Determination of optimal imaging parameters of hyperspectral images using the identification module by Chilikin Andrey, Pupin Daniil

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The manipulator behind “Scissors”: γ -secretase and its modulators in Alzheimer’s disease by Gao Ning, Gao Ning, Xing Fan, Du Juan, Du Juan, Zhao wenxue, Wang Sijia, Chen Meinei, Chen Meinei, Dong Xiaolong, Qi Yiming

“…These components are sequentially assembled into a functional complex. γ-secretase is ubiquitously expressed in all cells and tissues and exhibits enzymatic activity akin to “molecular scissors” by cleaving various type I transmembrane proteins. …”
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Adenosine signaling in glia modulates metabolic state-dependent behavior in Drosophila by Jean-François De Backer, Thomas Karges, Julia Papst, Zeynep Nigar Pınar, Cristina Coman, Robert Ahrends, Yanjun Xu, Cristina García-Cáceres, Ilona C. Grunwald Kadow

“…Instead, glia fulfill this highly evolutionarily conserved function in addition to modulating neuronal activity and behavior. …”
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Preferential allosteric modulation of Otop1 channels by small molecule compounds by Xiangjin Kong, Jie Sun, Hanhan Zhang, Yuan Yin, Xinyao Liang, Yan Chen, Guoqing Luo, Huixin Xia, Youjun Wang, Zhonghua Liu, Cheng Tang

“…Here, we report the functional characterization of three small molecule positive allosteric modulators of Otop1—MFaN, HIMOP, and B2FAMP—that enhance proton gating in a pH-dependent manner, potentiating Otop1 activity under weak acidic but not strong acidic conditions. …”
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Modulated quasi-static tensile testing for advanced characterization of elastomer mechanics by Mahmoud Hussein, Daniel Mathieu, Gildas L'hostis, Bernard Durand

“…The mechanical results, including the load-elongation relationship and field measurements, reveal distinct differences between the quasi-static and modulated components. These differences are particularly evident in the evolution of the elastic modulus and Poisson's ratio as a function of elongation. …”
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Interactions between CNS regulation and serotonergic modulation of crayfish hindgut motility by Spandan Pathak, Norma Peña-Flores, Phillip Alvarez, Jenna Feeley, Reza Ghodssi, Wolfgang Losert, Jens Herberholz

“…Motility is a critical function of the gastrointestinal (GI) system governed by neurogenic and myogenic processes. …”
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TP63 as a modulator of ferroptosis in TP53 mutations glioblastoma by Haiping Cai, Jiahao Yang, Feifei Luo, Wu Gan, Yanwen Li, Liang Zhang, Xueying Ke, Alafate Wahafu, Danian Dai, Peng Wang, Dong Zhou

“…Notably, TP63 (mainly ΔNp63 isoform) expression was markedly upregulated in TP53-mutant GBM. Functional experiments demonstrated that TP63 suppresses ferroptosis by reducing reactive oxygen species (ROS) accumulation and lipid peroxidation. …”
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Modulation of copper homeostasis and cuproptosis by PDHA1 in acute myeloid leukemia by Tianping Chen, Nan Wei, Wenxiu Lv, Lijun Qu, Qian Qu, Chaohong Wu, Yuan Ling, Haipeng Liu, Hongjun Liu

“…This study investigates the expression and functional significance of CRGs, particularly PDHA1, in AML progression and cuproptosis regulation Methods We integrated bioinformatics analysis and experimental validation. …”
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Efficient Phase Retrieval via Improved Binary Amplitude Modulation Masks by Chao Yang, Cheng Xu, Hui Pang, Jun Lan, Lixin Zhao, Song Hu, Wei Yan, Xianchang Zhu

“…Multimodal amplitude modulation introduces physical constraints to tackle the underdetermination challenge. …”
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Uniaxial strain tuning of charge modulation and singularity in a kagome superconductor by Chun Lin, Armando Consiglio, Ola Kenji Forslund, Julia Küspert, M. Michael Denner, Hechang Lei, Alex Louat, Matthew D. Watson, Timur K. Kim, Cephise Cacho, Dina Carbone, Mats Leandersson, Craig Polley, Thiagarajan Balasubramanian, Domenico Di Sante, Ronny Thomale, Zurab Guguchia, Giorgio Sangiovanni, Titus Neupert, Johan Chang

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Pathophysiology of Alzheimer’s Disease: Focus on H3 Receptor Modulators and Their Implications by Nagaraju Bandaru, Sarad Pawar Naik Bukke, Veera Mani Deepika Pedapati, Gurugubelli Sowjanaya, Vangmai Swaroopa Suggu, Swathi Nalla, Prashik Bhimrao Dudhe, Joseph Obiezu Chukwujekwu Ezeonwumelu, Abdullateef Isiaka Alagbonsi, Hope Onohuean

