Therapeutic potential of gut microbiota modulation in epilepsy: A focus on short-chain fatty acids by Rong Yan, Linhai Zhang, Ya Chen, Yongsu Zheng, Ping Xu, Zucai Xu

“…Recent studies have indicated that SCFAs not only regulate seizures by maintaining intestinal barrier integrity and modulating intestinal immune responses, but also affect the structure and function of the blood-brain barrier (BBB) and regulate neuroinflammation. …”
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A New Era of Muscarinic Acetylcholine Receptor Modulators in Neurological Diseases, Cancer and Drug Abuse by Helena Tsimpili, Grigoris Zoidis

“…The cholinergic pathways in the central nervous system (CNS) play a pivotal role in different cognitive functions of the brain, such as memory and learning. …”
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Innate immune pathway activation to modulate mesenchymal stromal cell (MSC) interactions with synovium and cartilage by Peter Linde, Lyndah Chow, Isabella Sabino, Zoë Williams, Renata Impastato, Steven Dow, Lynn Pezzanite

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The cAMP responsive element modulator (CREM) transcription factor influences susceptibility to undernutrition and infection by Audrey C. Brown, Md. Jashim Uddin, Rebecca M. Munday, Farha Naz, G. Brett Moreau, Girija Ramakrishnan, Stephen S. Rich, Rashidul Haque, Genevieve L. Wojcik, Priya Duggal, Chelsea Marie, William A. Petri

“…Upregulation of mitochondrial function was mirrored by plasma metabolomics profiles concordant with a shift toward mitochondrial respiration. …”
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Testosterone Replacement Modulates Cardiac Metabolic Remodeling after Myocardial Infarction by Upregulating PPARα by Jing Yang, Fengyue Wang, Weiju Sun, Yanli Dong, Mingyu Li, Lu Fu

“…Taken together, our findings suggest that testosterone can modulate myocardial metabolic remodeling by upregulating PPARα after myocardial infarction, exerting a protective effect on cardiac function.…”
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Modulation of NLRP3 Inflammasome Activation by QYHT Decoction: Implications for the Treatment of Erectile Dysfunction in Hyperuricemia by Pingyu Ge, Yinxue Guo, Bangwei Che, Hang Jin, Lan Chen, Zhichao Chen, Kaifa Tang

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Cinnamon pretreatment modulates gene expression of tight junction proteins in a rat model of stroke by Solmaz Najjary, Hossein Mostafavi, Hadi Feizi, Fatemeh Moradi, Mehdi Eskandari

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GluA2 palmitoylation by SELENOK modulates AMPAR assembly and synaptic plasticity in Alzheimer's disease by Jiaying Peng, Zhiyu Cai, Pei Ouyang, Shujing Lin, Shurui Zhang, Danchan Liang, Ziqi Feng, Changbin Chen, Xilin Ye, Guoli Song, Zhonghao Zhang

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Sustained and specific multiplexed immune checkpoint modulation in CAR T cells induced by targeted epigenome editing by Maria Silvia Roman Azcona, Gianni Monaco, Melissa Whitehead, Masako Monika Kaufmann, Jamal Alzubi, Toni Cathomen, Claudio Mussolino

“…Epigenetically modified CAR T cells are indistinguishable from parental cells across a range of functional assays. Although the model does not fully mimic T cell exhaustion, limiting functional assessment, gene silencing remains durable across multiple divisions and repeated CAR stimulations. …”
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A multiscale model of the action of a capsid assembly modulator for the treatment of chronic hepatitis B. by Sarafa A Iyaniwura, Tyler Cassidy, Ruy M Ribeiro, Alan S Perelson

“…While existing treatments effectively inhibit the HBV life cycle, viral rebound frequently occurs following treatment interruption. Consequently, functional cure rates of chronic HBV infection remain low and there is increased interest in a novel treatment modality, capsid assembly modulators (CAMs). …”
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Autoinducer-2 relieves soil stress-induced dormancy of Bacillus velezensis by modulating sporulation signaling by Qin Xiong, Huihui Zhang, Xia Shu, Xiting Sun, Haichao Feng, Zhihui Xu, Ákos T. Kovács, Ruifu Zhang, Yunpeng Liu

