Differential impact of glycoprotein glycosylation on Akkermansia muciniphila growth dynamics by Jia-Xin Zhang, Yun-Sheng Lyu, Josef Voglmeir, Li Liu

“…The present results show the complex interactions between A. muciniphila’s dietary interactions and underscore the necessity for in-depth studies focused on monosaccharide composition and glycan structural nuances to better comprehend their functional roles in A. muciniphila's probiotic activity.…”
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Tomato detection in natural environment based on improved YOLOv8 network by Wancheng Dong, Yipeng Zhao, Jiaxing Pei, Zuolong Feng, Zhikai Ma, Leilei Wang, Simon Shemin Wang

“…At the same time, it introduces the SCYLLA-IoU (SIoU) as a bounded YOLOv8 frame regression loss function, effectively solving the mismatch problem between the predicted frame and the actual frame and improving recognition accuracy. …”
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Wolfram syndrome 2 gene (CISD2) deficiency disrupts Ca2+-mediated insulin secretion in β-cells by Zhao-Qing Shen, Wen-Tai Chiu, Cheng-Heng Kao, Yu-Chen Chen, Li-Hsien Chen, Tsai-Wen Teng, Shao-Yu Hsiung, Tsai-Yu Tzeng, Chien-Yi Tung, Chi-Chang Juan, Ting-Fen Tsai

“…Thirdly, transcriptomic analysis of β-islets reveals that Cisd2 modulates proteostasis and ER stress, mitochondrial function, insulin secretion and vesicle transport. …”
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A low illumination target detection method based on a dynamic gradient gain allocation strategy by Zhiqiang Li, Jian Xiang, Jiawen Duan

“…This method optimizes the model through enhancements in multi-scale feature fusion, feature extraction, detection head, and loss function. Firstly, efficient multi-scale feature fusion is performed by using a new neck structure in the original model so that it can fully exchange high-level semantic information and low-level spatial information. …”
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Research on X-Ray Weld Defect Detection of Steel Pipes by Integrating ECA and EMA Dual Attention Mechanisms by Guanli Su, Xuanhe Su, Qunkai Wang, Weihong Luo, Wei Lu

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Targeting revascularization via tryptophan-indole-NETs axis: the synergistic power of acupuncture and rt-PA thrombolysis in ischemic stroke by Siqi Chang, Siqi Chang, Yi Zhao, Yi Zhao, Chengfeng Li, Chengfeng Li, Xinyu Liu, Xinyu Liu, Zixuan Fang, Zixuan Fang, Zihao Peng, Zihao Peng, Mingliang Gao, Mingliang Gao, Yawen Xia, Yawen Xia, Yawen Xia, Guangxia Ni, Guangxia Ni

“…Acupuncture and NETs inhibitors both offer similar vascular protection during ultra-time window rt-PA thrombolysis, with acupuncture being more effective in reducing cerebral infarction.ConclusionThe degradation of NETs via the tryptophan-indole pathway may facilitate the restoration of vascular structure and function following ischemic stroke. Acupuncture has the potential to modulate this pathway, thereby possibly extending the therapeutic window for rt-PA thrombolysis.…”
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Identification of BDNF sensitive electrophysiological markers of synaptic activity and their structural correlates in healthy subjects using a genetic approach utilizing the functi... by Fruzsina Soltész, John Suckling, Phil Lawrence, Roger Tait, Cinly Ooi, Graham Bentley, Chris M Dodds, Sam R Miller, David R Wille, Misha Byrne, Simon M McHugh, Mark A Bellgrove, Rodney J Croft, Bai Lu, Edward T Bullmore, Pradeep J Nathan

