Effects of spironolactone and eplerenone on left ventricular diastolic function and neurohumoral factors in patients with heart failure by N. A. Nuritdinov, U. K. Kamilova

“…To study the effects  of spironolactone  and eplerenone on left ventricular diastolic function and neurohumoral factors in patients with heart failure (HF).Material and methods. …”
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MATHEMATICAL MODEL OF THE FUNCTIONING PROCESS OF A RUBBER BUSHING ON THE HOOKE AND SAINT-VENANT ELEMENTS’ BASIS by D. A. Tikhov-Tinnikov, V. S. Baradiev, A. I. Fedotov, A. V. Alekseev

“…The paper presents a mathematical description of the bushing simulation functioning results, accuracy of approach, areas of application of the mathematical model.Materials and methods. …”
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Patients with STEMI after Revascularization: Is There a Relationship Between Coronary Artery Lesion and Renal Function? by Anna V. Broniuk, Lesia V. Rasputina

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Disorders of the aggregation function of platelets against the background of a deficiency of certain vitamins and microelements in children by O. B. Gordeeva, A. V. Dobrotok, D. S. Ovchinnikov, M. A. Soloshenko, N. L. Aleshenko

“…The mechanisms of platelet activation are different. They depend on blood plasma composition, functional state and structure of both platelet membranes and functional state of endothelium. …”
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Dynamic Expression and Functional Implications of the Cell Polarity Gene, Dchs1, During Cardiac Development by Kathryn Byerly, Cayla Wolfe, Hannah Parris, Charlotte Griggs, Emily Wilson, Matthew Huff, Molly Griggs, Jordan Morningstar, Lilong Guo, Fulei Tang, Jan Guz, Taylor Petrucci, Ranan Phookan, Brian Loizzi, Cortney Gensemer, Russell A. Norris

“…Dachsous1 (Dchs1), an atypical cadherin linked to mitral valve prolapse, is a core planar cell polarity protein whose function in the developing heart has not been fully elucidated. …”
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Functional characterization of COMT genes in Chinese white pear (Pyrus bretschneideri) and their role in lignin synthesis by Xiaofeng Feng, Xiaofeng Feng, Xianang Wu, Xianang Wu, Jiayi Hong, Jiayi Hong, Zihui Guo, Zihui Guo, Yasmin Khan, Yasmin Khan, Dongyi Wei, Dongyi Wei, Honghong Fan, Honghong Fan, Yongping Cai, Yongping Cai

“…Although COMT has been extensively studied in model organisms, its function in pears remains less explored.ResultsIn this study, we identified 29 COMT genes in the pear variety ‘Dangshan Su’, classified into five subfamilies. …”
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Development of bombesin-tubulysin conjugates using multicomponent chemistry to functionalize both the payload and the homing peptide by Dayma Llanes, Robert Rennert, Paul Jänicke, Ibrahim Morgan, Leslie Reguera, Leslie Reguera, Daniel G. Rivera, Daniel G. Rivera, Manuel G. Ricardo, Manuel G. Ricardo, Ludger A. Wessjohann

“…In this study, we designed and synthesized novel PDCs by conjugating new thiol-functionalized tubulysin analogs (tubugis) to bombesin, a peptide ligand with a relevant role in cancer research. …”
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Ferroportin 1 depletion in neural stem cells promotes hippocampal neurogenesis and cognitive function in mice by Yiqian Ding, Shanshan Yao, Shuxin Guo, Wei Meng, Jie Li, Fudi Wang, Jianhua Zhang, Yan-Zhong Chang, Guofen Gao

“…In the adult brain, newborn granule cells continuously integrate into the hippocampal circuits, and fine-tuning the regulation of this process is crucial for improving hippocampal function. Iron is an essential element for the development and functionality of the brain. …”
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Proteolysis and volatile compounds in Mediterranean buffalo milk blue cheese: Quality determinants and functional peptides by Federica Della Cerra, Giuseppina Garro, Rosaria Cozzolino, Sabrina De Pascale, Mariapia Esposito, Gianluca Picariello, Simonetta Caira, Andrea Scaloni, Francesca Marino, Francesco Addeo

