Modulating mitochondria with natural extract compounds: from bench to clinical therapeutic opportunities for COPD by Qiao Wang, Ziling Zeng, Linlin Guo, Kent E. Williams, Yun Zhang, Yun Zhang, Hongmei Tang, Hang Hu, Hang Hu, Gang Qin, Kaijin Wang, Xing Wang

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Module Partition Method of the Modular Design of Reducer based on Simulated Annealing and Genetic Algorithm by Zhao Han, Zhang Nan, Zong Wei

“…The module partition is the key step and foundation of module design. …”
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Modulation of the Toll-like Receptor 3-Mediated Intestinal Immune Response by Water Kefir by Stefania Dentice Maidana, Ramiro Ortiz Moyano, Mariano Elean, Yoshiya Imamura, Leonardo Albarracín, Fu Namai, Yoshihito Suda, Keita Nishiyama, Julio Villena, Haruki Kitazawa

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Advancing immunosuppression in liver transplantation: the role of regulatory T cells in immune modulation and graft tolerance by Ji Won Han, Su-Hyung Park

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A Novel, Noncanonical BMP Pathway Modulates Synapse Maturation at the Drosophila Neuromuscular Junction. by Mikolaj J Sulkowski, Tae Hee Han, Carolyn Ott, Qi Wang, Esther M Verheyen, Jennifer Lippincott-Schwartz, Mihaela Serpe

“…Thus, BMP pathway may monitor synapse activity then function to adjust synapse growth and maturation during development.…”
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Structural basis for regulation of CELSR1 by a compact module in its extracellular region by Sumit J. Bandekar, Krassimira Garbett, Szymon P. Kordon, Ethan E. Dintzner, Jingxian Li, Tanner Shearer, Richard C. Sando, Demet Araç

“…Cell-based assays reveal the N-terminal CADH1-8 repeat is required for cell-cell adhesion and the C-terminal CADH9-GAIN compact module can regulate cellular adhesion. Our work provides molecular insight into how one of the largest GPCRs uses defined structural modules to regulate receptor function.…”
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The Drosophila homologue of the amyloid precursor protein is a conserved modulator of Wnt PCP signaling. by Alessia Soldano, Zeynep Okray, Pavlina Janovska, Kateřina Tmejová, Elodie Reynaud, Annelies Claeys, Jiekun Yan, Zeynep Kalender Atak, Bart De Strooper, Jean-Maurice Dura, Vítězslav Bryja, Bassem A Hassan

“…APP's in vivo function in the brain and the mechanisms underlying it remain unclear and controversial. …”
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PCSK9 Modulates Macrophage Polarization-Mediated Ventricular Remodeling after Myocardial Infarction by Feifei Wang, Min Li, Aidong Zhang, Hairui Li, Can Jiang, Jun Guo

“…Correlation analysis showed that higher PCSK9 expression indicated worse cardiac function after AMI, and PCSK9 knockout reduced infarct size, improved cardiac function, and attenuated inflammatory cell infiltration compared to WT mice. …”
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Magnetite particle size and spatial distribution may modulate neural oscillation in the human brain by Gunther Kletetschka, Robert Bazala

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Defect Diagnosis of Photovoltaic Module Visible Light Images Under Imbalanced Sample Conditions by Huiqing Rao, Qiong Li, Long Chen, Sha Jin, Yong Lu, Zhiguang Li

“…Secondly, a self-attention mechanism is introduced into both the generator and the discriminator to enhance the ability of DCGAN to extract image features, allowing the model to capture small defects or subtle differences in defects on PV modules more accurately. Finally, to address the issue of DCGAN generating repeated and similar images, an image similarity measurement function is introduced into the loss function. …”
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Spatial Division Multiplexing-Based Reflective Intensity-Modulated Fiber Optics Displacement Sensor by Tianye Lan, Cong Zhang, Songnian Fu, Benpeng Zhu, Ming Tang, Weijun Tong

