Extracellular PHF-tau modulates astrocyte mitochondrial dynamics and mediates neuronal connectivity by Valentin Zufferey, Aatmika Barve, Enea Parietti, Luc Belinga, Audrey Bringaud, Yvan Varisco, Kerstin Fabbri, Francesca Capotosti, Paola Bezzi, Nicole Déglon, Pierre Marquet, Nicolas Preitner, Kevin Richetin

“…Similarly, astrocyte-specific overexpression of PGC1alpha produced a comparable pattern of synaptic vesicle production, indicating that astrocytic mitochondrial adaptation to ePHF-tau may significantly influence synaptic function. Conclusions These findings suggest that the accumulation of PHF-tau within astrocytes drives changes in mitochondrial biogenesis, which may influence synaptic regulation. …”
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A citrullinated histone H3 monoclonal antibody for immune modulation in sepsis by Wenlu Ouyang, Yuchen Chen, Tao Tan, Yujing Song, Tao Dong, Xin Yu, Kyung Eun Lee, Xinyu Zhou, Zoe Tetz, Sophia Go, Xindi Zeng, Liujiazi Shao, Chao Quan, Ting Zhao, Yuzi Tian, Katsuo Kurabayashi, Hua Jin, Jichun Ma, Jingdong Qin, Brandon Williams, Qingtian Li, Gui-dong Zhu, Hasan B. Alam, Kathleen A. Stringer, Yongqing Li, Jianjie Ma

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Modulation of endogenous plasmalogens by genetic ablation of lysoplasmalogenase (Tmem86b) in mice by Sudip Paul, Pooranee Morgan, Gerard Pernes, Yvette Schooneveldt, Thy Duong, Natalie A. Mellett, Kevin Huynh, Andrew J. Murphy, Graeme I. Lancaster, Peter J. Meikle

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Implantable Biophotonic Device for Wirelessly Cancer Real‐Time Monitoring and Modulable Treatment by Renhao Nie, Qingyan Jia, Yuanying Li, Changhan Yan, Xiyin Liu, Yaolan Tao, Jianhong Zhang, Peng Li, Wei Huang

“…The µ‐LED in the biophotonic device can function as a light source for in situ photodynamic therapy while simultaneously monitoring the oxygen consumption during the treatment process. …”
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The bacterial microbiome modulates the initiation of brain metastasis by impacting the gut-to-brain axis by Matteo Massara, Michelle Ballabio, Bastien Dolfi, Golnaz Morad, Vladimir Wischnewski, Eleni Lamprou, Joao Lourenco, Stéphanie Claudinot, Hector Gallart-Ayala, Rui Santalla Méndez, Annamaria Kauzlaric, Nadine Fournier, Ashish V. Damania, Matthew C. Wong, Julijana Ivanisevic, Nadim J. Ajami, Jennifer A. Wargo, Johanna A. Joyce

“…In parallel, we quantified circulating metabolites, revealing kynurenic acid as a differentially abundant molecule that impaired the interaction between cancer cells and the brain vasculature in ex vivo functional assays. Together, these results illuminate the potential role of gut microbiota in modulating breast-BrM via the gut-to-brain axis.…”
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Ref-1 redox activity modulates canonical Wnt signaling in endothelial cells by Gabriella D. Hartman, Kamakshi Sishtla, Eyram K. Kpenu, Mahmut Mijit, Anbukkarasi Muniyandi, Ha-Neul Jo, Harald J. Junge, Aaron Shaw, Daniela Bischof, Sheng Liu, Jun Wan, Mark R. Kelley, Timothy W. Corson

“…Previous studies demonstrate that targeting the redox-mediated transcriptional regulatory function of APE1/Ref-1 reduces pathological neovascularization. …”
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Dietary iron interacts with diet composition to modulate the endocannabinoidome and the gut microbiome in mice by Fredy Alexander Guevara Agudelo, Nadine Leblanc, Isabelle Bourdeau-Julien, Gabrielle St-Arnaud, Fadil Dahhani, Nicolas Flamand, Alain Veilleux, Vincenzo Di Marzo, Frédéric Raymond

“…Iron (Fe) is an essential micronutrient for the function of enzymes involved in energy and lipid metabolism. …”
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Design and validation of a power modulation system for residential demand-side management by Aaron Goldin, Elizabeth Buechler, Ram Rajagopal, Juan M. Rivas-Davila

“…Residential loads have great potential to provide flexibility and other services to the grid, but many legacy or non-networked loads need additional hardware to enable such functionality. Currently available devices (e.g., smart thermostats or load control switches) that equip legacy loads with energy management features, provide narrow functionality to address specific use cases.We propose the Smart Dim Fuse (SDF), a unified system with general purpose hardware, to enable legacy residential loads with versatile grid-interactive functionalities. …”
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Better Evidence and UpToDate Training Module 2: Personalizing the User Experience by Kabale University Library

