The impact of anabolic androgenic steroids abuse and type of training on left ventricular remodeling and function in competitive athletes by Ilić Ivan, Đorđević Vitomir, Stanković Ivan, Vlahović-Stipac Alja, Putniković Biljana, Babić Rade, Nešković Aleksandar N.

“…The aim of this study was to determine whether the use of anabolic androgenic steroids (AAS) could affect echocardiographic parameters of left ventricular (LV) morphology and function in elite strength and endurance athletes. …”
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STAT6 blockade ameliorates thyroid function in Graves’ disease via downregulation of the sodium/iodide symporter by Qian Yang, Qinnan Zhang, Fanfan Pan, Bingbing Zha

“…Finally, we confirm that transcription factor STAT6 can mediate NIS transcription and co-activator P100 protein can enhance STAT6-dependent transcriptional activation. Conclusion: In GD, TSAb induces STAT6 signaling to upregulate NIS expression, and STAT6 blockade ameliorates thyroid function via downregulation of the NIS. …”
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Causal links between iron status, mitochondrial function, and laryngeal and hypopharyngeal cancers: a Mendelian study by Jiandong Zhao, Liwei Chen, Bing Han, Siyang Li, Yongxia Zhang, Ge Gao, Jinjing Liu

“…Abstract Background This Mendelian randomization (MR) study aimed to investigate bidirectional causal relationships between genetically predicted iron homeostasis, mitochondrial function, and the risk of laryngeal and hypopharyngeal cancers. …”
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Functional characterization of conserved small open reading frames on the genomic RNA of sonchus yellow net virus by Mengxin Gao, Shuang Ni, Yaqin Wang, Zhenghe Li, Pan Gong, Xueping Zhou, Fangfang Li

“…Using the ORF prediction software ViralORFfinder, we found that SYNV genomic RNA (gRNA) might contain small putative open reading frames (sORFs). However, the functions of these additional sORFs remain largely unexplored. …”
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Effects of functional antioxidants on the expansion of gamma delta T-cells and their cellular cytotoxicity against bladder cancer cells by Yueh Pan, Hung-Jen Shih, Shu-Han Chuang, Chin-Pao Chang, Chi-Hao Hsiao, Ya-Hsu Chiu, Pai-Fu Wang, Chi-Chen Lin, Ping-Hsiao Shih

“…Thus, modulating ROS metabolism using antioxidants during naïve T-cell activation may promote the expansion and generation of functional T-cells. Notably, urothelial cancer is a sex-specific malignancy with high mortality rates worldwide. …”
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New Applications of Elliptic Functions and Integrals in GPS Inter-Satellite Communications with Account of General Relativity Theory by Bogdan Dimitrov

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Development and techno-functional characterization of gluten-free flour from rice, Cardaba banana, and pigeon-pea by Oluwadamilare Adedeji Adewole, Olusola Samuel Jolayemi, Helen Nwakego Ayo-Omogie, Adebanjo Ayobamidele Badejo

“…A biplots in the context of principal component analysis model with 78% explained variance (R2 = 0.78), graphically revealed the distinctive nutritional and functional attributes of each of the flour blend. Therefore, depending on the intended application, blends of rice, Cardaba banana, and pigeon pea flour at various percentages may result in a gluten-free flour with a range of nutritional and techno-functional properties.…”
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The role of structural and functional parameters in designing pathology-specific tDCS protocols for primary progressive aphasia by Sagarika Bhattacharjee, P. T. Sivakumar, Ganesan Venkatasubramanian, Kenichi Oishi, Kyrana Tsapkini, S. H. Annabel Chen, Brenda Rapp, John E. Desmond, T. N. Sathyaprabha, Kaviraja Udupa, Rajan Kashyap

“…Since tDCS current distribution depends on brain structure and function, variant-specific montages are essential. …”
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Quantitative longitudinal T2* mapping for assessing placental function and association with adverse pregnancy outcomes across gestation. by Matthias C Schabel, Victoria H J Roberts, Karen J Gibbins, Monica Rincon, Jessica E Gaffney, Aaron D Streblow, Adam M Wright, Jamie O Lo, Byung Park, Christopher D Kroenke, Kathryn Szczotka, Nathan R Blue, Jessica M Page, Kathy Harvey, Michael W Varner, Robert M Silver, Antonio E Frias

“…Existing methods for evaluating in vivo placental function fail to reliably detect pregnancies at-risk for adverse outcomes prior to maternal and/or fetal morbidity. …”
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Effects of exercise intervention on executive function in children with overweight and obesity: a systematic review and meta-analysis by Pengfei Wang, Ying Meng, Jinnian Tong, Tiance Jiang

“…Background Weight control in children depends on executive function. Previous studies have shown that exercise interventions can effectively improve children’s executive function. …”
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Role of collateral circulation in the recovery of left ventricular function after recanalization of chronic coronary total occlusion by A. G. Badoyan, D. A. Khelimsky, A. A. Baranov, N. R. Obedinskaya, T. A. Bergen, V. Yu. Usov, S. N. Manukyan, O. V. Krestyaninov