“…The development of such "synaptogenic" therapies depend on the availability of BDNF sensitive markers of synaptic function that could be utilized as biomarkers for examining target engagement or drug efficacy in humans. …”
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Mediation of Time‐Related Blood Pressure Variability on Intensive Blood Pressure Lowering and Functional Outcomes Post Endovascular Therapy: A Post Hoc Analysis of the OPTIMAL‐BP T... by Jun Young Chang, Jae Young Park, Jeong Yun Song, Jun Sang Yoo, Kyu Bong Lee, Jae Wook Jung, Ji Sung Lee, Young Dae Kim, Byung Moon Kim, Bang‐Hoon Cho, Seong Hwan Ahn, Sung‐Il Sohn, Tae‐Jin Song, Yoonkyung Chang, Kwon‐Duk Seo, Sukyoon Lee, Jang‐Hyun Baek, Han‐Jin Cho, Dong Hoon Shin, Jinkwon Kim, Kyung‐Yul Lee, Yang‐Ha Hwang, Chi Kyung Kim, Jae Guk Kim, Sun U. Kwon, Oh Young Bang, Ji Hoe Heo, Hyo Suk Nam

“…Background We investigated whether the association between blood pressure (BP) management in patients with successful reperfusion following endovascular therapy (EVT) and functional outcomes is mediated by BP variability parameters. …”
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Identification of the SWEET gene family and functional characterization of PsSWEET1a and PsSWEET17b in the regulation of sugar accumulation in ‘Fengtang’ plum (Prunus salicina Lind... by Shan Liu, Xiaoshuang Nie, Hong Chen, Xinjie Shen

“…Subcellular localization analyses indicated that PsSWEET1a is localized to the nucleus and cytoplasm, while PsSWEET17b is associated with the vacuolar membrane. Gene function was further validated through transient silencing and overexpression of the PsSWEET1a and PsSWEET17b genes in plum fruits, which significantly impacted their soluble sugar content. …”
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Mediating role of gut microbiota on Baduanjin for cognitive function in community-dwelling older adults with mild cognitive impairment: a study protocol for a cluster randomised co... by Guohua Zheng, Liwei Sun, Qian Geng

“…As a typical traditional Chinese mind-body exercise, regular Baduanjin training has been shown to improve cognitive function and modulate the gut microbiome in community-dwelling older adults. …”
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Impact of Transchalcone on Neurological Outcomes in Cerebral Ischemia-reperfusion Injury in Rat: Role of AMP-activated Protein Kinase-mitochondrial Signaling Pathways by Xiuyun Xue, Jingjing Du, Shaik Althaf Hussain, Narendra Maddu, Jing Xiong

“…TCH provides significant neuroprotection against CIR injury by activating AMPK/PGC-1α and AMPK/NRF2 signaling, preserving mitochondrial function, and modulating inflammation. These findings highlight the therapeutic potential of TCH for ischemic stroke management.…”
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Metabolism effector links in diet-induced and genetically-based obesity: A full-transcriptome study of liver tissue in experimental models in rodents by S. A. Apryatin, N. V. Trusov, I. V. Gmoshinski, V. A. Tutelyan

“…The importance of the expression of Tat gene encoding tyrosine aminotransferase in the modulation of biogenic amines synthesis in diet-induced obesity was shown, which may represent a new neurometabolic regulatory function of the liver in response to the consumption of high-calorie diets.Conclusion. …”
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Supplementation with dimethylglycine sodium salt improves lipid metabolism disorder in intrauterine growth-retarded pigs by Kaiwen Bai, Luyi Jiang, Tian Wang

“…The expressions of lipid metabolism and mitochondrial function-related genes and proteins were upregulated (P < 0.05) compared to the IUGR-C group. …”
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hUMSC-Exosomes suppress TREM1-p38 MAPK signaling via HMGB1-dependent mechanisms to reprogram microglial function and promote neuroprotection in ischemic stroke by Zengyu Zhang, Rong Ji, Zhuohang Liu, Zhiwen Jiang, Min Chu, Yong Wang, Jing Zhao

“…Mechanistically, hUMSC-Exos attenuated NF-κB/p38 MAPK signaling, with TREM1 functioning upstream of p38 (validated by overexpression/reversal). …”
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Harnessing miRNA dynamics in HIV-1-infected macrophages: Unveiling new targeted therapeutics using systems biology by R. Harshithkumar, Mollina Kaul, Madhuri Chandane-Tak, Nikhat J. Siddiqi, Abdul Malik, Abdul Arif Khan, Anupam Mukherjee

