Acute Exposure to Aerosolized Nanoplastics Modulates Redox-Linked Immune Responses in Human Airway Epithelium by Joshua D. Breidenbach, Benjamin W. French, Upasana Shrestha, Zaneh K. Adya, R. Mark Wooten, Andrew M. Fribley, Deepak Malhotra, Steven T. Haller, David J. Kennedy

“…Airway epithelium was exposed to aerosolized 50 nm polystyrene NPs at concentrations ranging from 2.5 to 2500 µg/mL for three minutes per day over three days. Functional assays revealed no significant alterations in tissue integrity, cell survival, mucociliary clearance, or cilia beat frequency, suggesting intact epithelial function post-exposure. …”
Get full text

Haploid-specific variations of kiwifruit WAKL genes modulate immune-related responses in Nicotiana benthamiana by Zupeng Wang, Zhenting Sun, Hui Pan, Caihong Zhong, Li Li

“…Our findings highlight the importance of haploid-specific variations and PAVs in shaping WAKL gene function, providing new insights into how these genomic features modulate immune responses and offering potential implications for enhancing disease resistance in kiwifruit breeding.…”
Get full text

ACE Loss Drives Renal Cell Carcinoma Growth and Invasion by Modulating AKT-FOXO1 by Yin L, Mao L, Yin R, Lv C, Shi X, Yue C, Chen Y, Lu C, Wu Z, Xu K, Cao W

Get full text

Integrated analysis of microRNAs and lncRNAs expression profiles reveals regulatory modules during adventitious shoot induction in Moringa oleifera Lam by Endian Yang, Mengxia Zheng, Limei Zhang, Xiaoyang Chen, Junjie Zhang

Get full text

The biological activity and potential of probiotics-derived extracellular vesicles as postbiotics in modulating microbiota-host communication by Xiaoming Zhang, Ye Wang, Qiyu E, Muhammad Naveed, Xiuli Wang, Yinhui Liu, Ming Li

Get full text

A genetic polymorphism of the endogenous opioid dynorphin modulates monetary reward anticipation in the corticostriatal loop. by Mikhail Votinov, Mikhail Votinov, Juergen Pripfl, Christian Windischberger, Klaudius Kalcher, Alexander Zimprich, Fritz Zimprich, Ewald Moser, Claus Lamm, Uta Sailer

“…It has been shown that alleles with 3 or 4 repeats (HH genotype) of the variable nucleotide tandem repeat (68-bp VNTR) functional polymorphism of the prodynorphin (PDYN) gene are associated with higher levels of dynorphin peptides than alleles with 1 or 2 repeats (LL genotype). …”
Get full text

Modulation of Working Memory and Resting-State fMRI by tDCS of the Right Frontoparietal Network by Monika Pupíková, Patrik Šimko, Martin Gajdoš, Irena Rektorová

“…Many cognitive functions, including working memory, are processed within large-scale brain networks. …”
Get full text

A Study of Automatic Operation System Principle Module for Open-pit Mine Truck Transportation by LU Xiangyang, TAN Shaojun, LI Xun, XU Biao, HE Haixing, HE Yunxiang, HU Jian

“…By resolving the task of each layer into appropriate function blocks and specifying the function requirement for each block, the principle that how the truck operates automatically according to human desire is expounded, hence the top design outline of the automatic truck operation system is delineated. …”
Get full text

Age modulates, religious coping mediates: the role of attitude to self in cancer patients’ quality of life by Maria-Chidi C. Onyedibe, Runcie C.W. Chidebe, Runcie C.W. Chidebe, Runcie C.W. Chidebe, Barbara L. Andersen, Uzoamaka F. Ugwoke, Lawrence Ejike Ugwu, Lawrence Ejike Ugwu

Get full text

The insulator EACBE regulates V(D)J recombination of Tcrd gene by modulating chromatin organization by Yongchang Zhu, Yongchang Zhu, Ranran Dai, Ranran Dai, Hao Zhao, Junwei Luo, Keyi Li, Wei Xue, Litao Qin, Hongyuan Pan, Shixiu Liao, Bingtao Hao, Bingtao Hao

Get full text

Modulating the Focus of Attention for Spoken Words at Encoding Affects Frontoparietal Activation for Incidental Verbal Memory by Thomas A. Christensen, Kyle R. Almryde, Lesley J. Fidler, Julie L. Lockwood, Sharon M. Antonucci, Elena Plante

