Targeted delivery of a phosphoinositide 3‐kinase γ inhibitor to restore organ function in sepsis by Adrian T Press, Petra Babic, Bianca Hoffmann, Tina Müller, Wanling Foo, Walter Hauswald, Jovana Benecke, Martina Beretta, Zoltán Cseresnyés, Stephanie Hoeppener, Ivo Nischang, Sina M Coldewey, Markus H Gräler, Reinhard Bauer, Falk Gonnert, Nikolaus Gaßler, Reinhard Wetzker, Marc Thilo Figge, Ulrich S Schubert, Michael Bauer

“…Applying this strategy to a murine model of sepsis, we observed the PI3Kγ‐dependent restoration of biliary canalicular architecture, maintained excretory liver function, and improved survival without impairing host defense mechanisms. …”
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GDNF overexpression in astrocytes enhances branching and partially preserves hippocampal function in an Alzheimer’s rat model by Ana Abril Vidal Escobedo, Facundo Peralta, Gustavo Ramón Morel, Martino Avallone, Tomas Björklund, Paula Cecilia Reggiani, Joaquín Pardo

“…These findings demonstrate the capacity of the AAV-GFAP-GDNF-TdTom construct to induce astrocytic branching and partially preserve memory function. They also underscore its partial therapeutic potential in a neuroinflammatory, metabolically compromised and neurodegenerative context.…”
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Concurrent optoacoustic tomography and magnetic resonance imaging of resting-state functional connectivity in the mouse brain by Irmak Gezginer, Zhenyue Chen, Hikari A. I. Yoshihara, Xosé Luís Deán-Ben, Valerio Zerbi, Daniel Razansky

“…Although functional magnetic resonance imaging (fMRI) remains a cornerstone in the field of rsFC recordings, its interpretation is often hindered by the convoluted physiological origin of the blood-oxygen-level-dependent (BOLD) contrast affected by multiple factors. …”
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Three anti-inflammatory polysaccharides from Lonicera japonica Thunb.: insights into the structure-function relationships by Yu Liu, Hongjing Dong, Dongxiao Sun-Waterhouse, Wenwen Li, Bin Zhang, Jinqian Yu, Zhichang Qiu, Zhenjia Zheng

“…The three polysaccharides differed in chemical composition, molecular weight (Mw) distribution, glycosidic linkage pattern, functional groups and morphology. They exhibited excellent protective effects (in a dose-dependent manner) in lipopolysaccharide-injured RAW264.7 macrophages and CuSO4-damaged zebrafish via reducing NO production and inhibiting the overexpressions of inflammation-related transcription factors, inflammatory proteins and cytokines in the NF-κB/MAPK signaling pathways. …”
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Function and firing of the Streptomyces coelicolor contractile injection system requires the membrane protein CisA by Bastien Casu, Joseph W Sallmen, Peter E Haas, Govind Chandra, Pavel Afanasyev, Jingwei Xu, Martin Pilhofer, Susan Schlimpert

“…We show by cryo-electron tomography imaging and in vivo assays that CISSc contraction and function depend on CisA. Using single-particle cryo-electron microscopy, we provide an atomic model of the extended CISSc apparatus; however, CisA is not part of the complex. …”
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APOE4 and sedentary lifestyle synergistically impair neurovascular function in the visual cortex of awake mice by Silvia Anderle, Orla Bonnar, Joseph Henderson, Kira Shaw, Andre M. Chagas, Letitia McMullan, Alexandra Webber, Kirsty McGowan, Sarah L. King, Catherine N. Hall

“…Energy supply and demand are mismatched in APOE4 mice, with smaller increases in cerebral blood flow, blood volume and blood oxygenation occurring during neuronal activation as blood vessels frequently fail to dilate. Exercise dose-dependently overall improves neurovascular function, with an increased impact of exercise apparent after longer exposure times. …”
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Research regarding the subjective improvement of knee joint function after treatment with hydrolysed collagen formulation by Iliuță Daniel, Daniela Tarnita, Mihai Mesina, Bogdan Capitanescu, Ovidiu Zlatian, Dănuț Nicolae Tarniță

“…The hydrolysed collagen formulation had alleviated the pain at the level of knee joint and improved the subjective joint functionality expressed through the WOMAC index after 6 months of administration on all subgroups of patients depending on sex, weight and age. …”
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Probiotic Bifidobacterium bifidum strains desialylate MUC13 and increase intestinal epithelial barrier function by Celia Segui-Perez, Liane Z. X. Huang, Fernanda L. Paganelli, Elke Lievens, Karin Strijbis

“…Here, we screened probiotic bacterial strains for their capacity to modulate MUC13 and enhance intestinal barrier function. Of these probiotic bacteria, a Bifidobacterium bifidum strain uniquely degraded the MUC13 O-glycosylated extracellular domain. …”
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MS CETSA deep functional proteomics uncovers DNA repair programs leading to gemcitabine resistance by Ying Yu Liang, Khalidah Khalid, Hai Van Le, Hui Min Vivian Teo, Mindaugas Raitelaitis, Marc-Antoine Gerault, Jane Jia Hui Lee, Jiawen Lyu, Allison Chan, Anand Devaprasath Jeyasekharan, Wai Leong Tam, Pär Nordlund, Nayana Prabhu

