IL-10 Dampens the Th1 and Tc Activation through Modulating DC Functions in BCG Vaccination by Hui Xu, Yanjuan Jia, Yonghong Li, Chaojun Wei, Wanxia Wang, Rui Guo, Jing Jia, Yu Wu, Zhenhao Li, Zhenhong Wei, Xiaoming Qi, Yuanting Li, Xiaoling Gao

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Bavachin enhances paclitaxel sensitivity in ovarian cancer cells through modulation of mitochondrial function and ER stress by Sang-Jin Lee, Kee K. Kim, Jin-Young Lee

“…Bavachin significantly inhibited cell proliferation and spheroid formation while inducing caspase-dependent apoptosis through modulation of Bcl-2 family proteins. Mechanistically, bavachin disrupted mitochondrial function by inducing membrane depolarization and calcium dysregulation, leading to comprehensive impairment of cellular bioenergetics including both oxidative phosphorylation and glycolysis. …”
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Nutritional supplement Youtianli regulates Treg function and gut immunity via SCFA-producing microbiota modulation by Hexiu Yuan, Yichun Xiao, Yubo Huang, Leming Huang

“…These findings suggest that YTL improves immune function by modulating gut microbiota and enhancing SCFA metabolism. …”
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Validation of Hv1 channel functions in BV2 microglial cells using small molecule modulators by Ashutosh Sharma, Ashutosh Sharma, Nandini B. Kale, Priyanka Yadav, Priyanka Yadav, Shivani Yadav, Shivani Yadav, Madhavi Ranawat, Madhavi Ranawat, Valmik S. Shinde, Valmik S. Shinde, Aravind Singh Kshatri, Aravind Singh Kshatri

“…Thus, we characterized and validated the microglial Hv1 channel’s functions using the recently reported Hv1 inhibitor (YHV98-4) and a novel Hv1 activator (S-023-0515) in a model of lipopolysaccharide (LPS)-induced neuroinflammation. …”
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Gamma Function Based Signal Compensation for Transmission Distance Tolerant Multilevel Modulation in Optical Camera Communication by Sung-Jin Kim, Joon-Woo Lee, Do-Hoon Kwon, Sang-Kook Han

“…In this paper, we propose gamma function based signal compensation to overcome the nonlinearity and improve the performance of multilevel transmission. …”
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Transforming Growth Factor‐β Pathway: Biological Functions and Therapeutic Targets by Reham Hassan Mekky, Mohammed E. Abo‐El Fetoh, Safaa A. Faheem, Abdullah F. Radwan, Mariam H. Fawzy, Aya M. Mustafa, Mohamed A. Said, Daniela Calina, Javad Sharifi‐Rad, William C. Cho

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Understanding the Functionality of Probiotics on the Edge of Artificial Intelligence (AI) Era by Remziye Asar, Sinem Erenler, Dilara Devecioglu, Humeyra Ispirli, Funda Karbancioglu-Guler, Hale Inci Ozturk, Enes Dertli

“…AI-aided omics technologies, including genomics, transcriptomics, and proteomics, offer new insights into the genetic and functional properties of probiotics. Furthermore, AI can be used to elucidate key probiotic activities such as microbiota modulation, metabolite production, and immune system interactions to enable an improved understanding of their health impacts. …”
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Metagenomic analysis reveals rumen microbiome enrichment and functional genes adjustment in carbohydrate metabolism induced by different sorting behavior in mid-lactation dairy cow... by Abdallah Alaa Mousa, Han Zhang, Hongwei Duan, Jiyou Zhang, Shengyong Mao

“…Carbohydrate-active enzyme (CAZyme) annotation revealed that the SES group showed increased abundance of GH13 and GH65 enzymes, while exhibiting decreased abundance of GH1, GH3, GH5, GH6, and GH94. Functional profiling of Kyoto encyclopedia of genes and genomes (KEGG) modules revealed that compared to the SLS group, the rumen microbiota in the SES group upregulated the abundance of carbohydrate metabolism, amino acid metabolism, energy metabolism, and lipid metabolism. …”
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Processing demands modulate the activities and functional connectivity patterns of the posterior (VWFA-1) and anterior (VWFA-2) VWFA by Aqian Li, Chuansheng Chen, Xiaoyan Wu, Yuan Feng, Jingyu Yang, Xiaoxue Feng, Rui Hu, Leilei Mei

