Integrated course on ocular anatomy for ophthalmology clerkship by Li Huang, Xinyu Liu, Yuxian Zou, Xianchai Lin, Zhen Mao

“…Conclusions This integrated ocular anatomy course can aid students in better understanding and retaining the anatomy and function of ocular structures, serving as a valuable adjunct teaching strategy that can be further applied to ophthalmology clerkship.…”
Get full text

Atypical Cases of Leptospirosis: Insights From Georgia by Arash Ghani Dehkordi, Salah Rabea Salah Al-Tamary, Ashraf Rabea Salah Al-Tamary, Hamza Rabea Salah Al-Tamary, Shams Samih Ahmad Albarari, Alaaldin Mohammad Zeyad Assad, Ghena Mohammad Othman Hamdan, Ia Mikadze

“…An outpatient follow-up after discharge was advised to assess liver and kidney function. The second case involved an 87-year-old woman with a fever, weakness and hypertension. …”
Get full text

Sensory integration of the proprioceptive sensory system ofchildren with intellectual disabilities by Naim Salkić, Ana Budimir, Namik Trtak, Daniel Maleč, Eldad Kaljić, Safet Velić

“…Irregularities or disturbances in brain function that make it difficult to integrate sensory input from stimuli lead to sensory disintegration. …”
Get full text

Comorbidity of esophageal achalasia, mixed anxiety and depressive reaction in a young female patient: problems of diagnosis and treatment by N.. P. Garganeeva, M. F. Belokrylova, A. K. Kostin, A. P. Koshel, E. M. Epanchintseva, V. F. Lebedeva, M. M. Aksenov, O. E. Perchatkina, I. G. Kartashova, V. A. Rudnitsky, Yu. N. Gorbatsevich, E. V. Tsybulskaya, V. A. Alekseev

“…Achalasia cardia (“cardiospasm”, “phrenospasm”, “dolichoesophagus”, “megaesophagus”, “stenosis of cardia”) represents a primary impairment of esophageal motor function associated with impaired lower esophageal sphincter relaxation and peristalsis defects of the thoracic esophagus. …”
Get full text

Chronotherapeutic intervention targeting emotion regulation brain circuitry, symptoms, and suicide risk in adolescents and young adults with bipolar disorder: a pilot randomised tr... by Jihoon A Kim, Anjali Sankar, Rebecca Marks, Erin Carrubba, Bernadette Lecza, Susan Quatrano, Linda Spencer, R. Todd Constable, Brian Pittman, Eli R Lebowitz, Wendy K Silverman, Holly A Swartz, Hilary P Blumberg

“…Nineteen BE-SMART-DR and 16 BE-SMART-ER participants completed the intervention, with 11 and 13, respectively, having pre-intervention and post-intervention functional MRI data.Findings In addition to demonstrating feasibility, only BE-SMART-DR showed pre-treatment to post-treatment improvements in DR regularity (Cohen’s d=0.55; 95% CI [0.06, 1.03]), associated with reductions in left amygdala responses to emotional face stimuli (pFWE (family-wise error)-SVC (small volume correction)<0.05), difficulties in emotion regulation (d=0.75; 95% CI [0.23, 1.25]) and suicide risk (d=0.65; 95% CI [0.15, 1.14]). …”
Get full text

Measurement and optimization of inductive elements in control systems of combined heat and power supply based on renewable energy sources by A. V. Volkov, A. M. Dobrenko, N. A. Drobnitskiy, A. A. Druzhinin, D. V. Mylkin, M. O. Sheykin

“…The actual state of the technology in this field is described and the functional concept of test current generators is presented. …”
Get full text

Cognitive weaknesses or impairments on the NIH toolbox cognition battery in children and adolescents: base rates in a normative sample and proposed methods for classification by Nathan E. Cook, Nathan E. Cook, Nathan E. Cook, Grant L. Iverson, Grant L. Iverson, Grant L. Iverson, Grant L. Iverson, Justin E. Karr

