Aqueous extract of Solanum americanum Mill. relieves functional constipation by modulating the enteric nervous system and gut micro-ecosystems by Xiaoyu Gao, Xiaoyu Gao, Xiaoyu Gao, Yanan Li, Yifan Hu, Yifan Hu, Weixing Yang, Lei Peng, Jun Sheng, Yang Tian, Lu Yao, Yan Zhao

“…The present study evaluated the laxative activity of Solanum americanum Mill. aqueous extract (SAAE) using loperamide-induced functional constipation (FC) mouse model. The results demonstrated that SAAE is abundant in nucleotides and polysaccharides. …”
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Quiescence modulates age-related changes in the functional capacity of highly proliferative canine lung mesenchymal stromal cell populations. by Nakesha Agyapong, Leslie Dominguez-Ortega, Brian Macdonough, Patrick Mulluso, Sagar Patel, Briti Prajapati, Brian Saville, Andrew Shapiro, Ethan Trim, Kara Battaglia, Jocelyn Herrera, Gianna Garifo-MacPartland, Dianne Newcomb, Latoya Okundaye, Heather Paglia, Julia Paxson

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Dissecting the functions and regulatory mechanisms of disulfidoptosis-related RPN1 in pan-cancer: modulation of immune microenvironment and cellular senescence by Lexin Qin, Tingting Liang, Hailong Zhang, Xian Gong, Meidan Wei, Xiangrong Song, Yaoyu Hu, Xinyu Zhu, Wentao Hu, Jianxiang Li, Jin Wang

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Adaptation and validation of the Washington group/unicef child functioning module in a nationally representative sample of Canadian children and youth by Emma Nolan, Katherine Cost, Ryan Miller, Li Wang, Chen Yun-Ju, Jordan Edwards, Eric Duku, Stelios Georgiades, Peter Szatmari, Harriet MacMillian, Charlotte Waddell, Katholiki Georgiades

Subjects: “…Washington group/Unicef child functioning module…”
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Synbiotic-driven modulation of the gut microbiota and metabolic functions related to obesity: insights from a human gastrointestinal model by Kevin Mok, Putsawee Tomtong, Takuma Ogawa, Kenshiro Nagai, Pitchsupang Torrungruang, Suvimol Charoensiddhi, Jiro Nakayama, Bandhita Wanikorn, Sunee Nitisinprasert, Wanwipa Vongsangnak, Massalin Nakphaichit

“…Abstract Synbiotic interventions have gained increasing attention for modulating gut microbiota and metabolic functions in obesity-related disorders. …”
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VISTA functions as a protective immune checkpoint in indirect acute respiratory distress syndrome by modulating systemic and compartmentalized inflammation by Baoji Hu, Baoji Hu, Baoji Hu, Chun-Shiang Chung, Chyna Gray, Yaping Chen, Jihong Jiang, Jihong Jiang, Jianrong Guo, Jianrong Guo, Alfred Ayala

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Thresholds and Trade-Offs: Fire Severity Modulates Soil Microbial Biomass-Function Coupling in Taiga Forests, Northeast of China by Huijiao Qu, Siyu Jiang, Zhichao Cheng, Dan Wei, Libin Yang, Jia Zhou

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Mannose-B from Codonopsis pilosula modulates LAMB1 expression to enhance trophoblast function and alleviate subchorionic hematoma by Qian Sun, Yuan Gao, Kadirya Asan, Jing Ji, Jinjin Xu, Xiaoyan Wu, Jie Ren, Wen Feng, Mengwei Song, Sen Wang, Boyu Zhang, Ying Zhou, Conghui Han, Shun Liu, Wen Yang

“…Mannose-B from Codonopsis pilosula may alleviate SCH progression by modulating LAMB1 expression and enhancing trophoblast cell function. …”
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2’-Fucosyllactose modulates the function of intestinal microbiota to reduce intestinal permeability in mice colonized by feces from healthy infants by Qingxue Chen, Liu Yang, Fangqin Xiang, Ignatius Man-Yau Szeto, Yalu Yan, Biao Liu, Jinju Cheng, Lu Liu, Bailiang Li, Sufang Duan

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Achieving burst Li+ channels via quasi-two-dimensional fluorinated metal-organic framework modulating functionalized interface by Lingchen Kong, Yu Li, Cong Peng, Ziyue Zhao, Junwei Xiao, Yimin Zhao, Wei Feng

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Noncoding function of super enhancer derived Cpox pre-mRNA in modulating neighbouring gene expression and chromatin interactions by Bingning Xie, Ann Dean

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Quiescence modulates age-related changes in the functional capacity of highly proliferative canine lung mesenchymal stromal cell populations by Nakesha Agyapong, Leslie Dominguez-Ortega, Brian Macdonough, Patrick Mulluso, Sagar Patel, Briti Prajapati, Brian Saville, Andrew Shapiro, Ethan Trim, Kara Battaglia, Jocelyn Herrera, Gianna Garifo-MacPartland, Dianne Newcomb, Latoya Okundaye, Heather Paglia, Julia Paxson

