GeneSurfer enables transcriptome-wide exploration and annotation of gene co-expression modules in 3D spatial transcriptomics data by Chang Li, Julian Thijssen, Thomas Kroes, Ximaine van der Burg, Louise van der Weerd, Thomas Höllt, Boudewijn Lelieveldt

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Effect of Bio-Electro-Magnetic-Energy-Regulation (BEMER) Horse Therapy on Cardiopulmonary Function and Recovery Quality After Isoflurane Anesthesia in 100 Horses Subjected to Pars-... by Olivier Brandenberger, Andrey Kalinovskiy, Jens Körner, Hermann Genn, Ralph Burger, Stephan Leser

“…Visually identical blankets were used in the two groups (1:1 ratio), one with a functional BEMER module and the other with a placebo module. …”
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Personalized brain functional sectors guided theta burst transcranial magnetic stimulation for treatment-resistant depression: a study protocol for a multi-centre, randomised, doub... by Ling Zhang, Ping Zhang, Wuxiang Xie, Hao Cheng, Kai Wang, Yongbo Hu, Qiyong Gong, Weihong Kuang, Meiyun Wang, Gang Wang, Liang Li, Wen Qin, Weihua Yue, Dai Zhang, Lijuan Chen, Gongjun Ji, Hesheng Liu, Meiling Li, Chunshui Yu, Ziqiang Li, Yuyanan Zhang, Yansheng Jiang, Sixiang Liang, Xiaoyue Sun, Zekun Yang

“…This trial aims to evaluate the clinical efficacy of iTBS as an additional treatment to a stable antidepressant regimen in patients with treatment-resistant depression (TRD) by modulating brain circuits identified through personalized brain functional sectors compared with sham treatment. …”
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Enhanced remote sensing image feature classification using STFF-PSPNet by Haiying Li, Jiaqi Gao, Yang Liu, Chenxi Huang, Lijun Li, Liqiang Zhang

“…By replacing ResNet with the STFF network for better global feature extraction, adding attention modules, and using a combined loss function, the improved model shows excellent performance. …”
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A novel cancer-associated lncRNA, LINC01123, participates in tumor progression, metabolism, immune escape, and resistance by Qiang Liu, He Huang, Shuwen Zhang, Fangteng Liu, Ting Lou

“…LINC01123 is regulated by multiple transcription factors and participates in gene regulation through protein interactions and competitive endogenous RNA (ceRNA) networks, thereby modulating cancer-promoting effects. This work systematically elucidates its primary functions and molecular mechanisms driving cancer initiation and progression, suggesting that LINC01123 might serve as a novel potential oncogenic driver and biomarker in various cancers.…”
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Advances in α-Lipoic Acid for Disease Prevention: Mechanisms and Therapeutic Insights by Yonglian Wang, Shuxia Jiang, Yaoxuan He, Ping Pang, Hongli Shan

“…α-Lipoic acid (ALA) is a naturally occurring compound with diverse biological functions, widely distributed in animal and plant tissues. …”
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DETERMINATION OF SURFACE DEFORMATION OF CONTINUOUSLY INHOMOGENEOUS THERMOELASTIC HALF-SPACE UNDER LOCAL HEATING by Leonid Ivanovich Krenev, Sergey Mikhailovich Aizikovich, Boris Igorevich Mitrin

“…At first, the solution is reduced to solving a two-point boundary problem for the ODEs system with varying coefficients of the sixth order. The modulating functions method is used to provide a stable numerical solution to the ordinary differential system. …”
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CIRCULAR PUNCH INDENTATION INTO CONTINUOUSLY INHOMOGENEOUS THERMOELASTIC HALF-SPACE UNDER GIVEN CONSTANT TEMPERATURE AT ITS FLAT BOTTOM by Leonid Ivanovich Krenev, Sergey Mikhaylovich Aizikovich, Boris Igorevivich Mitrin

“…An axial ly symmetric quasistatic thermoelasticity problem on the indentation of a flat - ended cylindrical punch with a constant temperature at its base into the functionally - graded half - space which elasticity modulus, Poisson ratio, heat conductivity and expansion coefficients are independently continuously varying in the boundary layer, is considered. …”
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Exploring the Impact of Solid-State Fermentation on Fava Bean Flour: A Comparative Study of <i>Aspergillus oryzae</i> and <i>Rhizopus oligosporus</i> by Ophélie Gautheron, Laura Nyhan, Maria Garcia Torreiro, Ali Zein Alabiden Tlais, Claudia Cappello, Marco Gobbetti, Andreas Klaus Hammer, Emanuele Zannini, Elke K. Arendt, Aylin W. Sahin

“…Solid-state fermentation (SSF) can modify the composition of plant proteins, modulate its functionality, and enhance the sensory aspects. …”
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Volatile oil of Acori tatarinowii rhizoma: potential candidate drugs for mitigating dementia by Yifan Bu, Songzhe Li, Ting Ye, Yuqing Wang, Mingrong Song, Jing Chen