“…Under the condition of single-input single-output, we experimentally compare the transfer function of RIMFODS by using a pair of standard single-mode fibers (SSMFs), single seven-core-single-mode fiber, and single seven-core-few-mode fiber. …”
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Hybrid virtual screening and molecular dynamics approach for identification of allosteric modulator of EAAT2 by Chennu Manisha, Nagarjuna Palathoti, Jagdish Chand, Akey Krishna Swaroop, Jubie Selvaraj, B.R. Prashantha Kumar, Prisil Naveentha X, Brindha Durairaj, Antony Justin

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Modulating the gut microbiota and inflammation is involved in the effect of diosgenin against diabetic nephropathy in rat by Jiang Shanshan, Pan Shu, Hu Xiao, Kudelaidi Kuerban, Zhu Hao, Wang Yujie, Wang Rong, Shi Yuhuan, Yuan Yongfang

“…The study assessed the effects on metabolic and renal function parameters, renal apoptosis and fibrosis, gut microbiota diversity, and NLRP3 inflammasome activation in the kidney.ResultsDIO treatment ameliorated the progression of DN, improving metabolic and renal function. …”
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Oxytocin‐Mediate Modulation of Splenic Immunosuppression in Chronic Social Stress Through Neuroendocrine Pathways by Yi‐Shu Zhang, Hai‐Chao Chen, Jia‐Xin Cao, Si‐Wei Zhou, Yue‐Zhang Ma, Yu‐Hong Jing

“…Abstract Chronic social stress (CSS) is a significant public health challenge that negatively impacts behavior and immune function through brain‐spleen interactions. Oxytocin (OT), a neuropeptide critical for social behavior and immune regulation, is upregulated during CSS, though its underlying mechanisms remain unclear. …”
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Neurotrophic factor Neuritin modulates T cell electrical and metabolic state for the balance of tolerance and immunity by Hong Yu, Hiroshi Nishio, Joseph Barbi, Marisa Mitchell-Flack, Paolo DA Vignali, Ying Zheng, Andriana Lebid, Kwang-Yu Chang, Juan Fu, Makenzie Higgins, Ching-Tai Huang, Xuehong Zhang, Zhiguang Li, Lee Blosser, Ada Tam, Charles Drake, Drew Pardoll

“…Here, we report in mice that neuritin (Nrn1) contributes to tolerance development by modulating regulatory and effector T cell function. …”
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Prodynorphin-expressing neurons in the ventromedial hypothalamus respond to the predatory odor and modulate defensive behaviors by Ting He

“…Furthermore, optogenetic activation of these PDYN-expressing neurons induced escape-like behaviors and place aversion in male mice, highlighting their functional involvement in threat processing. These findings indicate that PDYN-expressing neurons in the VMH are specifically tuned to detect threat stimuli and play a role in modulating defensive behaviors.…”
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Sinapic Acid Ameliorates Cadmium-Induced Hepatotoxicity: Modulation of Oxidative Stress, Inflammation, and Apoptosis by Yomna A. Farahat, Norhan M. El-Sayed, Reem M. Hazem, Eman T. Mehanna, Asmaa Radwan

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ADAM9 Genetic Variants and Their Role in Modulating Enzyme Activity in Diabetes and Metabolic Traits by Hana Drobiova, Fahd Al-Mulla, Rabeah Al-Temaimi

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ALOXE3 expression predicts poor prognosis and modulates immune infiltration in colon adenocarcinoma by Liwen Zhao, Liya Zhao, Siyu Ye, Shengnan Jing, Han Yang, Yixin Qi, Zhaofeng Li, Zaiqing Jiang, Xuechuan Yan, Ke Wang, Yong-Jing Gao, Tianzhen He

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The OsSAPK10-OsPAL1 module contributes to rice blast resistance by Zhijuan Diao, Houli Zhou, Xun Wang, Bangsheng Wang, Ling Lu, Na Xia, Fanyu Kong, Kexin Ji, Sirui Xie, Shengping Li, Dingzhong Tang

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