“…This study aims to explore the impact of HIV-1 infection on macrophage microRNA (miRNA) expression profiles using a systems biology approach to uncover the potential role of miRNAs in modulating macrophage functionality and identify key miRNA targets that may serve as therapeutic avenues. …”
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Investigating the effects of a randomized, double-blinded aerobic, resistance, and cognitive training clinical trial on neurocognitive function in older adults with cardiovascular... by Louis Bherer, Louis Bherer, Louis Bherer, Tudor Vrinceanu, Emma Gabrielle Dupuy, Emma Gabrielle Dupuy, Mathieu Gayda, Thomas Vincent, Pierre-Olivier Magnan, Pierre-Olivier Magnan, Hanieh Mohammadi, Claudine Gauthier, Claudine Gauthier, Christine Gagnon, Simon Duchesne, Kirk I. Erickson, Daniel Gagnon, Frédéric Lesage, Sonia Lupien, Judes Poirier, Marie-Pierre Dubé, Éric Thorin, Martin Juneau, Juliana Breton, Sylvie Belleville, Sylvie Belleville, Guylaine Ferland, Guylaine Ferland, Flavie Gaudreau-Majeau, Flavie Gaudreau-Majeau, Caroll-Ann Blanchette, Caroll-Ann Blanchette, Paolo Vitali, Anil Nigam, Anil Nigam

“…Latest studies suggest that combining cognitive training with exercise training might have an added benefit. Moreover, functional and structural cerebral mechanisms involved are still poorly documented. …”
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JAK2/STAT3/HMGCS2 signaling aggravates mitochondrial dysfunction and oxidative stress in hyperuricemia-induced cardiac dysfunction by Dewei Peng, Xiaoli He, Bowen Ren, Qian Wang, Lulu Peng, Yue Jiang, Shengqi Huo, Lintong Men, Wei Shi, Pengcheng Luo, Mengyin Zhu, Cuntai Zhang, Jiagao Lv, Li Lin, Sheng Li

“…Moreover, these treatments also reversed cardiac function abnormalities. Conclusions The JAK2/STAT3/HMGCS2 pathway may contributes to uric acid-induced cardiac dysfunction by affecting mitochondrial function, oxidative stress, and ATP metabolism, offering a potential therapeutic strategy for mitigating high uric acid-induced cardiac damage. …”
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<em>Fasciola gigantica</em> Recombinant Abelson Tyrosine Protein Kinase (r<em>Fg</em>Abl) Regulates Various Functions of Buffalo Peripheral Blood Mononuclear Cells by Min Zhao, Yu Zou, Wanting Chen, Dongqi Wu, Chengjun Xian, Haoqing Yang, Jiacheng Tan, Wenda Di, Wende Wu, Dongying Wang

“…To investigate the immunoregulatory function of Abl in <i>Fasciola gigantica</i>, we cloned and expressed the <i>Fasciola</i> gigantica Abl protein and assessed its effect on specific immune functions of buffalo peripheral blood mononuclear cells (PBMCs). …”
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White Matter Anomaly Associated Cognitive Impairment During Systemic Inflammation Is Related to CX3CR1 Mediated Microglia-Node Interactions That Impacts the Conductive Function of... by Shi X, Zhang J, Zhao H, Yang X, Gao F

“…However, defects in cognitive performance and CC WM tract conductivity, and disruption of microglia-node contact by systemic LPS were protected by CX3CR1 knockout.Conclusion: CX3CR1 is involved in modulating CC WM microglia-node contact, maintaining the CC WM tract conductive function, and improving cognitive performance. …”
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Bisphenol B restrains rat leydig cell function via H3K27me3/H3K9me3 histone modifications by Jiayi He, Huiqian Zhang, Hehua Quan, Qingyuan Wang, Congcong Wen, Yiyan Wang, Yang Zhu, Ren-Shan Ge, Xiaoheng Li

“…BPB could potentially hinder the growth and function of Leydig cells by modulating H3K27me3 and H3K9me3. …”
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