“…Furthermore, the study highlights the limitations of existing research and offers insights into future research directions.ResultsThe volatile oil of ATR mitigates dementia through multiple pathways, including reducing abnormal protein aggregation, promoting neurogenesis, inhibiting neuronal apoptosis, regulating neurotransmitters, improving synaptic function, modulating autophagy, countering cellular stress, reducing neuroinflammation, and alleviating vascular risk factors.ConclusionThe multi-pathway pharmacological effects of the volatile oil of ATR are well-aligned with the complex mechanisms of dementia progression, highlighting its significant therapeutic potential for anti-dementia applications. …”
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Automation of Formal Verification of Programs in the Pifagor Language by M. S. Ushakova, A. I. Legalov

“…In this article a proof process of correctness of functional data-flow parallel programs in the Pifagor language is considered. …”
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Machine learning modeling and analysis of prognostic hub genes in cervical adenocarcinoma: a multi target therapy for enhancement in immunosurveillance by Madiha Jabeen Abbasi, Rashid Abbasi, ShuPeng Wu, Md Belal Bin Heyat, Ding Xianfeng, Huijie Jia, Aiwen Zheng

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Use of natural rumen modulators to replace monensin plus virginiamycin in high-grain diets for cattle by Saulo Alberto do Carmo Araújo, Bruno Borges Deminicis, Norberto da Silva Rocha, Felippe Meira Lourenço, Fernanda de Oliveiro Carvalho

“…A Latin square experimental design was adopted, represented by four treatments (functional oil, yeast, tannin and control monensin and virginiamycin) in four experimental periods, with four animals cannulated in the rumen. l The natural ruminal modulators fully replaced the ionophores monensin and virginiamycin in the concentrate. …”
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Effects of TrkB-related induced metaplasticity within the BLA on anxiety, extinction learning, and plasticity in BLA-modulated brain regions by Joyeeta Dutta Hazra, Kuldeep Shrivastava, Lisa-Sophie Wüstner, Rachel Anunu, Erez Chervinsky, Somoday Hazra, Simone Beuter, Martin Kriebel, Mouna Maroun, Hansjuergen Volkmer, Gal Richter-Levin

“…Conclusions Taken together, these findings reveal the dissociative involvement of BLA function, on the one hand, in anxiety, which is affected by the knockdown of TrkB, and, on the other hand, in extinction learning, which is more significantly affected by the combination of intra-BLA-induced metaplasticity and exposure to emotional trauma.…”
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Engineering Stepped Structures on Hydroxyapatite Surfaces: A Potential Strategy to Modulate Bone Marrow Mesenchymal Stem Adhesion, Spreading, and Proliferation by Yongmei Wang, Fang Wang, Min Gong, Lidan Chen, Yun Wang, Pu Xu, Zhu Zeng, Zuquan Hu, Jin Chen

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Identification of Post-Transcriptional Modulators of Breast Cancer Transcription Factor Activity Using MINDy. by Thomas M Campbell, Mauro A A Castro, Bruce A J Ponder, Kerstin B Meyer

“…To better understand the pathways or sub-networks in which these TFs mediate their function we sought to identify upstream modulators of their activity. …”
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IL-17A inhibitors modulate skin microbiome in psoriasis: implications for microbial homeostasis by Ying Lv, Huiying Bian, Yanjia Jing, Jing Zhou

“…Conclusions Psoriasis patients exhibit significant heterogeneity in both the composition and functionality of their skin microbiota. Although IL-17A inhibitor treatment fails to fundamentally alter its taxonomic composition, this therapy effectively enhances microbial community stability by increasing alpha diversity and modulating the relative abundance of various taxa. …”
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The role of gut microbiota and metabolomic pathways in modulating the efficacy of SSRIs for major depressive disorder by Ying Jiang, Yucai Qu, Lingyi Shi, Mengmeng Ou, Zhiqiang Du, Zhenhe Zhou, Hongliang Zhou, Haohao Zhu

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BCG-INDUCED PRO-INFLAMMATORY PHENOTYPE OF MESENCHYMAL STEM CELLS: EFFECT OF IMMUNE MODULATORS by A. Sh. Shvarts, S. N. Belogorodtsev, A. E. Petrenko, L. O. Degtyareva, A. I. Shakhmuradova

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PCES-YOLO: High-Precision PCB Detection via Pre-Convolution Receptive Field Enhancement and Geometry-Perception Feature Fusion by Heqi Yang, Junming Dong, Cancan Wang, Zhida Lian, Hui Chang

“…Finally, the Shape-IoU loss function is incorporated, focusing on bounding box shape and scale for more accurate regression and enhanced defect localization precision. …”
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