Pigment-dispersing factor neuropeptides act as multifunctional hormones and modulators in tardigrades by Soumi Dutta, Lars Hering, Milena M. Grollmann, Niklas Metzendorf, Vladimir Gross, Kazuharu Arakawa, Susanne Neupert, Monika Stengl, Friedrich W. Herberg, Georg Mayer

Get full text

Carfilzomib modulates tumor microenvironment to potentiate immune checkpoint therapy for cancer by Qian Zhou, Jinxia Liang, Tong Yang, Jin Liu, Bo Li, Yingchang Li, Zhenzhen Fan, Weida Wang, Wensheng Chen, Sujing Yuan, Meng Xu, Qigui Xu, Zhidong Luan, Zhongjun Xia, Penghui Zhou, Yadong Huang, Liang Chen

Get full text

An Improved YOLOv8-Based Method for Detecting Pests and Diseases on Cucumber Leaves in Natural Backgrounds by Jiacong Xie, Xingliu Xie, Wu Xie, Qianxin Xie

“…Finally, the original CIOU loss function of YOLOv8 is replaced with the Focaler-SIOU loss function. …”
Get full text

PECTIN METHYLESTERASE51 Affects Stomatal Dimensions, Rosette Area, and Root Length in Arabidopsis thaliana by Angelica L. Dunham, Chetana Tamadaddi, Rayna Marshall, Charles T. Anderson

“…Although a few pectin methylesterases have been implicated in stomatal development and function, this large family of proteins has not been fully characterized with respect to how they modulate stomatal guard cells. …”
Get full text

Research Progress on Modulation Format Recognition Technology for Visible Light Communication by Shengbang Zhou, Weichang Du, Chuanqi Li, Shutian Liu, Ruiqi Li

Get full text

Effects of device-assisted practice of activities of daily living in a close-to-normal pattern on upper extremity motor recovery in individuals with moderate to severe stroke: stud... by Justin M. Drogos, Carolina Carmona, Riegele Arceo, Jun Yao

“…The very few studies incorporating these techniques with the severely impaired population do not utilize volitional FES control or modulated loading, which has been shown to promote greater motor recovery and functional improvement. …”
Get full text

Exploring the repository of de novo-designed bifunctional antimicrobial peptides through deep learning by Ruihan Dong, Rongrong Liu, Ziyu Liu, Yangang Liu, Gaomei Zhao, Honglei Li, Shiyuan Hou, Xiaohan Ma, Huarui Kang, Jing Liu, Fei Guo, Ping Zhao, Junping Wang, Cheng Wang, Xingan Wu, Sheng Ye, Cheng Zhu

“…Our study provides feasible means to uncover the sequences that simultaneously encode antimicrobial and antiviral activities, thus bolstering the function spectra of AMPs to combat a wide range of drug-resistant infections.…”
Get full text

Axial-UNet++ Power Line Detection Network Based on Gated Axial Attention Mechanism by Ding Hu, Zihao Zheng, Yafei Liu, Chengkang Liu, Xiaoguo Zhang

“…Secondly, to address the imbalance in training samples, a new loss function is developed by combining traditional binary cross-entropy loss with focal loss, enhancing the precision of image semantic segmentation. …”
Get full text

Inhibition of miR-615-3p enhances dentinogenesis in scaps via PVT1-mediated mitochondrial regulation by Haoqing Yang, Yishu Huang, Jiaxin Song, Xiao Han, Fengning Yuan, Zhipeng Fan

“…Methods Quantitative PCR (qPCR), Western blot analysis, alkaline phosphatase (ALP) activity assay, and Alizarin Red staining (ARS) were performed to assess odontogenic differentiation following miR-615-3p modulation in SCAPs. Mitochondrial function was evaluated by measuring reactive oxygen species (ROS) levels, membrane potential, and respiratory activity. …”
Get full text

Causal associations between circulating metabolites and chronic kidney disease: a Mendelian randomization study by Jie He, Lin Li, Hongjie Hu

“…Notably, lowering glycine levels may increase the risk of cholelithiasis and cholecystitis, while reducing N-acetylornithine could have unintended effects on tinnitus.Conclusion Glycine and N-acetylornithine represent promising therapeutic targets for CKD and renal function preservation, but their modulation requires careful risk-benefit assessment to avoid adverse effects.…”
Get full text

