Much More Than the Malady: The Promise of a Web-Based Digital Platform Incorporating Self-Report for Research and Clinical Care in Mild Cognitive Impairment by Andrew McGarry, MD, Oliver Roesler, PhD, Jackson Liscombe, PhD, Michael Neumann, PhD, Hardik Kothare, PhD, Abhishek Hosamath, MBM, Lakshmi Arbatti, MS, Anusha Badathala, MD, Stephen Ruhmel, BS, MPH, Bryan J. Hansen, PhD, Madeline Quall, BA, Sandrine Istas, MBio, Arthur Wallace, MD, PhD, David Suendermann-Oeft, PhD, Vikram Ramanarayanan, PhD, Ira Shoulson, MD

“…Traditional clinical trials in neurodegenerative disorders have utilized combinations of examination-based outcomes, global assessments by investigators and participants, and scales aimed at function, some of which are patient-reported outcomes. …”
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Free Vibration Analysis of Patch Repaired Plates with a Through Crack by p-Convergent Layerwise Element by Jae S. Ahn, Seung H. Yang, Kwang S. Woo

“…For the elements, higher-order shape functions are derived by combination of one- and two-dimensional shape functions based on higher-order Lobatto shape functions, not using pure higher-order three-dimensional shape functions. …”
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Investigation into the characteristics of silicon photovoltaic converters of solar batteries in case of overheating by A. V. Ivanchenko, S. V. Mazuryk, A. S. Tonkoshkur

“…Recently, solar panels have become one of the most desirable sources of renewable electrical energy, and thus the requirements for their reliability, in particular to maintain the basic functional properties at elevated temperatures, are increasing. …”
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Efficacy of melatonin with behavioural sleep-wake scheduling for delayed sleep-wake phase disorder: A double-blind, randomised clinical trial. by Tracey L Sletten, Michelle Magee, Jade M Murray, Christopher J Gordon, Nicole Lovato, David J Kennaway, Stella M Gwini, Delwyn J Bartlett, Steven W Lockley, Leon C Lack, Ronald R Grunstein, Shantha M W Rajaratnam, Delayed Sleep on Melatonin (DelSoM) Study Group

“…<h4>Background</h4>Delayed Sleep-Wake Phase Disorder (DSWPD) is characterised by sleep initiation insomnia when attempting sleep at conventional times and difficulty waking at the required time for daytime commitments. …”
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Percepções de idosos sobre a utilização de fraldas durante a hospitalização [Nursing staffs’ perceptions of the use of adult diapers in hospital] by Luise de Almeida Ferreira Alves, Rosimere Ferreira Santana, Renata da Silva Schulz

“…Content analysis indicated two categories identifying dimensions of ease and dif­ficulty in diaper use. Diapers figure as a care technology bound up with institutional routines, which may contribute directly to conditions of dependency and functional incapacity. …”
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Adaptive zero velocity correction method for fiber optic inertial navigation system in coal mining roadheader by Qinghua MAO, Qing ZHOU, Jianquan CHAI, Yanzhang CHEN, Wenjuan YANG, Xusheng XUE

“…Secondly, the time-frequency domain features of IMF components are extracted, and the principal component analysis method is used to reduce the dimension to reduce the complexity of the diagnostic model and the difficulty of data analysis. Finally, the accuracy of zero-speed detection is improved by introducing the sandcat swarm optimization algorithm to optimize the kernel function and penalty parameters.Aiming at the problem of high cost and error accumulation with time of high-precision fiber-optic inertial navigation, an adaptive zero-speed correction method is proposed. …”
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Arthrodesis with Hybrid Nail-Frame Construct Allows for Expedited Frame Removal During Neuropathic Limb Salvage by William Polachek MD, Philip H. Locker MD, Jacob R. Zide MD, Veerabhadra Reddy MD, David Vier MD

“…Neuropathic patients lack protective sensation and, as a result, often have significant difficulty limiting their weightbearing postoperatively. …”
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From Barriers to Breakthroughs: Rethinking Autonomous Vehicle Design for Visually Impaired Users by Myungbin Choi, Taehun Kim, Seungjae Kim, Taejin Kim, Wonjoon Kim

“…Then, it was delivered to visually impaired people, and a utility test was performed on the new concept and functions. Six functions were proposed in scenarios for each moving process, and the evaluation results showed that drop-off notification using multi-senses showed the highest utilization. …”
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Efficient feature selection for histopathological image classification with improved multi-objective WOA by Ravi Sharma, Kapil Sharma, Manju Bala

“…Abstract The difficulty of selecting features efficiently in histopathology image analysis remains unresolved. …”
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Unmasking the Mystery of A Hidden Syrinx: Case Report of Progressive Paralysis in A 20-Year-Old Male with Intact Pain and Temperature Sensations by Muhammad Sohail Ajmal Ghoauri, Nauman Ismat Butt, Mutahra Khaliq, Muhammad Bilal Rasheed, Muhammad Umair Javed, Dur-e- Sabeh

“…Sensory system, cerebellum and higher motor functions were intact. MRI scan revealed an abnormal intramedullary multifocal T2WI hyper intense signal in cervical and thoracic spinal cord consistent with syrinx and he was diagnosed with Syringomyelia. …”
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Quantitative proteomics identifies the Myb-binding protein p160 as a novel target of the von Hippel-Lindau tumor suppressor. by Yanlai Lai, Mei Qiao, Meihua Song, Susan T Weintraub, Yuzuru Shiio

