Long non-coding rnas as key modulators of the immune microenvironment in hepatocellular carcinoma: implications for Immunotherapy by Siqi Zhao, Fei Chen, Lingyu Hu, Xiaoping Li, Zhaofeng Gao, Minjie Chen, Xiaoguang Wang, Zhengwei Song

“…Long non-coding RNAs (lncRNAs) have emerged as critical regulators of various biological processes, including gene expression and immune cell function. This review explores the multifaceted roles of lncRNAs in modulating the immune microenvironment of HCC. …”
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Reward integration in prefrontal-cortical and ventral-hippocampal nucleus accumbens inputs cooperatively modulates engagement by Eshaan S. Iyer, Peter Vitaro, Serena Wu, Jessie Muir, Yiu Chung Tse, Vedrana Cvetkovska, Rosemary C. Bagot

“…Abstract The nucleus accumbens, a highly integrative brain region controlling motivated behavior, receives various glutamatergic inputs, yet the relative functional specialization of these inputs is unclear. …”
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First person state/psychological imagery modulates the orbital frontal gyrus and the putamen in individuals with depression by Barbara Tomasino, Maria Chiara Piani, Eleonora Maggioni, Eleonora Maggioni, Carolina Bonivento, Serena D’Agostini, Matteo Balestrieri, Paolo Brambilla, Paolo Brambilla

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LDPC-coded unitary space-time modulation with low-complexity iterative demodulate-decoding scheme by Li-jiao WANG, Lin ZHANG, Ling-ling YANG, Li PENG, Da-wei FU

“…A practical low-density parity-check(LDPC) coded unitary space-time modulation (USTM) noncoherent MIMO communication system over Rayleigh flat fading and additive white Gaussian noise (AWGN) channel was con-structed, where the LDPC code is selected from IEEE 802.16e Standard and USTM is constructed by the unitary matrix based on the sinc-cosinc function, SC-USTM for short. …”
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Modulation of lipid metabolism by exercise: exploring its potential as a therapeutic target in cancer endocrinology by Haodong Liu, Tong Yang, Seongbeom Choi

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Acute dentate nucleus deep brain stimulation modulates corticomotor excitability in chronic stroke survivors by Xin Li, Kenneth B. Baker, Kyle O'Laughlin, Yin-Liang Lin, Kelsey Baker, Robert Chen, Jacqueline Chen, Andre G. Machado, Ela B. Plow

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Modulation of Biological Membranes Using Small-Molecule Compounds to Counter Toxicity Caused by Amyloidogenic Proteins by Raina Marie Seychell, Adam El Saghir, Neville Vassallo

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NOVEL MULTI-MODAL OBSTRUCTION MODULE FOR DIABETES MELLITUS CLASSIFICATION USING EXPLAINABLE MACHINE LEARNING by Reehana SHAIK, Ibrahim SIDDIQUE

“…Furthermore, the detection and classification of DM using PPG and ECG can involve analyzing the functional performance of these modalities. By extracting the features like R wave (W1) and QRS complex (W2) in the ECG signals and Pulse Width (S1) and Pulse Amplitude Variation (S2) can detect DM and can be classified into DM and Non-DM. …”
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The Desmoplastic Stroma Plays an Essential Role in the Accumulation and Modulation of Infiltrated Immune Cells in Pancreatic Adenocarcinoma by Vegard Tjomsland, Lina Niklasson, Per Sandström, Kurt Borch, Henrik Druid, Charlotte Bratthäll, Davorka Messmer, Marie Larsson, Anna Spångeus

“…Immunostainings indicated that the different immune cells and inflammatory factors are mainly localized to the desmoplastic stroma. Therapies modulating the inflammatory tumor microenvironment to promote the attraction of DCs and differentiation of monocytes into functional DCs might improve the survival of PDAC patients.…”
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Modulation of Short-Chain Fatty Acids as Potential Therapy Method for Type 2 Diabetes Mellitus by Ruiqi Tang, Lanjuan Li

