Hemispherical Retina Emulated by Plasmonic Optoelectronic Memristors with All‐Optical Modulation for Neuromorphic Stereo Vision by Xuanyu Shan, Zhongqiang Wang, Jun Xie, Jiaqi Han, Ye Tao, Ya Lin, Xiaoning Zhao, Daniele Ielmini, Yichun Liu, Haiyang Xu

“…Therefore, retinomorphic electronics with structural and functional similarities to biological eyes are always highly desired to develop stereo vision perception system. …”
Get full text

Distinct structural mechanisms of LGR4 modulation by Norrin and RSPOs in Wnt/β-catenin signaling by Huarui Qiao, Fangzheng Hu, Yiang Wang, Lu Wang, Siyu Zhou, Shaojue Guo, Yiwen Xu, Jianfeng Xu, Qianqian Cui, Qilun Yang, H. Eric Xu, Jianwei Zhu, Yong Geng

“…Disease-linked mutations map to distinct functional regions: those disrupting LGR4 interaction are associated with familial exudative vitreoretinopathy (FEVR), while others impairing Frizzled4 binding are linked to Norrie disease. …”
Get full text

MatE transporter affects methane metabolism in Methermicoccus shengliensis and is modulated by methoxylated aromatic compounds by Huan Leng, Dong Wang, Qing Yang, Shuxin Wang, Leizhou Guo, Pengyan Zhao, Yi Chen, Lirong Dai, Guihong Cha, Liping Bai, Frank Delvigne

Get full text

Epigenetic modulation by life–style: advances in diet, exercise, and mindfulness for disease prevention and health optimization by José Ostaiza-Cardenas, Andrea C. Tobar, Stefany Carolina Costa, Diana Sofia Calero, Alisson López-Carrera, Fátima German Bermúdez, Fátima German Bermúdez, Andrea Orellana-Manzano, Andrea Orellana-Manzano

“…Physical activities, such as high-intensity interval training and hybrid training, induced epigenetic modifications, improving metabolic function, mitochondrial biogenesis, and insulin sensitivity. …”
Get full text

Platelet-Released Growth Factors Modulate the Secretion of Cytokines in Synoviocytes under Inflammatory Joint Disease by Mersedeh Tohidnezhad, Andreas Bayer, Biljana Rasuo, Jennifer Vanessa Phi Hock, Nisreen Kweider, Athanassios Fragoulis, Tolga Taha Sönmez, Holger Jahr, Thomas Pufe, Sebastian Lippross

Get full text

Acupuncture modulates the microbiota-gut-brain axis: a new strategy for Parkinson’s disease treatment by Zimo Zang, Fang Yang, Liang Qu, Minghui Ge, Liang Tong, Lihui Xue, Xiuye Sun, Ying Hai

Get full text

Immune dysregulation in endometrial tuberculosis: elevated HLA-G and IL-1Ra as key modulators by Dan Huang, Dan Huang, Jinlong Dai, Haotian Yu, Wen Chen

“…IL-1Ra and IL-10 are key regulators of endometrial immune homeostasis, counterbalancing inflammatory responses that could otherwise disrupt reproductive function. These immunoregulatory factors are crucial in maintaining immune tolerance within the endometrium and may influence immune responses associated with endometrial tuberculosis.…”
Get full text

Modulation of gut microbiota and immune response by soy peptides mitigates irinotecan induced intestinal toxicity by Yongfa Jing, Dongli Yan

“…Soy peptides (SPs), bioactive compounds with anti-inflammatory and prebiotic properties, have shown potential in enhancing intestinal barrier function. This study investigates SPs’ protective effects against irinotecan-induced intestinal injury, focusing on microbiota modulation, immune regulation, and mucosal repair.MethodsFemale C57BL/6 mice were randomly divided into four groups (n = 10/group): Control, Irinotecan, Pre-SPs+ Irinotecan, and SPs+ Irinotecan. …”
Get full text

Modulating the Adhesion of Haematopoietic Stem Cells with Chemokines to Enhance Their Recruitment to the Ischaemically Injured Murine Kidney. by Rebecca L White, Gerard Nash, Dean P J Kavanagh, Caroline O S Savage, Neena Kalia

Get full text

Colostrum-Derived Melatonin Plus PEG Microspheres Modulate the Oxidative Metabolism of Human Colostrum Phagocytes by Caroline G. Silva, Viviane F. Luz, Victor L. Nunes, Ana B. M. Verzoto, Aron C. de M. Cotrim, Wagner B. dos Santos, Eduardo L. França, Adenilda C. Honorio-França

“…Background/Objectives: Exogenous melatonin adsorbed onto PEG microspheres can modulate the functional activity of phagocytes in colostrum, but no data are available on the activity of melatonin found in colostrum. …”
Get full text

Liprotide-encapsulated vitamin D3 modulates circulated PTH levels and improved bone microstructure by Claradhita Ayu Shauma, Faizah Fulyani, Adriyan Pramono, Endang Mahati, Sylvia Rahmi Putri, Reza Achmad Maulana, Gemala Anjani

