CUEDC2 modulates cardiomyocyte oxidative capacity by regulating GPX1 stability by Zhao Jian, Bing Liang, Xin Pan, Guang Xu, Sai‐Sai Guo, Ting Li, Tao Zhou, Ying‐Bin Xiao, Ai‐Ling Li

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Sphingosine-1-Phosphate Modulation in Neurological Disorders: Insights from MS and Stroke by Briana Maktabi, Faheem Shehjar, Zachary Senger, Logan Kountz, Syed Hasan, Kenan Maaieh, Kylee Hoersten, Jovana Duric, Zahoor A. Shah

“…A stroke is characterized by a sudden impairment of neurological function resulting from the loss or restriction of blood flow due to acute damage to a localized area of the central nervous system, including the brain, retina, or spinal cord. …”
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Frequency-specific modulation of motor cortical excitability by transcranial alternating current stimulation by Lei Tingting, Chen Lilin, Wang Chuangjia, Si Jiamen, Zhang Shuxian, Ai Yinan, Liu Hanjun, Zheng Haiqing

“…Conclusion These findings provide evidence that tACS induces frequency-dependent effects on cortical excitability and neuroplasticity within the M1. This selective modulation of cortical excitability with γ-tACS suggests its potential as a therapeutic intervention for optimizing motor function and rehabilitation. …”
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Modulators of Alpha-2 Macroglobulin Upregulation by High Glucose in Glomerular Mesangial Cells by Jackie Trink, Renzhong Li, Bo Gao, Chao Lu, Joan C. Krepinsky

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Akkermansia mono-colonization modulates microglia and astrocytes in a strain specific manner by Luke A. Schwerdtfeger, Toby B. Lanser, Federico Montini, Thais Moreira, Danielle S. LeServe, Laura M. Cox, Howard L. Weiner

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Scalable modulation of CRISPR‒Cas enzyme activity using photocleavable phosphorothioate DNA by Menglu Hu, Bingni Zhang, Yuanyue Shan, Feng Cao, Yihui Wang, Weiwei Qi, Xue Wang, Yuting Shen, Xinyi Guo, Mengmeng Zhang, Tian Tian, Wei Xie, Mingfeng Zhang, Fang Liang, Duanqing Pei, Xiaoming Zhou

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The network map of mucin 1 mediated signaling in cancer progression and immune modulation by Akhina Palollathil, Shobha Dagamajalu, Mukhtar Ahmed, Manavalan Vijayakumar, Thottethodi Subrahmanya Keshava Prasad, Rajesh Raju

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Dietary macronutrients modulate the proteome of brown adipose tissue in males and their female offspring by Erin L. Macartney, Alistair M. Senior, Angela J. Crean, Lewin Small, Lou Ruffino, Tamara J. Pulpitel, Marcelo A. Nobrega, Romain Barrès, Stephen J. Simpson

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Megavirus baoshanense Mb0671 modulates host translation and increases viral fitness by Wenya Bian, Jie Yang, Yucheng Xia, Yun Li, Yanjin Cheng, Yuchen Wu, Jianhua Gan, Jiang Zhong

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Role of extracellular vesicles in immune modulation, angiogenesis, progression and therapeutic resistance of glioblastoma by Muhammad Izhar, Ahed H. Kattaa, Amirhossein Akhavan-Sigari, Elaheh Shaghaghian, Yusuke S. Hori, Fred C. Lam, Deyaaldeen AbuReesh, Sara C. Emrich, Louisa Ustrzynski, Armine Tayag, Steven D. Chang, David J. Park

“…Within the context of immune modulation, EVs derived from GBM cells contain immunosuppressive molecules that alter the function of immune cells in the TME, enabling the tumor to escape immune surveillance. …”
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Voluntary exercise alleviates ischemic brain injury in mice by modulating mitochondrial dysfunction by Beibei Li, Ye Zhou, Guifen Yang, Bo Li, Mingjin Zhu, Dan Lu, Senge Dai, Guoyuan Pan