“…The modules illustrates How to Conduct a Search, Personalizing the User Experience,Topic Navigation and Functionality…”
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Phytochemical-mediated modulation of signaling pathways: A promising avenue for drug discovery by Jibon Kumar Paul, Mahir Azmal, ANM Shah Newaz Been Haque, Omar Faruk Talukder, Meghla Meem, Ajit Ghosh

“…Phytochemicals such as curcumin from turmeric, resveratrol from grapes, and epigallocatechin gallate (EGCG) from green tea, exert their effects primarily by modulating key pathways like PI3K/AKT, MAPK-ERK, Wnt, and Hedgehog, which are integral to cellular functions and disease progression. …”
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The gut microbiome, immune modulation, and cognitive decline: insights on the gut-brain axis by Ruyi Zhang, Ruyi Zhang, Ning Ding, Xicui Feng, Wenli Liao

“…The gut microbiome has emerged as a pivotal area of research due to its significant influence on the immune system and cognitive functions. Cognitive disorders, including dementia and Parkinson’s disease, represent substantial global health challenges. …”
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Biomaterial-based strategies for bone cement: modulating the bone microenvironment and promoting regeneration by Jiawei Jiang, Juan Wang, Pan Fan, Zhe Zhao, Hongjian Deng, Jian Li, Yi Wang, Yuntao Wang

“…Recent developments in biomaterial science have opened new avenues for enhancing bone cement functionality through innovative modifications. These advanced materials demonstrate promising capabilities in modulating the bone microenvironment through their distinct physicochemical properties. …”
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Interference of parallel phase-freqency-modulated signals with double phase-shift manipulation by Aleksandr Olegovich Malofey, Julia Olegovna Kharechkina

“…There were obtained functions of the energy spectra for this type of signal. …”
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Mechanisms of microbial-gut-brain axis modulation by electroconvulsive therapy in the treatment of depression by Jiaming Ji, Jinyan Guo, Jirong Yang, Siyang Zeng, Xue Han, Ziqing Hei, Weifeng Yao, Chaojin Chen

“…Conclusion ECT exerts its antidepressant effects by modulating gut microbiota and enhancing the functionality of the gut-brain axis.…”
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Physical cues in biomaterials modulate macrophage polarization for bone regeneration: a review by Tianxiao Yang, Zhurun Fang, Jin Zhang, Shengnai Zheng

“…This review summarizes macrophage functions across bone healing phases and critically examines how physical cues—such as stiffness, topography, pore architecture, hydrophilicity, electromagnetic stimuli, and metal composition—modulate macrophage polarization. …”
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Macrophages in sepsis-induced acute lung injury: exosomal modulation and therapeutic potential by Kaiying Lv, Qun Liang

“…This review explores the role of exosomes in modulating macrophage functions, focusing on the cellular interactions within the lung microenvironment and their potential as therapeutic targets. …”
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Modulating the JAK/STAT pathway with natural products: potential and challenges in cancer therapy by Bhagyalakshmi Nair, Anjana Menon, M. Rithwik Kalidas, Lekshmi R. Nath, Daniela Calina, Javad Sharifi-Rad

“…Abstract The Janus Kinase/Signal Transducer and Activator of Transcription (JAK/STAT) pathway is a critical signaling network governing cellular functions such as immune responses, proliferation, and apoptosis. …”
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Dermal white adipose tissue: A new modulator in wound healing and regeneration by Zhongyu Wu, Zhanqi Wang, Tao Chen, Dongyang Wang, Feng Zhou, Guorui Zhang, Shan Wei, Yingying Wu

“…Dermal white adipose tissue (dWAT), distinguished by its origin from cells within the dermis and independence from subcutaneous fat tissue, has garnered significant attention for its non-metabolic functions. Characterized by strong communication with other components of the skin, dWAT mediates the proliferation and recruitment of various cell types by releasing adipogenic and inflammatory factors. …”
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Sequence-encoded intermolecular base pairing modulates fluidity in DNA and RNA condensates by Sumit Majumder, Sebastian Coupe, Nikta Fakhri, Ankur Jain

“…Abstract Nature uses bottom-up self-assembly to build structures with remarkable complexity and functionality. Understanding how molecular-scale interactions translate to macroscopic properties remains a major challenge and requires systems that effectively bridge these two scales. …”
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A microscopy-based screen identifies cellular kinases modulating mitochondrial translation by Roya Yousefi, Luis Daniel Cruz-Zaragoza, Anusha Valpadashi, Carina Hansohn, Drishan Dahal, Ricarda Richter-Dennerlein, Silvio Rizzoli, Henning Urlaub, Peter Rehling, David Pacheu-Grau

“…Overall, our work provides a reliable approach to identify protein functions for mitochondrial gene expression in a high-throughput manner.…”
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