“…Preclinical studies have shown that antagonists of H3R or inverse agonists enhance the cognitive function in animal models with dementia by increasing the release of neurotransmitters associated with learning and memory. …”
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Cyclodextrins as Modulators of Gut Microbiota: Pharmaceutical Applications and Impact on Intestinal Health by Renata Maria Varut, Mircea Sorin Ciolofan, Maria Elena Veronica, Kristina Radivojević, Diana Maria Trasca, Cristina Popescu, Oana Diaconu, Cristina Elena Singer

“…This review aims to synthesize current knowledge regarding the effects of CDs on the composition and function of the gut microbiota. <b>Methods</b>: A literature search following PRISMA guidelines was conducted in PubMed, ScienceDirect, and Google Scholar to identify studies on cyclodextrins and their interactions with gut microbiota. …”
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459 Development of small molecules targeting an epigenetic modulator for pediatric neuroblastoma by Joseph McPherson, William Pomerantz, Molly Sneddon, Anang Shelat, Wenwei Lin, Taosheng Chen, Marcus Fischer, Natalia Tretyakova

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Exosomes and MicroRNAs: key modulators of macrophage polarization in sepsis pathophysiology by Mohamed J. Saadh, Tamara Nazar Saeed, Karar H. Alfarttoosi, Gaurav Sanghvi, R. Roopashree, Vishal Thakur, L. Lakshmi, Aziz Kubaev, Waam Mohammed Taher, Mariem Alwan, Mahmood Jasem Jawad, Ali M. Ali Al-Nuaimi

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Modulating contact properties by molecular layers in organic thin‐film transistors by Li Sun, Yating Li, Jiacheng Xie, Liqi Zhou, Peng Wang, Jian‐Bin Xu, Yi Shi, Xinran Wang, Daowei He

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Phosphorus Vacancy‐Induced Built‐In Electric Field for Electromagnetic Properties Modulation by Yu Zhang, Pengfei Hu, Pei‐Yan Zhao, Bo Cai, Hualong Peng, Shu‐Hao Yang, Martin C. Koo, Chenming Liang, Guang‐Sheng Wang

“…It is concluded that the high content of VP establishes more intense BIEFs, forming permanent induced dipoles that function as polarization centers, thus enhancing defect‐induced polarization and improving permittivity and dielectric loss. …”
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Organic and inorganic fertilizers modulate the response of the soil microbiome to salinity stress by Halima Malal, Halima Malal, Joshua A. Garcia, Anna Marrs, Mohamed Ait Hamza, Courtney Emerson, Mallika Nocco, Hicham Lakhtar, Cristina Lazcano

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ATP Alters the Oxylipin Profiles in Astrocytes: Modulation by High Glucose and Metformin by Alexey I. Drozhdev, Vladislav O. Gorbatenko, Sergey V. Goriainov, Dmitry V. Chistyakov, Marina G. Sergeeva

“…These results should be considered in the development of anti-inflammatory therapeutic approaches aimed at modulating astrocyte function in various pathologies.…”
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Sensory modulation difficulties and complex PTSD among child abuse survivors by Nitzan Avigail Kidra, Lee Gafter, Tami Bar-Shalita, Yael Lahav

“…However, previous research has primarily explored the relationship between sensory modulation and PTSD, without examining the role of sensory modulation in both PTSD and CPTSD.Objective: This study aimed to bridge this knowledge gap by exploring (1) sensory modulation response patterns as a function of a history of CA; (2) the relationships between sensory modulation, PTSD, and disturbances in self-organization (DSO) in CA survivors; and (3) The role of sensory modulation response patterns in the likelihood of being diagnosed with PTSD or CPTSD.Method: An online survey was conducted among a convenience sample of Israeli female adults (n = 426), including 288 (67.6%) CA survivors and 138 (32.4%) participants without a history of CA. …”
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Allosteric modulation and direct activation of glycine receptors by a tricyclic sulfonamide by César O. Lara, Carlos F. Burgos, Katherine Fariña-Oliva, Ana M. Marileo, Victoria P. San Martín, David Flaig, Paul Soto-Ortega, Omayra V. Contreras, Anggelo Sazo, Krishna Gaete-Riquelme, Jeremías Corradi, Carola Muñoz-Montesino, Jorge Fuentealba, Patricio A. Castro, Luis G. Aguayo, Cecilia Bouzat, Gustavo Moraga-Cid, Gonzalo E. Yévenes

“…Mutational analyses on the tricyclic sulfonamide site confirm the molecular determinants contributing to functional activity. Our findings further define the mechanistic framework underlying the GlyR modulation by this PAM class, suggesting that further structure-driven exploration within the tricyclic sulfonamide site may originate novel glycinergic modulators for future development.…”
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