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Gut Microbiota Modulation by Lysozyme as a Key Regulator of Vascular Inflammatory Aging by Chenyang Zhang, Xin Zhao, Hang Zhang, Tongtong Wang, Zhenyu Zhang, Yilin Yin, Hui Wang, Xiao Tong, Yuzheng Xue, Yahong Zhou, Fenglai Yuan, Xiuwu Bian, Hong Wei, Yuan Huang, Tianhao Liu

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Synaptic modulation of glutamate in striatum of the YAC128 mouse model of Huntington disease by Judy Cheng, Ellen T. Koch, Daniel Ramandi, James P. Mackay, Timothy P. O’Leary, William Rees-Jones, Lynn A. Raymond

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Allosteric modulation of serotonin and dopamine transporters: New insights from computations and experiments by Hoang Nguyen, Mary Hongying Cheng, Ji Young Lee, Shaili Aggarwal, Ole Valente Mortensen, Ivet Bahar

“…We present here a comparative study of the structural dynamics and ligand-binding properties of two MATs, dopamine transporter (DAT) and serotonin transporter (SERT), with focus on the allosteric modulation of their transport function by drugs or substrates that consistently bind a secondary site S2, proposed to serve as an allosteric site. …”
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Electroacupuncture mitigates cognitive impairments in chronic hypoxia-induced mice by modulating neuroinflammation by Fang Wan, Kun Zhuang, Ziyu Li, Xiaoqing Wang, Wenyan Li, Yunlong Hou, Wanhui You, Yibing Jiang, Mingye Wang, Pengyu Zhu

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Decellularized Adipose Matrix Rejuvenates Photoaged Skin through Immune Microenvironment Modulation by Jialiang Zhou, Shengjie Jiang, Liyun Wang, Kaili Lin, Jianyong Wu, Haijun Gui, Zhen Gao

“…Current clinical interventions primarily target structural defects, while immune modulation remains underexplored. Therefore, developing biomaterials with both extracellular matrix (ECM) replenishment and immune regulatory functions is crucial for skin regeneration. …”
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Modulation of molecular markers in the duodenum and jejunum of piglets induced by an isotonic protein mixture by O. A. Sheptukha, D. M. Masiuk

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Microbiota Dysbiosis: A Key Modulator in Preeclampsia Pathogenesis and Its Therapeutic Potential by Johnatan Torres-Torres, Jorge Alberto Basurto-Serrano, Zaira Alexi Camacho-Martinez, Francisco Rafael Guadarrama-Sanchez, Irma Eloisa Monroy-Muñoz, Javier Perez-Duran, Juan Mario Solis-Paredes, Raigam Martinez-Portilla, Salvador Espino-y-Sosa, Andrea Ramirez-Gonzalez, Rodrigo Guadarrama-Mora, Lourdes Rojas-Zepeda

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Dietary modulation of gut microbiota affects susceptibility to drug-induced liver injury by Han Pan, Delei Song, Zhiyi Wang, Xin Yang, Pei Luo, Wei Li, Yan Li, Mengxue Gong, Chenhong Zhang

“…In the clinical intervention of subjects with prediabetes (N = 330), dietary fiber intervention enriches intestinal L. acidophilus, elevates serum ILA levels, and improves liver function. Conversely, WSD induces disturbance in bile acid metabolism and dysbiosis in gut microbiota, which impairs the intestinal barrier and facilitates the translocation of lipopolysaccharides (LPS) to the liver, thus triggering inflammatory responses and exacerbating DILI. …”
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HnRNPM modulates alternative splicing in germ cells by recruiting PTBP1 by Peng Lv, Wenchao Xu, Sheng Xin, Yuanxuan Deng, Bin Yang, Dengjianyi Xu, Jian Bai, Deilin Ma, Tao Wang, Jihong Liu, Xiaming Liu

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