“…In this review, we summarize the effects of SCFAs on glucose homeostasis and energy homeostasis and the mechanism through which SCFAs regulate the function of metabolically active organs (brain, liver, adipose tissue, skeletal muscle, and pancreas) and discuss the potential role of modulation of SCFAs as a therapeutic method for T2DM.…”
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Dbo/Henji Modulates Synaptic dPAK to Gate Glutamate Receptor Abundance and Postsynaptic Response. by Manyu Wang, Pei-Yi Chen, Chien-Hsiang Wang, Tzu-Ting Lai, Pei-I Tsai, Ying-Ju Cheng, Hsiu-Hua Kao, Cheng-Ting Chien

“…In addition, dPAK associated with Henji through the Kelch repeats which is the domain essential for Henji localization and function at postsynapses. We propose that Henji acts at postsynapses to restrict both presynaptic bouton growth and postsynaptic GluRIIA abundance by modulating dPAK.…”
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Extrasynaptic α6 subunit-containing GABAA receptors modulate excitability in turtle spinal motoneurons. by Carmen Andres, Justo Aguilar, Ricardo González-Ramírez, David Elias-Viñas, Ricardo Felix, Rodolfo Delgado-Lezama

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Charge-surrounded pockets and electrostatic interactions with small ions modulate the activity of retroviral fusion proteins. by Daniel Lamb, Alexander W Schüttelkopf, Daan M F van Aalten, David W Brighty

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Cysteine Peptidase B Regulates Leishmania mexicana Virulence through the Modulation of GP63 Expression. by Pierre-André Casgrain, Caroline Martel, W Robert McMaster, Jeremy C Mottram, Martin Olivier, Albert Descoteaux

“…We initially examined the impact of L. mexicana infection on the trafficking of VAMP3 and VAMP8, two endocytic SNARE proteins associated with phagolysosome biogenesis and function. Using a CPB-deficient mutant, we found that both VAMP3 and VAMP8 were down-modulated in a CPB-dependent manner. …”
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Infra-slow scale-free dynamics modulate the connection of neural and behavioral variability during attention by Yujia Ao, Philipp Klar, Yasir Catal, Yifeng Wang, Georg Northoff

“…In this study, we recruited 49 participants and recorded functional magnetic resonance imaging (fMRI) resting-state and task data during a sustained attention task paradigm to investigate how the three measures—SD, SE, and PLE—modulate the dynamics of behavioral performance. …”
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Modulating Reaction Kinetics Using an Electrolytic Method to Achieve Efficient Vehicle Identification Number Reappearance by Jintao Wang, Xiaoshun Zhang, Mengfan Chen, Xihao Zhang, Zhongliang Zhang, Jianguo Liu

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The stress-response factor SigH modulates the interaction between Mycobacterium tuberculosis and host phagocytes. by Noton K Dutta, Smriti Mehra, Alejandra N Martinez, Xavier Alvarez, Nicole A Renner, Lisa A Morici, Bapi Pahar, Andrew G Maclean, Andrew A Lackner, Deepak Kaushal

“…The differential expression of these genes manifested into functional differences in chemotaxis and apoptosis in cells infected with these two strains. …”
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GPCR-A17 MAAP: mapping modulators, agonists, and antagonists to predict the next bioactive target by Ana B. Caniceiro, Ana M. B. Amorim, Nícia Rosário-Ferreira, Irina S. Moreira

“…To address the growing need for effective treatments, the GPCR-A17 Modulator, Agonist, Antagonist Predictor (MAAP) was introduced as an advanced ensemble machine learning model that combines XGBoost, Random Forest, and LightGBM to predict the functional roles of agonists, antagonists, and modulators in GPCR-A17 interactions. …”
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Trait anxiety negatively modulates the coupling of motor event-related desynchronization and event-related synchronization by Chia-Hsiung Cheng, Pei-Ying S. Chan, Si-Yu Chen, Yu-Han Chen, Hsinjie Lu, Chia-Yih Liu

“…Abstract Background Recent neurophysiological studies showed that patients with psychiatric disorders demonstrated abnormalities in sensorimotor functions in addition to cognitive deficits. These findings intrigued us to investigate whether trait anxiety, a persistent inclination towards being anxious in multiple contexts, would affect motor cortical functions. …”
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Genetic Background Modulates lncRNA-Coordinated Tissue Response to Low Dose Ionizing Radiation by Jonathan Tang, Yurong Huang, David H. Nguyen, Sylvain V. Costes, Antoine M. Snijders, Jian-Hua Mao

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