Vehicle detection method based on multi-layer selective feature for UAV aerial images by Yinbao Ma, Yuyu Meng, Jiuyuan Huo

“…For the detection head, a Generalized Wasserstein Distance Loss (GWDLoss) function is proposed to quantify positional and scale discrepancies, improving the adaptability of bounding box regression to geometric variations. …”
Get full text

Prebiotic Oligosaccharides in Skin Health: Benefits, Mechanisms, and Cosmetic Applications by Meijun Zeng, Yang Li, Jie Cheng, Jingyu Wang, Qiyu Liu

“…Prebiotic oligosaccharides have attracted significant interest in dermatology and skin health due to their ability to modulate the skin microbiome and microbiota–host interactions. …”
Get full text

Integrating attention mechanism and boundary detection for building segmentation from remote sensing images by Ping Liu, Yu Gao, Xiangtian Zheng, Hesong Wang, Yimeng Zhao, Xinru Wu, Zehao Lu, Zhichuan Yue, Yuting Xie, Shufeng Hao

“…Additionally, a weighted boundary loss function is designed to replace the traditional semantic segmentation cross-entropy loss to detect the boundary of a building. …”
Get full text

A Comparison Between High- and Low-Performing Lambs and Their Impact on the Meat Quality and Development Level Using a Multi-Omics Analysis of Rumen Microbe–Muscle–Liver Interactio... by Haibo Wang, Jinshun Zhan, Shengguo Zhao, Haoyun Jiang, Haobin Jia, Yue Pan, Xiaojun Zhong, Junhong Huo

Get full text

AFN-Net: Adaptive Fusion Nucleus Segmentation Network Based on Multi-Level U-Net by Ming Zhao, Yimin Yang, Bingxue Zhou, Quan Wang, Fu Li

Get full text

RFCS-YOLO: Target Detection Algorithm in Adverse Weather Conditions via Receptive Field Enhancement and Cross-Scale Fusion by Gang Liu, Yingzheng Huang, Shuguang Yan, Enxiang Hou

“…Also, a new Focaler-Minimum Point Distance Intersection over Union (F-MPDIoU) loss function is proposed. It makes the model converge faster and deals with issues of leakage and false detection. …”
Get full text

Response Monitoring Theta-Band Activities Across Emotional Contexts in Schizophrenia and Bipolar Spectrum Disorders by Takakuni Suzuki, Margo W. Menkes, Melvin G. McInnis, Jian Kang, Tara A. Niendam, Maureen A. Walton, Patricia J. Deldin, Ivy F. Tso, Stephan F. Taylor

Get full text

Blind recognition of STBC-OFDM signals based on modified K-S test by Qing LING, Li-min ZHANG, Wen-jun YAN

“…Aiming at the problem that existed blind classification of STBC-OFDM in multiple input single output (MISO) communication system,an efficient method for blind classification of space-time block coded orthogonal frequency-division multiplexing (STBC-OFDM) signals based on modified Kolmogorov-Smirnov (K-S) test was proposed,when a single receiver antenna was employed at the receiver.Firstly,the model of received STBC-OFDM signals in MISO systems was given.Secondly,with the correlation of the coding matrix of STBC-OFDM signals,and the discrimination features function provided by the empirical cumulative distribution (CDFs) of the received OFDM blocks was constructed.Finally,the distance between CDFs was tested by the two-sample K-S test,which could blindly classify the STBC-OFDM signals.The proposed algorithm didn't need the estimation of channel,noise statistics and modulation type,and consequently,was well suited for non-cooperative communication context.Theoretical analysis and experimental verify its validity.…”
Get full text

Bacteroides fragilis capsular polysaccharide A ameliorates ulcerative colitis in rat by recovering intestinal barrier integrity and restoring gut microbiota by Yijia Zhong, Xiujuan Chang, Zihan Zhao, Lijun Zheng, Gaobo Kuang, Ping Li, Chenxuexuan Liu, Yuqin Fan, Zhixuan Liang, Ke Zhuang, Qiuling Xie, Yangyang Liu

Get full text

The Roles of Deubiquitination in Age-related Diseases by XU Linhui, LI Pengfei, WU Miaomiao, KANG Lihua, JI Min, YU Ying, GUAN Huaijin

“…DUBs play an important and complex regulatory role in age-related diseases by modulating mechanisms such as protein homeostasis, mitochondrial function, and cell cycle in aging cells.…”
Get full text