“…The identification of health-promoting peptides reinforces its potential as a functional food. Future studies should investigate the bioavailability and systemic activity of these peptides in vivo.…”
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Impaired Cerebral Hemodynamics in Asymptomatic Carotid Artery Stenosis Assessed by Resting-State Functional MRI by Kaio F. Secchinato, Pedro H. R. da Silva, Guilherme R. Rodrigues, Ana P. A. C. Ferreira, Octavio M. Pontes-Neto, Renata F. Leoni

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Single-cell transcriptomics reveals metabolic remodeling and functional specialization in the immune microenvironment of bone tumors by Jun Chen, Na Cui, Shao-Hui He, Chun-Yan Xia, Wei-Qing Li

“…Results We identified 12 major immune cell clusters with distinct functional and metabolic characteristics. Naïve T cells exhibited amino acid metabolism-dependent activation potential, whereas NK cells relied on lipid metabolism and the TCA cycle for cytotoxic activity. …”
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Impact of rheumatoid factors on the function of therapeutic monoclonals specific for PD-1/PD-L1 by Barry D. Hock, Liping Goddard, Lachlan J. Dobson, Sean A. MacPherson, John L. O’Donnell, Judith L. McKenzie, Alexander D. McLellan

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Development of a novel sugar-free functional beverage containing pistachio green hull extract by Maedeh Tavakoli, Mohsen Barzegar, Mohammad Ali Sahari, Narges Hosseinmardi

“…Total phenolic content (TPC) and IC50 were considered as dependent variables. The optimized formulation, based on maximum TPC and antioxidant activity, was identified, and sensory results indicated that functional beverage 1 (FB1, containing 8.0 % PGHE, 0.18 % stevia, 2.0 % mannitol, and 0.39 % w/v vanilla) is the best formulation. …”
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Recommendation of Electric Vehicle Charging Stations in Driving Situations Based on a Preference Objective Function by Dayeon Lee, Dong Sik Kim, Beom Jin Chung, Young Mo Chung

“…We first propose a preference objective function that considers the factors of distance, time, and fees, and then analyze the recommendation results based on both synthetic and real-world charging environments. …”
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Understanding the impact of moxifloxacin on immune function: Findings from cytokine analyses and immunological assays in mice. by Mehmood Ahmad, Naeem Rasool, Rana Muhammad Zahid Mushtaq, Sammina Mahmood, Abdur Rauf Khalid, Waqas Ahmad, Bilal Mahmood Beg, Mostafa A Abdel Maksoud, Abdul Aziz Alamri, Adeel Sattar

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A cytoplasmic new catalytic subunit of calcineurin in Trypanosoma cruzi and its molecular and functional characterization. by Patricio R Orrego, Héctor Olivares, Esteban M Cordero, Albert Bressan, Mauro Cortez, Hernán Sagua, Ivan Neira, Jorge González, José Franco da Silveira, Nobuko Yoshida, Jorge E Araya

“…In this study, we cloned a new isoform of the gene coding for CL strain catalytic subunit CaNA (TcCaNA2) and characterized it molecularly and functionally. There is one copy of the TcCaNA2 gene per haploid genome. …”
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Opinion dynamics of leaders and followers with multi-criteria influence functions for urban transport project application by Julius Selle, Rica Villarosa, Charldy Wenceslao, Dharyll Prince Abellana, Rhoda Namoco, John Kevin Padro, Lanndon Ocampo

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Simulating Solar Neighborhood Brown Dwarfs. I. The Luminosity Function above and below the Galactic Plane by Easton J. Honaker, John E. Gizis

“…We present the simulated luminosity function and its evolution with distance from the Galactic plane. …”
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Exploring the Impact of Magnetic Water on the Physiological and Functional Parameters of Maize as a Vital Industrial Crop by Hamid Bakhtiari, Mohsen Okhovat

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Alterations in Human Hippocampus Subregions across the Lifespan: Reflections on White Matter Structure and Functional Connectivity by Jianling Tan, Zhongyan Wang, Yi Tang, Yin Tian

“…However, age-related changes of hippocampus subregions on structure and function are still unclear. Here, we investigated age-related structural and functional characteristics of 106 participants (7-85 years old) in resting state based on fractional anisotropy (FA) and functional connectivity (FC) in aHipp and pHipp in the lifespan. …”
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