“…<h4>Conclusions/significance</h4>A major barrier to understanding the functions of ubiquitin ligases has been the difficulty in pinpointing their ubiquitination substrates. …”
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Postural Orthostatic Tachycardia Syndrome as a Manifestation of Post-COVID-19 Syndrome by E. L. Trisvetova

“…The pandemic of coronavirus infection, the complex and insufficiently studied mechanisms of which cause disorders in the functions of many organs and systems of the body, has led to the emergence of new problems that are far from being resolved. …”
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Simulation and analysis of geometric errors in high-precision bevel gear rolling testers by SHI Jian, LI Jinfeng, XIAO Jianming, ZHANG Jingcai

“…ObjectiveIn fields such as aviation, requirements for the vibration performance and service life reliability of bevel gear transmissions are continuously increasing, driving the upgrading of bevel gear rolling testers towards higher detection accuracy and multi-functionality. Currently, the shaft angle positioning accuracy of the world’s most advanced rolling testers has reached within 10 arcseconds, the adjustment accuracy of mounting distance and offset distance has achieved the micron level, and they are integrated with fatigue life and vibration testing functions, thus significantly increasing the difficulty of development.MethodsAgainst the background of developing high-precision bevel gear rolling testers, to ensure the geometric motion accuracy of the tester, a kinematic model of the rolling tester was established using multi-body system kinematics theory. …”
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Optimization model of electricity metering management based on MOPSO by Sheng Li, Xiaodan Zhou

“…The study uses Schaffer and Griewank functions to test its performance. The optimized algorithm performed well on both Schaffer and Griewank functions, indicating that the algorithm still had high computational efficiency while ensuring computational accuracy. …”
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Long-term endocrine outcomes and quality of life in paediatric and young chronic myeloid leukaemia patients on tyrosine kinase inhibitor therapy: a prospective study from India by Rajiv Mohan, Chitrakshi Nagpal, Swasthik Upadhya, Akash Kumar, Rajesh Khadgawat, Sameer Bakhshi, Deepam Pushpam

“…There was less impact on glucose, lipid profile, and adrenal function. In the QoL analysis, social functioning was affected among the functional scales, while financial difficulties, appetite loss, and fatigue were impacted in the symptom scales. …”
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LINGUISTIC FEATURES OF BUSINESS ENGLISH DISCOURSE THESAURUS by Nataliia V. Zinukova

“…Based on the continuous sampling method (to identify lexical units of institutional Business English discourse for further analysis), the method of dictionary definitions (to study the semantics of lexical units), contrastive method (to establish common and distinctive features for translation) and descriptive method (to identify and systematization of features and difficulties of translation of lexical units of Business English discourse) the features of functioning of Business English discourse thesaurus are analyzed. …”
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Any closer to successful therapy of multiple myeloma? CAR-T cell is a good reason for optimism by Faroogh Marofi, Safa Tahmasebi, Heshu Sulaiman Rahman, Denis Kaigorodov, Alexander Markov, Alexei Valerievich Yumashev, Navid Shomali, Max Stanley Chartrand, Yashwant Pathak, Rebar N. Mohammed, Mostafa Jarahian, Roza Motavalli, Farhad Motavalli Khiavi

“…The cancerous plasma cells produce immunoglobulins (antibodies) uncontrollably which consequently damage the tissues and organs and break the immune system function. Although the last few years have seen significant progressions in the treatment of MM, still a complete remission remains unconvincing. …”
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Acute Issues of Cognitive Modeling of Semi-Structured and Poorly Formalized Systems by A. A. Mikryukov, M. E. Mazurov, D. A. Suzdalsky, K. E. Chikunov

“…These systems are characterized by uncertainty of data-in and data-out and they cannot be described by precise formal dependencies. Difficulty of studying poorly formalized systems is connected with the necessity to take into account various and often contradicting figures and criteria, which would not allow us to describe formally components of the system and its functions. …”
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Neuroscience applied to learning alphabetic principles: new proposals by Leonor Scliar-Cabral

“…    This study reviews recent data on functional illiteracy and advances on neuroscience about the reading process. alarming figures on functional illiteracy will be presented with examples of UK and brazil. …”
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Complex Approach to the Diagnosis of Children with Nasal and Nasopharyngeal Pathology. Key Results by Leyla S. Namazova-Baranova, Viktor A. Gankovsky, Irina V. Zelenkova, Svetlana G. Gubanova, Alexander V. Pashkov, George A. Karkashadze, Elena A. Vishneva, Elena V. Kaytukova, Kamilla E. Efendieva

“…The following practical guidelines have been proposed: 1) all patients with complaints on prolonged nasal breathing difficulties require not only otorhinolaryngologist examination, but also diagnostic endoscopy of nasal cavity and nasopharynx; 2) in case of nasal septum deviation and complaints on prolonged nasal breathing difficulties, it is necessary to perform functional methods for nasal breathing evaluating (RRM, RMM) to choose adequate treatment method; 3) the use of RRM, RMM would help to choose the optimal treatment approach in children with complaints on prolonged nasal breathing difficulties and confirmed diagnosis of allergic disease (allergic rhinitis, hay fever, etc.), also associated with adenoid hypertrophy and/or nasal cavity and nasopharynx inflammatory diseases; 4) all patients with confirmed chronic diseases of ENT-organs should be examined by allergist, and, if necessary, should undergo comprehensive allergological examination. …”
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