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Src Family Kinases Modulate the Loss of Endothelial Barrier Function in Response to TNF-α: Crosstalk with p38 Signaling. by Alejandro P Adam, Anthony M Lowery, Nina Martino, Hiba Alsaffar, Peter A Vincent

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Transplanted human striatal progenitors exhibit functional integration and modulate host circuitry in a Huntington’s disease animal model by Linda Scaramuzza, Marta Ribodino, Christian Cassarino, Marta Morrocchi, Gabriela B Gomez Gonzalez, Roberta Parolisi, Edoardo Sozzi, Giacomo Turrini, Valentina Cerrato, Paola Conforti, Eriola Hoxha, Riccardo Tognato, Greta Galeotti, Chiara Cordiglieri, Maria Cristina Crosti, Stefano Zucca, Martina Lorenzati, Serena Bovetti, Paolo Spaiardi, Claudio de’Sperati, Gerardo Biella, Linda Ottoboni, Malin Parmar, Simone Maestri, Dario Besusso, Elena Cattaneo, Annalisa Buffo

“…Altogether, these results provide preclinical evidence that hSP-grafts can reconstruct striatal circuits and modulate functionally relevant behaviors. The ability to generate a scalable, molecularly defined progenitor population capable of in vivo functional integration supports the potential of hSPs for clinical application in HD and related basal ganglia disorders.…”
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High-resolution transcriptome atlas of bladder cancer highlights the functional myeloid subsets in modulating immune microenvironmentResearch in context by Jiachen Liu, Zhen Shi, Yajian Li, Jie Ma, Jiaying Yao, Zan Yuan, Yuanhao Wang, Chunyuan Yang, Xiao Li, Nianzeng Xing, Yunping Zhu, Jianhong Zhang, Li Wu

“…Furthermore, our study demonstrates that TREM2 and APP function as immune-modulating molecules, with potential therapeutic implications in the context of bladder cancer. …”
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Structural and functional studies of rabbit SAMD9 reveal a distinct tRNase module that underlies the antiviral activity. by Juhi Chaturvedi, Fushun Zhang, Chen Zhang, Sonal Badhe, Yan Xiang, Junpeng Deng

“…These findings demonstrate that lagomorph SAMD9 preserves core tRNA-targeting and antiviral functions despite a key residue variation and the need for an extended tRNase module.…”
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The integrative genomic and functional immunological analyses of colorectal cancer initiating cells to modulate stemness properties and the susceptibility to immune responses by Issam Tout, Salim Bougarn, Mohammed Toufiq, Neha Gopinath, Ola Hussein, Abbirami Sathappan, Evonne Chin-Smith, Fazulur Rehaman, Rebecca Mathew, Lisa Mathew, Kun Wang, Li Liu, Abdulrahman Salhab, Oleksandr Soloviov, Sara Tomei, Waseem Hasan, Sahar Da’as, Yosra Bejaoui, Nady El Hajj, Karama Makni Maalej, Said Dermime, Kakil Rasul, Paolo Dellabona, Giulia Casorati, Alice Turdo, Matilde Todaro, Giorgio Stassi, Soldano Ferrone, Xinhui Wang, Cristina Maccalli

“…Methods We conducted a multi-omics analysis—encompassing DNA methylation, total RNA sequencing, and microRNAs (miRNAs; N = 800) profiling on primary CICs and differentiated tumor cell lines, including autologous pairs. Functional immunological assays were performed to assess the impact of miRNA modulation. …”
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Distinct mechanisms of electroacupuncture and manual acupuncture in modulating hypothalamic GnRH–tanycyte unit function of polycystic ovary syndrome by Yu Wang, Yicong Wang, Yuning Chen, Wenhan Lu, Xiaoyu Tong, Jiajia Li, Wenhao Gao, Rui Huang, Wei Hu, Yi Feng

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Structural and Functional Models for Building New Generation Automated and Robotic Dairy Farms by V. V. Kirsanov

“…The authors received the criterion equation for the total functional of the dairy farm. (Results and discussion) The authors analyzed the structural and functional diagrams of various configuration and size dairy farms (T-H-shaped), including combined storage farms, which make it possible to create a combined functional and logistics infrastructure consisting of standard modular units. …”
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Exercise Volume Can Modulate the Regenerative Response to Spinal Cord Injury in Mice by Anne Caroline Rodrigues dos Santos, Renata Pereira Laurindo, Fernanda Marques Pestana, Luiza dos Santos Heringer, Nathalie Henrique Silva Canedo, Ana Maria Blanco Martinez, Suelen Adriani Marques

“…Traumatic spinal cord injury (SCI) causes debilitating motor and sensory deficits that impair functional performance, and physical rehabilitation is currently the only established therapeutic reality in the clinical setting. …”
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