Get full text

Mitochondrial membrane hyperpolarization modulates nuclear DNA methylation and gene expression through phospholipid remodeling by Mateus Prates Mori, Oswaldo A. Lozoya, Ashley M. Brooks, Carl D. Bortner, Cristina A. Nadalutti, Birgitta Ryback, Brittany P. Rickard, Marta Overchuk, Imran Rizvi, Tatiana Rogasevskaia, Kai Ting Huang, Prottoy Hasan, György Hajnóczky, Janine H. Santos

Get full text

Hemocyanin controls Vibrio levels in hemolymph by modulating intracellular ROS via p38 MAPK by Jiawei Cheng, Yunyu Shi, Yonghui Kong, Yuxi Wu, Yankang Wang, Jude Juventus Aweya, Shiyuan Bao, Junjie Nie, Qian Feng, Yongzhen Zhao, Yueling Zhang, Zhihong Zheng

“…This study investigates the role of the respiratory protein hemocyanin in regulating redox-related genes, reactive oxygen species (ROS) levels in shrimp hemocytes, and its influence on immune function and hemolymph Vibrio abundance. Our results show that hemocyanin is crucial in the regulation of the redox system, as hemocyanin knockdown disrupts the expression of antioxidant (PvPOD and PvGPX) and pro-oxidant (PvXOX) genes and redox enzyme activities, leading to elevated ROS levels in hemocytes. …”
Get full text

Exploration of the potential neurotransmitter or neuromodulator-like properties of harmine: evidence from synthesis to synaptic modulation by Zhejun Xie, Ning Cao, Manlin Li, Hanxue Wang, Huida Guan, Xuemei Cheng, Changhong Wang

Get full text

A Novel SSVEP Brain-Computer Interface System Based on Simultaneous Modulation of Luminance and Motion by Meng Li, Ning Li, Xiaorong Gao, Ruijuan Ma, Jianwei Dong, Xiaogang Chen, Hongyan Cui

“…In addition to luminance modulation, at the same time, visual flickers also moved horizontally towards right and left at different frequencies (i.e., 0, 0.2, 0.4, and 0.6 Hz) following a sinusoidal function. …”
Get full text

Esketamine attenuates traumatic brain injury by modulating STAT3-mediated Glycolysis and immune responses by Yufang Liu, Zheng Gong, Longfei Zhang, Xian Yang, Jie Zhu, Xin Zhou, Xingzhi Liao

“…Mice were treated with esketamine, either alone or combined with the STAT3 activator colivelin, or the glycolysis inhibitor 2-deoxyglucose (2-DG). Neurological function, BBB permeability, immune cell infiltration, macrophage polarization, and glycolytic activity were assessed using immunohistochemistry, flow cytometry, quantitative PCR, and enzyme-linked immunosorbent assay (ELISA). …”
Get full text

Resveratrol Increases Cisplatin Sensitivity in Pancreatic Cancer Cells by Modulating Dihydroorotatede Hydrogenase-Mediated Ferroptosis by ZHENG Yanxia, LÜ Siyi, LI Tingting, DING Yusong

Get full text

Dendritic cell-associated miRNAs are modulated via chromatin remodeling in response to different environments. by Shiyue Mei, Yuanhang Liu, Yue Bao, Yuan Zhang, Siping Min, Yifei Liu, Yun Huang, Xidi Yuan, Yue Feng, Jiandang Shi, Rongcun Yang

“…Thus, H3K4me3 and H3K27me3 epigenetic modification may play an important role in regulating DC differentiation and function in the presence of tumor or inflammatory environments.…”
Get full text

CDC20 protects the heart from doxorubicin-induced cardiotoxicity by modulating CCDC69 degradation by Zhenyu Feng, Ningning Zhang, Liang Wang, Xumin Guan, Yunpeng Xie, Yun-long Xia

“…C57BL/6 mice were treated with DOX for 4 weeks after tail vein injection of CDC20 myocardial-specific knockout mice, AAV9-cTNT-(si) CDC20, or intraperitoneal injection of apcin. Cardiac function and pathological changes were evaluated by echocardiography and pathological staining, respectively. …”
Get full text

Lactobacillus rhamnosus GG attenuates MASLD/MASH progression by modulating gut microbiota and metabolic pathways by Shi-Long Wang, Si Liang, Si Liang, Si-Yu Li, Jin-Wen Fu, Zi-Yi-Ru Wang, Dong-Qing Zhu, Nan Chen

“…Furthermore, LGG restored intestinal barrier function, reduced intestinal permeability, and prevented harmful substances like endotoxins from entering the liver, further alleviating hepatic inflammation and fibrosis.DiscussionAlthough LGG shows promise in the treatment of MASLD and MASH, its mechanisms of action and long-term effects require further investigation. …”
Get full text