“…Results of the present study indicate that processing demands induced by tasks modulate both the local activity and functional connectivity patterns of the VWFA, providing new insights for understanding its domain-general function.…”
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Tai Chi’s synergistic modulation on autonomic nervous activity and central autonomic networks in functional constipation patients: a randomized controlled trial by Yuke Teng, Siyuan Tao, Jingwen Chen, Furong Zhang, Yuyi Guo, Rongtao Ying, Yuxin Wang, Yi Liu, Huilin Zeng, Kunnan Xie, Shi Zhao, Zhengjie Li, Sha Yang, Tianyu Liu, Fang Zeng

“…Notably, the neuroimaging findings suggested that Tai Chi effectively modulated the abnormal functional connectivity of the anterior insula within the central autonomic network in FCon patients, which was not observed in the aerobic exercise group. …”
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Targeting necroptosis in Alzheimer’s disease: can exercise modulate neuronal death? by Donglei Lu, Wenyu Zhang, Ruiyu Li, Sijie Tan, Yan Zhang

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Music tempo modulates emotional states as revealed through EEG insights by Zengyao Yang, Qiruo Su, Jieren Xie, Hechong Su, Tianrun Huang, Chengcheng Han, Sicong Zhang, Kai Zhang, Guanghua Xu

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Evolutionary conserved regulation of TFEB stability by the E3 ubiquitin ligase WWP2 modulates response to stress in vivo by Juan A. Garcia-Sanchez, Estelle Bonnet, Céline Loubatier, Anne Doye, Guillaume Paillier, Fabien Segui, Frédéric Larbret, Paul Chaintreuil, Ludovic Batistic, Cédric Torre, Marcel Deckert, Jolanta Polanowska, Patrick Munro, Laurent Boyer, Orane Visvikis

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Ginseng-derived nanoparticles accelerate diabetic wound healing by modulating macrophage polarization and restoring endothelial cell function by Liangliang Fan, Xuxia Jia, Fusong Dong, Song Yang, Wenjing Li, Ronghua Zhao, Lijia Yin, Daqing Zhao, Jiawen Wang

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Prostaglandin E2 Does Not Modulate CCR7 Expression and Functionality after Differentiation of Blood Monocytes into Macrophages by Marc-André Allaire, Bérengère Tanné, Sandra C. Côté, Nancy Dumais

“…Our data indicate that monocyte differentiation induces the loss of CCR7 expression and that PGE2 is unable to modulate CCR7 expression and functionality as shown previously in monocytes.…”
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Natural ligand 3,3’-diindolylmethane functions as an AHR agonist to modulate angiogenesis and organ development in chicken embryos by Gee-yea Lim, Hao Chen, Woo-seon Song, Dong-hee Koh, Dong-ha Kim, Hisato Iwata, Eun-Young Kim

“…Aryl hydrocarbon receptor (AHR) is a ligand-dependent transcription factor that is crucial for regulating various toxicological responses and physiological functions. Recent studies have highlighted that interactions between AHR and certain natural ligands can modulate inflammation and immune responses, offering therapeutic potential for a wide range of diseases. …”
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Insular Cortex Modulation by Repetitive Transcranial Magnetic Stimulation with Concurrent Functional Magnetic Resonance Imaging: Preliminary Findings by Daphné Citherlet, Olivier Boucher, Manon Robert, Catherine Provost, Arielle Alcindor, Ke Peng, Louis De Beaumont, Dang Khoa Nguyen

“…This study aimed to stimulate the insula with rTMS and assess blood oxygen level-dependent (BOLD) signal modulation using concurrent functional magnetic resonance imaging (fMRI). …”
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HIV-1 and Human PEG10 Frameshift Elements Are Functionally Distinct and Distinguished by Novel Small Molecule Modulators. by Tony S Cardno, Yosuke Shimaki, Brad E Sleebs, Kurt Lackovic, John P Parisot, Rebecca M Moss, Caillan Crowe-McAuliffe, Suneeth F Mathew, Christina D Edgar, Torsten Kleffmann, Warren P Tate

“…In this study we have compared the HIV-1 and PEG10 frameshift elements and shown they have distinct functional characteristics. Frameshifting occurs at several points within each element. …”
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Listeria monocytogenes membrane vesicles disrupting intestinal epithelial barrier function via modulating macrophage inflammatory responses by Yao Lei, Kehan Chen, Mingyuan Tang, Qiuyang Zhang, Jie Yu, Yunwen Zhang, Tian Tang, Chuan Wang

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Designer polyQ fusion proteins sequester USP7/HDM2 for modulating P53 functionality by Xiang-Le Zhang, Hong-Wei Yue, Ya-Jun Liu, Jian-Yang Wang, Heng-Tong Duan, Yin-Hu Liu, Lei-Lei Jiang, Hong-Yu Hu

“…The polyQ-fusion strategy is feasible to modulate the P53 stability and functionality, furnishing a therapeutic potential for cancers.…”
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