“…To obtain extended data on the impact of collateral circulation on the recovery of left ventricular (LV) function after recanalization of chronic coronary total occlusion (CTO), especially in patients with reduced left ventricle ejection fraction (LVEF).Material and methods. …”
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Classification of Cell Therapy Products by Cell Manipulation Degree and Functions Performed: Analysis of International Regulatory Approaches by M. A. Vodyakova, N. S. Pokrovsky, I. S. Semenova, V. A. Merkulov, E. V. Melnikova

“…The degree of processing (manipulation) of cells included in a cell product and the functions performed after administration (homologous/non-homologous use) determine the classification of the cell product as a transplant or an advanced therapy medicinal product (ATMP) and, hence, the regulatory aspects of the product’s life cycle. …”
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Interferon-γ Signaling in Eosinophilic Esophagitis Affects Epithelial Barrier Function and Programmed Cell DeathSummary by Megha Lal, Caitlin M. Burk, Ravi Gautam, Zoe Mrozek, Karina E. Canziani, Tina Trachsel, Jarad Beers, Margaret C. Carroll, Duncan M. Morgan, Amanda B. Muir, Wayne G. Shreffler, Melanie A. Ruffner

“…The functional impact of IFN-α and IFN-γ on epithelial cells was investigated using organoid models. …”
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Universal Nonthermal Power-law Distribution Functions from the Self-consistent Evolution of Collisionless Electrostatic Plasmas by Uddipan Banik, Amitava Bhattacharjee, Wrick Sengupta

“…Using a quasi-linear analysis of the perturbed Vlasov–Poisson equations, we show that the coarse-grained mean distribution function (DF), f _0 , follows a quasi-linear diffusion equation with a diffusion coefficient D ( v ) that depends on v through the plasma dielectric constant. …”
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Molecular mapping and functional validation of GLP-1R cholesterol binding sites in pancreatic beta cells by Affiong Ika Oqua, Kin Chao, Liliane El Eid, Lisa Casteller, Billy P Baxter, Alba Miguéns-Gómez, Sebastian Barg, Ben Jones, Jorge Bernardino de la Serna, Sarah L Rouse, Alejandra Tomas

“…Here, we unveil the detrimental effect of a high cholesterol diet on GLP-1R-dependent glucoregulation in vivo, and the improvement in GLP-1R function that a reduction in cholesterol synthesis using simvastatin exerts in pancreatic islets. …”
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IgG detection in human serum employing non-functionalized chromium doped zinc gallate nanoparticles by Zied Ferjaoui, Capucine Zimmer, Celina Matuszewska, Corinne Chanéac, Bruno Viana, Cédric Bouzigues, Daniel Scherman, Nathalie Mignet, Cyrille Richard

“…Based on these results, these non-functionalized nanoparticles were successfully used to develop a persistent luminescence-based sandwich immunoassay for autofluorescence-free detection of antigens in undiluted human serum samples, using rabbit IgG as a model antigen. …”
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Overexpression of Chromosome 21 miRNAs May Affect Mitochondrial Function in the Hearts of Down Syndrome Fetuses by Antonella Izzo, Rosanna Manco, Tiziana de Cristofaro, Ferdinando Bonfiglio, Rita Cicatiello, Nunzia Mollo, Marco De Martino, Rita Genesio, Mariastella Zannini, Anna Conti, Lucio Nitsch

“…Dosage-dependent upregulation of most of chromosome 21 (Hsa21) genes has been demonstrated in heart tissues of fetuses with Down syndrome (DS). …”
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EV‐Elute: A universal platform for the enrichment of functional surface marker‐defined extracellular vesicle subpopulations by Willemijn S. deVoogt, Rowan Frunt, Raul M. Leandro, Casper S. Triesscheijn, Bella Monica, Ioanna Paspali, Mark Tielemans, Jerney J. J. M. François, Cor W. Seinen, Olivier G. deJong, Sander A. A. Kooijmans

“…Given that surface molecules on EVs determine their interactions with their environment, EV functionality likely differs between subpopulations with varying surface compositions. …”
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Predictive Factors for Morphological and Functional Improvements in Long-Lasting Central Serous Chorioretinopathy Treated with Photodynamic Therapy by Maciej Gawęcki, Krzysztof Kiciński, Jan Kucharczuk, Monika Gołębiowska-Bogaj, Andrzej Grzybowski

“…The goal of our study was to evaluate the morphological and functional effects of PDT in patients with long-lasting CSCR and determine the related predictive factors for improvement. …”
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Polymer-Functionalized Magnetic Nanoparticles for Targeted Quercetin Delivery: A Potential Strategy for Colon Cancer Treatment by Júlia Borges de Macedo, Julia Narayana Schoroeder Bueno, Carla Cristine Kanunfre, José Ricardo de Arruda Miranda, Andris Figueiroa Bakuzis, Priscileila Colerato Ferrari

“…<b>Methods</b>: After FA-CS synthesis and 3² factorial design, polymer-functionalized MNPs were produced for quercetin loading, characterized, and evaluated by drug dissolution and cytotoxicity assay. …”
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