“…Here we use a deep functional proteomics implementation of the Cellular Thermal Shift Assay to reveal a range of induced biochemical responses to gemcitabine in resistant and sensitive diffuse large B cell lymphoma cell lines. …”
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Functional Brain Network Disruptions in Parkinson’s Disease: Insights from Information Theory and Machine Learning by Ömer Akgüller, Mehmet Ali Balcı, Gabriela Cioca

“…Functional networks were constructed using the Nonlinear Autoregressive Distributed Lag (NARDL) model, which captures nonlinear and asymmetric dependencies between regions of interest (ROIs). …”
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Metaphor Functioning in Military Discourse and Ways of Its Translation into Russian (on Material of English-language Periodicals) by K. A. Degtyarenko, E. V. Kuritskaya

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Characterization of analog rice produced from various carbohydrate sources and their functional components: a review by Dwi Ghina Nadhifa, Meta Mahendradatta, Ariny Poespitasari, Februadi Bastian, Andi Yuyun Adhnitasari

“…Research on analog rice has shown that analog rice has different characteristics and functional benefits that are influenced by the raw materials used. …”
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The modern view of the idea of gamma-aminobutyric acid and its metabolite use to restore the motor function by А. G. Rodinskij, Т. V. Dемchenko, A. V. Моzgunov, К. V. Pysarevska

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The Armadillo repeat protein PF16 is essential for flagellar structure and function in Plasmodium male gametes. by Ursula Straschil, Arthur M Talman, David J P Ferguson, Karen A Bunting, Zhengyao Xu, Elizabeth Bailes, Robert E Sinden, Anthony A Holder, Elizabeth F Smith, Juliet C Coates, Rita Tewari

“…Very little is known about the identity or function of proteins in the parasite's flagellar biology. …”
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Cerebrospinal fluid concentration of brain-derived neurotrophic factor and cognitive function in non-demented subjects. by Ge Li, Elaine R Peskind, Steven P Millard, Peter Chi, Izabela Sokal, Chang-En Yu, Lynn M Bekris, Murray A Raskind, Douglas R Galasko, Thomas J Montine

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The Effect of Grazing on Central Anatolian Steppe Vegetation: A Modeling Approach Using Functional Traits by Anıl Bahar, Çağatay Tavşanoğlu

“…Our simulations incorporated a range of plant functional traits to predict changes across five different vegetation types in Central Anatolia, including woodland steppes and treeless steppes. …”
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Identification of methionine metabolism related prognostic model and tumor suppressive functions of BHMT in hepatocellular carcinoma by Wenli Liu, Kaiheng Hu, Yaqing Fu, Tianmin Zhou, Qingmei Zhong, Wu Wang, Yang Gui, Ping Zhang, Di Yao, Xiaohong Yang, Weifeng Zhu, Zhuoqi Liu, Daya Luo, Yingqun Xiao

“…In summary, this study innovatively provides first methionine metabolism-related prognostic model and unveils the tumor suppressive function of BHMT in HCC, providing potential mechanism by which BHMT exert its function.…”
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Exploring the Addition of Mango Peel in Functional Semolina Sourdough Bread Production for Sustainable Bio-Reuse by María Eugenia Chulibert, Pasquale Roppolo, Carla Buzzanca, Antonio Alfonzo, Enrico Viola, Lino Sciurba, Ilenia Tinebra, Angela D’Amico, Vittorio Farina, Daniela Piazzese, Vita Di Stefano, Marcella Barbera, Raimondo Gaglio, Luca Settanni

“…In an effort to repurpose mango peel, this study dehydrated it to create mango peel powder (MPP), which was then incorporated into sourdough bread to produce functional breads with enhanced nutritional value. Semolina was replaced with MPP at levels of 5% (MPP-5) and 10% (MPP-10) (<i>w</i>/<i>w</i>). …”
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Morpho-functional groups as an efficient tool for monitoring and management of the Billings reservoir (São Paulo, Brazil) by Ana Carolina Peixoto Chamizo, Cacilda Thais Janson Mercante, Munique de Almeida Bispo Moraes, Clóvis Ferreira do Carmo, Matheus Barbosa Herbst de Oliveira, João Alexandre Saviolo Osti

“…This research applied the Morphology-Based Functional Groups (MBFGs) combined with classical approaches, such as community descriptor species and phytoplankton classes in the Billings reservoir. …”
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Evaluating the hepatoprotective effects of polyherbal extracts a comprehensive study on liver function and health in rat by A.A. Ammari, A.R. Alhimaidi, R.A. Amran, A. Rady, H. aljawdah, F. Al-Mekhlafi

“…Liver enzyme levels (ALT, AST, ALP) were measured to assess liver function, and histopathological examinations were conducted to evaluate liver tissue integrity. …”
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