“…The present study combined an incidental memory paradigm with event-related functional MRI to examine the effect of attention at encoding on the subsequent neural activation associated with unintended perceptual memory for spoken words. …”
Get full text

Therapeutic potential of formononetin in cirrhotic portal hypertension: modulating hepatic fibrosis, macrophage polarization, and lymphangiogenesis by Zhenghao Wu, Guqing Luo, Hongjie Li, Min Chen, Guangbo Wu, Qiang Fan, Chihao Zhang, Jiwei Yu, Jiayun Lin, Jinbo Zhao, Xiaoliang Qi, Haizhong Huo, Meng Luo, Lei Zheng

“…IntroductionFormononetin regulates intrahepatic fibrogenesis and macrophage polarization to improve portal pressure and liver function in rats with cirrhotic PHT through SMAD3, STAT1, STAT3 and GSK-3β signaling pathways, and modulates lymphangiogenesis through direct action and macrophage polarization-mediated indirect effects. …”
Get full text

Channel Modeling and Performance Analysis of Modulating Retroreflector FSO Systems Under Weak Turbulence Conditions by Guowei Yang, Zhipeng Li, Meihua Bi, Xuefang Zhou, Ran Zeng, Tianshu Wang, Jing Li

“…Then, the probability density function (PDF) and cumulative distribution function (CDF) of the channel model are derived in closed form. …”
Get full text

Phosphorylation of S776 and 14-3-3 binding modulate ataxin-1 interaction with splicing factors. by Cesira de Chiara, Rajesh P Menon, Molly Strom, Toby J Gibson, Annalisa Pastore

Get full text

Hypoglycaemia after Initiation of CFTR Modulator Therapy in a Cystic Fibrosis Patient without Diabetes by Marie Yskout, Joke Vliebergh, Hakan Bor, Lieven Dupont, Natalie Lorent, Pascal Van Bleyenbergh, Pieter Gillard, Bart Van der Schueren, Ann Mertens, Chantal Mathieu, Roman Vangoitsenhoven

“…Cystic fibrosis transmembrane regulator (CFTR) modulator therapies improve respiratory function and glycaemic control in patients with cystic fibrosis (CF). …”
Get full text

Allergic Bronchopulmonary Aspergillosis (ABPA) in the Era of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Modulators by Paulami Chatterjee, Carson Tyler Moss, Sarah Omar, Ekroop Dhillon, Carlos Daniel Hernandez Borges, Alan C. Tang, David A. Stevens, Joe L. Hsu

“…The treatment of patients with CF (pwCF) has been revolutionized by the efficacy of cystic fibrosis transmembrane conductance regulator (CFTR) modulator therapy. Pharmacological improvement in CFTR function with highly effective elexacaftor/tezacaftor/ivacaftor (ETI) provides unprecedented improvements in lung function and other clinical outcomes of pwCF. …”
Get full text

M6A Methyltransferase METTL3 Modulates Traumatic Brain Injury by Targeting Ferroptosis by Fei Qin, Fan Li, Wenxiao Zhao, Suqin Zhang, Jiang Shen, Xinyu Yang

“…Background: Traumatic brain injury (TBI) is a disease caused by external forces that damage brain structure and function. After TBI, iron accumulation and reactive oxygen species (ROS) increase lipid peroxidation, promoting ferroptosis. …”
Get full text

A Drosophila Smyd4 homologue is a muscle-specific transcriptional modulator involved in development. by Elizabeth C Thompson, Andrew A Travers

Get full text

Propagation Properties of Laguerre–Gaussian Beams with Three Variable Coefficient Modulations in the Fractional Schrödinger Equation by Xinru Hao, Yong Liang, Min Zou, Bin Zhong, Chao Tan

“…This article investigates the transmission characteristics of Laguerre–Gaussian (LG) beams under cosine modulation, power function modulation and linear modulation based on the variable coefficient fractional Schrödinger equation (FSE), respectively. …”
Get full text

Merkel cell polyomavirus protein ALTO modulates TBK1 activity to support persistent infection. by Ranran Wang, Taylor E Senay, Tiana T Luo, Wei Liu, James M Regan, Nicholas J H Salisbury, Denise A Galloway, Jianxin You

“…Our previous findings suggest that STING also functions as a tumor suppressor in MCPyV-driven oncogenesis. …”
Get full text