“…IntroductionThe National Institutes of Health Toolbox for Assessment of Neurological and Behavioral Function Cognition Battery (NIHTB-CB) is a brief neuropsychological battery for the assessment of crystalized (i.e., vocabulary and word reading) and fluid cognition (i.e., working memory, visual episodic memory, processing speed, and executive functions). …”
Get full text

Gully-ERFNet: a novel lightweight deep learning model for extracting erosion gullies in the black soil region of Northeast China by Qingyao Li, Jiuchun Yang, Jiaqi Wang, Zhi Li, Jianwei Fan, Liwei Ke, Xue Wang

“…We employed the Adaptive Correction Loss function to reduce the impact of incorrect labels on model performance. …”
Get full text

Characterization of shrouding supersonic gas-solid jet with different center pipe insertion depths and powder flow rates by Ceng Li, Guangsheng Wei, Rong Zhu, Fuhai Liu, Chengjin Han, Linghui Meng

“…The dual-function configuration maintains oxygen jet impact velocity while injecting lime powder via high-speed gas-solid jets toward the slag-metal interface, optimizing flux utilization efficiency. …”
Get full text

Association Between Visual Impairment and Daily Internet Use Among Older Japanese Individuals: Cross-Sectional Questionnaire Study by Atsuhide Takesue, Yoshimune Hiratsuka, Katsunori Kondo, Jun Aida, Atsushi Nakagomi, Shintaro Nakao

“… Abstract BackgroundOlder adults might not use computers due to psychological barriers, environmental barriers such as not owning a computer or lack of internet access, and health-related barriers such as difficulties with fine motor skills, low cognitive function, or low vision. …”
Get full text

The impact of a heat therapy intervention on pain and fibromyalgia symptoms in patients with fibromyalgia: a pilot study by Andrea L. Chadwick, Chloe Shi, Miranda McMillan, Josh Miller, Jinxiang Hu, Paige C. Geiger

“…IntroductionFM is characterized by widespread musculoskeletal pain and associated somatic symptoms including fatigue, cognitive difficulties, and problems with sleeping. Multidisciplinary treatment of fibromyalgia including pharmacologic and non-pharmacologic interventions are recommended to improve symptoms and physical functioning. …”
Get full text

Benefits and safety of gabapentinoids in chronic low back pain: A systematic review and meta-analysis of randomized controlled trials. by Harsha Shanthanna, Ian Gilron, Manikandan Rajarathinam, Rizq AlAmri, Sriganesh Kamath, Lehana Thabane, Philip J Devereaux, Mohit Bhandari

“…Functional and emotional improvements were reported by few studies and showed no significant improvements.…”
Get full text

Vaccination and its social and behavioural drivers in children with disability in Fiji by Susan Woolfenden, Nadia Badawi, Sarah Mcintyre, Israt Jahan, Gulam Khandaker, Kristine Macartney, Margie Danchin, Hayley Smithers-Sheedy, Donald Wilson, William May, Meru Sheel, Ilisapeci Tuibeqa, Rachel Devi, Litiana Volavola, Rosalie Power, Unise Vakaloloma, Sureni Perera, Lanieta Tuimabu

“…Caregivers were interviewed using a questionnaire to collect data on sociodemographic, functional characteristics (UNICEF’s child-functioning tool), child’s vaccination status according to Fiji’s National Immunisation Programme (NIP), and drivers of vaccination using the WHO-UNICEF Behavioural and Social Drivers Tool. …”
Get full text

Study protocol for a randomized controlled trial of Regulating Together (RT), a group therapy for emotion dysregulation in school-age autistic youth and their caregivers by Walker S. McKinney, Lauren J. Tadevich, Lauren M. Schmitt, Paul S. Horn, Jennnifer R. Ruberg, Susan W. White, Debra L. Reisinger, Karen W. Burkett, Shivali Sarawgi, Sungeun Kang, Rebecca C. Shaffer

“…Methods This is a five-year randomized controlled trial comparing Regulating Together to Achieving Independence and Mastery in School (AIMS), an active control condition targeting executive functioning difficulties, in an outpatient hospital setting. …”
Get full text

