Altered connection properties of the left dorsolateral superior frontal gyrus in de novo drug-naïve insomnia disorder by Hui Wang, Xianjun Ma, Xingru Xu, Qian Ning, Benyu Qiao, Bofeng Yang, Na Sun, Dong Xu, Xin Tang

“…The results indicate that altered DC properties of the left dorsolateral SFG might serve as a diagnostic marker for ID and a potential therapeutic target for brain function modulation.…”
Get full text

Impact of SGLT2i on Cardiac Remodeling and the Soleus Muscle of Infarcted Rats by Lidiane Moreira Souza, Felipe Cesar Damatto, Bruna Brasil Brandão, Eder Anderson Rodrigues, Anna Clara Consorti Santos, Rafael Campos França Silva, Mariana Gatto, Luana Urbano Pagan, Paula Felippe Martinez, Gilson Masahiro Murata, Leonardo Antonio Mamede Zornoff, Paula Schmidt Azevedo Gaiolla, Inês Falcão-Pires, Katashi Okoshi, Marina Politi Okoshi

Get full text

Effects of the 5-Hydroxytryptamine 3 Receptor Antagonist Palonosetron on Hemostasis: An In Vitro Study Using Thromboelastography by Hyun-Jung Shin, Bon-Wook Koo, Ji-Na Kim, Ji-In Park, Hyo-Seok Na

“…This study hypothesized that the 5-HT₃ receptor antagonist palonosetron may inhibit platelet function and aimed to evaluate its effects on blood coagulation using thromboelastography (TEG). …”
Get full text

Shexiang Tongxin Dripping Pills regulates SOD/TNF-α/IL-6 pathway to inhibit inflammation and oxidative stress to improve myocardial ischemia-reperfusion injury in mice by Wanying Du, Wanying Du, Chenguang Zhai, Chenguang Zhai, Huijie Zhang, Huijie Zhang, Jun Ren, Jun Ren, Xiaoyang Chen, Xiaoyang Chen, Xuejing Sun, Xuejing Sun, Chun Li, Chun Li, Wei Wang, Wei Wang, Yijun Chen, Yijun Chen, Yijun Chen

“…TTC staining confirmed a reduction in myocardial infarction size. Cardiac function assessments showed STDP improved both contractility and diastolic function post-MIRI and reduced arrhythmia incidence.DiscussionSTDP ameliorates MIRI in mice by inhibiting inflammatory responses and oxidative stress, primarily through modulation of the SOD/TNF-α/IL-6 pathway. …”
Get full text

Meeting international self-report muscle strengthening guidelines is associated with better cardiovagal baroreflex sensitivity in adults by Jocelyn Waghorn, Beverly D. Schwartz, Madeline E. Shivgulam, Madeline E. Shivgulam, Yanlin Wu, Yanlin Wu, Derek S. Kimmerly, Myles W. O’Brien, Myles W. O’Brien, Myles W. O’Brien

Get full text

2′-Fucosyllactose mitigates cognitive deficits in Alzheimer models: targeting amyloid pathology, oxidative stress, and synaptic plasticity by Yeasmin Akter Munni, Khoa Nguyen Tran, Seon-Min Jeon, Meeyul Hwang, Jong-Won Yoon, Young-Ha Song, Tae Woo Oh, Tae Woo Oh, Sang Il Gum, In-Jun Yang

“…This study aimed to investigate the therapeutic potential of 2′-FL in an aging mouse model of AD and to explore the underlying mechanisms involved.Methods5xFAD transgenic mice were treated with 2′-FL and assessed for cognitive function using the Morris water maze and Y-maze tests. …”
Get full text

Neural mechanism of dopamine modulating singing related behavior in songbirds: an updated review by Linghua Zhong, Weiting Li, Mengjiao Liu, Wei Sun, Zhibin Liu, Songhua Wang

Get full text

Transketolase attenuates the chemotherapy sensitivity of glioma cells by modulating R-loop formation by Minjie Fu, Mengli Zhang, Licheng Zhang, Yuan Feng, Chao Gao, Hao Xu, Jinsen Zhang, Huaichao Zhang, Tianping Peng, Youjun Chu, Yonghe Wu, Pu Wang, Dan Ye, Ying Mao, Wei Hua

Get full text

Blood-brain barrier biomarkers modulate the associations of peripheral immunity with Alzheimer’s disease by Jia-Hui Hou, De-Ming Jiang, Min Chu, Li-Yong Wu

Get full text

The glymphatic system as a therapeutic target: TMS-induced modulation in older adults by Mark H. Sundman, Yilin Liu, Nan-kuei Chen, Ying-hui Chou, Ying-hui Chou

“…Our sham-controlled findings reveal the capacity for TBS interventions to modulate glymphatic function and highlight a significant APOE ε4 effect. …”
Get full text

