar Moreno, José Luis Fajardo Castiblanco, Laura Camila Riaño Rodriguez, Paula Marcela Barrios Ospina, Carlos Andrés Zabala Bello, Esther Natalia Muñoz Roa, Hernán Mauricio Rivera Escobar

“…Evidence suggests that the differential modulation of ROS-mediated oxidative stress occurs in the pathogenesis and progression of melanoma, and that this imbalance in redox homeostasis appears to be functionally linked to microRNA (miRNA o miRs)-mediated non-mutational epigenetic reprogramming involving genes and transcription factors. …”
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Microtopography-induced changes in cell nucleus morphology enhance bone regeneration by modulating the cellular secretome by Xinlong Wang, Yiming Li, Zitong Lin, Indira Pla, Raju Gajjela, Basil Baby Mattamana, Maya Joshi, Yugang Liu, Huifeng Wang, Amy B. Zun, Hao Wang, Ching-Man Wai, Vasundhara Agrawal, Cody L. Dunton, Chongwen Duan, Bin Jiang, Vadim Backman, Tong-Chuan He, Russell R. Reid, Yuan Luo, Guillermo A. Ameer

“…Abstract Nuclear morphology plays a critical role in regulating gene expression and cell functions. While most research has focused on the direct effects of nuclear morphology on cell fate, its impact on the cell secretome and surrounding cells remains largely unexplored. …”
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Astrocytes at the Hub of the Stress Response: Potential Modulation of Neurogenesis by miRNAs in Astrocyte-Derived Exosomes by Alejandro Luarte, Pablo Cisternas, Ariel Caviedes, Luis Federico Batiz, Carlos Lafourcade, Ursula Wyneken, Roberto Henzi

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Precise Crop Pest Detection Based on Co-Ordinate-Attention-Based Feature Pyramid Module by Chenrui Kang, Lin Jiao, Kang Liu, Zhigui Liu, Rujing Wang

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Role of Na+/Ca2+ exchanger (NCX) in modulating postovulatory aging of mouse and rat oocytes. by Chuan-Xin Zhang, Wei Cui, Min Zhang, Jie Zhang, Tian-Yang Wang, Jiang Zhu, Guang-Zhong Jiao, Jing-He Tan

“…It was concluded that (a) the NCX activity was involved in the modulation of oocyte aging and spontaneous activation; (b) ROS and Na+ regulated the NCX activity in aging oocytes by altering its density as well as functioning; and (c) cytoplasmic Ca2+ elevation was essential for NCX activation in the oocyte.…”
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Silicon Nanoparticles and Apoplastic Protein Interaction: A Hypothesized Mechanism for Modulating Plant Growth and Immunity by Guopeng Miao, Juan Han, Taotao Han

“…Additionally, SiNPs may indirectly influence heavy metal transporter activity through redox state regulation and broadly modulate plant physiological functions via transcription factor regulatory networks. …”
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The dual role of microglia in ischemic stroke and its modulation via extracellular vesicles and stem cells by Matteo Haupt, Stefan T. Gerner, Thorsten R. Doeppner

“…We also discuss the multifaceted contributions of microglia to stem cell‐ and EV‐based neuroprotection during an ischemic stroke to provide a comprehensive understanding of microglial functions and their potential implications in stroke therapies.…”
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Tumor-Associated Macrophages as Key Modulators of Disease Progression in Diffuse Large B-Cell Lymphoma by Corina Joldes, Laura Jimbu, Oana Mesaros, Mihnea Zdrenghea, Bogdan Fetica

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Enhancing neural stem cell integration in the injured spinal cord through targeted PTEN modulation by Simay Genişcan, Hee Hwan Park, Hyung Soon Kim, Seokjin Yoo, Hyunmi Kim, Byeong Seong Jang, Dong Hoon Hwang, Kevin K Park, Byung Gon Kim

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Context-dependent autophagy in cancer: deciphering cytoprotective vs. cytotoxic roles and therapeutic modulation strategies by Samer Osama Kostandy, Salwa Aburageh Abuiessa, Mai Mostafa Helmy, Maged Wasfy Helmy

“…Given its context-dependent functions, a deeper understanding of autophagy’s intricate regulation is crucial for developing precision medicine approaches to effectively integrate autophagy-targeting strategies in cancer treatment.…”
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Selective Co‐Assembly of Water‐Soluble Conjugated Polyelectrolyte with Discernable Fluorescence Modulation for Antibiotic Detection by Hyena Ji, Yesica Fernanda Florez‐Villabona, Youngsun Kim, Yerim Kim, Yongju Kim, Seungyun Baik, Young Hun Seo, Sehoon Kim

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Modulating inflammatory prostaglandin E2 signaling to mitigate neurobehavioral comorbidities associated with seizure disorders by Chenyao Jiang, Ying Yu, Jiawang Liu, Jianxiong Jiang

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Extensive modulation of the circulating blood proteome by hormonal contraceptive use across two population studies by Nikola Dordevic, Clemens Dierks, Essi Hantikainen, Vadim Farztdinov, Fatma Amari, Vinicius Verri Hernandes, Alessandro De Grandi, Francisco S. Domingues, Orr Shomroni, Kathrin Textoris-Taube, Vivien Bahr, Hannah Schmid, Ilja Demuth, Florian Kurth, Michael Mülleder, Peter Paul Pramstaller, Johannes Rainer, Markus Ralser

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Physical activity modulates inhibitory control: EEG insights from P300 and theta oscillations by Liqing Liu, Liqing Liu, Liqing Liu, Yan Hao, Zhihui Zhao, Qing Liu

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DEPDC1 facilitated malignant phenotypes and disease progression of liposarcoma by modulating KIF20A by Mingwei Yu, Huishan Zhao, Yujie Sun

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Prospects for the use of allosteric drugs in real-world clinical practice by I. R. Svechkareva, A. S. Kolbin

“…While the clinical validity of the use of allosteric regulation is known, scientists are working on the discovery of new methods for the development of allosteric drugs that can modulate the functions of enzymes, depending on the desired therapeutic effect, and have a broader safety profile compared with alternative drugs. …”
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