Sleep duration, sleep disturbances and skeletal muscle mass change over time: A population-based longitudinal analysis in Peru [version 4; peer review: 1 approved, 2 approved with... by Enrique S. Nuñez-del-Arco, Renzo A. Agurto-García, Rodrigo M. Carrillo-Larco, J. Jaime Miranda, Antonio Bernabe-Ortiz

“…Background The skeletal muscle has mainly a structural function and plays a role in human’s metabolism. Besides, the association between sleep quality and muscle mass, in the form of sarcopenia, has been reported. …”
Get full text

Speech sound discrimination in background noise across the lifespan: a comparative study in Mongolian gerbils and humans by Carolin Jüchter, Carolin Jüchter, Chieh-Ju Chi, Rainer Beutelmann, Rainer Beutelmann, Georg Martin Klump, Georg Martin Klump

“…Many elderly listeners have difficulties with speech-in-noise perception, even if auditory thresholds in quiet are normal. …”
Get full text

Next-generation immunotherapeutic approaches for blood cancers: Exploring the efficacy of CAR-T and cancer vaccines by Kiavash Hushmandi, Abbas Ali Imani Fooladi, Russel J. Reiter, Najma Farahani, Liping Liang, Amir Reza Aref, Noushin Nabavi, Mina Alimohammadi, Le Liu, Gautam Sethi

“…Challenges include the heterogeneous immune profiles of tumors, variability in antigen expression, difficulties in therapeutic delivery, T cell exhaustion, and reduced cytotoxic activity at the tumor site. …”
Get full text

Plasticity and Co-Factor-Dependent Structural Changes in the RecA Nucleoprotein Filament Studied by Small-Angle X-Ray Scattering (SAXS) Measurements and Molecular Modeling by Satomi Inaba-Inoue, Afra Sabei, Anne-Elisabeth Molza, Mara Prentiss, Tsutomu Mikawa, Hiroshi Sekiguchi, Chantal Prévost, Masayuki Takahashi

“…Structural analyses of protein filaments formed by self-assembly, such as actin, tubulin, or recombinase filaments, have suffered for decades from technical issues due to difficulties in crystallization, their large size, or the dynamic behavior inherent to their cellular function. …”
Get full text

Clinical management and diagnosis of CLN2 disease: consensus of the Brazilian experts group by Leticia Pereira de Brito Sampaio, Maria Luiza Giraldes de Manreza, André Pessoa, Juliana Gurgel-Giannetti, Ana Carolina Coan, Hélio van der Linden Júnior, Emília Katiane Embiruçu, Adélia Maria de Miranda Henriques-Souza, Fernando Kok

“…Enzyme replacement therapy with Cerliponase α is an innovative treatment approved in Brazil since 2018; it delays functional decline and provides quality of life. Given the difficulties for the diagnosis and treatment of rare diseases in our public health system, the early diagnosis of CLN2 needs improvement as enzyme replacement therapy is available and modifies the prognosis of patients.…”
Get full text

Initial co-ideation phase of a shared decision-making tool aimed at promoting physical activity in primary care: views expressed by patients, academics, and healthcare professional... by Maria Valle Ramirez-Duran, Lola Prieto-López, Cristina Antón-Rodríguez, Andrés García-Ramos, Diana Monge-Martín, Juan Gómez-Salgado, Juan Gómez-Salgado, Valle Coronado-Vázquez, Valle Coronado-Vázquez

“…Within the second topic, four other categories emerged: Functional value of SDM tools: personalisation, relevance, and shared responsibility; Collaborative dynamics between patients and professionals; Structural and relational barriers to shared decision-making such as time constraints in consultations and lack of training in motivational communication and Implementation difficulties related to digital literacy and access; Tailoring SDM tools: personalisation, inclusivity, and real-life applicability such simplifying the language, co-designing the tool with patients, and integrating it into routine clinical workflows were the recommended strategies to facilitate adoption.ConclusionThis initial co-ideation process revealed key user preferences and implementation challenges that should be considered when developing a shared decision-making tool for promoting physical activity in primary care. …”
Get full text