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Butyric Acid Modulates Gut Microbiota to Alleviate Inflammation and Secondary Bone Loss in Ankylosing Spondylitis by Ke You, Lianjun Yang, Zhihai Su, Jun Shen, Xinyang Fan, Yuanqing Guo, Zhen Yuan, Hai Lu

“…Furthermore, BA was found to impact the intestinal barrier function positively. Notably, BA was associated with the downregulation of harmful inflammatory factors and the reversal of bone loss, suggesting its protective effects against AS. …”
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Effects of cardiac contractility modulation on autophagy and apoptosis of cardiac myocytes in rabbits with chronic heart failure. by Qingqing Hao, Shilin Lv, Jing Zhang, Huiliang Liu

“…<h4>Background</h4>Cardiac contractility modulation (CCM) is non-excitatory electrical stimulation for improving cardiac function. …”
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Transcriptional control of C. albicans white-opaque switching and modulation by environmental cues and strain background by Anupam Sharma, Ameen Homayoon, Michael Weyler, Corey Frazer, Bernardo Ramírez-Zavala, Joachim Morschhäuser, Richard J. Bennett

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The stabilizing potential of the supraspinatus is inhibited in tear-associated scapula shapes but can be modulated by kinematic adjustments by Erin C. S. Lee, Nathan M. Young, Ellen Y. Li, Rebekah L. Lawrence, Michael J. Rainbow

“…The magnitude of kinematic perturbations required to modulate function exceeded the magnitude of shape differences, indicating that the perturbations are not correcting for a simple offset, but rather complex changes in muscle geometry that occur due to 3D shape differences.…”
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Structural basis for spermidine recognition and modulation of Acinetobacter baumannii multidrug efflux regulator AmvR by Na Wang, Xu Wang, Mengxiang Zhou, Qingsong Lu, Yaling Xu, Ying Wang, Haiyun Wang, Beibei Yang, Shibing He, Liuliu Xu, Jie Li, Honghua Ge, Jinming Ma

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Probiotic biofilm modified bioceramics for bone defect healing via osteogenesis, angiogenesis, and immune modulation by Junwei Su, Huiyun Gu, Xiang Huang, Ying Yuan, Yunchang Zhao, Fan Yang, Yong Zhao

“…The failure to repair bone defects in a timely manner has a detrimental effect on patients’ quality of life and functional status. Consequently, there are increasing demands for medical interventions to promote healing of bone defects. …”
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Ubp2 modulates DJ-1-mediated redox-dependent mitochondrial dynamics in Saccharomyces cerevisiae. by Sananda Biswas, Patrick D'Silva

“…Intriguingly, the loss of Ubp2 restores the mitochondrial integrity in the DJ-1 deletion background by modulating the ubiquitination status of Fzo1. Besides, the loss of Ubp2 in the absence of DJ-1 restores mitochondrial respiration and functionality by regulating the mitophagic flux. …”
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Cyclo-Oxygenase 2 Modulates Chemoresistance in Breast Cancer Cells Involving NF-κB by Maria Chiara Zatelli, Daniela Molè, Federico Tagliati, Mariella Minoia, Maria Rosaria Ambrosio, Ettore Degli Uberti

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Fractalkine/CX3CR1-Dependent Modulation of Synaptic and Network Plasticity in Health and Disease by N. P. Camacho-Hernández, F. Peña-Ortega

“…Through its key role in microglia-neuron communication, the FKN/CX3CR1 axis regulates microglial state, neuronal survival, synaptic plasticity, and a variety of synaptic functions, as well as neuronal excitability via cytokine release modulation, chemotaxis, and phagocytosis. …”
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