Nutritional modulation of skeletal muscle weakness in an experimental model of repetitive COPD exacerbations by Lieke E.J. van Iersel, Charlotte E. Pelgrim, Aletta D. Kraneveld, Ingrid van Ark, Ardy van Helvoort, Marco C.J.M. Kelders, Ramon C.J. Langen, Rosanne J.H.C.G. Beijers, Annemie M.W.J. Schols, Harry R. Gosker

Get full text

The role of metabolite sensors in metabolism‐immune interaction: New targets for immune modulation by Qiqing Yang, Ce Guo, Long Zhang

“…Metabolites such as lactate, succinate, itaconate, and β‐hydroxybutyrate influence immune cell function by interacting with specific sensors. These metabolites act as signaling molecules, linking cellular metabolic changes to immune responses. …”
Get full text

Performance Analysis of RIS-Aided Hybrid RF-FSO Communications With Index Modulation by Yuna He, Wenchao Qi, Pengfei Shen, Lu Lu

“…We derive exact closed-form expressions for the probability density function (PDF), cumulative distribution function (CDF), and moment-generating function (MGF) of the signal-to-noise ratio (SNR) for RIS-assisted FSO links. …”
Get full text

Stachyose modulates gut microbiota and alleviates DSS-induced ulcerative colitis in mice by Chen Wang, Junying Bai, Botao Wang, Leilei Yu, Fengwei Tian, Jianxin Zhao, Hao Zhang, Huayi Suo, Wei Chen, Qixiao Zhai

Get full text

Laminin Peptide-Immobilized Hydrogels Modulate Valve Endothelial Cell Hemostatic Regulation. by Liezl Rae Balaoing, Allison Davis Post, Adam Yuh Lin, Hubert Tseng, Joel L Moake, K Jane Grande-Allen

Get full text

Modulation of beta oscillatory dynamics in motor and frontal areas during physical fatigue by Pierre-Marie Matta, Robin Baurès, Julien Duclay, Andrea Alamia

“…In the current study, we aimed to reconcile the functional role of beta oscillations during physical fatigue within the status quo theory. …”
Get full text

Effects of phase noise on subcarrier modulation performance over Malaga turbulence channel by Xizheng KE, Chenhao WANG, Dan CHEN

“…The performance of wireless optical system employing subcarrier phase-shift keying modulation was researched,which was influenced by phase noise of system demodulator under on Malaga atmospheric turbulence channel.Combined Fourier series and MeijerG function properties,the probability density function of instantaneous signal to noise ratio in the Malaga turbulence model was got.The Fourier series of receiving signal phase and the closed form expression of symbol error probability were derived,which were in the wireless optical subcarrier shift keying modulation system.Under different modulation order and light intensity fluctuation variance,the influence of phase noise on the system symbol error rate was analyzed.The numeric results present that the system symbol error rate increases with the light intensity fluctuation variance when the phase noise is lower.When the phase noise is larger,the influence of modulation order is greater than of turbulence intensity to the error-rate floor appearing.And with the increasing of modulation order,the corresponding average signal to noise is lower when symbol error-rate floor appears.…”
Get full text

Probiotic potential of Phocaeicola coprocola in modulating learning and memory behaviors in the honeybee model by Mengqi Xu, Mengqi Xu, Xiaohan Zhang, Xiaohan Zhang, Xi Luo, Guanzhou Zhou, Guanzhou Zhou, Nana Zhang, Xiaoyan Chi, Xiaoyan Chi, Rongrong Ren, Lihua Peng, Gang Sun, Yunsheng Yang, Yunsheng Yang

“…IntroductionGut microbial therapy has emerged as a prominent research topic for brain function and disorders. The depletion of Phocaeicola coprocola has been reported in various brain-related conditions, suggesting its possible neuroprotective and cognitive benefits. …”
Get full text

Modulation of retinal inflammation delays degeneration in a mouse model of geographic atrophy by Raela B. Ridley, Brianna M. Tischner, Jieun Lee, Erin Walsh, Michael T. Massengill, Alfred S. Lewin, Cristhian J. Ildefonso

“…Mice injected with the rAAV delivering M013 had transient protection of their retinal function at 3 months. Based on ERG evaluations, the intravitreal injection of rAAV delivering sGFP-TatM013v5 significantly delayed the loss of retinal function. …”
Get full text

Modulator-refractory cystic fibrosis: Defining the scope and challenges of an emerging at-risk population by Lindsay Somerville, Larry Borish, Imre Noth, Dana Albon

“…Cystic fibrosis (CF) causes life-shortening respiratory and systemic disease due to dysfunction of the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel. Highly effective modulator therapies (HEMT) improve the lives of many people with cystic fibrosis (PwCF) by correcting the structure and function of the defective CFTR channel at the molecular level. …”
Get full text